Motif ID: Myog_Tcf12

Z-value: 0.842

Transcription factors associated with Myog_Tcf12:

Gene SymbolEntrez IDGene Name
Myog ENSMUSG00000026459.4 Myog
Tcf12 ENSMUSG00000032228.10 Tcf12

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf12mm10_v2_chr9_-_72111651_72111712-0.852.1e-11Click!


Activity profile for motif Myog_Tcf12.

activity profile for motif Myog_Tcf12


Sorted Z-values histogram for motif Myog_Tcf12

Sorted Z-values for motif Myog_Tcf12



Network of associatons between targets according to the STRING database.



First level regulatory network of Myog_Tcf12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_122611238 7.854 ENSMUST00000028624.8
 Gatm
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr13_+_83504032 7.538 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr6_-_148444336 7.255 ENSMUST00000060095.8
ENSMUST00000100772.3
 Tmtc1

transmembrane and tetratricopeptide repeat containing 1

chr13_+_16011851 6.953 ENSMUST00000042603.6
 Inhba
inhibin beta-A
chr15_-_71727815 6.722 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B
chr15_-_66831625 5.648 ENSMUST00000164163.1
 Sla
src-like adaptor
chr19_-_57197556 5.596 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr19_-_57197435 5.491 ENSMUST00000111550.1
 Ablim1
actin-binding LIM protein 1
chr1_+_75507077 5.481 ENSMUST00000037330.4
 Inha
inhibin alpha
chr19_-_57197377 5.407 ENSMUST00000111546.1
 Ablim1
actin-binding LIM protein 1
chr19_-_57197496 5.346 ENSMUST00000111544.1
 Ablim1
actin-binding LIM protein 1
chr16_-_22439719 5.330 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr16_-_22439570 4.850 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr16_+_91269759 4.450 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr11_-_67922136 4.390 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr10_+_123264076 4.359 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr15_-_66812593 4.299 ENSMUST00000100572.3
 Sla
src-like adaptor
chr11_+_111066154 4.207 ENSMUST00000042970.2
 Kcnj2
potassium inwardly-rectifying channel, subfamily J, member 2
chr11_-_6065538 3.792 ENSMUST00000101585.3
ENSMUST00000066431.7
ENSMUST00000109815.2
ENSMUST00000109812.2
ENSMUST00000101586.2
ENSMUST00000093355.5
ENSMUST00000019133.4
 Camk2b






calcium/calmodulin-dependent protein kinase II, beta






chr13_-_92131494 3.720 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 372 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 20.4 GO:0030032 lamellipodium assembly(GO:0030032)
2.1 12.4 GO:0046880 regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884)
2.2 10.8 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
1.1 10.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.6 7.9 GO:0071374 cellular response to parathyroid hormone stimulus(GO:0071374)
2.6 7.9 GO:0006601 creatine biosynthetic process(GO:0006601)
0.2 7.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
1.3 6.3 GO:0032423 regulation of mismatch repair(GO:0032423)
0.1 5.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 4.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.7 4.7 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
1.5 4.5 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.9 4.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.1 4.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 4.0 GO:0016579 protein deubiquitination(GO:0016579)
0.8 3.9 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
1.3 3.8 GO:0032430 inhibitory G-protein coupled receptor phosphorylation(GO:0002030) positive regulation of phospholipase A2 activity(GO:0032430) activation of meiosis involved in egg activation(GO:0060466)
0.2 3.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 3.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.2 3.6 GO:1900673 olefin metabolic process(GO:1900673)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 29.9 GO:0097060 synaptic membrane(GO:0097060)
0.2 24.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.6 16.1 GO:0031430 M band(GO:0031430)
4.1 12.4 GO:0043512 inhibin A complex(GO:0043512)
0.1 12.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 9.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 7.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.3 5.4 GO:1990635 proximal dendrite(GO:1990635)
0.1 5.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 4.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 4.2 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 4.2 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.0 GO:0005925 focal adhesion(GO:0005925)
0.1 3.8 GO:0051233 spindle midzone(GO:0051233)
0.9 3.6 GO:0044307 dendritic branch(GO:0044307)
0.8 3.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 3.4 GO:1902710 GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1 3.1 GO:0001772 immunological synapse(GO:0001772)
0.1 3.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.6 2.9 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 16.9 GO:0003779 actin binding(GO:0003779)
0.2 14.0 GO:0015459 potassium channel regulator activity(GO:0015459)
1.4 12.2 GO:0034711 inhibin binding(GO:0034711)
0.3 11.3 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 9.5 GO:0003924 GTPase activity(GO:0003924)
0.2 9.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.5 7.8 GO:0045499 chemorepellent activity(GO:0045499)
0.5 7.5 GO:0003680 AT DNA binding(GO:0003680)
0.3 7.4 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 6.8 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
2.1 6.3 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.7 5.9 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.3 5.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 4.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 4.6 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.9 4.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.2 4.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.7 4.4 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 4.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.2 PID_ALK1_PATHWAY ALK1 signaling events
0.3 9.5 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.2 8.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 7.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 6.9 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 6.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.2 5.7 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.3 4.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 4.0 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.7 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 3.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.5 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.0 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 2.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.2 2.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 2.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.8 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 2.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.9 PID_P73PATHWAY p73 transcription factor network
0.1 1.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 23.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.6 16.1 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
3.1 12.4 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.2 7.9 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.2 7.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.2 6.9 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 6.7 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 6.2 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 5.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.2 5.1 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 4.8 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 4.4 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 4.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 3.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.2 3.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 3.1 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.2 3.0 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 2.9 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.4 2.9 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols