Motif ID: Mef2c

Z-value: 0.586


Transcription factors associated with Mef2c:

Gene SymbolEntrez IDGene Name
Mef2c ENSMUSG00000005583.10 Mef2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2cmm10_v2_chr13_+_83504032_83504050-0.038.7e-01Click!


Activity profile for motif Mef2c.

activity profile for motif Mef2c


Sorted Z-values histogram for motif Mef2c

Sorted Z-values for motif Mef2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 175 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_69785507 2.706 ENSMUST00000182993.1
 Ank3
ankyrin 3, epithelial
chr12_-_34528844 2.329 ENSMUST00000110819.2
 Hdac9
histone deacetylase 9
chr4_+_144892813 1.875 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr13_+_16011851 1.728 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr3_-_85722474 1.593 ENSMUST00000119077.1
 Fam160a1
family with sequence similarity 160, member A1
chr4_+_144893077 1.574 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr5_+_66745835 1.570 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr19_-_5802640 1.529 ENSMUST00000173523.1
ENSMUST00000173499.1
ENSMUST00000172812.2
 Malat1


metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)


chr1_-_64122256 1.453 ENSMUST00000135075.1
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr14_+_101840501 1.422 ENSMUST00000159026.1
 Lmo7
LIM domain only 7
chr7_+_112742025 1.396 ENSMUST00000164363.1
 Tead1
TEA domain family member 1
chrX_-_51681856 1.356 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr14_+_101840602 1.345 ENSMUST00000159314.1
 Lmo7
LIM domain only 7
chrX_-_51681703 1.339 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr4_+_144893127 1.213 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr6_+_108213086 1.114 ENSMUST00000032192.6
 Itpr1
inositol 1,4,5-trisphosphate receptor 1
chr1_-_64121389 0.957 ENSMUST00000055001.3
 Klf7
Kruppel-like factor 7 (ubiquitous)
chr5_-_122002340 0.951 ENSMUST00000134326.1
 Cux2
cut-like homeobox 2
chr4_+_46039202 0.928 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr6_+_112273758 0.887 ENSMUST00000032376.5
 Lmcd1
LIM and cysteine-rich domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 4.7 GO:0042572 retinol metabolic process(GO:0042572)
0.4 2.7 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 2.5 GO:0048813 dendrite morphogenesis(GO:0048813)
0.2 2.3 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
0.3 1.7 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 1.5 GO:0035063 nuclear speck organization(GO:0035063)
0.1 1.5 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.1 1.4 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 1.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 1.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.0 GO:0007614 short-term memory(GO:0007614)
0.3 0.9 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.2 0.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.2 0.9 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.0 0.8 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.8 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 0.8 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 2.7 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 2.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.6 1.7 GO:0043512 inhibin A complex(GO:0043512)
0.1 1.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.3 1.4 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 1.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 1.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.9 GO:0010369 chromocenter(GO:0010369)
0.0 0.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.6 GO:0031941 filamentous actin(GO:0031941)
0.1 0.5 GO:0090537 CERF complex(GO:0090537)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 GO:0030507 spectrin binding(GO:0030507)
0.7 4.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.7 2.7 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 2.6 GO:0042805 actinin binding(GO:0042805)
0.4 2.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 1.5 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.4 1.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 1.1 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 1.0 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 0.9 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 0.8 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.8 GO:0070410 co-SMAD binding(GO:0070410)
0.2 0.7 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.7 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.7 PID_ALK1_PATHWAY ALK1 signaling events
0.0 1.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.2 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 1.7 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.0 1.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.4 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.0 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.8 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.8 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.0 0.3 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.0 0.3 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.2 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 0.2 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling