Motif ID: Myb

Z-value: 1.826


Transcription factors associated with Myb:

Gene SymbolEntrez IDGene Name
Myb ENSMUSG00000019982.8 Myb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybmm10_v2_chr10_-_21160925_211609840.772.2e-08Click!


Activity profile for motif Myb.

activity profile for motif Myb


Sorted Z-values histogram for motif Myb

Sorted Z-values for motif Myb



Network of associatons between targets according to the STRING database.



First level regulatory network of Myb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_118437331 13.394 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr5_+_123749696 11.595 ENSMUST00000031366.7
 Kntc1
kinetochore associated 1
chr2_-_127831817 11.425 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr2_+_118814237 11.297 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chrX_+_58030999 10.268 ENSMUST00000088631.4
ENSMUST00000088629.3
 Zic3

zinc finger protein of the cerebellum 3

chr2_+_118814195 10.204 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 9.981 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr6_+_124829540 8.953 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr8_-_110168204 8.386 ENSMUST00000003754.6
 Calb2
calbindin 2
chr6_+_124829582 8.207 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr9_+_72438519 8.144 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438534 8.036 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr18_+_5591860 7.873 ENSMUST00000025081.5
ENSMUST00000159390.1
 Zeb1

zinc finger E-box binding homeobox 1

chrX_+_58030622 7.411 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr1_+_57995971 7.263 ENSMUST00000027202.8
 Sgol2
shugoshin-like 2 (S. pombe)
chr11_+_23665615 6.674 ENSMUST00000109525.1
ENSMUST00000020520.4
 Pus10

pseudouridylate synthase 10

chr17_-_33890584 6.655 ENSMUST00000114361.2
ENSMUST00000173492.1
 Kifc1

kinesin family member C1

chr2_-_172370506 6.591 ENSMUST00000109139.1
ENSMUST00000028997.7
ENSMUST00000109140.3
 Aurka


aurora kinase A


chr2_+_119047116 6.423 ENSMUST00000152380.1
ENSMUST00000099542.2
 Casc5

cancer susceptibility candidate 5

chr15_+_57912199 6.348 ENSMUST00000022992.6
 Tbc1d31
TBC1 domain family, member 31

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 35.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0 20.9 GO:0051301 cell division(GO:0051301)
2.9 17.7 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
1.0 16.2 GO:0070986 left/right axis specification(GO:0070986)
1.0 16.2 GO:0030953 astral microtubule organization(GO:0030953)
1.9 13.4 GO:0000279 M phase(GO:0000279)
4.2 12.5 GO:0072382 minus-end-directed vesicle transport along microtubule(GO:0072382)
1.2 12.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
3.8 11.4 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1 11.2 GO:0007093 mitotic cell cycle checkpoint(GO:0007093)
0.3 9.4 GO:0007099 centriole replication(GO:0007099)
0.9 7.9 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 7.7 GO:0008360 regulation of cell shape(GO:0008360)
1.5 7.6 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
1.1 7.6 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2 7.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.9 7.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
2.2 6.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.3 6.3 GO:0000920 cell separation after cytokinesis(GO:0000920)
1.5 6.2 GO:0035609 C-terminal protein deglutamylation(GO:0035609)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 31.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 30.6 GO:0005813 centrosome(GO:0005813)
0.2 18.6 GO:0005814 centriole(GO:0005814)
0.2 16.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 16.2 GO:0005882 intermediate filament(GO:0005882)
0.5 13.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 12.8 GO:0000776 kinetochore(GO:0000776)
0.7 12.5 GO:0031616 spindle pole centrosome(GO:0031616)
3.9 11.6 GO:1990423 RZZ complex(GO:1990423)
2.9 11.4 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.2 10.7 GO:0005871 kinesin complex(GO:0005871)
0.3 9.2 GO:0034451 centriolar satellite(GO:0034451)
0.2 9.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.3 6.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.3 6.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
2.2 6.6 GO:0042585 germinal vesicle(GO:0042585)
0.1 6.5 GO:0005801 cis-Golgi network(GO:0005801)
0.2 6.2 GO:0005697 telomerase holoenzyme complex(GO:0005697)
1.0 6.1 GO:0098536 deuterosome(GO:0098536)
0.0 5.4 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 17.8 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
1.2 16.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
2.2 13.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 12.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 12.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 10.7 GO:0003777 microtubule motor activity(GO:0003777)
0.3 8.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 7.3 GO:0005509 calcium ion binding(GO:0005509)
1.7 6.8 GO:0097100 supercoiled DNA binding(GO:0097100)
0.1 6.7 GO:0070888 E-box binding(GO:0070888)
1.3 6.6 GO:0035174 histone serine kinase activity(GO:0035174)
1.1 6.5 GO:0008494 translation activator activity(GO:0008494)
0.1 6.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.3 6.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.4 5.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.4 5.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 5.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 4.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 4.3 GO:0004386 helicase activity(GO:0004386)
1.0 3.9 GO:0050220 prostaglandin-E synthase activity(GO:0050220)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 42.2 PID_PLK1_PATHWAY PLK1 signaling events
0.4 16.2 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 6.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 6.2 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 6.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.2 5.6 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.2 5.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 4.4 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 3.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.1 3.8 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.2 3.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 3.4 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.3 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.7 PID_ATM_PATHWAY ATM pathway
0.0 2.7 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.1 2.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 2.0 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 1.9 PID_PRL_SIGNALING_EVENTS_PATHWAY Signaling events mediated by PRL
0.1 1.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 52.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.7 18.8 REACTOME_KINESINS Genes involved in Kinesins
0.7 17.3 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.2 10.1 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS Genes involved in Activation of ATR in response to replication stress
0.8 6.8 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 6.7 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.1 6.6 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.2 5.6 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 5.4 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.1 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 4.7 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.9 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 3.6 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.6 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.2 3.4 REACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1 3.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.9 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 2.7 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.2 2.2 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.2 2.0 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs