Motif ID: Nfatc1

Z-value: 5.102


Transcription factors associated with Nfatc1:

Gene SymbolEntrez IDGene Name
Nfatc1 ENSMUSG00000033016.9 Nfatc1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc1mm10_v2_chr18_-_80713062_807130800.192.6e-01Click!


Activity profile for motif Nfatc1.

activity profile for motif Nfatc1


Sorted Z-values histogram for motif Nfatc1

Sorted Z-values for motif Nfatc1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 146.061 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 144.781 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3013140 128.635 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3023547 124.215 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3004457 121.320 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3037111 113.640 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3017408 109.117 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3025417 105.457 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr9_+_3036877 105.144 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3034599 99.519 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3005125 96.167 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr2_-_98667264 90.713 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3015654 88.981 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr14_-_19418930 87.929 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 73.297 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr2_+_98662227 69.439 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chrX_+_103422010 25.926 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr10_-_130280218 13.370 ENSMUST00000061571.3
 Neurod4
neurogenic differentiation 4
chr1_-_165934900 10.773 ENSMUST00000069609.5
ENSMUST00000111427.2
ENSMUST00000111426.4
 Pou2f1


POU domain, class 2, transcription factor 1


chr18_+_64340225 10.505 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 864.2 GO:0008150 biological_process(GO:0008150)
5.1 15.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.0 13.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.5 13.0 GO:0010842 retina layer formation(GO:0010842)
3.2 12.6 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
1.7 12.1 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.2 11.5 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
1.0 10.9 GO:0036159 inner dynein arm assembly(GO:0036159)
1.5 10.8 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
1.0 10.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.2 9.9 GO:1904627 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
1.8 8.8 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.9 8.4 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.7 7.4 GO:0072189 ureter development(GO:0072189)
1.7 6.9 GO:0097393 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
1.0 6.9 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.2 6.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.0 6.0 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
2.0 6.0 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.7 5.4 GO:0072615 interleukin-17 secretion(GO:0072615)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1069.6 GO:0005575 cellular_component(GO:0005575)
0.2 9.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 8.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.4 8.8 GO:0005605 basal lamina(GO:0005605)
1.7 6.9 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1 6.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.2 4.6 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.4 4.4 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.3 4.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 4.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 3.9 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 3.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 3.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.2 GO:0002080 acrosomal membrane(GO:0002080)
0.2 3.1 GO:0097449 astrocyte projection(GO:0097449)
0.9 2.6 GO:0071914 prominosome(GO:0071914)
0.5 2.4 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 2.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 2.3 GO:0034451 centriolar satellite(GO:0034451)
0.1 2.0 GO:0005614 interstitial matrix(GO:0005614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 997.4 GO:0003674 molecular_function(GO:0003674)
1.0 19.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 12.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 10.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
3.3 9.9 GO:0098770 FBXO family protein binding(GO:0098770)
0.2 9.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
1.0 6.9 GO:0015616 DNA translocase activity(GO:0015616)
0.2 6.7 GO:0042805 actinin binding(GO:0042805)
1.0 6.0 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.7 6.0 GO:0036122 BMP binding(GO:0036122)
1.2 4.8 GO:0008142 oxysterol binding(GO:0008142)
1.2 4.6 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.5 4.6 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.2 4.6 GO:0003785 actin monomer binding(GO:0003785)
0.2 4.5 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.4 4.3 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 4.3 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 3.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
1.0 3.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 3.4 GO:0097157 pre-mRNA intronic binding(GO:0097157)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 23.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 17.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 12.5 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.3 10.1 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.1 9.0 PID_P73PATHWAY p73 transcription factor network
1.1 8.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 6.0 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 4.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.4 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 4.0 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 3.4 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 3.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 2.8 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 2.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 2.6 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.1 2.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 2.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 1.7 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.7 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.1 1.4 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 23.4 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 9.9 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 9.6 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 9.5 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 7.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.5 4.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.6 3.2 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 3.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 3.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.6 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.3 2.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 2.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 2.4 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.3 2.3 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.2 2.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 2.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 2.0 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.1 1.9 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation