Motif ID: Mef2d_Mef2a

Z-value: 1.437

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142328_881424830.464.1e-03Click!
Mef2amm10_v2_chr7_-_67372846_673728580.192.7e-01Click!


Activity profile for motif Mef2d_Mef2a.

activity profile for motif Mef2d_Mef2a


Sorted Z-values histogram for motif Mef2d_Mef2a

Sorted Z-values for motif Mef2d_Mef2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83573577 17.334 ENSMUST00000185052.1
 Mef2c
myocyte enhancer factor 2C
chr13_-_113663670 12.820 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr13_+_5861489 12.235 ENSMUST00000000080.6
 Klf6
Kruppel-like factor 6
chr9_-_112232449 11.196 ENSMUST00000035085.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr5_+_24985840 11.086 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr5_-_128953303 9.164 ENSMUST00000111346.1
 Rimbp2
RIMS binding protein 2
chr9_+_34904913 8.809 ENSMUST00000045091.6
 Kirrel3
kin of IRRE like 3 (Drosophila)
chr11_+_111066154 8.231 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr6_-_136171722 8.019 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_-_83649349 7.843 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr1_+_75375271 7.577 ENSMUST00000087122.5
 Speg
SPEG complex locus
chr19_+_38264761 7.441 ENSMUST00000087252.5
 Lgi1
leucine-rich repeat LGI family, member 1
chr1_-_134234492 6.736 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr7_+_91090697 6.454 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 6.349 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr3_-_20155069 5.981 ENSMUST00000184552.1
ENSMUST00000178328.1
 Gyg

glycogenin

chr6_+_137410721 5.237 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr6_+_121300227 4.803 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr10_+_90576872 4.794 ENSMUST00000182550.1
ENSMUST00000099364.5
 Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_+_101840501 4.717 ENSMUST00000159026.1
 Lmo7
LIM domain only 7

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 130 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.5 GO:0034605 cellular response to heat(GO:0034605)
5.8 17.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.9 12.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.0 11.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
1.5 9.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.8 8.8 GO:0002121 inter-male aggressive behavior(GO:0002121)
2.9 8.7 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.2 8.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
1.7 8.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
2.0 8.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.9 7.8 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 7.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 7.6 GO:0060541 respiratory system development(GO:0060541)
2.2 6.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.0 6.7 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.0 6.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.8 5.9 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 5.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
1.0 5.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.7 4.8 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 19.8 GO:0016607 nuclear speck(GO:0016607)
0.1 18.3 GO:0001650 fibrillar center(GO:0001650)
0.6 12.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.7 12.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 12.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 11.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 10.3 GO:0016605 PML body(GO:0016605)
0.0 8.5 GO:0030426 growth cone(GO:0030426)
2.8 8.3 GO:0043512 inhibin A complex(GO:0043512)
0.4 8.3 GO:0032279 asymmetric synapse(GO:0032279)
0.4 7.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 6.4 GO:0005814 centriole(GO:0005814)
0.1 6.1 GO:0043198 dendritic shaft(GO:0043198)
1.6 4.7 GO:0045160 myosin I complex(GO:0045160)
0.0 4.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.8 4.6 GO:0035976 AP1 complex(GO:0035976)
0.1 3.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.9 3.6 GO:0090537 CERF complex(GO:0090537)
0.0 3.5 GO:0015630 microtubule cytoskeleton(GO:0015630)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 17.3 GO:0035198 miRNA binding(GO:0035198)
0.1 13.3 GO:0005516 calmodulin binding(GO:0005516)
0.5 12.8 GO:0004385 guanylate kinase activity(GO:0004385)
1.2 12.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.7 10.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 10.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
2.3 9.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.5 9.0 GO:0030275 LRR domain binding(GO:0030275)
1.0 8.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.3 8.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 7.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 7.0 GO:0042805 actinin binding(GO:0042805)
1.0 6.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.0 6.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 6.2 GO:0030165 PDZ domain binding(GO:0030165)
0.7 6.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 5.7 GO:0008017 microtubule binding(GO:0008017)
0.1 5.6 GO:0042562 hormone binding(GO:0042562)
0.2 5.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.3 5.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 22.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 13.0 PID_FGF_PATHWAY FGF signaling pathway
0.3 11.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 11.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.3 8.3 PID_ALK1_PATHWAY ALK1 signaling events
0.2 8.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.3 7.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 7.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.3 3.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 3.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.1 1.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 16.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.4 10.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 10.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 9.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 8.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
2.1 8.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 7.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 7.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 6.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.3 4.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.4 4.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 4.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 4.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 4.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 4.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 3.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 3.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 2.9 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis