ISMARA results: Nfat5

Motif ID: Nfat5

Z-value: 0.520

Transcription factors associated with Nfat5:

Gene Symbol	Entrez ID	Gene Name
Nfat5	ENSMUSG00000003847.10	Nfat5

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Nfat5	mm10_v2_chr8_+_107293463_107293483	0.27	1.1e-01	Click!

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Top targets:

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Showing 1 to 20 of 85 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr6_-_101377897	3.259	ENSMUST00000075994.6	Pdzrn3	PDZ domain containing RING finger 3
chr14_-_101609033	2.639	ENSMUST00000161991.1 ENSMUST00000100340.3	Tbc1d4	TBC1 domain family, member 4
chr4_-_82505707	1.774	ENSMUST00000107248.1 ENSMUST00000107247.1	Nfib	nuclear factor I/B
chr4_-_82505749	1.644	ENSMUST00000107245.2 ENSMUST00000107246.1	Nfib	nuclear factor I/B
chr7_-_97417730	1.579	ENSMUST00000043077.7	Thrsp	thyroid hormone responsive
chr5_-_104021919	1.435	ENSMUST00000031251.9	Hsd17b11	hydroxysteroid (17-beta) dehydrogenase 11
chr5_-_104021799	1.220	ENSMUST00000119025.1	Hsd17b11	hydroxysteroid (17-beta) dehydrogenase 11
chr10_-_95415484	1.182	ENSMUST00000172070.1 ENSMUST00000150432.1	Socs2	suppressor of cytokine signaling 2
chr5_-_148392810	1.125	ENSMUST00000138257.1	Slc7a1	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr10_-_95415283	0.979	ENSMUST00000119917.1	Socs2	suppressor of cytokine signaling 2
chr7_-_80402743	0.947	ENSMUST00000122232.1	Furin	furin (paired basic amino acid cleaving enzyme)
chr6_+_120773633	0.947	ENSMUST00000112682.2	Slc25a18	solute carrier family 25 (mitochondrial carrier), member 18
chr4_-_138396438	0.931	ENSMUST00000105032.2	Fam43b	family with sequence similarity 43, member B
chr14_+_17660956	0.886	ENSMUST00000022303.7 ENSMUST00000091471.4	Thrb	thyroid hormone receptor beta
chr15_-_98881255	0.881	ENSMUST00000024518.9	Rhebl1	Ras homolog enriched in brain like 1
chr5_+_90772435	0.879	ENSMUST00000031320.6	Pf4	platelet factor 4
chr7_+_99535652	0.862	ENSMUST00000032995.8 ENSMUST00000162404.1	Arrb1	arrestin, beta 1
chr5_+_139423151	0.835	ENSMUST00000066211.4	Gper1	G protein-coupled estrogen receptor 1
chr11_+_102836296	0.777	ENSMUST00000021302.8 ENSMUST00000107072.1	Higd1b	HIG1 domain family, member 1B
chr5_-_124354671	0.766	ENSMUST00000031341.4	Cdk2ap1	CDK2 (cyclin-dependent kinase 2)-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Showing 1 to 20 of 32 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	3.4	GO:2000795	negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.1	3.3	GO:0007528	neuromuscular junction development(GO:0007528)
0.7	2.7	GO:0006710	androgen catabolic process(GO:0006710)
0.3	2.6	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.1	2.2	GO:0071378	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.3	2.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.1	1.6	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
0.2	1.4	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.2	1.4	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.3	1.2	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1	1.1	GO:0015809	arginine transport(GO:0015809)
0.3	0.9	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.2	0.9	GO:0090472	dibasic protein processing(GO:0090472)
0.2	0.9	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.0	0.8	GO:0060325	face morphogenesis(GO:0060325)
0.1	0.7	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	0.7	GO:0006682	galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2	0.6	GO:0033364	mast cell secretory granule organization(GO:0033364)
0.1	0.6	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.1	0.6	GO:0007262	STAT protein import into nucleus(GO:0007262)

Gene overrepresentation in cellular_component category:

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Showing 1 to 14 of 14 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.4	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	3.4	GO:0005811	lipid particle(GO:0005811)
0.0	3.3	GO:0031594	neuromuscular junction(GO:0031594)
0.0	2.0	GO:0005777	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	1.4	GO:0031143	pseudopodium(GO:0031143)
0.1	0.9	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.1	0.9	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.1	0.8	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.7	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.1	0.6	GO:0042629	mast cell granule(GO:0042629)
0.0	0.4	GO:0042382	paraspeckles(GO:0042382)
0.0	0.4	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0030123	AP-3 adaptor complex(GO:0030123)

Gene overrepresentation in molecular_function category:

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Showing 1 to 20 of 34 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.4	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	3.3	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	3.0	GO:0017137	Rab GTPase binding(GO:0017137)
0.4	2.7	GO:0004303	estradiol 17-beta-dehydrogenase activity(GO:0004303)
0.4	2.2	GO:0008269	JAK pathway signal transduction adaptor activity(GO:0008269)
0.5	2.0	GO:0004092	carnitine O-acetyltransferase activity(GO:0004092)
0.1	1.7	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.5	1.4	GO:0031896	V2 vasopressin receptor binding(GO:0031896)
0.1	1.1	GO:0015181	arginine transmembrane transporter activity(GO:0015181)
0.2	0.9	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	0.9	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.1	0.9	GO:0048406	nerve growth factor binding(GO:0048406)
0.1	0.9	GO:0005314	high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.0	0.8	GO:0070182	DNA polymerase binding(GO:0070182)
0.2	0.7	GO:0047275	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1	0.7	GO:0031419	cobalamin binding(GO:0031419)
0.1	0.7	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.1	0.6	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.6	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.6	GO:0042813	Wnt-activated receptor activity(GO:0042813)

Gene overrepresentation in C2:CP category:

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Showing 1 to 11 of 11 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.2	PID_HNF3A_PATHWAY	FOXA1 transcription factor network
0.1	2.6	PID_INSULIN_GLUCOSE_PATHWAY	Insulin-mediated glucose transport
0.0	2.2	PID_IL2_1PATHWAY	IL2-mediated signaling events
0.0	1.4	PID_IL8_CXCR1_PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	1.2	PID_P75_NTR_PATHWAY	p75(NTR)-mediated signaling
0.0	0.9	PID_CXCR3_PATHWAY	CXCR3-mediated signaling events
0.0	0.8	ST_FAS_SIGNALING_PATHWAY	Fas Signaling Pathway
0.0	0.7	PID_VEGFR1_2_PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.6	PID_ERBB_NETWORK_PATHWAY	ErbB receptor signaling network
0.0	0.6	NABA_PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.3	PID_GLYPICAN_1PATHWAY	Glypican 1 network

Gene overrepresentation in C2:CP:REACTOME category:

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Showing 1 to 12 of 12 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.8	REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.1	2.2	REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING	Genes involved in Growth hormone receptor signaling
0.1	2.0	REACTOME_PEROXISOMAL_LIPID_METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.1	1.7	REACTOME_SYNTHESIS_OF_PA	Genes involved in Synthesis of PA
0.0	1.4	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	1.4	REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1	0.9	REACTOME_COMMON_PATHWAY	Genes involved in Common Pathway
0.1	0.9	REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.9	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.6	REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	0.3	REACTOME_ANDROGEN_BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.2	REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1	Genes involved in IKK complex recruitment mediated by RIP1