Motif ID: Nfat5

Z-value: 0.520


Transcription factors associated with Nfat5:

Gene SymbolEntrez IDGene Name
Nfat5 ENSMUSG00000003847.10 Nfat5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfat5mm10_v2_chr8_+_107293463_1072934830.271.1e-01Click!


Activity profile for motif Nfat5.

activity profile for motif Nfat5


Sorted Z-values histogram for motif Nfat5

Sorted Z-values for motif Nfat5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfat5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_101377897 3.259 ENSMUST00000075994.6
Pdzrn3
PDZ domain containing RING finger 3
chr14_-_101609033 2.639 ENSMUST00000161991.1
ENSMUST00000100340.3
Tbc1d4

TBC1 domain family, member 4

chr4_-_82505707 1.774 ENSMUST00000107248.1
ENSMUST00000107247.1
Nfib

nuclear factor I/B

chr4_-_82505749 1.644 ENSMUST00000107245.2
ENSMUST00000107246.1
Nfib

nuclear factor I/B

chr7_-_97417730 1.579 ENSMUST00000043077.7
Thrsp
thyroid hormone responsive
chr5_-_104021919 1.435 ENSMUST00000031251.9
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr5_-_104021799 1.220 ENSMUST00000119025.1
Hsd17b11
hydroxysteroid (17-beta) dehydrogenase 11
chr10_-_95415484 1.182 ENSMUST00000172070.1
ENSMUST00000150432.1
Socs2

suppressor of cytokine signaling 2

chr5_-_148392810 1.125 ENSMUST00000138257.1
Slc7a1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_-_95415283 0.979 ENSMUST00000119917.1
Socs2
suppressor of cytokine signaling 2
chr7_-_80402743 0.947 ENSMUST00000122232.1
Furin
furin (paired basic amino acid cleaving enzyme)
chr6_+_120773633 0.947 ENSMUST00000112682.2
Slc25a18
solute carrier family 25 (mitochondrial carrier), member 18
chr4_-_138396438 0.931 ENSMUST00000105032.2
Fam43b
family with sequence similarity 43, member B
chr14_+_17660956 0.886 ENSMUST00000022303.7
ENSMUST00000091471.4
Thrb

thyroid hormone receptor beta

chr15_-_98881255 0.881 ENSMUST00000024518.9
Rhebl1
Ras homolog enriched in brain like 1
chr5_+_90772435 0.879 ENSMUST00000031320.6
Pf4
platelet factor 4
chr7_+_99535652 0.862 ENSMUST00000032995.8
ENSMUST00000162404.1
Arrb1

arrestin, beta 1

chr5_+_139423151 0.835 ENSMUST00000066211.4
Gper1
G protein-coupled estrogen receptor 1
chr11_+_102836296 0.777 ENSMUST00000021302.8
ENSMUST00000107072.1
Higd1b

HIG1 domain family, member 1B

chr5_-_124354671 0.766 ENSMUST00000031341.4
Cdk2ap1
CDK2 (cyclin-dependent kinase 2)-associated protein 1
chr2_-_30415302 0.757 ENSMUST00000132981.2
ENSMUST00000129494.1
Crat

carnitine acetyltransferase

chr1_+_24678536 0.738 ENSMUST00000095062.3
Lmbrd1
LMBR1 domain containing 1
chr11_-_88863717 0.734 ENSMUST00000107904.2
Akap1
A kinase (PRKA) anchor protein 1
chr15_-_75894474 0.726 ENSMUST00000023237.6
Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr2_-_30415389 0.713 ENSMUST00000142096.1
Crat
carnitine acetyltransferase
chr2_+_68117713 0.711 ENSMUST00000112346.2
B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr9_-_13446753 0.595 ENSMUST00000167906.2
Gm17571
predicted gene, 17571
chr7_-_46958475 0.592 ENSMUST00000094398.4
Uevld
UEV and lactate/malate dehyrogenase domains
chr10_-_62507737 0.589 ENSMUST00000020271.6
Srgn
serglycin
chr3_-_129755305 0.574 ENSMUST00000029653.2
Egf
epidermal growth factor
chr18_+_36559972 0.558 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr15_-_38078842 0.547 ENSMUST00000110336.2
Ubr5
ubiquitin protein ligase E3 component n-recognin 5
chr2_-_30415509 0.511 ENSMUST00000134120.1
ENSMUST00000102854.3
Crat

carnitine acetyltransferase

chr7_+_99535439 0.500 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr10_-_78351690 0.478 ENSMUST00000166360.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr17_+_43389436 0.469 ENSMUST00000113599.1
Gpr116
G protein-coupled receptor 116
chr6_-_144209471 0.464 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr6_-_144209558 0.463 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr10_-_78352053 0.455 ENSMUST00000105388.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr6_-_144209448 0.448 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr16_-_55838827 0.433 ENSMUST00000096026.2
ENSMUST00000036273.6
ENSMUST00000114457.1
Nfkbiz


nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta


chrX_+_139684980 0.399 ENSMUST00000096313.3
Tbc1d8b
TBC1 domain family, member 8B
chr10_-_78352212 0.396 ENSMUST00000146899.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr19_-_5845471 0.382 ENSMUST00000174287.1
ENSMUST00000173672.1
Neat1

nuclear paraspeckle assembly transcript 1 (non-protein coding)

chr6_-_142964404 0.372 ENSMUST00000032421.3
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr10_+_84622365 0.372 ENSMUST00000077175.5
Polr3b
polymerase (RNA) III (DNA directed) polypeptide B
chr7_+_6371364 0.365 ENSMUST00000086323.4
ENSMUST00000108559.2
Zfp78

zinc finger protein 78

chr10_-_78351711 0.350 ENSMUST00000105390.1
Agpat3
1-acylglycerol-3-phosphate O-acyltransferase 3
chr18_+_36560581 0.346 ENSMUST00000155329.2
Ankhd1
ankyrin repeat and KH domain containing 1
chr9_-_71771535 0.336 ENSMUST00000122065.1
ENSMUST00000121322.1
ENSMUST00000072899.2
Cgnl1


cingulin-like 1


chr12_-_86079019 0.328 ENSMUST00000003687.6
Tgfb3
transforming growth factor, beta 3
chr5_-_69592311 0.317 ENSMUST00000031117.6
Gnpda2
glucosamine-6-phosphate deaminase 2
chr3_-_98724543 0.294 ENSMUST00000107022.1
ENSMUST00000107021.1
Hsd3b2

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

chr4_+_110397764 0.289 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4

ATP/GTP binding protein-like 4

chr4_+_110397661 0.285 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4



ATP/GTP binding protein-like 4



chr6_+_91684061 0.248 ENSMUST00000032185.7
Slc6a6
solute carrier family 6 (neurotransmitter transporter, taurine), member 6
chr8_-_107403197 0.224 ENSMUST00000003947.8
Nqo1
NAD(P)H dehydrogenase, quinone 1
chr9_+_92457369 0.219 ENSMUST00000034941.7
Plscr4
phospholipid scramblase 4
chrX_+_74429671 0.185 ENSMUST00000114127.1
ENSMUST00000064407.3
ENSMUST00000156707.1
Ikbkg


inhibitor of kappaB kinase gamma


chr7_-_126625676 0.181 ENSMUST00000032961.3
Nupr1
nuclear protein transcription regulator 1
chr7_-_81493725 0.162 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr4_+_141444654 0.159 ENSMUST00000006377.6
Zbtb17
zinc finger and BTB domain containing 17
chr12_+_102948843 0.157 ENSMUST00000101099.5
Unc79
unc-79 homolog (C. elegans)
chr17_+_91236787 0.157 ENSMUST00000057074.8
Gm6741
predicted gene 6741
chr8_-_46124146 0.155 ENSMUST00000170416.1
Snx25
sorting nexin 25
chr3_-_69004565 0.131 ENSMUST00000169064.1
Ift80
intraflagellar transport 80
chr9_-_29963112 0.122 ENSMUST00000075069.4
Ntm
neurotrimin
chr19_+_10525244 0.119 ENSMUST00000038379.3
Cpsf7
cleavage and polyadenylation specific factor 7
chr8_+_86745679 0.117 ENSMUST00000098532.2
Gm10638
predicted gene 10638
chr15_+_5185700 0.112 ENSMUST00000081640.5
Ttc33
tetratricopeptide repeat domain 33
chr13_+_73626886 0.106 ENSMUST00000022104.7
Tert
telomerase reverse transcriptase
chr11_-_118401826 0.104 ENSMUST00000106290.3
ENSMUST00000043722.3
Lgals3bp

lectin, galactoside-binding, soluble, 3 binding protein

chr1_+_83159733 0.086 ENSMUST00000113436.1
ENSMUST00000065436.3
ENSMUST00000065403.6
Daw1


dynein assembly factor with WDR repeat domains 1


chr2_-_177925604 0.082 ENSMUST00000108934.2
ENSMUST00000081529.4
C330013J21Rik

RIKEN cDNA C330013J21 gene

chr6_-_92183972 0.079 ENSMUST00000140438.1
Mrps25
mitochondrial ribosomal protein S25
chr12_+_98920567 0.070 ENSMUST00000085109.3
ENSMUST00000079146.6
Ttc8

tetratricopeptide repeat domain 8

chr10_+_21994666 0.056 ENSMUST00000020145.5
Sgk1
serum/glucocorticoid regulated kinase 1
chr13_+_44840686 0.053 ENSMUST00000173906.1
Jarid2
jumonji, AT rich interactive domain 2
chr7_-_141918481 0.047 ENSMUST00000151890.1
Tollip
toll interacting protein
chr9_-_7835255 0.042 ENSMUST00000074246.6
Birc2
baculoviral IAP repeat-containing 2
chr6_-_58907120 0.040 ENSMUST00000059539.3
Nap1l5
nucleosome assembly protein 1-like 5
chrX_-_155216338 0.037 ENSMUST00000112551.3
Sat1
spermidine/spermine N1-acetyl transferase 1
chrX_-_155216444 0.027 ENSMUST00000026318.8
Sat1
spermidine/spermine N1-acetyl transferase 1
chr14_-_55116935 0.013 ENSMUST00000022819.5
Jph4
junctophilin 4
chr7_-_43533171 0.013 ENSMUST00000004728.5
ENSMUST00000039861.5
Cd33

CD33 antigen


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 3.4 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.7 2.7 GO:0006710 androgen catabolic process(GO:0006710)
0.3 0.9 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.3 2.6 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.2 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 2.0 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 0.9 GO:0090472 dibasic protein processing(GO:0090472)
0.2 1.4 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 0.6 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.2 0.5 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.2 0.9 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.2 1.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 0.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 0.6 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.1 2.2 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.1 0.7 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.7 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 1.1 GO:0015809 arginine transport(GO:0015809)
0.1 1.6 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.1 3.3 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:1900369 negative regulation of RNA interference(GO:1900369) regulation of histone demethylase activity (H3-K4 specific)(GO:1904173)
0.0 0.1 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.0 0.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.0 0.5 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.8 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.4 GO:0030575 nuclear body organization(GO:0030575)
0.0 0.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.2 GO:0048149 behavioral response to ethanol(GO:0048149)
0.0 0.0 GO:1902527 positive regulation of protein K48-linked ubiquitination(GO:1902524) positive regulation of protein monoubiquitination(GO:1902527)
0.0 0.1 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.0 0.2 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.2 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.4 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.4 GO:0031143 pseudopodium(GO:0031143)
0.1 0.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.9 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.9 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 0.4 GO:0042382 paraspeckles(GO:0042382)
0.0 3.4 GO:0005811 lipid particle(GO:0005811)
0.0 3.3 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.7 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.4 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 2.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.1 GO:0030123 AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.5 1.4 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.4 2.2 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 2.7 GO:0004303 estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.2 0.7 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.2 0.9 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.9 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 1.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.7 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.3 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.1 3.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.9 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 0.3 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.7 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.9 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.1 0.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.2 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.7 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0 0.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.8 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.0 0.4 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.0 GO:0098770 FBXO family protein binding(GO:0098770)
0.0 0.1 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.2 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 3.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 3.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 1.4 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.9 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.0 2.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.2 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 0.3 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.7 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.8 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.1 3.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.9 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.2 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 2.0 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 0.3 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.1 1.7 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 1.4 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.6 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.2 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+