Motif ID: Mzf1

Z-value: 1.121


Transcription factors associated with Mzf1:

Gene SymbolEntrez IDGene Name
Mzf1 ENSMUSG00000030380.10 Mzf1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mzf1mm10_v2_chr7_-_13054665_13054764-0.057.9e-01Click!


Activity profile for motif Mzf1.

activity profile for motif Mzf1


Sorted Z-values histogram for motif Mzf1

Sorted Z-values for motif Mzf1



Network of associatons between targets according to the STRING database.



First level regulatory network of Mzf1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_104367549 5.806 ENSMUST00000106830.2
 Dab1
disabled 1
chr4_-_68954351 5.326 ENSMUST00000030036.5
 Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr6_-_23248264 4.509 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr17_+_28142267 4.406 ENSMUST00000043503.3
 Scube3
signal peptide, CUB domain, EGF-like 3
chr10_-_109010955 4.260 ENSMUST00000105276.1
ENSMUST00000064054.7
 Syt1

synaptotagmin I

chr3_+_96596628 4.178 ENSMUST00000058943.7
 Ankrd34a
ankyrin repeat domain 34A
chr14_-_39472825 3.980 ENSMUST00000168810.2
ENSMUST00000173780.1
ENSMUST00000166968.2
 Nrg3


neuregulin 3


chr7_-_34812677 3.490 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr1_+_167001457 3.409 ENSMUST00000126198.1
 Fam78b
family with sequence similarity 78, member B
chr11_-_89302545 3.407 ENSMUST00000061728.3
 Nog
noggin
chr5_+_139543889 3.353 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_126740151 3.273 ENSMUST00000112242.1
 Kcna6
potassium voltage-gated channel, shaker-related, subfamily, member 6
chr9_+_34486125 3.207 ENSMUST00000115148.2
ENSMUST00000183580.1
 Kirrel3
RP24-225I21.1
kin of IRRE like 3 (Drosophila)
RP24-225I21.1
chr13_+_91461050 3.025 ENSMUST00000004094.8
ENSMUST00000042122.8
 Ssbp2

single-stranded DNA binding protein 2

chr12_+_105336922 3.024 ENSMUST00000180503.1
 2810011L19Rik
RIKEN cDNA 2810011L19 gene
chr2_+_121295437 2.901 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr1_+_75400070 2.723 ENSMUST00000113589.1
 Speg
SPEG complex locus
chr11_+_70018421 2.701 ENSMUST00000108588.1
 Dlg4
discs, large homolog 4 (Drosophila)
chr2_+_180499893 2.690 ENSMUST00000029084.2
 Ntsr1
neurotensin receptor 1
chr1_-_154725920 2.605 ENSMUST00000004214.8
 Cacna1e
calcium channel, voltage-dependent, R type, alpha 1E subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 314 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 8.9 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
1.2 7.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
2.1 6.3 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 6.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.9 5.8 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 5.6 GO:0042711 maternal behavior(GO:0042711)
0.5 4.3 GO:0005513 detection of calcium ion(GO:0005513)
0.4 3.9 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.2 3.5 GO:0016486 peptide hormone processing(GO:0016486)
0.9 3.4 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.3 3.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.5 3.3 GO:0098703 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.6 3.2 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.2 3.2 GO:1903859 regulation of dendrite extension(GO:1903859)
0.6 3.1 GO:0015671 oxygen transport(GO:0015671)
0.4 3.0 GO:0099645 protein localization to postsynaptic specialization membrane(GO:0099633) neurotransmitter receptor localization to postsynaptic specialization membrane(GO:0099645)
0.2 3.0 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 3.0 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.5 2.9 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.3 2.9 GO:0071420 cellular response to histamine(GO:0071420)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.2 GO:0060076 excitatory synapse(GO:0060076)
0.5 10.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 9.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 7.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.3 6.1 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 5.7 GO:0030427 site of polarized growth(GO:0030427)
0.1 5.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 5.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 5.3 GO:0071565 nBAF complex(GO:0071565)
0.3 4.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 4.8 GO:0043034 costamere(GO:0043034)
0.1 4.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 4.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.3 4.3 GO:0031045 dense core granule(GO:0031045)
0.0 3.6 GO:0043209 myelin sheath(GO:0043209)
0.0 3.4 GO:0005643 nuclear pore(GO:0005643)
0.2 3.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.7 2.7 GO:0032280 symmetric synapse(GO:0032280)
0.1 2.7 GO:0070822 Sin3-type complex(GO:0070822)
0.0 2.6 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.4 GO:0005096 GTPase activator activity(GO:0005096)
1.1 8.6 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.2 7.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 5.9 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.3 4.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 4.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.1 4.3 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 3.9 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529)
0.2 3.8 GO:0045499 chemorepellent activity(GO:0045499)
0.1 3.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.4 3.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.1 3.6 GO:0005246 calcium channel regulator activity(GO:0005246)
0.9 3.5 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 3.5 GO:0005518 collagen binding(GO:0005518)
0.3 3.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 3.2 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 3.2 GO:0051082 unfolded protein binding(GO:0051082)
0.6 3.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 3.1 GO:0004385 guanylate kinase activity(GO:0004385)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 57 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 8.1 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 4.8 PID_NFAT_3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.1 4.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 4.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.3 4.0 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.1 3.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.1 3.2 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.1 3.0 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.1 3.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.0 PID_TNF_PATHWAY TNF receptor signaling pathway
0.1 1.9 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.9 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 1.6 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 1.5 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.5 PID_LKB1_PATHWAY LKB1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 5.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 5.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 5.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 4.5 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.2 4.4 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.4 4.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 4.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 3.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.2 3.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 3.1 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 3.0 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 2.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.3 2.4 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.4 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 2.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.3 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.2 REACTOME_PTM_GAMMA_CARBOXYLATION_HYPUSINE_FORMATION_AND_ARYLSULFATASE_ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 2.2 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling