Motif ID: Nanog

Z-value: 0.863


Transcription factors associated with Nanog:

Gene SymbolEntrez IDGene Name
Nanog ENSMUSG00000012396.6 Nanog

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nanogmm10_v2_chr6_+_122707489_1227076080.153.6e-01Click!


Activity profile for motif Nanog.

activity profile for motif Nanog


Sorted Z-values histogram for motif Nanog

Sorted Z-values for motif Nanog



Network of associatons between targets according to the STRING database.



First level regulatory network of Nanog

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_65890237 4.789 ENSMUST00000045802.6
 2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr1_-_52490736 3.951 ENSMUST00000170269.1
 Nab1
Ngfi-A binding protein 1
chr7_-_115846080 3.934 ENSMUST00000166207.1
 Sox6
SRY-box containing gene 6
chr2_+_134786154 3.654 ENSMUST00000110116.1
 Plcb1
phospholipase C, beta 1
chr12_+_72441933 3.456 ENSMUST00000161284.1
 Lrrc9
leucine rich repeat containing 9
chr7_+_67647405 3.445 ENSMUST00000032774.8
ENSMUST00000107471.1
 Ttc23

tetratricopeptide repeat domain 23

chr6_-_67037399 3.235 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr3_+_88081997 2.916 ENSMUST00000071812.5
 Iqgap3
IQ motif containing GTPase activating protein 3
chr8_-_61902669 2.855 ENSMUST00000121785.1
ENSMUST00000034057.7
 Palld

palladin, cytoskeletal associated protein

chr13_-_89742244 2.736 ENSMUST00000109543.2
ENSMUST00000159337.1
ENSMUST00000159910.1
ENSMUST00000109544.2
 Vcan



versican



chr12_+_72441852 2.723 ENSMUST00000162159.1
 Lrrc9
leucine rich repeat containing 9
chr14_+_73237891 2.706 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr6_+_80018877 2.642 ENSMUST00000147663.1
ENSMUST00000128718.1
ENSMUST00000126005.1
ENSMUST00000133918.1
 Lrrtm4



leucine rich repeat transmembrane neuronal 4



chr6_+_80019008 2.610 ENSMUST00000126399.1
ENSMUST00000136421.1
 Lrrtm4

leucine rich repeat transmembrane neuronal 4

chr4_-_109665249 2.608 ENSMUST00000063531.4
 Cdkn2c
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
chr13_-_89742490 2.560 ENSMUST00000109546.2
 Vcan
versican
chr15_+_25773985 2.433 ENSMUST00000125667.1
 Myo10
myosin X
chr8_-_89044162 2.407 ENSMUST00000034090.6
 Sall1
sal-like 1 (Drosophila)
chr14_-_12345847 2.333 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr10_+_58394381 2.292 ENSMUST00000105468.1
 Lims1
LIM and senescent cell antigen-like domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 6.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.3 5.3 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.1 5.3 GO:0008347 glial cell migration(GO:0008347)
0.9 4.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 4.0 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.4 3.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.4 3.9 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
1.2 3.7 GO:0070671 monocyte extravasation(GO:0035696) activation of meiosis involved in egg activation(GO:0060466) response to interleukin-12(GO:0070671) positive regulation of acrosome reaction(GO:2000344) regulation of monocyte extravasation(GO:2000437)
0.2 3.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 2.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.7 2.8 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 2.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.6 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.8 2.4 GO:0072092 ureteric bud invasion(GO:0072092)
0.0 2.4 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.4 2.3 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 2.2 GO:0060349 bone morphogenesis(GO:0060349)
0.2 2.0 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 1.8 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 1.8 GO:2000651 positive regulation of sodium ion transmembrane transporter activity(GO:2000651)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0016607 nuclear speck(GO:0016607)
0.1 5.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 4.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 3.6 GO:0016604 nuclear body(GO:0016604)
0.0 3.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.5 2.8 GO:0044305 calyx of Held(GO:0044305)
0.0 2.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 2.4 GO:0010369 chromocenter(GO:0010369)
0.0 2.4 GO:0016459 myosin complex(GO:0016459)
0.2 2.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 2.0 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.0 1.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.2 1.7 GO:0030478 actin cap(GO:0030478)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.5 1.4 GO:0000801 central element(GO:0000801)
0.1 1.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.3 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 1.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.4 6.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 5.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.3 5.1 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 4.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 4.5 GO:0003779 actin binding(GO:0003779)
0.5 3.8 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 3.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 3.2 GO:0001047 core promoter binding(GO:0001047)
0.1 3.1 GO:0030507 spectrin binding(GO:0030507)
0.6 2.9 GO:0032027 myosin light chain binding(GO:0032027)
0.9 2.8 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 2.7 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 2.6 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.6 GO:0002039 p53 binding(GO:0002039)
0.1 1.5 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.6 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 5.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.2 5.3 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 3.9 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 3.7 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 2.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.1 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 1.6 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.4 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.3 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 1.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.0 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.0 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 0.7 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.3 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 4.5 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 4.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.5 3.7 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 3.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 2.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 2.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.3 2.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 2.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 2.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 2.0 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.7 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.5 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.3 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.1 1.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins