ISMARA results: Mybl2

Motif ID: Mybl2

Z-value: 2.043

Transcription factors associated with Mybl2:

Gene Symbol	Entrez ID	Gene Name
Mybl2	ENSMUSG00000017861.5	Mybl2

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Mybl2	mm10_v2_chr2_+_163054682_163054693	0.87	4.6e-12	Click!

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Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr18_+_5591860	18.742	ENSMUST00000025081.5 ENSMUST00000159390.1	Zeb1	zinc finger E-box binding homeobox 1
chr1_-_169531343	13.830	ENSMUST00000028000.7	Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr14_-_67715585	12.694	ENSMUST00000163100.1 ENSMUST00000132705.1 ENSMUST00000124045.1	Cdca2	cell division cycle associated 2
chr1_+_57995971	11.911	ENSMUST00000027202.8	Sgol2	shugoshin-like 2 (S. pombe)
chr2_+_13573927	11.243	ENSMUST00000141365.1 ENSMUST00000028062.2	Vim	vimentin
chr1_-_169531447	11.106	ENSMUST00000111368.1	Nuf2	NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr19_-_41802028	9.832	ENSMUST00000026150.8 ENSMUST00000177495.1 ENSMUST00000163265.1	Arhgap19	Rho GTPase activating protein 19
chr13_+_51645232	9.516	ENSMUST00000075853.5	Cks2	CDC28 protein kinase regulatory subunit 2
chr1_+_191821444	8.790	ENSMUST00000027931.7	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2
chr4_-_124936852	7.864	ENSMUST00000030690.5 ENSMUST00000084296.3	Cdca8	cell division cycle associated 8
chr9_+_65890237	7.607	ENSMUST00000045802.6	2810417H13Rik	RIKEN cDNA 2810417H13 gene
chr16_+_14163275	7.215	ENSMUST00000023359.6 ENSMUST00000117958.1	Nde1	nuclear distribution gene E homolog 1 (A nidulans)
chr6_+_113531675	7.211	ENSMUST00000036340.5 ENSMUST00000101051.2	Fancd2	Fanconi anemia, complementation group D2
chr3_-_36571952	7.076	ENSMUST00000029270.3	Ccna2	cyclin A2
chr13_-_59675754	6.955	ENSMUST00000022039.5 ENSMUST00000095739.2	Golm1	golgi membrane protein 1
chr11_-_106999369	6.730	ENSMUST00000106768.1 ENSMUST00000144834.1	Kpna2	karyopherin (importin) alpha 2
chr9_-_94538075	6.551	ENSMUST00000113028.1	1190002N15Rik	RIKEN cDNA 1190002N15 gene
chr6_-_93913678	6.481	ENSMUST00000093769.5	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1
chr8_-_80739497	6.278	ENSMUST00000043359.8	Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr2_+_25372315	6.255	ENSMUST00000028329.6 ENSMUST00000114293.2 ENSMUST00000100323.2	Sapcd2	suppressor APC domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 166 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	25.2	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
2.1	18.7	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.6	15.0	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336)
0.2	13.0	GO:0035307	positive regulation of protein dephosphorylation(GO:0035307)
0.4	12.6	GO:0007099	centriole replication(GO:0007099)
2.2	11.2	GO:1900147	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
2.5	10.0	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.2	9.5	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.4	9.4	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)
1.5	8.9	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.5	8.9	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.1	8.9	GO:0006413	translational initiation(GO:0006413)
0.4	7.8	GO:0060009	Sertoli cell development(GO:0060009)
0.4	7.6	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.1	7.3	GO:0006997	nucleus organization(GO:0006997)
1.0	7.2	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)
0.4	7.2	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.3	7.1	GO:0016572	histone phosphorylation(GO:0016572)
0.2	7.0	GO:0048741	skeletal muscle fiber development(GO:0048741)
0.9	6.8	GO:0071557	histone H3-K27 demethylation(GO:0071557)

Gene overrepresentation in cellular_component category:

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Showing 1 to 20 of 96 entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.9	29.6	GO:0031262	Ndc80 complex(GO:0031262)
0.0	19.5	GO:0005667	transcription factor complex(GO:0005667)
0.2	17.4	GO:0000922	spindle pole(GO:0000922)
0.0	13.2	GO:0005694	chromosome(GO:0005694)
0.2	12.2	GO:0005643	nuclear pore(GO:0005643)
2.8	11.2	GO:0045098	type III intermediate filament(GO:0045098)
0.2	8.9	GO:0005871	kinesin complex(GO:0005871)
0.2	8.5	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5	8.4	GO:0031616	spindle pole centrosome(GO:0031616)
1.6	7.9	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	7.6	GO:0043296	apical junction complex(GO:0043296)
1.1	7.5	GO:0001940	male pronucleus(GO:0001940)
0.5	6.6	GO:0030126	COPI vesicle coat(GO:0030126)
0.2	6.5	GO:0030992	intraciliary transport particle B(GO:0030992)
0.2	6.5	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	6.5	GO:0005814	centriole(GO:0005814)
0.6	6.3	GO:0005677	chromatin silencing complex(GO:0005677)
0.9	6.2	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1	6.2	GO:0001669	acrosomal vesicle(GO:0001669)
1.8	5.4	GO:0097059	CNTFR-CLCF1 complex(GO:0097059)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 124 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.3	GO:0042393	histone binding(GO:0042393)
0.4	18.7	GO:0070888	E-box binding(GO:0070888)
0.2	11.8	GO:0003743	translation initiation factor activity(GO:0003743)
2.8	11.2	GO:1990254	keratin filament binding(GO:1990254)
0.3	10.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.2	9.9	GO:0051879	Hsp90 protein binding(GO:0051879)
2.4	9.5	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1	8.9	GO:0003777	microtubule motor activity(GO:0003777)
0.1	7.1	GO:0097472	cyclin-dependent protein kinase activity(GO:0097472)
0.0	7.1	GO:0008017	microtubule binding(GO:0008017)
0.2	6.9	GO:0070182	DNA polymerase binding(GO:0070182)
1.0	6.8	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.4	6.5	GO:0051393	alpha-actinin binding(GO:0051393)
0.1	5.8	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	5.7	GO:0019902	phosphatase binding(GO:0019902)
0.9	5.4	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.3	5.4	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3	5.3	GO:0070300	phosphatidic acid binding(GO:0070300)
0.2	4.7	GO:0097602	cullin family protein binding(GO:0097602)
1.5	4.6	GO:0051870	methotrexate binding(GO:0051870)

Gene overrepresentation in C2:CP category:

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Showing 1 to 20 of 28 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	28.0	PID_AURORA_B_PATHWAY	Aurora B signaling
0.3	15.7	PID_ILK_PATHWAY	Integrin-linked kinase signaling
0.4	11.6	PID_SMAD2_3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	9.4	PID_BARD1_PATHWAY	BARD1 signaling events
0.2	8.8	PID_FOXM1_PATHWAY	FOXM1 transcription factor network
0.2	8.8	PID_PLK1_PATHWAY	PLK1 signaling events
0.5	7.1	SA_REG_CASCADE_OF_CYCLIN_EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	6.5	PID_E2F_PATHWAY	E2F transcription factor network
0.1	3.4	PID_THROMBIN_PAR1_PATHWAY	PAR1-mediated thrombin signaling events
0.3	3.3	PID_RANBP2_PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	2.7	PID_WNT_SIGNALING_PATHWAY	Wnt signaling network
0.1	2.7	PID_TELOMERASE_PATHWAY	Regulation of Telomerase
0.1	2.5	PID_HEDGEHOG_GLI_PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.2	2.2	PID_ALK2_PATHWAY	ALK2 signaling events
0.1	2.0	PID_IL2_PI3K_PATHWAY	IL2 signaling events mediated by PI3K
0.0	1.8	PID_RHOA_PATHWAY	RhoA signaling pathway
0.2	1.7	PID_S1P_S1P4_PATHWAY	S1P4 pathway
0.1	1.4	PID_TOLL_ENDOGENOUS_PATHWAY	Endogenous TLR signaling
0.0	1.3	PID_FCER1_PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.0	1.3	NABA_COLLAGENS	Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 20 of 47 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	58.2	REACTOME_MITOTIC_PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.4	18.9	REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2	12.6	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
0.5	11.2	REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6	9.7	REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1	9.2	REACTOME_SIGNALING_BY_RHO_GTPASES	Genes involved in Signaling by Rho GTPases
0.4	8.9	REACTOME_KINESINS	Genes involved in Kinesins
0.7	7.2	REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.5	7.1	REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	6.9	REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	5.6	REACTOME_HS_GAG_BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.3	4.6	REACTOME_G1_S_SPECIFIC_TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.1	3.8	REACTOME_GLUTATHIONE_CONJUGATION	Genes involved in Glutathione conjugation
0.4	3.4	REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	3.3	REACTOME_ENOS_ACTIVATION_AND_REGULATION	Genes involved in eNOS activation and regulation
0.0	3.1	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3	2.9	REACTOME_PURINE_CATABOLISM	Genes involved in Purine catabolism
0.0	2.8	REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S	Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
0.2	2.7	REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.7	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	Genes involved in O-linked glycosylation of mucins