Motif ID: Mef2d_Mef2a

Z-value: 1.437

Transcription factors associated with Mef2d_Mef2a:

Gene SymbolEntrez IDGene Name
Mef2a ENSMUSG00000030557.10 Mef2a
Mef2d ENSMUSG00000001419.11 Mef2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mef2dmm10_v2_chr3_+_88142328_881424830.464.1e-03Click!
Mef2amm10_v2_chr7_-_67372846_673728580.192.7e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_83573577 17.334 ENSMUST00000185052.1
Mef2c
myocyte enhancer factor 2C
chr13_-_113663670 12.820 ENSMUST00000054650.4
Hspb3
heat shock protein 3
chr13_+_5861489 12.235 ENSMUST00000000080.6
Klf6
Kruppel-like factor 6
chr9_-_112232449 11.196 ENSMUST00000035085.5
Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr5_+_24985840 11.086 ENSMUST00000075081.6
1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr5_-_128953303 9.164 ENSMUST00000111346.1
Rimbp2
RIMS binding protein 2
chr9_+_34904913 8.809 ENSMUST00000045091.6
Kirrel3
kin of IRRE like 3 (Drosophila)
chr11_+_111066154 8.231 ENSMUST00000042970.2
Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr6_-_136171722 8.019 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_-_83649349 7.843 ENSMUST00000001008.5
Ccl3
chemokine (C-C motif) ligand 3
chr1_+_75375271 7.577 ENSMUST00000087122.5
Speg
SPEG complex locus
chr19_+_38264761 7.441 ENSMUST00000087252.5
Lgi1
leucine-rich repeat LGI family, member 1
chr1_-_134234492 6.736 ENSMUST00000169927.1
Adora1
adenosine A1 receptor
chr7_+_91090697 6.454 ENSMUST00000107196.2
Dlg2
discs, large homolog 2 (Drosophila)
chr7_+_91090728 6.349 ENSMUST00000074273.3
Dlg2
discs, large homolog 2 (Drosophila)
chr3_-_20155069 5.981 ENSMUST00000184552.1
ENSMUST00000178328.1
Gyg

glycogenin

chr6_+_137410721 5.237 ENSMUST00000167002.1
Ptpro
protein tyrosine phosphatase, receptor type, O
chr6_+_121300227 4.803 ENSMUST00000064580.7
Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr10_+_90576872 4.794 ENSMUST00000182550.1
ENSMUST00000099364.5
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr14_+_101840501 4.717 ENSMUST00000159026.1
Lmo7
LIM domain only 7
chr11_+_75655873 4.716 ENSMUST00000108431.2
Myo1c
myosin IC
chrX_-_51681703 4.707 ENSMUST00000088172.5
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr2_+_118663235 4.659 ENSMUST00000099557.3
Pak6
p21 protein (Cdc42/Rac)-activated kinase 6
chr13_+_42680565 4.638 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chrX_-_51681856 4.580 ENSMUST00000114871.1
Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr14_+_101840602 4.491 ENSMUST00000159314.1
Lmo7
LIM domain only 7
chr9_-_49798905 4.376 ENSMUST00000114476.2
Ncam1
neural cell adhesion molecule 1
chr9_-_49798729 4.358 ENSMUST00000166811.2
Ncam1
neural cell adhesion molecule 1
chr9_-_77347816 4.321 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
Mlip



muscular LMNA-interacting protein



chr14_-_66280949 4.260 ENSMUST00000111121.1
ENSMUST00000022622.7
ENSMUST00000089250.2
Ptk2b


PTK2 protein tyrosine kinase 2 beta


chr13_+_16011851 4.238 ENSMUST00000042603.6
Inhba
inhibin beta-A
chr12_+_69241832 4.180 ENSMUST00000063445.6
Klhdc1
kelch domain containing 1
chr3_+_68584154 4.178 ENSMUST00000182997.1
Schip1
schwannomin interacting protein 1
chr17_-_67950908 4.140 ENSMUST00000164647.1
Arhgap28
Rho GTPase activating protein 28
chr13_+_16014457 4.073 ENSMUST00000164993.1
Inhba
inhibin beta-A
chr14_+_101729907 3.948 ENSMUST00000100337.3
Lmo7
LIM domain only 7
chr16_+_7069825 3.850 ENSMUST00000056416.7
Rbfox1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr14_-_64455903 3.812 ENSMUST00000067927.7
Msra
methionine sulfoxide reductase A
chr19_-_46327121 3.731 ENSMUST00000041391.4
ENSMUST00000096029.5
Psd

pleckstrin and Sec7 domain containing

chr9_-_112187766 3.534 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr9_-_77347787 3.440 ENSMUST00000184848.1
ENSMUST00000184415.1
Mlip

muscular LMNA-interacting protein

chr3_-_56183678 3.351 ENSMUST00000029374.6
Nbea
neurobeachin
chr2_+_72054598 3.342 ENSMUST00000028525.5
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_152766281 3.338 ENSMUST00000111859.1
ENSMUST00000148865.1
Rgl1

ral guanine nucleotide dissociation stimulator,-like 1

chr5_+_75152274 3.330 ENSMUST00000000476.8
Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chr9_+_104566677 3.321 ENSMUST00000157006.1
Cpne4
copine IV
chr9_+_99629496 3.299 ENSMUST00000131095.1
ENSMUST00000078367.5
ENSMUST00000112885.2
Dzip1l


DAZ interacting protein 1-like


chr9_-_112187898 3.256 ENSMUST00000178410.1
ENSMUST00000172380.3
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr3_+_96596628 3.169 ENSMUST00000058943.7
Ankrd34a
ankyrin repeat domain 34A
chr1_-_64122256 3.146 ENSMUST00000135075.1
Klf7
Kruppel-like factor 7 (ubiquitous)
chr9_+_99629823 3.070 ENSMUST00000112886.2
Dzip1l
DAZ interacting protein 1-like
chr15_+_101266839 3.033 ENSMUST00000023779.6
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr13_+_23934434 3.030 ENSMUST00000072391.1
Hist1h2aa
histone cluster 1, H2aa
chr5_+_66745835 2.952 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
Limch1



LIM and calponin homology domains 1



chr2_+_19658055 2.912 ENSMUST00000052168.4
Otud1
OTU domain containing 1
chrX_-_59568068 2.903 ENSMUST00000119833.1
ENSMUST00000131319.1
Fgf13

fibroblast growth factor 13

chr2_-_57124003 2.888 ENSMUST00000112629.1
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr19_-_5924797 2.823 ENSMUST00000055458.4
Cdc42ep2
CDC42 effector protein (Rho GTPase binding) 2
chr9_-_110742577 2.813 ENSMUST00000006005.7
Pth1r
parathyroid hormone 1 receptor
chr9_-_70141484 2.792 ENSMUST00000034749.8
Fam81a
family with sequence similarity 81, member A
chr8_+_76902277 2.766 ENSMUST00000109912.1
ENSMUST00000128862.1
ENSMUST00000109911.1
Nr3c2


nuclear receptor subfamily 3, group C, member 2


chr17_+_70522083 2.763 ENSMUST00000148486.1
ENSMUST00000133717.1
Dlgap1

discs, large (Drosophila) homolog-associated protein 1

chr19_-_37176055 2.758 ENSMUST00000142973.1
ENSMUST00000154376.1
Cpeb3

cytoplasmic polyadenylation element binding protein 3

chr12_-_112929415 2.688 ENSMUST00000075827.3
Jag2
jagged 2
chr2_-_168712853 2.659 ENSMUST00000123156.1
ENSMUST00000156555.1
Atp9a

ATPase, class II, type 9A

chr15_-_95528228 2.620 ENSMUST00000075275.2
Nell2
NEL-like 2
chr2_-_65022740 2.583 ENSMUST00000028252.7
Grb14
growth factor receptor bound protein 14
chr7_-_127824469 2.563 ENSMUST00000106267.3
Stx1b
syntaxin 1B
chr18_+_60963517 2.546 ENSMUST00000115295.2
ENSMUST00000039904.6
Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr14_-_93888732 2.529 ENSMUST00000068992.2
Pcdh9
protocadherin 9
chr9_-_77347889 2.515 ENSMUST00000185039.1
Mlip
muscular LMNA-interacting protein
chr4_-_95052188 2.490 ENSMUST00000107094.1
Jun
Jun oncogene
chr6_+_58831748 2.473 ENSMUST00000126292.1
ENSMUST00000031823.5
Herc3

hect domain and RLD 3

chr14_-_36919314 2.454 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr1_-_172297989 2.452 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr18_+_67464849 2.442 ENSMUST00000025411.7
Slmo1
slowmo homolog 1 (Drosophila)
chr4_+_5724304 2.356 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr9_-_101198999 2.339 ENSMUST00000066773.7
Ppp2r3a
protein phosphatase 2, regulatory subunit B'', alpha
chr8_-_24438937 2.337 ENSMUST00000052622.4
1810011O10Rik
RIKEN cDNA 1810011O10 gene
chr2_-_77703252 2.225 ENSMUST00000171063.1
Zfp385b
zinc finger protein 385B
chr17_-_45592569 2.220 ENSMUST00000163492.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr3_+_138065052 2.217 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr11_-_107716517 2.214 ENSMUST00000021065.5
Cacng1
calcium channel, voltage-dependent, gamma subunit 1
chr14_-_36919513 2.212 ENSMUST00000182042.1
Ccser2
coiled-coil serine rich 2
chr11_+_31872100 2.196 ENSMUST00000020543.6
ENSMUST00000109412.2
Cpeb4

cytoplasmic polyadenylation element binding protein 4

chr11_+_116532441 2.184 ENSMUST00000106386.1
ENSMUST00000145737.1
ENSMUST00000155102.1
ENSMUST00000063446.6
Sphk1



sphingosine kinase 1



chr5_+_33018816 2.157 ENSMUST00000019109.7
Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr7_-_16874845 2.146 ENSMUST00000181501.1
9330104G04Rik
RIKEN cDNA 9330104G04 gene
chr15_+_25940846 2.110 ENSMUST00000110438.1
Fam134b
family with sequence similarity 134, member B
chr4_-_95052170 2.093 ENSMUST00000058555.2
Jun
Jun oncogene
chr12_+_108334341 2.086 ENSMUST00000021684.4
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
chr18_+_76059458 2.055 ENSMUST00000167921.1
Zbtb7c
zinc finger and BTB domain containing 7C
chr3_+_68869563 1.986 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr10_-_69212996 1.944 ENSMUST00000170048.1
A930033H14Rik
RIKEN cDNA A930033H14 gene
chrX_-_59567348 1.923 ENSMUST00000124402.1
Fgf13
fibroblast growth factor 13
chr2_-_25469742 1.895 ENSMUST00000114259.2
ENSMUST00000015234.6
Ptgds

prostaglandin D2 synthase (brain)

chr2_-_27027909 1.848 ENSMUST00000102890.4
ENSMUST00000153388.1
ENSMUST00000045702.5
Slc2a6


solute carrier family 2 (facilitated glucose transporter), member 6


chr6_-_138422898 1.828 ENSMUST00000161450.1
ENSMUST00000163024.1
ENSMUST00000162185.1
Lmo3


LIM domain only 3


chr1_-_64121389 1.815 ENSMUST00000055001.3
Klf7
Kruppel-like factor 7 (ubiquitous)
chr6_+_116650674 1.787 ENSMUST00000067354.5
ENSMUST00000178241.1
8430408G22Rik

RIKEN cDNA 8430408G22 gene

chr2_+_32625431 1.786 ENSMUST00000113277.1
Ak1
adenylate kinase 1
chr16_-_57754707 1.769 ENSMUST00000089332.4
Col8a1
collagen, type VIII, alpha 1
chr4_-_9643638 1.765 ENSMUST00000108333.1
ENSMUST00000108334.1
ENSMUST00000108335.1
ENSMUST00000152526.1
ENSMUST00000103004.3
Asph




aspartate-beta-hydroxylase




chr14_+_65968483 1.761 ENSMUST00000022616.6
Clu
clusterin
chr5_+_138280516 1.719 ENSMUST00000048028.8
Stag3
stromal antigen 3
chr18_-_38601268 1.703 ENSMUST00000025295.6
Spry4
sprouty homolog 4 (Drosophila)
chr13_-_107890059 1.699 ENSMUST00000105097.2
Zswim6
zinc finger SWIM-type containing 6
chr1_+_177445660 1.695 ENSMUST00000077225.6
Zbtb18
zinc finger and BTB domain containing 18
chr5_+_19907774 1.681 ENSMUST00000115267.2
Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_-_24842579 1.674 ENSMUST00000030787.8
Rheb
Ras homolog enriched in brain
chr5_-_51553896 1.623 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr2_+_107290590 1.609 ENSMUST00000037012.2
Kcna4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr4_+_62663620 1.602 ENSMUST00000126338.1
Rgs3
regulator of G-protein signaling 3
chr17_-_45592485 1.600 ENSMUST00000166119.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr5_+_138280538 1.589 ENSMUST00000162245.1
ENSMUST00000161691.1
Stag3

stromal antigen 3

chr3_-_103737995 1.557 ENSMUST00000029440.8
Olfml3
olfactomedin-like 3
chr6_-_34317442 1.552 ENSMUST00000154655.1
ENSMUST00000102980.4
Akr1b3

aldo-keto reductase family 1, member B3 (aldose reductase)

chr2_-_25470031 1.551 ENSMUST00000114251.1
Ptgds
prostaglandin D2 synthase (brain)
chr13_+_102693522 1.532 ENSMUST00000022124.3
ENSMUST00000171267.1
ENSMUST00000167144.1
ENSMUST00000170878.1
Cd180



CD180 antigen



chr13_-_102906046 1.532 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr9_-_75599124 1.501 ENSMUST00000098552.2
Tmod2
tropomodulin 2
chr6_-_128124312 1.471 ENSMUST00000127105.1
Tspan9
tetraspanin 9
chr10_-_25200110 1.398 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr17_+_85028347 1.398 ENSMUST00000024944.7
Slc3a1
solute carrier family 3, member 1
chr16_+_45093611 1.394 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr6_+_55336424 1.384 ENSMUST00000004774.3
Aqp1
aquaporin 1
chr2_+_91096744 1.379 ENSMUST00000132741.2
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chrX_-_47892502 1.373 ENSMUST00000077569.4
ENSMUST00000101616.2
ENSMUST00000088973.4
Smarca1


SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1


chr8_-_46080284 1.365 ENSMUST00000177186.1
Snx25
sorting nexin 25
chr8_-_71671723 1.363 ENSMUST00000177517.1
ENSMUST00000030170.8
Unc13a

unc-13 homolog A (C. elegans)

chr8_+_119666498 1.357 ENSMUST00000024107.5
Wfdc1
WAP four-disulfide core domain 1
chr1_+_134193432 1.322 ENSMUST00000038445.6
Mybph
myosin binding protein H
chr2_-_164833438 1.317 ENSMUST00000042775.4
Neurl2
neuralized-like 2 (Drosophila)
chr17_-_14694223 1.292 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chr1_+_180851131 1.278 ENSMUST00000038091.6
Sde2
SDE2 telomere maintenance homolog (S. pombe)
chr1_-_191183244 1.267 ENSMUST00000027941.8
Atf3
activating transcription factor 3
chr13_-_23934156 1.233 ENSMUST00000052776.2
Hist1h2ba
histone cluster 1, H2ba
chr19_+_47228804 1.202 ENSMUST00000111807.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr2_+_32628390 1.201 ENSMUST00000156578.1
Ak1
adenylate kinase 1
chr13_-_102905740 1.192 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr14_-_101729690 1.183 ENSMUST00000066461.3
Gm9922
predicted gene 9922
chr4_+_156215920 1.174 ENSMUST00000105572.1
2310042D19Rik
RIKEN cDNA 2310042D19 gene
chrX_-_47892396 1.163 ENSMUST00000153548.2
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr16_-_35769356 1.151 ENSMUST00000023554.8
Dirc2
disrupted in renal carcinoma 2 (human)
chr2_+_164486856 1.133 ENSMUST00000109349.2
Dbndd2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_-_45366714 1.121 ENSMUST00000107779.1
Ppfia3
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
chr18_+_37473538 1.119 ENSMUST00000050034.1
Pcdhb15
protocadherin beta 15
chr4_+_99955715 1.112 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr1_-_64121456 1.099 ENSMUST00000142009.1
ENSMUST00000114086.1
Klf7

Kruppel-like factor 7 (ubiquitous)

chr2_-_172043466 1.070 ENSMUST00000087950.3
Cbln4
cerebellin 4 precursor protein
chr1_+_34121250 1.062 ENSMUST00000183006.1
Dst
dystonin
chrX_-_47892432 1.036 ENSMUST00000141084.2
Smarca1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr4_-_127313980 1.029 ENSMUST00000053753.7
Gja4
gap junction protein, alpha 4
chr15_-_82912134 1.016 ENSMUST00000048966.5
ENSMUST00000109510.2
Tcf20

transcription factor 20

chrX_+_6577259 0.994 ENSMUST00000089520.2
Shroom4
shroom family member 4
chr1_-_16520106 0.984 ENSMUST00000162435.1
Stau2
staufen (RNA binding protein) homolog 2 (Drosophila)
chr4_-_36951223 0.971 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr14_-_60197173 0.970 ENSMUST00000131670.1
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
chr7_-_80371197 0.966 ENSMUST00000098346.3
Man2a2
mannosidase 2, alpha 2
chrX_-_64276937 0.962 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr7_+_30121915 0.950 ENSMUST00000098596.3
ENSMUST00000153792.1
Zfp382

zinc finger protein 382

chr19_-_31765027 0.936 ENSMUST00000065067.6
Prkg1
protein kinase, cGMP-dependent, type I
chr2_-_32694120 0.935 ENSMUST00000028148.4
Fpgs
folylpolyglutamyl synthetase
chr4_-_4138432 0.927 ENSMUST00000070375.7
Penk
preproenkephalin
chr11_-_69369377 0.866 ENSMUST00000092971.6
ENSMUST00000108661.1
Chd3

chromodomain helicase DNA binding protein 3

chr4_-_44066960 0.866 ENSMUST00000173234.1
ENSMUST00000173274.1
Gne

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

chr2_-_140671462 0.857 ENSMUST00000110057.2
Flrt3
fibronectin leucine rich transmembrane protein 3
chr17_-_45592262 0.774 ENSMUST00000164769.1
Slc29a1
solute carrier family 29 (nucleoside transporters), member 1
chr2_-_33371486 0.774 ENSMUST00000113165.1
Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr12_-_109600328 0.769 ENSMUST00000149046.2
Rtl1
retrotransposon-like 1
chr2_-_140671400 0.752 ENSMUST00000056760.3
Flrt3
fibronectin leucine rich transmembrane protein 3
chr18_-_37969742 0.736 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr1_+_131827977 0.725 ENSMUST00000086559.6
Slc41a1
solute carrier family 41, member 1
chr2_-_140671440 0.708 ENSMUST00000099301.1
Flrt3
fibronectin leucine rich transmembrane protein 3
chr16_-_14159232 0.698 ENSMUST00000090300.4
Marf1
meiosis arrest female 1
chr10_+_69785507 0.694 ENSMUST00000182993.1
Ank3
ankyrin 3, epithelial
chr3_+_19957037 0.693 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr5_-_62765618 0.690 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_106034661 0.686 ENSMUST00000170669.2
Gm4540
predicted gene 4540
chr1_-_16520020 0.684 ENSMUST00000144138.2
ENSMUST00000145092.1
Stau2

staufen (RNA binding protein) homolog 2 (Drosophila)

chr6_-_142702259 0.666 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr1_-_16520067 0.665 ENSMUST00000131257.2
ENSMUST00000153966.2
Stau2

staufen (RNA binding protein) homolog 2 (Drosophila)

chr2_+_3513035 0.656 ENSMUST00000036350.2
Cdnf
cerebral dopamine neurotrophic factor
chr11_-_79059872 0.651 ENSMUST00000141409.1
Ksr1
kinase suppressor of ras 1
chr16_-_4523056 0.613 ENSMUST00000090500.3
ENSMUST00000023161.7
Srl

sarcalumenin

chr2_-_33371400 0.608 ENSMUST00000113164.1
ENSMUST00000091039.2
ENSMUST00000042615.6
Ralgps1


Ral GEF with PH domain and SH3 binding motif 1


chr7_+_16875302 0.593 ENSMUST00000108493.1
Dact3
dapper homolog 3, antagonist of beta-catenin (xenopus)
chr2_-_65567465 0.576 ENSMUST00000066432.5
Scn3a
sodium channel, voltage-gated, type III, alpha
chr2_-_65567505 0.554 ENSMUST00000100069.2
Scn3a
sodium channel, voltage-gated, type III, alpha
chr9_+_75071579 0.539 ENSMUST00000136731.1
Myo5a
myosin VA
chr11_+_103966716 0.527 ENSMUST00000057921.3
ENSMUST00000063347.5
Arf2

ADP-ribosylation factor 2

chrX_-_165004829 0.502 ENSMUST00000114890.2
Gm17604
predicted gene, 17604
chr11_+_102284931 0.481 ENSMUST00000036376.6
ENSMUST00000100387.4
Tmub2

transmembrane and ubiquitin-like domain containing 2

chr12_+_41024329 0.463 ENSMUST00000134965.1
Immp2l
IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr3_+_84593547 0.463 ENSMUST00000062623.3
Tigd4
tigger transposable element derived 4
chr3_+_32817520 0.448 ENSMUST00000072312.5
ENSMUST00000108228.1
Usp13

ubiquitin specific peptidase 13 (isopeptidase T-3)

chr16_+_19028232 0.436 ENSMUST00000074116.4
Gm10088
predicted gene 10088
chr13_+_119606650 0.432 ENSMUST00000178948.1
Gm21967
predicted gene, 21967
chr1_+_16688405 0.429 ENSMUST00000026881.4
Ly96
lymphocyte antigen 96
chr5_+_107497718 0.415 ENSMUST00000112671.2
A830010M20Rik
RIKEN cDNA A830010M20 gene

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.8 17.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
2.9 8.7 GO:0001928 regulation of exocyst assembly(GO:0001928)
2.2 6.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
2.0 8.0 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
1.8 8.8 GO:0002121 inter-male aggressive behavior(GO:0002121)
1.7 8.3 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
1.5 9.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
1.4 4.3 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
1.1 3.3 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
1.0 5.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
1.0 4.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.0 6.7 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
0.9 4.7 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.9 2.8 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.9 4.6 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.9 12.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.9 7.8 GO:0043615 astrocyte cell migration(GO:0043615)
0.9 2.6 GO:1903538 meiotic cell cycle process involved in oocyte maturation(GO:1903537) regulation of meiotic cell cycle process involved in oocyte maturation(GO:1903538)
0.8 5.9 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.8 3.3 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.8 3.3 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.8 2.5 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.8 2.3 GO:0007525 somatic muscle development(GO:0007525)
0.8 2.3 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.7 4.8 GO:0098909 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.7 3.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.7 4.6 GO:0015862 uridine transport(GO:0015862)
0.6 2.6 GO:1904048 negative regulation of synaptic vesicle recycling(GO:1903422) regulation of spontaneous neurotransmitter secretion(GO:1904048)
0.6 1.8 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.5 1.6 GO:0006059 hexitol metabolic process(GO:0006059) alditol biosynthetic process(GO:0019401)
0.5 3.0 GO:0046103 ADP biosynthetic process(GO:0006172) inosine biosynthetic process(GO:0046103)
0.5 1.4 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.4 0.9 GO:0061300 cerebellum vasculature development(GO:0061300)
0.4 1.6 GO:2000182 regulation of progesterone biosynthetic process(GO:2000182)
0.4 4.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.4 20.5 GO:0034605 cellular response to heat(GO:0034605)
0.4 2.3 GO:0098964 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
0.3 2.7 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.3 4.2 GO:0001553 luteinization(GO:0001553)
0.3 1.3 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.3 0.9 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.3 0.9 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.3 0.9 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.3 1.8 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.3 2.6 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.3 4.2 GO:0006706 steroid catabolic process(GO:0006706)
0.3 1.4 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.3 1.4 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.3 2.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.2 2.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.2 2.8 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 2.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.2 2.1 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.2 1.4 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.2 1.1 GO:0046684 response to pyrethroid(GO:0046684)
0.2 2.2 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.2 2.8 GO:0070842 aggresome assembly(GO:0070842)
0.2 2.5 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 1.7 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.2 1.7 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.2 0.4 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 1.2 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.2 8.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 2.8 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.2 0.7 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.2 1.1 GO:0019388 galactose catabolic process(GO:0019388)
0.2 0.6 GO:0014874 response to stimulus involved in regulation of muscle adaptation(GO:0014874)
0.2 0.3 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.2 1.2 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.4 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K6-linked deubiquitination(GO:0044313)
0.1 0.7 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.1 3.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 1.0 GO:0061092 involuntary skeletal muscle contraction(GO:0003011) regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.4 GO:1902109 ADP transport(GO:0015866) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1 2.9 GO:0070536 protein K63-linked deubiquitination(GO:0070536)
0.1 0.4 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.1 1.0 GO:0006013 mannose metabolic process(GO:0006013)
0.1 0.9 GO:0035428 hexose transmembrane transport(GO:0035428)
0.1 7.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.3 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.1 0.2 GO:1903275 positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.1 5.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.1 1.4 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 2.2 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.1 1.3 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.1 3.6 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
0.1 0.5 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.1 1.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.4 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.1 0.7 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.4 GO:0015914 phospholipid transport(GO:0015914)
0.1 1.5 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.1 0.9 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.1 0.3 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 4.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.7 GO:0046688 response to copper ion(GO:0046688)
0.0 0.2 GO:0002024 diet induced thermogenesis(GO:0002024)
0.0 1.4 GO:0061045 negative regulation of wound healing(GO:0061045)
0.0 1.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.0 4.7 GO:0007613 memory(GO:0007613)
0.0 11.1 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 4.8 GO:0006836 neurotransmitter transport(GO:0006836)
0.0 3.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 4.6 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 1.1 GO:0007416 synapse assembly(GO:0007416)
0.0 0.1 GO:0090187 positive regulation of pancreatic juice secretion(GO:0090187)
0.0 0.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 3.8 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 3.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.6 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.0 3.1 GO:0006342 chromatin silencing(GO:0006342)
0.0 7.6 GO:0060541 respiratory system development(GO:0060541)
0.0 0.3 GO:0005980 polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 1.7 GO:0021766 hippocampus development(GO:0021766)
0.0 0.2 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 2.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 6.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 1.2 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.0 0.0 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.0 0.7 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:1902866 negative regulation of excitatory postsynaptic potential(GO:0090394) regulation of retina development in camera-type eye(GO:1902866)
0.0 1.4 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 1.4 GO:0006865 amino acid transport(GO:0006865)
0.0 0.3 GO:0051591 response to cAMP(GO:0051591)
0.0 0.2 GO:0035308 negative regulation of dephosphorylation(GO:0035305) negative regulation of protein dephosphorylation(GO:0035308)
0.0 0.2 GO:0006911 phagocytosis, engulfment(GO:0006911)
0.0 1.1 GO:0007568 aging(GO:0007568)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.3 GO:0043512 inhibin A complex(GO:0043512)
1.6 4.7 GO:0045160 myosin I complex(GO:0045160)
1.1 3.3 GO:0000802 transverse filament(GO:0000802)
0.9 3.6 GO:0090537 CERF complex(GO:0090537)
0.8 2.5 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.8 4.6 GO:0035976 AP1 complex(GO:0035976)
0.7 12.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.7 3.3 GO:0044316 cone cell pedicle(GO:0044316)
0.6 12.8 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.4 1.3 GO:0005927 muscle tendon junction(GO:0005927)
0.4 8.3 GO:0032279 asymmetric synapse(GO:0032279)
0.4 1.6 GO:0097454 Schwann cell microvillus(GO:0097454)
0.4 3.0 GO:0001520 outer dense fiber(GO:0001520)
0.4 7.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.4 2.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 1.4 GO:0032127 dense core granule membrane(GO:0032127)
0.3 1.4 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.3 0.9 GO:0098984 neuron to neuron synapse(GO:0098984)
0.3 0.9 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.3 1.1 GO:0031673 H zone(GO:0031673)
0.3 2.6 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.3 1.8 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.2 0.7 GO:0042642 actomyosin, myosin complex part(GO:0042642)
0.2 1.4 GO:0005859 muscle myosin complex(GO:0005859)
0.2 1.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 1.8 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 0.7 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.2 1.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.2 12.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 11.4 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.4 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.1 1.3 GO:0031091 platelet alpha granule(GO:0031091)
0.1 1.0 GO:0005922 connexon complex(GO:0005922)
0.1 18.3 GO:0001650 fibrillar center(GO:0001650)
0.1 0.4 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 2.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 10.3 GO:0016605 PML body(GO:0016605)
0.1 1.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 2.8 GO:0097440 apical dendrite(GO:0097440)
0.1 21.7 GO:0016324 apical plasma membrane(GO:0016324)
0.1 1.9 GO:0032420 stereocilium(GO:0032420)
0.1 6.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.1 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.3 GO:0005902 microvillus(GO:0005902)
0.1 3.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.4 GO:0016011 dystroglycan complex(GO:0016011)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 0.2 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 0.2 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.1 6.4 GO:0005814 centriole(GO:0005814)
0.1 19.8 GO:0016607 nuclear speck(GO:0016607)
0.1 0.3 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 1.1 GO:0048786 presynaptic active zone(GO:0048786)
0.0 8.5 GO:0030426 growth cone(GO:0030426)
0.0 0.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)
0.0 1.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.6 GO:0043204 perikaryon(GO:0043204)
0.0 2.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 4.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.7 GO:0031594 neuromuscular junction(GO:0031594)
0.0 2.9 GO:0008021 synaptic vesicle(GO:0008021)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.5 GO:0043235 receptor complex(GO:0043235)
0.0 2.3 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.5 GO:0015630 microtubule cytoskeleton(GO:0015630)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
1.7 10.0 GO:0070699 type II activin receptor binding(GO:0070699)
1.6 4.8 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
1.3 3.8 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
1.2 12.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
1.2 3.6 GO:0070615 nucleosome-dependent ATPase activity(GO:0070615)
1.0 8.2 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
1.0 6.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.9 17.3 GO:0035198 miRNA binding(GO:0035198)
0.9 3.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.8 4.7 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.7 3.3 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.7 6.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.5 2.2 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.5 3.7 GO:0001515 opioid peptide activity(GO:0001515)
0.5 12.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.5 9.0 GO:0030275 LRR domain binding(GO:0030275)
0.3 4.7 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.3 1.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.3 1.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 5.0 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.3 2.5 GO:1990239 steroid hormone binding(GO:1990239)
0.3 3.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.3 7.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.3 7.0 GO:0042805 actinin binding(GO:0042805)
0.3 4.6 GO:0035497 cAMP response element binding(GO:0035497)
0.3 8.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 0.9 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.2 2.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 5.0 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 0.9 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity(GO:0008761)
0.2 5.5 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 4.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 5.0 GO:0005112 Notch binding(GO:0005112)
0.1 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.1 3.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.3 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.4 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.1 0.7 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 5.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 0.7 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.5 GO:1990715 mRNA CDS binding(GO:1990715)
0.1 1.6 GO:0030955 potassium ion binding(GO:0030955)
0.1 2.1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 5.6 GO:0042562 hormone binding(GO:0042562)
0.1 0.4 GO:1904288 BAT3 complex binding(GO:1904288)
0.1 1.0 GO:0015924 mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1 1.4 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 1.8 GO:0051787 misfolded protein binding(GO:0051787)
0.1 3.3 GO:0030552 cAMP binding(GO:0030552)
0.1 3.6 GO:0051018 protein kinase A binding(GO:0051018)
0.1 10.0 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.1 13.3 GO:0005516 calmodulin binding(GO:0005516)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 0.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 3.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 2.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 2.2 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.1 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 4.7 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 1.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 2.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 6.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.4 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.2 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.7 GO:0015491 cation:cation antiporter activity(GO:0015491)
0.0 2.5 GO:0043022 ribosome binding(GO:0043022)
0.0 4.3 GO:0008201 heparin binding(GO:0008201)
0.0 0.9 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.8 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 3.0 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 5.7 GO:0008017 microtubule binding(GO:0008017)
0.0 0.9 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 3.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.7 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.0 6.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.8 GO:0002039 p53 binding(GO:0002039)
0.0 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 22.8 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.3 7.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.3 8.3 PID_ALK1_PATHWAY ALK1 signaling events
0.3 11.9 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.3 3.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.2 13.0 PID_FGF_PATHWAY FGF signaling pathway
0.2 8.2 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 7.5 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 5.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 4.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.2 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.1 2.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.1 2.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 11.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 3.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.7 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.7 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.2 PID_IL8_CXCR2_PATHWAY IL8- and CXCR2-mediated signaling events
0.0 0.9 PID_TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.7 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.3 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.3 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.5 16.3 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.5 6.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.5 4.6 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 10.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.4 10.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 4.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.3 7.8 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 4.9 REACTOME_SIGNAL_REGULATORY_PROTEIN_SIRP_FAMILY_INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 2.1 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.2 9.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 8.7 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.2 2.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 2.6 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2 2.7 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.2 7.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 0.7 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.1 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 4.3 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 1.3 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.1 1.7 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 4.7 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.0 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 4.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 3.8 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.4 REACTOME_PERK_REGULATED_GENE_EXPRESSION Genes involved in PERK regulated gene expression
0.1 1.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 3.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.2 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.4 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_TAK1_COMPLEX Genes involved in TRAF6 mediated induction of TAK1 complex
0.0 2.9 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.7 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.5 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.0 4.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.5 REACTOME_TOLL_RECEPTOR_CASCADES Genes involved in Toll Receptor Cascades
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.4 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism