Motif ID: Mnx1_Lhx6_Lmx1a

Z-value: 0.881

Transcription factors associated with Mnx1_Lhx6_Lmx1a:

Gene SymbolEntrez IDGene Name
Lhx6 ENSMUSG00000026890.13 Lhx6
Lmx1a ENSMUSG00000026686.8 Lmx1a
Mnx1 ENSMUSG00000001566.8 Mnx1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lmx1amm10_v2_chr1_+_167689108_1676892390.724.6e-07Click!
Lhx6mm10_v2_chr2_-_36105271_36105434-0.529.8e-04Click!


Activity profile for motif Mnx1_Lhx6_Lmx1a.

activity profile for motif Mnx1_Lhx6_Lmx1a


Sorted Z-values histogram for motif Mnx1_Lhx6_Lmx1a

Sorted Z-values for motif Mnx1_Lhx6_Lmx1a



Network of associatons between targets according to the STRING database.



First level regulatory network of Mnx1_Lhx6_Lmx1a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_-_61902669 10.871 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr5_+_139543889 9.496 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr5_-_62766153 8.957 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr3_+_55782500 6.637 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr15_+_25773985 5.992 ENSMUST00000125667.1
 Myo10
myosin X
chr9_+_118478182 5.513 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_65890237 5.398 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr9_+_118478344 5.328 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_25372315 4.900 ENSMUST00000028329.6
ENSMUST00000114293.2
ENSMUST00000100323.2
 Sapcd2


suppressor APC domain containing 2


chr2_+_20737306 4.725 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr4_-_97778042 3.933 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_172027269 3.878 ENSMUST00000027837.6
ENSMUST00000111264.1
 Vangl2

vang-like 2 (van gogh, Drosophila)

chr8_+_45658666 3.798 ENSMUST00000134675.1
ENSMUST00000139869.1
ENSMUST00000126067.1
 Sorbs2


sorbin and SH3 domain containing 2


chr13_-_97747373 3.766 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr8_+_45658731 3.658 ENSMUST00000143820.1
ENSMUST00000132139.1
 Sorbs2

sorbin and SH3 domain containing 2

chr2_-_72986716 3.613 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_-_88410295 3.517 ENSMUST00000056370.7
 Pmf1
polyamine-modulated factor 1
chr7_-_49636847 3.510 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr11_-_3931960 3.498 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr5_+_92809372 3.472 ENSMUST00000113054.2
 Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 10.9 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
3.6 10.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.2 9.5 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.2 9.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 8.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.6 6.5 GO:0015889 cobalamin transport(GO:0015889)
2.1 6.2 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.1 4.9 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.4 4.7 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 4.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.9 3.8 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.3 3.8 GO:0060539 diaphragm development(GO:0060539)
0.1 3.8 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 3.5 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.0 3.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.5 2.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 2.9 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.3 2.8 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.7 2.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.9 2.6 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.9 GO:0002102 podosome(GO:0002102)
0.1 8.3 GO:0070469 respiratory chain(GO:0070469)
1.6 6.2 GO:0060187 cell pole(GO:0060187)
0.1 6.0 GO:0016459 myosin complex(GO:0016459)
0.0 4.9 GO:0043296 apical junction complex(GO:0043296)
0.6 3.5 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 3.5 GO:0042788 polysomal ribosome(GO:0042788)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 2.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 2.2 GO:0000792 heterochromatin(GO:0000792)
0.0 2.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.5 1.9 GO:0008623 CHRAC(GO:0008623)
0.2 1.7 GO:0030478 actin cap(GO:0030478)
0.5 1.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.4 GO:0070382 exocytic vesicle(GO:0070382)
0.0 1.4 GO:0000776 kinetochore(GO:0000776)
0.2 1.2 GO:0098536 deuterosome(GO:0098536)
0.2 1.1 GO:0031523 Myb complex(GO:0031523)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.2 10.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 10.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 9.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 8.5 GO:0003779 actin binding(GO:0003779)
0.5 8.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 6.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 6.5 GO:0031419 cobalamin binding(GO:0031419)
0.0 6.5 GO:0051015 actin filament binding(GO:0051015)
0.1 6.3 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 6.1 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 4.1 GO:0030507 spectrin binding(GO:0030507)
0.2 3.8 GO:1900750 glutathione peroxidase activity(GO:0004602) glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 3.5 GO:0017091 AU-rich element binding(GO:0017091)
0.3 3.4 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 2.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 2.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 2.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 2.4 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 2.4 GO:0001784 phosphotyrosine binding(GO:0001784)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.2 10.5 PID_ARF6_PATHWAY Arf6 signaling events
0.1 6.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.7 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 4.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.5 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 1.5 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 1.2 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 1.2 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.1 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.0 PID_MYC_PATHWAY C-MYC pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 0.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.7 PID_FANCONI_PATHWAY Fanconi anemia pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.9 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 8.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 6.0 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 3.8 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 3.3 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 2.6 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 2.2 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.9 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.5 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.2 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 0.9 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 0.8 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 0.8 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 0.6 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 0.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.6 REACTOME_G1_PHASE Genes involved in G1 Phase