Motif ID: Meis1

Z-value: 0.535


Transcription factors associated with Meis1:

Gene SymbolEntrez IDGene Name
Meis1 ENSMUSG00000020160.12 Meis1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis1mm10_v2_chr11_-_19018714_190188280.758.3e-08Click!


Activity profile for motif Meis1.

activity profile for motif Meis1


Sorted Z-values histogram for motif Meis1

Sorted Z-values for motif Meis1



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 6.410 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_47411666 3.087 ENSMUST00000111778.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr14_-_98169542 2.759 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr1_-_138842429 2.395 ENSMUST00000112026.2
ENSMUST00000019374.7
 Lhx9

LIM homeobox protein 9

chr8_+_127064022 2.054 ENSMUST00000160272.1
ENSMUST00000079777.5
ENSMUST00000162907.1
 Pard3


par-3 (partitioning defective 3) homolog (C. elegans)


chr8_+_127064107 2.010 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chr11_+_44617310 1.982 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr9_+_87022014 1.947 ENSMUST00000168529.2
ENSMUST00000174724.1
ENSMUST00000173126.1
 Cyb5r4


cytochrome b5 reductase 4


chr6_+_4747306 1.879 ENSMUST00000175823.1
ENSMUST00000176204.1
ENSMUST00000166678.1
 Peg10


paternally expressed 10


chr3_+_109123104 1.839 ENSMUST00000029477.6
 Slc25a24
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
chr11_-_64436653 1.722 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chrX_-_23365044 1.591 ENSMUST00000115313.1
 Klhl13
kelch-like 13
chr16_-_50732707 1.506 ENSMUST00000169791.2
 5330426P16Rik
RIKEN cDNA 5330426P16 gene
chr13_+_108316395 1.494 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr7_+_51621830 1.465 ENSMUST00000032710.5
 Slc17a6
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
chr3_+_125404292 1.438 ENSMUST00000144344.1
 Ndst4
N-deacetylase/N-sulfotransferase (heparin glucosaminyl) 4
chr14_+_13284774 1.370 ENSMUST00000070323.5
 Synpr
synaptoporin
chr8_+_108714644 1.347 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr1_+_136467958 1.288 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr3_+_134828993 1.233 ENSMUST00000029822.4
 Tacr3
tachykinin receptor 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 6.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.7 4.1 GO:0003383 apical constriction(GO:0003383)
0.9 2.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.5 2.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 1.9 GO:0046677 response to antibiotic(GO:0046677)
0.4 1.8 GO:0015867 ATP transport(GO:0015867)
0.0 1.8 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512)
0.2 1.5 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.2 1.4 GO:0070474 positive regulation of uterine smooth muscle contraction(GO:0070474)
0.0 1.4 GO:0000910 cytokinesis(GO:0000910)
0.4 1.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 1.3 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 1.1 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1 1.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 0.9 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 0.8 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.8 GO:0050982 detection of mechanical stimulus(GO:0050982)
0.2 0.7 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.2 0.7 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.1 GO:0033269 internode region of axon(GO:0033269)
0.2 3.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 2.8 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.6 GO:0000792 heterochromatin(GO:0000792)
0.0 1.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.3 GO:0051233 spindle midzone(GO:0051233)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 1.0 GO:0008537 proteasome activator complex(GO:0008537)
0.0 1.0 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.9 GO:0097546 ciliary base(GO:0097546)
0.2 0.7 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.0 0.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.6 GO:0098536 deuterosome(GO:0098536)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.6 GO:0090544 BAF-type complex(GO:0090544)
0.0 0.6 GO:0016235 aggresome(GO:0016235)
0.0 0.6 GO:0016234 inclusion body(GO:0016234)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.0 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 2.9 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 2.8 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 2.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 1.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 1.8 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 1.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.2 1.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1 1.4 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 1.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 1.3 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.0 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.7 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.7 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.6 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.6 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.1 3.1 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 2.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.8 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.2 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.1 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.3 PID_IL27_PATHWAY IL27-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.6 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.4 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.4 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.2 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.8 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 0.7 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.6 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.5 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription