Motif ID: Meis2

Z-value: 1.115


Transcription factors associated with Meis2:

Gene SymbolEntrez IDGene Name
Meis2 ENSMUSG00000027210.14 Meis2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Meis2mm10_v2_chr2_-_116065047_116065133-0.428.9e-03Click!


Activity profile for motif Meis2.

activity profile for motif Meis2


Sorted Z-values histogram for motif Meis2

Sorted Z-values for motif Meis2



Network of associatons between targets according to the STRING database.



First level regulatory network of Meis2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_82074639 6.523 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr19_-_57197496 6.406 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197435 6.358 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197556 6.291 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr19_-_57197377 6.276 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr6_+_49822710 6.087 ENSMUST00000031843.6
 Npy
neuropeptide Y
chr4_+_42922253 4.430 ENSMUST00000139100.1
 N28178
expressed sequence N28178
chr9_+_53771499 4.018 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr5_-_100159261 3.998 ENSMUST00000139520.1
 Tmem150c
transmembrane protein 150C
chr7_+_48959089 3.923 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr9_+_120539801 3.889 ENSMUST00000047687.7
 Entpd3
ectonucleoside triphosphate diphosphohydrolase 3
chr2_+_158667119 3.760 ENSMUST00000045503.4
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr9_-_63711969 3.651 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr18_+_36939178 3.503 ENSMUST00000115662.2
 Pcdha2
protocadherin alpha 2
chr2_+_158666690 3.422 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr4_+_128058962 3.206 ENSMUST00000184063.1
 Csmd2
CUB and Sushi multiple domains 2
chr6_-_121081589 3.191 ENSMUST00000077159.5
 Mical3
microtubule associated monooxygenase, calponin and LIM domain containing 3
chr13_-_41079628 3.018 ENSMUST00000165087.1
ENSMUST00000070193.6
 Mak

male germ cell-associated kinase

chr19_+_55253369 2.944 ENSMUST00000043150.4
 Acsl5
acyl-CoA synthetase long-chain family member 5
chr19_+_42247544 2.941 ENSMUST00000122375.1
 Golga7b
golgi autoantigen, golgin subfamily a, 7B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 21.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.5 8.2 GO:0032098 regulation of appetite(GO:0032098)
1.4 7.2 GO:1903587 negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
2.2 6.5 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.1 5.8 GO:0006376 mRNA splice site selection(GO:0006376)
1.4 4.3 GO:0046168 glycerol-3-phosphate catabolic process(GO:0046168)
1.0 3.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.3 3.9 GO:0009143 nucleoside triphosphate catabolic process(GO:0009143)
0.0 3.8 GO:0008643 carbohydrate transport(GO:0008643)
1.2 3.7 GO:0044413 regulation of lung blood pressure(GO:0014916) evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 3.2 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.1 3.2 GO:0030042 actin filament depolymerization(GO:0030042)
0.2 3.1 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.4 3.0 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.5 2.9 GO:0010747 positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747)
0.3 2.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.7 2.8 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 2.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 2.8 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 2.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 8.0 GO:0043204 perikaryon(GO:0043204)
0.0 7.1 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.8 GO:0016607 nuclear speck(GO:0016607)
0.9 4.3 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 4.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.7 3.7 GO:0044316 cone cell pedicle(GO:0044316)
0.7 3.7 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 3.5 GO:0097542 ciliary tip(GO:0097542)
0.2 3.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 2.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 2.8 GO:0031430 M band(GO:0031430)
0.0 2.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.5 GO:0044292 dendrite terminus(GO:0044292)
0.0 2.5 GO:0001650 fibrillar center(GO:0001650)
0.1 2.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 2.1 GO:0043203 axon hillock(GO:0043203)
0.1 2.1 GO:0000242 pericentriolar material(GO:0000242)
0.1 1.9 GO:0035861 site of double-strand break(GO:0035861)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 21.7 GO:0003779 actin binding(GO:0003779)
0.4 7.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.5 6.5 GO:0004016 adenylate cyclase activity(GO:0004016)
0.1 6.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 5.1 GO:0036002 pre-mRNA binding(GO:0036002)
0.2 5.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.9 4.3 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.2 4.1 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.2 3.9 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.7 3.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 3.7 GO:0030507 spectrin binding(GO:0030507)
0.1 3.6 GO:0030552 cAMP binding(GO:0030552)
0.8 3.2 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.1 3.2 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.4 3.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 2.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.4 2.8 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.1 2.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.6 GO:0005125 cytokine activity(GO:0005125)
0.0 2.5 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 2.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.2 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 1.8 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.5 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.5 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.9 SIG_CHEMOTAXIS Genes related to chemotaxis
0.0 0.9 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 0.7 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.6 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.4 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 23.3 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.3 9.3 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 7.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.3 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 3.7 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 3.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 2.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.8 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 2.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.2 2.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 2.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.9 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.6 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 1.6 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 1.2 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 1.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.2 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 1.2 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels