Motif ID: Msx2_Hoxd4

Z-value: 1.160

Transcription factors associated with Msx2_Hoxd4:

Gene SymbolEntrez IDGene Name
Msx2 ENSMUSG00000021469.8 Msx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx2mm10_v2_chr13_-_53473074_53473074-0.105.6e-01Click!


Activity profile for motif Msx2_Hoxd4.

activity profile for motif Msx2_Hoxd4


Sorted Z-values histogram for motif Msx2_Hoxd4

Sorted Z-values for motif Msx2_Hoxd4



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx2_Hoxd4

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_36811361 9.331 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr1_-_190170671 8.675 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr5_-_62766153 7.547 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_190170178 6.945 ENSMUST00000177288.1
 Prox1
prospero-related homeobox 1
chr2_+_4017727 5.697 ENSMUST00000177457.1
 Frmd4a
FERM domain containing 4A
chr3_+_62419668 5.682 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr15_-_79285502 5.606 ENSMUST00000165408.1
 Baiap2l2
BAI1-associated protein 2-like 2
chr3_-_49757257 4.484 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr14_-_88471396 4.147 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr2_-_63184253 4.043 ENSMUST00000075052.3
ENSMUST00000112454.1
 Kcnh7

potassium voltage-gated channel, subfamily H (eag-related), member 7

chr1_-_163725123 3.752 ENSMUST00000159679.1
 Mettl11b
methyltransferase like 11B
chr3_-_85741389 3.696 ENSMUST00000094148.4
 Fam160a1
family with sequence similarity 160, member A1
chr3_+_68869563 3.560 ENSMUST00000054551.2
 1110032F04Rik
RIKEN cDNA 1110032F04 gene
chr15_+_21111452 3.408 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_+_159737510 3.133 ENSMUST00000111669.3
 Tnr
tenascin R
chr1_-_152625212 3.070 ENSMUST00000027760.7
 Rgl1
ral guanine nucleotide dissociation stimulator,-like 1
chr9_+_22454290 3.026 ENSMUST00000168332.1
 Gm17545
predicted gene, 17545
chr12_+_36314160 2.729 ENSMUST00000041407.5
 Sostdc1
sclerostin domain containing 1
chr11_+_103133303 2.694 ENSMUST00000107037.1
 Hexim2
hexamethylene bis-acetamide inducible 2
chr5_-_62765618 2.546 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 15.6 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
3.1 9.3 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 7.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 6.7 GO:0051291 protein heterooligomerization(GO:0051291)
0.3 5.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 5.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 5.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.2 5.1 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.2 4.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 4.3 GO:0070207 protein homotrimerization(GO:0070207)
0.1 3.8 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 3.8 GO:0007416 synapse assembly(GO:0007416)
0.8 3.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 2.9 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.9 2.7 GO:2000016 negative regulation of determination of dorsal identity(GO:2000016)
0.1 2.5 GO:0030903 notochord development(GO:0030903)
0.1 2.1 GO:0032060 bleb assembly(GO:0032060)
0.2 2.0 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.2 1.9 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.1 1.8 GO:0090083 regulation of inclusion body assembly(GO:0090083)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 34 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 GO:0031594 neuromuscular junction(GO:0031594)
0.6 5.6 GO:0071439 clathrin complex(GO:0071439)
0.0 5.5 GO:0005923 bicellular tight junction(GO:0005923)
0.0 5.1 GO:0016607 nuclear speck(GO:0016607)
1.1 4.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
1.0 3.1 GO:0072534 perineuronal net(GO:0072534)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.2 GO:0070469 respiratory chain(GO:0070469)
0.1 1.7 GO:0042588 zymogen granule(GO:0042588)
0.2 1.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 1.6 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.4 1.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 1.4 GO:0044327 dendritic spine head(GO:0044327)
0.1 1.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0 0.9 GO:0005815 microtubule organizing center(GO:0005815)
0.1 0.8 GO:0030126 COPI vesicle coat(GO:0030126)
0.1 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 15.6 GO:0050693 LBD domain binding(GO:0050693)
0.0 14.3 GO:0005509 calcium ion binding(GO:0005509)
0.2 10.1 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
3.1 9.3 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.3 6.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 5.7 GO:0030674 protein binding, bridging(GO:0030674)
0.6 5.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 4.3 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 4.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 3.6 GO:0005543 phospholipid binding(GO:0005543)
0.0 3.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.5 3.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2 3.1 GO:0046625 sphingolipid binding(GO:0046625)
0.1 2.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 2.8 GO:0005096 GTPase activator activity(GO:0005096)
0.4 2.7 GO:0098821 BMP receptor activity(GO:0098821)
0.1 2.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 2.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.9 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.6 GO:0097109 neuroligin family protein binding(GO:0097109)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 10.1 PID_ARF6_PATHWAY Arf6 signaling events
0.5 9.3 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.1 4.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.7 PID_BMP_PATHWAY BMP receptor signaling
0.1 1.9 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.4 PID_MYC_PATHWAY C-MYC pathway
0.0 1.4 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.2 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.0 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 6.5 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.7 4.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1 3.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 2.9 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 2.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.9 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.6 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.4 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.4 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.0 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 0.9 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.7 REACTOME_SIGNALING_BY_PDGF Genes involved in Signaling by PDGF
0.0 0.7 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.5 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.0 0.5 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.0 0.4 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.3 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac