Motif ID: Msx2_Hoxd4

Z-value: 1.160

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.105.6e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_36811361 9.331 ENSMUST00000101534.1
Ptn
pleiotrophin
chr1_-_190170671 8.675 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr5_-_62766153 7.547 ENSMUST00000076623.4
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170178 6.945 ENSMUST00000177288.1
Prox1
prospero-related homeobox 1
chr2_+_4017727 5.697 ENSMUST00000177457.1
Frmd4a
FERM domain containing 4A
chr3_+_62419668 5.682 ENSMUST00000161057.1
Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_79285502 5.606 ENSMUST00000165408.1
Baiap2l2
BAI1-associated protein 2-like 2
chr3_-_49757257 4.484 ENSMUST00000035931.7
Pcdh18
protocadherin 18
chr14_-_88471396 4.147 ENSMUST00000061628.5
Pcdh20
protocadherin 20
chr2_-_63184253 4.043 ENSMUST00000075052.3
ENSMUST00000112454.1
Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_163725123 3.752 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr3_-_85741389 3.696 ENSMUST00000094148.4
Fam160a1
family with sequence similarity 160, member A1
chr3_+_68869563 3.560 ENSMUST00000054551.2
1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr15_+_21111452 3.408 ENSMUST00000075132.6
Cdh12
cadherin 12
chr1_+_159737510 3.133 ENSMUST00000111669.3
Tnr
tenascin R
chr1_-_152625212 3.070 ENSMUST00000027760.7
Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr9_+_22454290 3.026 ENSMUST00000168332.1
Gm17545
predicted gene, 17545
chr12_+_36314160 2.729 ENSMUST00000041407.5
Sostdc1
sclerostin domain containing 1
chr11_+_103133303 2.694 ENSMUST00000107037.1
Hexim2
hexamethylene bis-acetamide inducible 2
chr5_-_62765618 2.546 ENSMUST00000159470.1
Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr4_+_136143497 2.485 ENSMUST00000008016.2
Id3
inhibitor of DNA binding 3
chr2_-_63184170 2.431 ENSMUST00000112452.1
Kcnh7
potassium voltage-gated channel, subfamily H (eag-related), member 7
chr12_+_74297474 2.424 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr11_+_103133333 2.422 ENSMUST00000124928.1
ENSMUST00000062530.4
Hexim2

hexamethylene bis-acetamide inducible 2

chr1_+_165788681 2.403 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
Cd247



CD247 antigen



chr2_-_33086366 2.084 ENSMUST00000049618.2
Garnl3
GTPase activating RANGAP domain-like 3
chr9_-_114390633 1.998 ENSMUST00000084881.4
Crtap
cartilage associated protein
chr13_+_75967704 1.980 ENSMUST00000022081.1
Spata9
spermatogenesis associated 9
chr2_+_125136692 1.949 ENSMUST00000099452.2
Ctxn2
cortexin 2
chr15_-_37459327 1.933 ENSMUST00000119730.1
ENSMUST00000120746.1
Ncald

neurocalcin delta

chr3_+_138065052 1.925 ENSMUST00000163080.2
1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr3_+_52268337 1.878 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr1_+_165788746 1.868 ENSMUST00000161559.2
Cd247
CD247 antigen
chr18_+_52767994 1.778 ENSMUST00000025413.7
ENSMUST00000163742.2
ENSMUST00000178011.1
Sncaip


synuclein, alpha interacting protein (synphilin)


chr16_-_44016387 1.729 ENSMUST00000036174.3
Gramd1c
GRAM domain containing 1C
chr4_+_124657646 1.655 ENSMUST00000053491.7
Pou3f1
POU domain, class 3, transcription factor 1
chr17_-_90088343 1.593 ENSMUST00000173917.1
Nrxn1
neurexin I
chr19_+_26749726 1.510 ENSMUST00000175842.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr4_-_129121889 1.442 ENSMUST00000139450.1
ENSMUST00000125931.1
ENSMUST00000116444.2
Hpca


hippocalcin


chr3_+_84952146 1.437 ENSMUST00000029727.7
Fbxw7
F-box and WD-40 domain protein 7
chr6_-_136171722 1.433 ENSMUST00000053880.6
Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_-_144527341 1.398 ENSMUST00000163701.1
ENSMUST00000081982.5
Dzank1

double zinc ribbon and ankyrin repeat domains 1

chr6_+_124304646 1.370 ENSMUST00000112541.2
ENSMUST00000032234.2
Cd163

CD163 antigen

chr3_-_66296807 1.351 ENSMUST00000029419.7
Veph1
ventricular zone expressed PH domain-containing 1
chrX_+_101640056 1.325 ENSMUST00000119299.1
ENSMUST00000044475.4
Ogt

O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)

chr14_+_115042752 1.311 ENSMUST00000134140.2
Mir17hg
Mir17 host gene 1 (non-protein coding)
chr13_+_51408618 1.241 ENSMUST00000087978.3
S1pr3
sphingosine-1-phosphate receptor 3
chrX_+_150547375 1.209 ENSMUST00000066337.6
ENSMUST00000112715.1
Alas2

aminolevulinic acid synthase 2, erythroid

chr18_+_37518341 1.129 ENSMUST00000097609.1
Pcdhb22
protocadherin beta 22
chr7_-_45921418 1.065 ENSMUST00000038876.5
Emp3
epithelial membrane protein 3
chr4_-_40722307 1.061 ENSMUST00000181475.1
Gm6297
predicted gene 6297
chr1_-_72284248 1.055 ENSMUST00000097698.4
ENSMUST00000027381.6
Pecr

peroxisomal trans-2-enoyl-CoA reductase

chr7_-_45920830 1.041 ENSMUST00000164119.1
Emp3
epithelial membrane protein 3
chr5_-_107875035 1.018 ENSMUST00000138111.1
ENSMUST00000112642.1
Evi5

ecotropic viral integration site 5

chr4_-_149126688 1.015 ENSMUST00000030815.2
Cort
cortistatin
chrX_+_56454871 0.993 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr1_-_163289214 0.993 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr16_+_14705832 0.976 ENSMUST00000023356.6
Snai2
snail homolog 2 (Drosophila)
chr17_-_25785324 0.976 ENSMUST00000150324.1
Haghl
hydroxyacylglutathione hydrolase-like
chr18_+_37320374 0.960 ENSMUST00000078271.2
Pcdhb5
protocadherin beta 5
chrX_+_159708593 0.950 ENSMUST00000080394.6
Sh3kbp1
SH3-domain kinase binding protein 1
chr15_-_37458523 0.947 ENSMUST00000116445.2
Ncald
neurocalcin delta
chr1_-_133921393 0.945 ENSMUST00000048432.5
Prelp
proline arginine-rich end leucine-rich repeat
chr18_+_37513652 0.940 ENSMUST00000061405.4
Pcdhb21
protocadherin beta 21
chr15_+_92597104 0.907 ENSMUST00000035399.8
Pdzrn4
PDZ domain containing RING finger 4
chr9_-_112187766 0.877 ENSMUST00000111872.2
ENSMUST00000164754.2
Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr3_-_146495115 0.874 ENSMUST00000093951.2
Spata1
spermatogenesis associated 1
chrX_-_8132770 0.860 ENSMUST00000130832.1
ENSMUST00000033506.6
ENSMUST00000115623.1
ENSMUST00000153839.1
Wdr13



WD repeat domain 13



chr10_+_39612934 0.841 ENSMUST00000019987.6
Traf3ip2
TRAF3 interacting protein 2
chr18_-_37969742 0.784 ENSMUST00000166148.1
ENSMUST00000163131.1
ENSMUST00000043437.7
Fchsd1


FCH and double SH3 domains 1


chr9_-_89705017 0.780 ENSMUST00000058488.6
Tmed3
transmembrane emp24 domain containing 3
chr5_-_146220901 0.775 ENSMUST00000169407.2
ENSMUST00000161331.1
ENSMUST00000159074.2
ENSMUST00000067837.3
Rnf6



ring finger protein (C3H2C3 type) 6



chr13_-_95250166 0.745 ENSMUST00000162153.1
ENSMUST00000160957.2
ENSMUST00000159598.1
ENSMUST00000162412.1
Pde8b



phosphodiesterase 8B



chrM_+_7759 0.727 ENSMUST00000082407.1
ENSMUST00000082408.1
mt-Atp8
mt-Atp6
mitochondrially encoded ATP synthase 8
mitochondrially encoded ATP synthase 6
chr17_-_14694223 0.723 ENSMUST00000170872.1
Thbs2
thrombospondin 2
chr3_+_19957037 0.721 ENSMUST00000091309.5
ENSMUST00000108329.1
ENSMUST00000003714.6
Cp


ceruloplasmin


chr7_-_101845300 0.697 ENSMUST00000094141.5
Folr2
folate receptor 2 (fetal)
chr8_-_70527645 0.691 ENSMUST00000132867.1
Kxd1
KxDL motif containing 1
chr15_+_85510812 0.664 ENSMUST00000079690.2
Gm4825
predicted pseudogene 4825
chr6_-_124779686 0.664 ENSMUST00000147669.1
ENSMUST00000128697.1
ENSMUST00000032218.3
ENSMUST00000112475.2
Lrrc23



leucine rich repeat containing 23



chr17_-_46327949 0.654 ENSMUST00000047970.7
Abcc10
ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr7_+_126950837 0.630 ENSMUST00000106332.1
Sez6l2
seizure related 6 homolog like 2
chr4_-_141078302 0.610 ENSMUST00000030760.8
Necap2
NECAP endocytosis associated 2
chr7_-_121074501 0.603 ENSMUST00000047194.2
Igsf6
immunoglobulin superfamily, member 6
chr3_+_144570409 0.583 ENSMUST00000082437.3
Sep15
selenoprotein
chr1_+_63176818 0.558 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr7_+_126950518 0.554 ENSMUST00000106335.1
ENSMUST00000146017.1
Sez6l2

seizure related 6 homolog like 2

chr7_+_96522342 0.551 ENSMUST00000129737.1
Tenm4
teneurin transmembrane protein 4
chr2_-_45110336 0.550 ENSMUST00000028229.6
ENSMUST00000152232.1
Zeb2

zinc finger E-box binding homeobox 2

chr7_+_126950687 0.544 ENSMUST00000106333.1
Sez6l2
seizure related 6 homolog like 2
chr10_-_33624587 0.532 ENSMUST00000160299.1
ENSMUST00000019920.6
Clvs2

clavesin 2

chrM_-_14060 0.528 ENSMUST00000082419.1
mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr18_+_59062462 0.527 ENSMUST00000058633.2
ENSMUST00000175897.1
ENSMUST00000118510.1
ENSMUST00000175830.1
A730017C20Rik



RIKEN cDNA A730017C20 gene



chr3_+_144570687 0.525 ENSMUST00000106211.1
Sep15
selenoprotein
chrM_+_2743 0.523 ENSMUST00000082392.1
mt-Nd1
mitochondrially encoded NADH dehydrogenase 1
chr1_-_186749304 0.514 ENSMUST00000001339.5
Rrp15
ribosomal RNA processing 15 homolog (S. cerevisiae)
chrM_+_10167 0.512 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr10_+_128303322 0.500 ENSMUST00000005825.6
Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)
chr2_-_45112890 0.498 ENSMUST00000076836.6
Zeb2
zinc finger E-box binding homeobox 2
chr2_+_72054598 0.496 ENSMUST00000028525.5
Rapgef4
Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_132847719 0.493 ENSMUST00000124836.1
ENSMUST00000154160.1
Crls1

cardiolipin synthase 1

chr11_-_109472611 0.484 ENSMUST00000168740.1
Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr7_-_38019505 0.469 ENSMUST00000085513.4
Uri1
URI1, prefoldin-like chaperone
chrX_-_150814265 0.464 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
Maged2


melanoma antigen, family D, 2


chr7_+_65693417 0.436 ENSMUST00000032726.7
ENSMUST00000107495.3
Tm2d3

TM2 domain containing 3

chr4_-_62519885 0.420 ENSMUST00000107444.1
ENSMUST00000030090.3
Alad

aminolevulinate, delta-, dehydratase

chr8_+_70527724 0.409 ENSMUST00000119353.2
ENSMUST00000075491.7
Fkbp8

FK506 binding protein 8

chr5_-_23616528 0.399 ENSMUST00000088392.4
Srpk2
serine/arginine-rich protein specific kinase 2
chr2_-_176144697 0.397 ENSMUST00000178872.1
Gm2004
predicted gene 2004
chr1_-_24612700 0.394 ENSMUST00000088336.1
Gm10222
predicted gene 10222
chr2_+_76650264 0.390 ENSMUST00000099986.2
Dfnb59
deafness, autosomal recessive 59 (human)
chr10_+_75037066 0.381 ENSMUST00000147802.1
ENSMUST00000020391.5
Rab36

RAB36, member RAS oncogene family

chr2_+_155751117 0.374 ENSMUST00000029140.5
ENSMUST00000132608.1
Procr

protein C receptor, endothelial

chr17_+_45506825 0.364 ENSMUST00000024733.7
Aars2
alanyl-tRNA synthetase 2, mitochondrial (putative)
chr7_+_144838590 0.350 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr12_-_85374696 0.346 ENSMUST00000040766.7
Tmed10
transmembrane emp24-like trafficking protein 10 (yeast)
chr1_+_180109192 0.325 ENSMUST00000143176.1
ENSMUST00000135056.1
Cdc42bpa

CDC42 binding protein kinase alpha

chr17_-_24073479 0.310 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr9_-_55919605 0.296 ENSMUST00000037408.8
Scaper
S phase cyclin A-associated protein in the ER
chr7_+_97400003 0.292 ENSMUST00000032882.8
Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
chr13_+_49544443 0.289 ENSMUST00000177948.1
ENSMUST00000021820.6
Aspn

asporin

chr3_-_144570136 0.288 ENSMUST00000043325.7
Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr10_-_14718191 0.285 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr7_+_65693447 0.284 ENSMUST00000143508.1
Tm2d3
TM2 domain containing 3
chr12_-_27160311 0.274 ENSMUST00000182473.1
ENSMUST00000177636.1
ENSMUST00000183238.1
Gm9866


predicted gene 9866


chr3_+_106113229 0.272 ENSMUST00000079132.5
ENSMUST00000139086.1
Chia

chitinase, acidic

chr15_-_50890396 0.258 ENSMUST00000185183.1
Trps1
trichorhinophalangeal syndrome I (human)
chrM_+_9870 0.246 ENSMUST00000084013.1
mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_+_191025350 0.213 ENSMUST00000181050.1
A230020J21Rik
RIKEN cDNA A230020J21 gene
chr1_-_133661318 0.191 ENSMUST00000027736.6
ENSMUST00000179598.1
Zc3h11a
Zbed6
zinc finger CCCH type containing 11A
zinc finger, BED domain containing 6
chr2_+_180710117 0.190 ENSMUST00000029090.2
Gid8
GID complex subunit 8 homolog (S. cerevisiae)
chr7_-_29906524 0.183 ENSMUST00000159920.1
ENSMUST00000162592.1
Zfp27

zinc finger protein 27

chr6_-_106800051 0.178 ENSMUST00000013882.7
ENSMUST00000049675.4
ENSMUST00000113239.3
Crbn


cereblon


chr6_+_136518820 0.178 ENSMUST00000032335.6
Atf7ip
activating transcription factor 7 interacting protein
chr1_-_132390301 0.175 ENSMUST00000132435.1
Tmcc2
transmembrane and coiled-coil domains 2
chr1_+_157458554 0.170 ENSMUST00000046743.4
ENSMUST00000119891.1
BC026585

cDNA sequence BC026585

chr7_-_84679346 0.159 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr9_+_64235201 0.140 ENSMUST00000039011.3
Uchl4
ubiquitin carboxyl-terminal esterase L4
chr5_+_48242549 0.126 ENSMUST00000172493.1
Slit2
slit homolog 2 (Drosophila)
chr6_+_29853746 0.126 ENSMUST00000064872.6
ENSMUST00000152581.1
ENSMUST00000176265.1
ENSMUST00000154079.1
Ahcyl2



S-adenosylhomocysteine hydrolase-like 2



chrM_+_9452 0.121 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr13_+_23555023 0.120 ENSMUST00000045301.6
Hist1h1d
histone cluster 1, H1d
chr10_+_5593718 0.119 ENSMUST00000051809.8
Myct1
myc target 1
chr7_-_73537621 0.110 ENSMUST00000172704.1
Chd2
chromodomain helicase DNA binding protein 2
chr17_+_46161021 0.109 ENSMUST00000024748.7
ENSMUST00000172170.1
Gtpbp2

GTP binding protein 2

chr2_-_164389095 0.100 ENSMUST00000167427.1
Slpi
secretory leukocyte peptidase inhibitor
chr6_-_13871477 0.095 ENSMUST00000139231.1
2610001J05Rik
RIKEN cDNA 2610001J05 gene
chr13_+_40859768 0.089 ENSMUST00000110191.2
Gcnt2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr19_+_46396885 0.084 ENSMUST00000039922.6
ENSMUST00000111867.2
ENSMUST00000120778.1
Sufu


suppressor of fused homolog (Drosophila)


chr11_+_78465697 0.083 ENSMUST00000001126.3
Slc46a1
solute carrier family 46, member 1
chr9_+_30942541 0.076 ENSMUST00000068135.6
Adamts8
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8
chr9_+_32116040 0.076 ENSMUST00000174641.1
Arhgap32
Rho GTPase activating protein 32
chr8_-_120228221 0.076 ENSMUST00000183235.1
A330074K22Rik
RIKEN cDNA A330074K22 gene
chr14_-_36919314 0.074 ENSMUST00000182797.1
Ccser2
coiled-coil serine rich 2
chr9_-_107770945 0.058 ENSMUST00000183248.1
ENSMUST00000182022.1
ENSMUST00000035199.6
ENSMUST00000182659.1
Rbm5



RNA binding motif protein 5



chrX_-_74246534 0.043 ENSMUST00000101454.2
ENSMUST00000033699.6
Flna

filamin, alpha

chr6_-_136941887 0.027 ENSMUST00000111891.1
Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_41830921 0.017 ENSMUST00000166917.1
Oxr1
oxidation resistance 1
chr19_-_53371766 0.014 ENSMUST00000086887.1
Gm10197
predicted gene 10197
chr3_-_150073620 0.008 ENSMUST00000057740.5
Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr5_-_31180110 0.003 ENSMUST00000043161.6
ENSMUST00000088010.5
Gtf3c2

general transcription factor IIIC, polypeptide 2, beta

chrM_+_8600 0.000 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
3.1 9.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 2.7 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.8 3.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.5 1.4 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.4 1.3 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 1.6 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.4 1.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.4 5.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.3 1.0 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.3 1.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.3 5.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 0.7 GO:0035106 operant conditioning(GO:0035106)
0.2 4.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 2.0 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.2 1.0 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 1.9 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.2 5.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 1.5 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 0.8 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 4.3 GO:0070207 protein homotrimerization(GO:0070207)
0.1 0.6 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 5.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.5 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 1.2 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.4 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 3.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.3 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.1 2.5 GO:0030903 notochord development(GO:0030903)
0.1 7.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.0 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 1.0 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.5 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.9 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.1 0.5 GO:0070294 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.1 1.1 GO:0030497 fatty acid elongation(GO:0030497)
0.1 1.7 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.1 1.0 GO:0045187 regulation of circadian sleep/wake cycle(GO:0042749) regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.1 1.4 GO:0006953 acute-phase response(GO:0006953)
0.1 0.3 GO:0030202 heparin metabolic process(GO:0030202)
0.1 0.8 GO:0015884 folic acid transport(GO:0015884)
0.1 0.3 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.1 1.8 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 0.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 1.7 GO:0032292 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 0.8 GO:0048305 positive regulation of defense response to virus by host(GO:0002230) immunoglobulin secretion(GO:0048305)
0.0 1.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.7 GO:0046688 response to copper ion(GO:0046688)
0.0 0.1 GO:0021972 chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.0 0.8 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 6.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 2.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.5 GO:0033194 response to hydroperoxide(GO:0033194)
0.0 0.5 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.0 0.1 GO:0072344 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966) rescue of stalled ribosome(GO:0072344)
0.0 3.8 GO:0007416 synapse assembly(GO:0007416)
0.0 0.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.1 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0 0.9 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:0000460 maturation of 5.8S rRNA(GO:0000460) maturation of LSU-rRNA(GO:0000470)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 0.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.0 0.4 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.6 GO:0045471 response to ethanol(GO:0045471)
0.0 0.4 GO:0021904 dorsal/ventral neural tube patterning(GO:0021904)
0.0 0.9 GO:0007569 cell aging(GO:0007569)
0.0 0.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0 0.7 GO:0032418 lysosome localization(GO:0032418)
0.0 0.2 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.0 3.1 GO:0072534 perineuronal net(GO:0072534)
0.6 5.6 GO:0071439 clathrin complex(GO:0071439)
0.4 1.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.2 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 0.5 GO:0031251 PAN complex(GO:0031251)
0.1 0.5 GO:0044316 cone cell pedicle(GO:0044316)
0.1 1.4 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.1 10.1 GO:0031594 neuromuscular junction(GO:0031594)
0.1 0.6 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.7 GO:0042588 zymogen granule(GO:0042588)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.7 GO:0031091 platelet alpha granule(GO:0031091)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.7 GO:0031083 BLOC-1 complex(GO:0031083)
0.0 5.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.2 GO:0000346 transcription export complex(GO:0000346)
0.0 2.2 GO:0070469 respiratory chain(GO:0070469)
0.0 0.6 GO:0030125 clathrin vesicle coat(GO:0030125)
0.0 0.5 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.3 GO:0005922 connexon complex(GO:0005922)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.9 GO:0005815 microtubule organizing center(GO:0005815)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 5.1 GO:0016607 nuclear speck(GO:0016607)
0.0 1.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 0.0 GO:0031523 Myb complex(GO:0031523)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.3 15.6 GO:0050693 LBD domain binding(GO:0050693)
0.6 5.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.5 3.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.4 1.3 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.4 1.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.4 2.7 GO:0098821 BMP receptor activity(GO:0098821)
0.4 1.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.3 6.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.3 1.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 0.7 GO:0051870 methotrexate binding(GO:0051870)
0.2 10.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 3.1 GO:0046625 sphingolipid binding(GO:0046625)
0.2 1.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 1.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 0.7 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.4 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 1.0 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 2.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 4.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 5.7 GO:0030674 protein binding, bridging(GO:0030674)
0.0 0.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.4 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 14.3 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.6 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.5 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 0.4 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 3.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.3 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.5 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.0 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.0 2.8 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 9.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.3 10.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 4.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 1.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 1.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 2.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 2.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 10.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.7 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 1.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 2.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 0.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac