Motif ID: Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.428

Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1:

Gene SymbolEntrez IDGene Name
Bhlha15 ENSMUSG00000052271.7 Bhlha15
Bhlhe22 ENSMUSG00000025128.6 Bhlhe22
Neurod2 ENSMUSG00000038255.6 Neurod2
Olig1 ENSMUSG00000046160.5 Olig1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bhlhe22mm10_v2_chr3_+_18054258_180543250.343.9e-02Click!
Neurod2mm10_v2_chr11_-_98329641_983296540.261.2e-01Click!
Olig1mm10_v2_chr16_+_91269759_91269778-0.028.9e-01Click!


Activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1.

activity profile for motif Neurod2_Bhlha15_Bhlhe22_Olig1


Sorted Z-values histogram for motif Neurod2_Bhlha15_Bhlhe22_Olig1

Sorted Z-values for motif Neurod2_Bhlha15_Bhlhe22_Olig1



Network of associatons between targets according to the STRING database.



First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

PNG image of the network

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Top targets:


Showing 1 to 20 of 156 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_75796048 2.493 ENSMUST00000021209.7
 Doc2b
double C2, beta
chr3_-_120886691 2.491 ENSMUST00000182099.1
ENSMUST00000183168.1
ENSMUST00000183276.1
ENSMUST00000182124.1
 6530403H02Rik



RIKEN cDNA 6530403H02 gene



chr4_-_42034726 1.890 ENSMUST00000084677.2
 Gm21093
predicted gene, 21093
chr2_+_65930117 1.697 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_+_42035113 1.344 ENSMUST00000098127.1
 Gm10597
predicted gene 10597
chr4_-_141598206 1.290 ENSMUST00000131317.1
ENSMUST00000006381.4
ENSMUST00000129602.1
 Fblim1


filamin binding LIM protein 1


chr3_-_126998408 1.165 ENSMUST00000182764.1
ENSMUST00000044443.8
 Ank2

ankyrin 2, brain

chr4_+_42714926 1.163 ENSMUST00000178454.1
 Gm21955
predicted gene, 21955
chr4_+_86053887 1.139 ENSMUST00000107178.2
ENSMUST00000048885.5
ENSMUST00000141889.1
ENSMUST00000120678.1
 Adamtsl1



ADAMTS-like 1



chr3_+_138065052 1.093 ENSMUST00000163080.2
 1110002E22Rik
RIKEN cDNA 1110002E22 gene
chr15_-_76126538 1.012 ENSMUST00000054022.5
ENSMUST00000089654.3
 BC024139

cDNA sequence BC024139

chr1_-_150392719 0.852 ENSMUST00000006167.6
ENSMUST00000094477.2
ENSMUST00000097547.3
 BC003331


cDNA sequence BC003331


chr3_-_27710413 0.825 ENSMUST00000046157.4
 Fndc3b
fibronectin type III domain containing 3B
chr13_-_62607499 0.757 ENSMUST00000091563.4
 6720489N17Rik
RIKEN cDNA 6720489N17 gene
chr2_-_80128834 0.723 ENSMUST00000102654.4
ENSMUST00000102655.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr5_+_124194894 0.687 ENSMUST00000159053.1
ENSMUST00000162577.1
 Gm16338

predicted gene 16338

chr4_+_42459563 0.571 ENSMUST00000098119.2
 Gm3883
predicted gene 3883
chr9_-_110742577 0.561 ENSMUST00000006005.7
 Pth1r
parathyroid hormone 1 receptor
chr2_-_80129458 0.546 ENSMUST00000102653.1
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr5_-_66618636 0.516 ENSMUST00000162382.1
ENSMUST00000160870.1
ENSMUST00000087256.5
ENSMUST00000160103.1
ENSMUST00000162349.1
 Apbb2




amyloid beta (A4) precursor protein-binding, family B, member 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 37 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 1.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 1.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 1.3 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 1.2 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.8 GO:0060510 Type II pneumocyte differentiation(GO:0060510)
0.0 0.6 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.2 0.5 GO:0002182 cytoplasmic translational elongation(GO:0002182) regulation of cytoplasmic translational elongation(GO:1900247) negative regulation of cytoplasmic translational elongation(GO:1900248)
0.1 0.4 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
0.1 0.4 GO:0032240 RNA import into nucleus(GO:0006404) mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.4 GO:0002121 inter-male aggressive behavior(GO:0002121)
0.0 0.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.3 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.1 0.3 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.1 0.3 GO:2001106 regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1 0.3 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.1 0.3 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.0 0.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0031201 SNARE complex(GO:0031201)
0.0 0.9 GO:0031430 M band(GO:0031430)
0.0 0.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.1 0.4 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.1 0.3 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.1 GO:0032426 stereocilium tip(GO:0032426)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.5 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.2 1.3 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.6 GO:0017046 peptide hormone binding(GO:0017046)
0.0 0.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.4 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.3 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.3 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.3 GO:0030275 LRR domain binding(GO:0030275)
0.0 0.3 GO:0016208 AMP binding(GO:0016208)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)

Gene overrepresentation in C2:CP category:

Showing 1 to 1 of 1 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.2 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.3 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 0.1 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE