Motif ID: Nfatc2

Z-value: 1.503


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168601620_1686016570.173.3e-01Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3000922 14.157 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 12.543 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3004457 12.201 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3023547 11.959 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3013140 11.588 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3017408 11.505 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3037111 10.704 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3005125 10.378 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3034599 10.288 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3036877 10.062 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chrX_-_61185558 9.831 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr9_+_3015654 9.778 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3025417 9.600 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_-_98667264 9.553 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr2_+_98662227 9.507 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr14_-_19418930 8.254 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 8.240 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chrX_+_103422010 5.846 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr19_-_5796924 3.816 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr19_-_5797410 2.475 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 262 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.2 6.1 GO:0035063 nuclear speck organization(GO:0035063)
1.0 4.0 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 3.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.1 2.4 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.2 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 2.1 GO:0002076 osteoblast development(GO:0002076)
0.4 2.0 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.3 2.0 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.1 2.0 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 1.9 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.9 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.6 1.8 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.4 1.8 GO:2000211 regulation of glutamate metabolic process(GO:2000211)
0.3 1.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 1.8 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.4 1.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 1.7 GO:0015701 bicarbonate transport(GO:0015701)
0.0 1.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.7 GO:0006813 potassium ion transport(GO:0006813)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 3.6 GO:0014069 postsynaptic density(GO:0014069)
0.1 3.5 GO:0043034 costamere(GO:0043034)
0.0 3.5 GO:0016607 nuclear speck(GO:0016607)
0.1 3.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 3.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 2.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 2.3 GO:0043197 dendritic spine(GO:0043197)
0.1 2.1 GO:0032039 integrator complex(GO:0032039)
0.7 2.0 GO:0043512 inhibin A complex(GO:0043512)
0.0 2.0 GO:0014704 intercalated disc(GO:0014704)
0.2 1.8 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 1.8 GO:0042641 actomyosin(GO:0042641)
0.2 1.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 1.4 GO:0044307 dendritic branch(GO:0044307)
0.0 1.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 1.3 GO:0042788 polysomal ribosome(GO:0042788)
0.1 1.3 GO:0032279 asymmetric synapse(GO:0032279)
0.3 1.2 GO:0031673 H zone(GO:0031673)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.5 GO:0008017 microtubule binding(GO:0008017)
0.2 3.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.4 2.7 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 2.2 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 2.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.4 1.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 1.8 GO:0050693 LBD domain binding(GO:0050693)
0.1 1.8 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.4 1.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.7 GO:0035064 methylated histone binding(GO:0035064)
0.2 1.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 1.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.5 GO:0070412 R-SMAD binding(GO:0070412)
0.4 1.4 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 1.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 1.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.4 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 1.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 2.6 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.1 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 2.0 PID_ATM_PATHWAY ATM pathway
0.0 1.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.1 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 1.1 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 0.8 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.8 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.7 PID_E2F_PATHWAY E2F transcription factor network
0.1 0.6 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 4.2 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 4.2 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.3 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 2.1 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.5 2.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 1.9 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.6 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.6 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.5 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.4 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.4 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 1.2 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 1.1 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.0 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events