Motif ID: Mybl1

Z-value: 0.908


Transcription factors associated with Mybl1:

Gene SymbolEntrez IDGene Name
Mybl1 ENSMUSG00000025912.10 Mybl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mybl1mm10_v2_chr1_-_9700209_97003290.047.9e-01Click!


Activity profile for motif Mybl1.

activity profile for motif Mybl1


Sorted Z-values histogram for motif Mybl1

Sorted Z-values for motif Mybl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mybl1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_112146187 3.308 ENSMUST00000128402.2
 Kif26a
kinesin family member 26A
chr17_+_29093763 2.973 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr2_+_118814237 2.402 ENSMUST00000028803.7
ENSMUST00000126045.1
 Knstrn

kinetochore-localized astrin/SPAG5 binding

chr4_-_118437331 2.235 ENSMUST00000006565.6
 Cdc20
cell division cycle 20
chr2_+_118814195 2.125 ENSMUST00000110842.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr2_+_118813995 2.048 ENSMUST00000134661.1
 Knstrn
kinetochore-localized astrin/SPAG5 binding
chr11_-_106999369 2.036 ENSMUST00000106768.1
ENSMUST00000144834.1
 Kpna2

karyopherin (importin) alpha 2

chr4_-_41695442 2.006 ENSMUST00000102961.3
ENSMUST00000064443.6
 Cntfr

ciliary neurotrophic factor receptor

chr14_+_65806066 1.830 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr14_+_46760526 1.794 ENSMUST00000067426.4
 Cdkn3
cyclin-dependent kinase inhibitor 3
chr11_-_106999482 1.717 ENSMUST00000018506.6
 Kpna2
karyopherin (importin) alpha 2
chr7_+_123982799 1.689 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_+_32276400 1.644 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr9_+_78191966 1.613 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr4_-_117182623 1.591 ENSMUST00000065896.2
 Kif2c
kinesin family member 2C
chr4_-_43499608 1.585 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr6_+_124829540 1.568 ENSMUST00000150120.1
 Cdca3
cell division cycle associated 3
chr6_+_124829582 1.537 ENSMUST00000024270.7
 Cdca3
cell division cycle associated 3
chr11_-_69921190 1.518 ENSMUST00000108607.1
 Eif5a
eukaryotic translation initiation factor 5A
chr4_-_41697040 1.484 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 228 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.2 5.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.8 4.8 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.9 3.5 GO:0003360 brainstem development(GO:0003360)
0.3 3.3 GO:0048484 enteric nervous system development(GO:0048484)
0.1 3.0 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.3 2.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 2.9 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 2.9 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
0.3 2.2 GO:0000279 M phase(GO:0000279)
0.1 2.1 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 2.0 GO:0006342 chromatin silencing(GO:0006342)
0.3 1.8 GO:0035701 hematopoietic stem cell migration(GO:0035701)
0.2 1.8 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.3 1.6 GO:0015671 oxygen transport(GO:0015671)
0.3 1.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 1.6 GO:0051451 myoblast migration(GO:0051451)
0.1 1.6 GO:0043248 proteasome assembly(GO:0043248)
0.1 1.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.1 1.5 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.2 GO:0035371 microtubule plus-end(GO:0035371)
0.4 4.6 GO:0005642 annulate lamellae(GO:0005642)
0.1 4.5 GO:0005643 nuclear pore(GO:0005643)
0.1 3.8 GO:0005871 kinesin complex(GO:0005871)
0.0 3.6 GO:0016607 nuclear speck(GO:0016607)
1.2 3.5 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.1 3.4 GO:0005680 anaphase-promoting complex(GO:0005680)
1.0 3.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 2.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.7 GO:0016234 inclusion body(GO:0016234)
0.0 2.6 GO:0036126 sperm flagellum(GO:0036126)
0.0 2.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 2.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.7 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 1.3 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 4.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 3.6 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.6 3.5 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.0 3.4 GO:0003735 structural constituent of ribosome(GO:0003735)
1.0 3.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 2.9 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 2.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 2.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 2.1 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 1.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 1.6 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.2 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 1.5 GO:1903136 cuprous ion binding(GO:1903136)
0.1 1.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.5 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 4.1 PID_PLK1_PATHWAY PLK1 signaling events
0.3 3.0 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.2 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 2.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.6 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 1.4 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.1 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.9 PID_E2F_PATHWAY E2F transcription factor network
0.1 0.7 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_PI3KCI_AKT_PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.6 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.5 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.5 PID_IGF1_PATHWAY IGF1 pathway
0.0 0.4 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.6 REACTOME_KINESINS Genes involved in Kinesins
0.1 5.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 5.1 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 4.8 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 3.3 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 2.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 2.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 2.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 2.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 2.1 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 1.9 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.1 1.8 REACTOME_FORMATION_OF_TUBULIN_FOLDING_INTERMEDIATES_BY_CCT_TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 1.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 1.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.7 REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.0 1.6 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.4 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.0 1.4 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening