Motif ID: Nfatc3

Z-value: 1.207


Transcription factors associated with Nfatc3:

Gene SymbolEntrez IDGene Name
Nfatc3 ENSMUSG00000031902.9 Nfatc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc3mm10_v2_chr8_+_106059562_106059623-0.115.1e-01Click!


Activity profile for motif Nfatc3.

activity profile for motif Nfatc3


Sorted Z-values histogram for motif Nfatc3

Sorted Z-values for motif Nfatc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 6.427 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_118478344 5.344 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 5.328 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr4_-_97584605 5.157 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 5.123 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr15_-_91191733 3.831 ENSMUST00000069511.6
 Abcd2
ATP-binding cassette, sub-family D (ALD), member 2
chr6_+_48841476 3.041 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr17_-_70849644 2.983 ENSMUST00000134654.1
ENSMUST00000172229.1
ENSMUST00000127719.1
 Tgif1


TGFB-induced factor homeobox 1


chr6_+_48841633 2.949 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr6_-_48841098 2.803 ENSMUST00000101429.4
 Tmem176b
transmembrane protein 176B
chr6_+_47244359 2.796 ENSMUST00000060839.6
 Cntnap2
contactin associated protein-like 2
chr6_-_48840988 2.776 ENSMUST00000164733.1
 Tmem176b
transmembrane protein 176B
chr14_-_16575456 2.742 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr6_-_48841373 2.741 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr7_-_49636847 2.570 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr18_-_80713062 2.558 ENSMUST00000170905.1
ENSMUST00000078049.4
 Nfatc1

nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1

chr16_-_59555752 2.471 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr2_-_118549668 2.425 ENSMUST00000090219.6
 Bmf
BCL2 modifying factor
chr3_-_86548268 2.421 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr10_+_4611971 2.283 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 14.3 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
3.6 10.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.1 6.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 4.8 GO:0060579 ventral spinal cord interneuron fate commitment(GO:0060579) cell fate commitment involved in pattern specification(GO:0060581)
0.5 4.3 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.3 4.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.4 4.0 GO:1990845 adaptive thermogenesis(GO:1990845)
0.3 3.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.7 3.3 GO:0060849 regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.4 3.3 GO:0072615 interleukin-17 secretion(GO:0072615)
1.0 2.9 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel lumenization(GO:0072554) blood vessel endothelial cell fate specification(GO:0097101) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of heart induction(GO:1901321) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.6 2.8 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.5 2.7 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.9 2.6 GO:0060854 patterning of lymph vessels(GO:0060854)
0.3 2.4 GO:0048102 autophagic cell death(GO:0048102)
0.1 2.4 GO:0051451 myoblast migration(GO:0051451)
0.8 2.3 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.6 2.3 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 2.3 GO:0051028 mRNA transport(GO:0051028)
0.6 2.2 GO:2000319 negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 3.9 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.5 GO:0016459 myosin complex(GO:0016459)
0.0 3.1 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 3.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 3.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.6 2.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.3 2.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.3 2.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 2.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 2.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.9 GO:0043218 compact myelin(GO:0043218)
0.1 1.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.5 GO:0001726 ruffle(GO:0001726)
0.0 1.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 1.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0005876 spindle microtubule(GO:0005876)
0.1 1.2 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.3 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 5.0 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 4.3 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.2 4.2 GO:0070410 co-SMAD binding(GO:0070410)
1.0 4.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.0 3.8 GO:0051015 actin filament binding(GO:0051015)
0.1 3.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 3.4 GO:0035326 enhancer binding(GO:0035326)
0.8 3.3 GO:0008142 oxysterol binding(GO:0008142)
0.3 3.3 GO:0001972 retinoic acid binding(GO:0001972)
0.0 3.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 2.9 GO:0002020 protease binding(GO:0002020)
0.0 2.8 GO:0030246 carbohydrate binding(GO:0030246)
0.2 2.7 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.9 2.6 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.1 2.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 2.5 GO:0032452 histone demethylase activity(GO:0032452)
0.8 2.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.8 2.3 GO:0004145 diamine N-acetyltransferase activity(GO:0004145)
0.4 2.0 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 15.1 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 7.6 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 4.9 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 4.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 3.2 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.1 2.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.9 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.9 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.7 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 1.6 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.1 1.4 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events
0.0 1.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.4 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 1.2 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 1.2 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.9 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.7 PID_IFNG_PATHWAY IFN-gamma pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 4.3 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 4.2 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.5 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 3.5 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.0 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.2 2.9 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 2.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 2.8 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 2.5 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 2.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.1 1.9 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.6 REACTOME_DIABETES_PATHWAYS Genes involved in Diabetes pathways
0.1 1.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.3 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.2 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 0.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.0 0.7 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D