Motif ID: Msx3

Z-value: 0.425


Transcription factors associated with Msx3:

Gene SymbolEntrez IDGene Name
Msx3 ENSMUSG00000025469.9 Msx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Msx3mm10_v2_chr7_-_140049140_1400491800.616.0e-05Click!


Activity profile for motif Msx3.

activity profile for motif Msx3


Sorted Z-values histogram for motif Msx3

Sorted Z-values for motif Msx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Msx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_14621805 3.442 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 2.009 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621494 1.993 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr15_+_44787746 1.937 ENSMUST00000181839.1
 2310069G16Rik
RIKEN cDNA 2310069G16 gene
chr4_+_102254739 1.695 ENSMUST00000106907.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr10_+_81257277 1.522 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr9_-_53975246 1.186 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr2_-_45117349 1.159 ENSMUST00000176438.2
 Zeb2
zinc finger E-box binding homeobox 2
chr2_-_33087169 1.138 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr2_+_125136692 1.046 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr2_-_33086366 1.027 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr10_+_39612934 0.994 ENSMUST00000019987.6
 Traf3ip2
TRAF3 interacting protein 2
chr3_-_116253467 0.889 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr10_+_88379217 0.840 ENSMUST00000130301.1
ENSMUST00000020251.8
 Gnptab

N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits

chr7_-_127895578 0.819 ENSMUST00000033074.6
 Vkorc1
vitamin K epoxide reductase complex, subunit 1
chr15_+_82252397 0.794 ENSMUST00000136948.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr10_+_88379127 0.733 ENSMUST00000127615.1
 Gnptab
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
chr4_+_94739276 0.650 ENSMUST00000073939.6
ENSMUST00000102798.1
 Tek

endothelial-specific receptor tyrosine kinase

chr17_-_24527830 0.534 ENSMUST00000176353.1
ENSMUST00000176237.1
 Traf7

TNF receptor-associated factor 7

chr12_+_102128718 0.525 ENSMUST00000159329.1
 Slc24a4
solute carrier family 24 (sodium/potassium/calcium exchanger), member 4
chr17_-_24527925 0.471 ENSMUST00000176652.1
 Traf7
TNF receptor-associated factor 7
chr13_+_83732438 0.459 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr12_-_71136611 0.454 ENSMUST00000021486.8
ENSMUST00000166120.1
 Timm9

translocase of inner mitochondrial membrane 9

chr9_+_44398176 0.447 ENSMUST00000165839.1
 Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr13_-_102958084 0.410 ENSMUST00000099202.3
ENSMUST00000172264.1
 Mast4

microtubule associated serine/threonine kinase family member 4

chr6_+_145934113 0.390 ENSMUST00000032383.7
 Sspn
sarcospan
chr18_+_37819543 0.388 ENSMUST00000055935.5
 Pcdhga9
protocadherin gamma subfamily A, 9
chr11_+_53433299 0.384 ENSMUST00000018382.6
 Gdf9
growth differentiation factor 9
chr7_+_3645267 0.356 ENSMUST00000038913.9
 Cnot3
CCR4-NOT transcription complex, subunit 3
chr11_+_70018421 0.354 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr8_+_107031218 0.325 ENSMUST00000034388.9
 Vps4a
vacuolar protein sorting 4a (yeast)
chr7_-_99141068 0.302 ENSMUST00000037968.8
 Uvrag
UV radiation resistance associated gene
chr1_-_52190901 0.293 ENSMUST00000156887.1
ENSMUST00000129107.1
 Gls

glutaminase

chr5_+_14514918 0.278 ENSMUST00000030691.10
ENSMUST00000182407.1
 Pclo

piccolo (presynaptic cytomatrix protein)

chr5_+_88583527 0.277 ENSMUST00000031229.6
 Rufy3
RUN and FYVE domain containing 3
chr3_+_106034661 0.259 ENSMUST00000170669.2
 Gm4540
predicted gene 4540
chr19_+_5474681 0.241 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr7_+_101896817 0.216 ENSMUST00000143835.1
 Anapc15
anaphase prompoting complex C subunit 15
chr15_+_38661904 0.206 ENSMUST00000022904.6
 Atp6v1c1
ATPase, H+ transporting, lysosomal V1 subunit C1
chrX_-_143933089 0.195 ENSMUST00000087313.3
 Dcx
doublecortin
chrX_-_143933204 0.191 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr1_-_158356258 0.181 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr3_+_66985947 0.152 ENSMUST00000161726.1
ENSMUST00000160504.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_66985647 0.145 ENSMUST00000162362.1
ENSMUST00000065074.7
 Rsrc1

arginine/serine-rich coiled-coil 1

chr3_+_83055516 0.139 ENSMUST00000150268.1
ENSMUST00000122128.1
 Plrg1

pleiotropic regulator 1, PRL1 homolog (Arabidopsis)

chr9_-_15301555 0.137 ENSMUST00000034414.8
 4931406C07Rik
RIKEN cDNA 4931406C07 gene
chr2_+_121956411 0.126 ENSMUST00000110578.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr2_+_121956651 0.117 ENSMUST00000110574.1
 Ctdspl2
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2
chr11_+_109543694 0.114 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr3_+_66985700 0.112 ENSMUST00000046542.6
ENSMUST00000162693.1
 Rsrc1

arginine/serine-rich coiled-coil 1

chr8_+_72219726 0.104 ENSMUST00000003123.8
 Fam32a
family with sequence similarity 32, member A
chr3_+_94837533 0.102 ENSMUST00000107270.2
 Pogz
pogo transposable element with ZNF domain
chr16_+_11406618 0.102 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr1_+_34439851 0.093 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr3_+_66985680 0.088 ENSMUST00000065047.6
 Rsrc1
arginine/serine-rich coiled-coil 1
chr1_-_34439672 0.066 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr16_-_75766758 0.059 ENSMUST00000114244.1
ENSMUST00000046283.8
 Hspa13

heat shock protein 70 family, member 13

chr7_+_103550368 0.048 ENSMUST00000106888.1
 Olfr613
olfactory receptor 613
chr2_-_174346712 0.036 ENSMUST00000168292.1
 Gm20721
predicted gene, 20721
chr13_+_67863324 0.022 ENSMUST00000078471.5
 BC048507
cDNA sequence BC048507
chr13_-_58354862 0.021 ENSMUST00000043605.5
 Kif27
kinesin family member 27
chr17_+_21383725 0.019 ENSMUST00000056107.4
ENSMUST00000162659.1
 Zfp677

zinc finger protein 677

chr4_-_129378116 0.015 ENSMUST00000030610.2
 Zbtb8a
zinc finger and BTB domain containing 8a
chr11_+_116843278 0.011 ENSMUST00000106370.3
 Mettl23
methyltransferase like 23
chr3_+_32515295 0.005 ENSMUST00000029203.7
 Zfp639
zinc finger protein 639

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.4 GO:0019532 oxalate transport(GO:0019532)
0.5 1.6 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.3 0.8 GO:0018214 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.2 0.9 GO:0061743 motor learning(GO:0061743)
0.2 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 1.2 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 0.4 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 1.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.3 GO:0009838 abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1 0.3 GO:0098928 presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526)
0.1 0.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 1.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 0.4 GO:0042701 progesterone secretion(GO:0042701)
0.1 0.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.1 1.0 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 0.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.5 GO:0097186 amelogenesis(GO:0097186)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.4 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 1.5 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0 0.3 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 1.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.5 GO:0046677 response to antibiotic(GO:0046677)
0.0 0.4 GO:0001829 trophectodermal cell differentiation(GO:0001829)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.3 GO:0099569 presynaptic cytoskeleton(GO:0099569)
0.1 1.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.3 GO:0071437 invadopodium(GO:0071437)
0.0 0.3 GO:0090543 ESCRT III complex(GO:0000815) Flemming body(GO:0090543)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.4 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.4 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.4 1.6 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.1 0.5 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.1 0.3 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.8 GO:0048038 quinone binding(GO:0048038)
0.1 1.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.0 0.4 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 1.5 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 1.2 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID_SHP2_PATHWAY SHP2 signaling
0.0 0.4 ST_GA12_PATHWAY G alpha 12 Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 8.0 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 1.7 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.0 0.3 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.5 REACTOME_SIGNALING_BY_ERBB2 Genes involved in Signaling by ERBB2
0.0 0.4 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.4 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport