Motif ID: Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.706


Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Lhx9mm10_v2_chr1_-_138848576_138848603-0.464.3e-03Click!
Msx1mm10_v2_chr5_-_37824580_378245840.391.6e-02Click!
Dlx6mm10_v2_chr6_+_6863769_68637970.221.8e-01Click!
Raxmm10_v2_chr18_-_65939048_65939089-0.048.3e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_134747241 8.474 ENSMUST00000015138.9
Eln
elastin
chr3_-_49757257 6.703 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr2_+_116067213 6.136 ENSMUST00000152412.1
G630016G05Rik
RIKEN cDNA G630016G05 gene
chr16_+_42907563 5.138 ENSMUST00000151244.1
ENSMUST00000114694.2
Zbtb20

zinc finger and BTB domain containing 20

chr5_-_62766153 4.858 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_116067391 4.377 ENSMUST00000140185.1
2700033N17Rik
RIKEN cDNA 2700033N17 gene
chr11_-_98053415 4.271 ENSMUST00000017544.2
Stac2
SH3 and cysteine rich domain 2
chr14_-_118052235 4.189 ENSMUST00000022725.2
Dct
dopachrome tautomerase
chr12_-_83487708 3.447 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr9_-_40346290 3.337 ENSMUST00000121357.1
Gramd1b
GRAM domain containing 1B
chr16_-_37384915 2.854 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr2_-_77703252 2.750 ENSMUST00000171063.1
Zfp385b
zinc finger protein 385B
chr19_+_26749726 2.744 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr3_+_66219909 2.736 ENSMUST00000029421.5
Ptx3
pentraxin related gene
chr1_+_104768510 2.703 ENSMUST00000062528.8
Cdh20
cadherin 20
chr13_+_44121167 2.534 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr1_-_155417394 2.128 ENSMUST00000111775.1
ENSMUST00000111774.1
Xpr1

xenotropic and polytropic retrovirus receptor 1

chr1_-_190170671 2.097 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr3_+_86070915 2.056 ENSMUST00000182666.1
Sh3d19
SH3 domain protein D19
chr16_-_37384940 2.030 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr9_+_118478182 1.939 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr17_-_49564262 1.880 ENSMUST00000057610.6
Daam2
dishevelled associated activator of morphogenesis 2
chr9_+_118478344 1.878 ENSMUST00000035020.8
Eomes
eomesodermin homolog (Xenopus laevis)
chr6_+_125552948 1.805 ENSMUST00000112254.1
ENSMUST00000112253.1
ENSMUST00000001995.7
Vwf


Von Willebrand factor homolog


chr18_+_57468478 1.623 ENSMUST00000091892.2
Ctxn3
cortexin 3
chr16_+_45093611 1.534 ENSMUST00000099498.2
Ccdc80
coiled-coil domain containing 80
chr10_+_99263224 1.429 ENSMUST00000020118.4
Dusp6
dual specificity phosphatase 6
chr5_-_123141067 1.422 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
AI480526


expressed sequence AI480526


chr5_-_62765618 1.405 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr18_-_37969742 1.401 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr15_+_25773985 1.240 ENSMUST00000125667.1
Myo10
myosin X
chr5_+_34999111 1.232 ENSMUST00000114283.1
Rgs12
regulator of G-protein signaling 12
chr15_-_8710734 1.218 ENSMUST00000005493.7
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr10_+_39612934 1.167 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr3_+_151437887 1.137 ENSMUST00000046977.7
Eltd1
EGF, latrophilin seven transmembrane domain containing 1
chr2_+_22622183 1.108 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr1_-_155417283 1.106 ENSMUST00000027741.5
Xpr1
xenotropic and polytropic retrovirus receptor 1
chr10_+_127421208 1.048 ENSMUST00000168780.1
R3hdm2
R3H domain containing 2
chr1_-_190170178 1.029 ENSMUST00000177288.1
Prox1
prospero-related homeobox 1
chr14_-_79771305 1.020 ENSMUST00000039568.5
Pcdh8
protocadherin 8
chr5_+_34999070 0.978 ENSMUST00000114280.1
Rgs12
regulator of G-protein signaling 12
chr13_+_75707484 0.957 ENSMUST00000001583.6
Ell2
elongation factor RNA polymerase II 2
chr17_+_75005523 0.955 ENSMUST00000001927.5
Ltbp1
latent transforming growth factor beta binding protein 1
chr9_-_103222063 0.951 ENSMUST00000170904.1
Trf
transferrin
chr3_+_62419668 0.925 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr5_+_34999046 0.924 ENSMUST00000114281.1
Rgs12
regulator of G-protein signaling 12
chr15_-_8710409 0.897 ENSMUST00000157065.1
Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr9_+_45370185 0.896 ENSMUST00000085939.6
Fxyd6
FXYD domain-containing ion transport regulator 6
chr13_+_118714678 0.893 ENSMUST00000022246.8
Fgf10
fibroblast growth factor 10
chr7_-_45103747 0.885 ENSMUST00000003512.7
Fcgrt
Fc receptor, IgG, alpha chain transporter
chr8_-_120228221 0.813 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr2_+_70474923 0.812 ENSMUST00000100043.2
Sp5
trans-acting transcription factor 5
chr10_-_25200110 0.797 ENSMUST00000100012.2
Akap7
A kinase (PRKA) anchor protein 7
chr10_-_53647080 0.755 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr13_+_83732438 0.721 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr11_-_26210553 0.720 ENSMUST00000101447.3
5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr5_+_64812336 0.719 ENSMUST00000166409.1
Klf3
Kruppel-like factor 3 (basic)
chr4_+_108719649 0.710 ENSMUST00000178992.1
3110021N24Rik
RIKEN cDNA 3110021N24 gene
chr3_+_68572245 0.704 ENSMUST00000170788.2
Schip1
schwannomin interacting protein 1
chr2_-_45117349 0.681 ENSMUST00000176438.2
Zeb2
zinc finger E-box binding homeobox 2
chr19_+_26750939 0.668 ENSMUST00000175953.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr5_+_13398688 0.592 ENSMUST00000125629.1
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr2_+_71528657 0.574 ENSMUST00000126400.1
Dlx1
distal-less homeobox 1
chr1_-_165934900 0.571 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
Pou2f1


POU domain, class 2, transcription factor 1


chr11_-_87359011 0.563 ENSMUST00000055438.4
Ppm1e
protein phosphatase 1E (PP2C domain containing)
chr1_-_158356258 0.551 ENSMUST00000004133.8
Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr18_+_9707639 0.548 ENSMUST00000040069.8
Colec12
collectin sub-family member 12
chr7_-_73541738 0.548 ENSMUST00000169922.2
Chd2
chromodomain helicase DNA binding protein 2
chr16_-_74411292 0.523 ENSMUST00000117200.1
Robo2
roundabout homolog 2 (Drosophila)
chr11_+_23306910 0.517 ENSMUST00000137823.1
Usp34
ubiquitin specific peptidase 34
chr6_-_136171722 0.501 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr13_+_16011851 0.489 ENSMUST00000042603.6
Inhba
inhibin beta-A
chrM_+_11734 0.483 ENSMUST00000082418.1
mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr10_-_86011833 0.482 ENSMUST00000105304.1
ENSMUST00000061699.5
Bpifc

BPI fold containing family C

chr6_+_63255971 0.473 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr14_+_79515618 0.470 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr7_+_103550368 0.458 ENSMUST00000106888.1
Olfr613
olfactory receptor 613
chr15_-_11037968 0.441 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr11_+_23306884 0.441 ENSMUST00000180046.1
Usp34
ubiquitin specific peptidase 34
chr4_+_21848039 0.420 ENSMUST00000098238.2
ENSMUST00000108229.1
Sfrs18

serine/arginine-rich splicing factor 18

chr4_+_154964117 0.403 ENSMUST00000030931.4
ENSMUST00000070953.4
Pank4

pantothenate kinase 4

chr7_-_73537621 0.401 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr9_+_96258697 0.378 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr7_+_126950687 0.374 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr12_-_91849081 0.370 ENSMUST00000167466.1
ENSMUST00000021347.5
ENSMUST00000178462.1
Sel1l


sel-1 suppressor of lin-12-like (C. elegans)


chr12_+_49382791 0.367 ENSMUST00000179669.1
Foxg1
forkhead box G1
chr18_+_24603952 0.366 ENSMUST00000025120.6
Elp2
elongator acetyltransferase complex subunit 2
chr17_-_29888570 0.365 ENSMUST00000171691.1
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
chr10_+_127421124 0.359 ENSMUST00000170336.1
R3hdm2
R3H domain containing 2
chr12_-_111813834 0.356 ENSMUST00000021715.5
Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3
chr3_-_55055038 0.355 ENSMUST00000029368.2
Ccna1
cyclin A1
chr6_+_145934113 0.339 ENSMUST00000032383.7
Sspn
sarcospan
chr17_+_45734506 0.325 ENSMUST00000180558.1
F630040K05Rik
RIKEN cDNA F630040K05 gene
chr2_-_72986716 0.316 ENSMUST00000112062.1
Gm11084
predicted gene 11084
chr1_-_87394721 0.308 ENSMUST00000113212.3
Kcnj13
potassium inwardly-rectifying channel, subfamily J, member 13
chr8_+_54954728 0.307 ENSMUST00000033915.7
Gpm6a
glycoprotein m6a
chrX_+_166344692 0.302 ENSMUST00000112223.1
ENSMUST00000112224.1
ENSMUST00000112229.2
ENSMUST00000112228.1
ENSMUST00000112227.2
ENSMUST00000112226.2
Gpm6b





glycoprotein m6b





chr7_+_126950518 0.302 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chrX_+_56454871 0.301 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr18_+_37819543 0.296 ENSMUST00000055935.5
Pcdhga9
protocadherin gamma subfamily A, 9
chrX_-_74246534 0.295 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr8_+_4238815 0.293 ENSMUST00000003027.7
ENSMUST00000110999.1
Map2k7

mitogen-activated protein kinase kinase 7

chr2_+_52038005 0.293 ENSMUST00000065927.5
Tnfaip6
tumor necrosis factor alpha induced protein 6
chr2_-_33086366 0.284 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr7_+_25681158 0.276 ENSMUST00000108403.3
B9d2
B9 protein domain 2
chr8_+_121116163 0.271 ENSMUST00000054691.6
Foxc2
forkhead box C2
chrX_-_75416533 0.266 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr4_+_116720920 0.265 ENSMUST00000045542.6
ENSMUST00000106459.1
Tesk2

testis-specific kinase 2

chr3_-_94412883 0.263 ENSMUST00000181305.1
1700040D17Rik
RIKEN cDNA 1700040D17 gene
chr2_+_73271925 0.235 ENSMUST00000090813.5
Sp9
trans-acting transcription factor 9
chr15_-_66812593 0.233 ENSMUST00000100572.3
Sla
src-like adaptor
chr10_+_127420334 0.232 ENSMUST00000171434.1
R3hdm2
R3H domain containing 2
chr8_+_4238733 0.231 ENSMUST00000110998.2
ENSMUST00000062686.4
Map2k7

mitogen-activated protein kinase kinase 7

chr10_+_18469958 0.231 ENSMUST00000162891.1
ENSMUST00000100054.3
Nhsl1

NHS-like 1

chr2_-_79456750 0.223 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr4_+_97777780 0.223 ENSMUST00000107062.2
ENSMUST00000052018.5
ENSMUST00000107057.1
Nfia


nuclear factor I/A


chr10_+_115569986 0.223 ENSMUST00000173620.1
A930009A15Rik
RIKEN cDNA A930009A15 gene
chr2_+_106693185 0.217 ENSMUST00000111063.1
Mpped2
metallophosphoesterase domain containing 2
chr6_-_126645784 0.216 ENSMUST00000055168.3
Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
chr7_+_126950837 0.203 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr2_+_152754156 0.201 ENSMUST00000010020.5
Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr11_+_116843278 0.199 ENSMUST00000106370.3
Mettl23
methyltransferase like 23
chr13_+_42680565 0.197 ENSMUST00000128646.1
Phactr1
phosphatase and actin regulator 1
chr13_-_73678005 0.196 ENSMUST00000022105.7
ENSMUST00000109680.2
ENSMUST00000109679.2
Slc6a18


solute carrier family 6 (neurotransmitter transporter), member 18


chr14_+_53324632 0.196 ENSMUST00000178100.1
Trav7n-6
T cell receptor alpha variable 7N-6
chr13_+_80883403 0.196 ENSMUST00000099356.2
Arrdc3
arrestin domain containing 3
chr15_+_79690869 0.185 ENSMUST00000046463.8
Gtpbp1
GTP binding protein 1
chr5_+_135106881 0.183 ENSMUST00000005507.3
Mlxipl
MLX interacting protein-like
chr10_-_80421847 0.183 ENSMUST00000156244.1
Tcf3
transcription factor 3
chr11_+_102285161 0.182 ENSMUST00000156326.1
Tmub2
transmembrane and ubiquitin-like domain containing 2
chr17_+_3397189 0.180 ENSMUST00000072156.6
Tiam2
T cell lymphoma invasion and metastasis 2
chr13_-_106847267 0.180 ENSMUST00000057427.4
Lrrc70
leucine rich repeat containing 70
chr1_+_132298606 0.180 ENSMUST00000046071.4
Klhdc8a
kelch domain containing 8A
chr17_-_29007925 0.175 ENSMUST00000009138.5
ENSMUST00000119274.1
Stk38

serine/threonine kinase 38

chr7_+_29071597 0.172 ENSMUST00000180926.1
Gm26604
predicted gene, 26604
chr4_-_126968124 0.164 ENSMUST00000106108.2
Zmym4
zinc finger, MYM-type 4
chr6_-_57535422 0.158 ENSMUST00000042766.3
Ppm1k
protein phosphatase 1K (PP2C domain containing)
chr8_+_83666827 0.157 ENSMUST00000019608.5
Ptger1
prostaglandin E receptor 1 (subtype EP1)
chr5_-_23616528 0.155 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr9_+_113930934 0.153 ENSMUST00000084885.5
ENSMUST00000009885.7
Ubp1

upstream binding protein 1

chr1_-_152625212 0.151 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr2_+_109917639 0.151 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr7_+_102210335 0.149 ENSMUST00000140631.1
ENSMUST00000120879.1
ENSMUST00000146996.1
Pgap2


post-GPI attachment to proteins 2


chr4_-_155056784 0.147 ENSMUST00000131173.2
Plch2
phospholipase C, eta 2
chr5_-_77115145 0.147 ENSMUST00000081964.5
Hopx
HOP homeobox
chr16_+_13358375 0.145 ENSMUST00000149359.1
Mkl2
MKL/myocardin-like 2
chr3_-_146682410 0.141 ENSMUST00000124931.1
ENSMUST00000147113.1
Samd13

sterile alpha motif domain containing 13

chr17_+_45506825 0.138 ENSMUST00000024733.7
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr12_+_111814170 0.133 ENSMUST00000021714.7
Zfyve21
zinc finger, FYVE domain containing 21
chr13_+_36117349 0.131 ENSMUST00000021857.5
ENSMUST00000099582.2
Fars2

phenylalanine-tRNA synthetase 2 (mitochondrial)

chr9_+_61372359 0.121 ENSMUST00000178113.1
ENSMUST00000159386.1
Tle3

transducin-like enhancer of split 3, homolog of Drosophila E(spl)

chr12_-_27160311 0.117 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr7_-_102210120 0.095 ENSMUST00000070165.5
Nup98
nucleoporin 98
chr12_-_48559971 0.094 ENSMUST00000169406.1
Gm1818
predicted gene 1818
chr5_-_122989260 0.093 ENSMUST00000118027.1
Kdm2b
lysine (K)-specific demethylase 2B
chr16_-_97170707 0.085 ENSMUST00000056102.7
Dscam
Down syndrome cell adhesion molecule
chr5_-_122988533 0.081 ENSMUST00000086200.4
ENSMUST00000156474.1
Kdm2b

lysine (K)-specific demethylase 2B

chr18_-_24603464 0.079 ENSMUST00000154205.1
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr11_+_60537978 0.077 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr2_-_6722187 0.076 ENSMUST00000182657.1
Celf2
CUGBP, Elav-like family member 2
chr12_+_21417872 0.074 ENSMUST00000180671.1
Gm4419
predicted gene 4419
chr2_-_6721890 0.073 ENSMUST00000114927.2
Celf2
CUGBP, Elav-like family member 2
chr19_-_59170978 0.063 ENSMUST00000172821.2
Vax1
ventral anterior homeobox containing gene 1
chr15_-_79285502 0.061 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chrM_+_2743 0.060 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr7_-_81493725 0.057 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr5_-_122989086 0.053 ENSMUST00000046073.9
Kdm2b
lysine (K)-specific demethylase 2B
chr5_+_14025305 0.049 ENSMUST00000073957.6
Sema3e
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr13_-_18382041 0.047 ENSMUST00000139064.2
ENSMUST00000175703.2
Pou6f2

POU domain, class 6, transcription factor 2

chr11_-_97700327 0.046 ENSMUST00000018681.7
Pcgf2
polycomb group ring finger 2
chr16_-_4880284 0.043 ENSMUST00000037843.6
Ubald1
UBA-like domain containing 1
chr15_+_81744848 0.035 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr16_-_57754707 0.035 ENSMUST00000089332.4
Col8a1
collagen, type VIII, alpha 1
chr3_+_32436151 0.035 ENSMUST00000029201.7
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
chr17_-_35697971 0.032 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr11_+_102604370 0.032 ENSMUST00000057893.5
Fzd2
frizzled homolog 2 (Drosophila)
chr8_-_84662841 0.031 ENSMUST00000060427.4
Ier2
immediate early response 2
chr17_+_46161021 0.029 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chr2_-_6721606 0.029 ENSMUST00000150624.2
ENSMUST00000142941.1
ENSMUST00000100429.4
ENSMUST00000182879.1
Celf2



CUGBP, Elav-like family member 2



chrX_-_143933089 0.027 ENSMUST00000087313.3
Dcx
doublecortin
chr13_+_89540636 0.026 ENSMUST00000022108.7
Hapln1
hyaluronan and proteoglycan link protein 1
chrX_-_157415286 0.024 ENSMUST00000079945.4
ENSMUST00000138396.1
Phex

phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)

chr11_-_33203588 0.019 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chrX_-_139871637 0.017 ENSMUST00000033811.7
ENSMUST00000087401.5
Morc4

microrchidia 4

chr7_+_49910112 0.009 ENSMUST00000056442.5
Slc6a5
solute carrier family 6 (neurotransmitter transporter, glycine), member 5
chr18_-_24603791 0.006 ENSMUST00000070726.3
Slc39a6
solute carrier family 39 (metal ion transporter), member 6
chr4_-_14621805 0.004 ENSMUST00000042221.7
Slc26a7
solute carrier family 26, member 7
chr14_-_108914237 0.002 ENSMUST00000100322.2
Slitrk1
SLIT and NTRK-like family, member 1

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 3.1 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.9 0.9 GO:0060667 fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.6 3.1 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.6 4.2 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.5 2.7 GO:0052428 modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205) negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.5 3.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 2.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 1.4 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.4 3.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.3 6.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.3 0.3 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.2 1.1 GO:0006538 glutamate catabolic process(GO:0006538)
0.2 0.6 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.2 0.5 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 1.0 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 0.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 5.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.4 GO:0021852 pyramidal neuron migration(GO:0021852)
0.1 1.0 GO:0098707 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1 0.6 GO:0021856 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.1 0.7 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.3 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.1 0.5 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.1 4.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 2.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 1.2 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.6 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.1 0.2 GO:0050975 sensory perception of touch(GO:0050975)
0.1 0.5 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.1 8.9 GO:0043149 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.1 0.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879) negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.2 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 0.4 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.4 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 0.2 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.9 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.1 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 1.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.1 0.5 GO:2000671 regulation of motor neuron apoptotic process(GO:2000671)
0.1 0.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.7 GO:0001553 luteinization(GO:0001553)
0.0 0.5 GO:1904861 excitatory synapse assembly(GO:1904861)
0.0 0.1 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.2 GO:0021993 initiation of neural tube closure(GO:0021993)
0.0 1.0 GO:0044253 positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0 0.2 GO:0097475 motor neuron migration(GO:0097475)
0.0 0.9 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.4 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.1 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 1.0 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.2 GO:0035063 nuclear speck organization(GO:0035063)
0.0 0.2 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.5 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.7 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.0 0.1 GO:0060060 post-embryonic retina morphogenesis in camera-type eye(GO:0060060)
0.0 0.2 GO:0072189 ureter development(GO:0072189)
0.0 0.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0 2.7 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.0 1.6 GO:0030168 platelet activation(GO:0030168)
0.0 1.9 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 0.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.9 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.0 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.1 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.0 1.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 0.3 GO:0007608 sensory perception of smell(GO:0007608)
0.0 0.3 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.1 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 8.5 GO:0071953 elastic fiber(GO:0071953)
0.4 1.8 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 1.0 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.3 6.9 GO:0071565 nBAF complex(GO:0071565)
0.2 0.5 GO:0043512 inhibin A complex(GO:0043512)
0.1 3.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.9 GO:0097433 dense body(GO:0097433)
0.1 1.5 GO:0005614 interstitial matrix(GO:0005614)
0.1 3.4 GO:0097440 apical dendrite(GO:0097440)
0.1 0.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.4 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.5 GO:0043083 NMDA selective glutamate receptor complex(GO:0017146) synaptic cleft(GO:0043083)
0.0 0.1 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)
0.0 0.2 GO:0070069 mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex IV(GO:0045277) cytochrome complex(GO:0070069)
0.0 0.9 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.2 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.3 GO:0036038 MKS complex(GO:0036038)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 2.2 GO:0001650 fibrillar center(GO:0001650)
0.0 2.3 GO:0043197 dendritic spine(GO:0043197)
0.0 0.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 2.7 GO:0001849 complement component C1q binding(GO:0001849)
0.4 2.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 4.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.3 2.7 GO:0019865 immunoglobulin binding(GO:0019865)
0.3 3.1 GO:0050693 LBD domain binding(GO:0050693)
0.2 1.0 GO:0050436 microfibril binding(GO:0050436)
0.2 0.9 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.2 8.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.2 1.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.1 1.0 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 6.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.4 GO:0004966 galanin receptor activity(GO:0004966)
0.1 0.5 GO:0008545 JUN kinase kinase activity(GO:0008545)
0.1 0.3 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.1 0.5 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.4 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 0.5 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.1 GO:0070064 proline-rich region binding(GO:0070064)
0.1 3.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 3.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 2.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 1.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.4 GO:0000150 recombinase activity(GO:0000150)
0.0 4.9 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.1 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.8 GO:0016208 AMP binding(GO:0016208)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004954 icosanoid receptor activity(GO:0004953) prostanoid receptor activity(GO:0004954) prostaglandin receptor activity(GO:0004955)
0.0 0.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 2.4 GO:0002039 p53 binding(GO:0002039)
0.0 0.5 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.0 0.1 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.2 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.3 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 1.8 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 0.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 2.3 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0005328 neurotransmitter transporter activity(GO:0005326) neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.1 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 1.0 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.2 PID_ARF6_PATHWAY Arf6 signaling events
0.1 11.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 3.8 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 3.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.4 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 1.3 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.5 PID_ALK1_PATHWAY ALK1 signaling events
0.0 0.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.5 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.1 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.8 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 0.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 0.9 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 1.1 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 2.3 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 6.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 0.5 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 2.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.5 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.5 REACTOME_SIGNALING_BY_ROBO_RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.6 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.1 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions