Motif ID: Nfatc4

Z-value: 0.547


Transcription factors associated with Nfatc4:

Gene SymbolEntrez IDGene Name
Nfatc4 ENSMUSG00000023411.5 Nfatc4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc4mm10_v2_chr14_+_55824795_55824889-0.831.4e-10Click!


Activity profile for motif Nfatc4.

activity profile for motif Nfatc4


Sorted Z-values histogram for motif Nfatc4

Sorted Z-values for motif Nfatc4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc4

PNG image of the network

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Top targets:


Showing 1 to 20 of 58 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 5.301 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr1_-_56978534 3.655 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr15_+_92051153 2.723 ENSMUST00000169825.1
 Cntn1
contactin 1
chr1_-_56969864 2.662 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr19_+_26623419 2.393 ENSMUST00000176584.1
 Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr11_+_97415527 2.301 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr15_+_3270767 2.106 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr1_-_193370225 1.710 ENSMUST00000169907.1
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr1_-_193370260 1.702 ENSMUST00000016323.4
 Camk1g
calcium/calmodulin-dependent protein kinase I gamma
chr4_+_48049080 1.693 ENSMUST00000153369.1
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr19_-_4943049 1.657 ENSMUST00000133254.1
ENSMUST00000120475.1
ENSMUST00000025834.7
 Peli3


pellino 3


chr12_+_91400990 1.494 ENSMUST00000021346.7
ENSMUST00000021343.6
 Tshr

thyroid stimulating hormone receptor

chr2_+_125136692 1.457 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr14_+_70555900 1.366 ENSMUST00000163060.1
 Hr
hairless
chr13_+_31806627 1.348 ENSMUST00000062292.2
 Foxc1
forkhead box C1
chr10_+_21993890 1.309 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr1_-_126830632 1.305 ENSMUST00000112583.1
ENSMUST00000094609.3
 Nckap5

NCK-associated protein 5

chr13_-_52981027 1.188 ENSMUST00000071065.7
 Nfil3
nuclear factor, interleukin 3, regulated
chr3_+_84925476 1.138 ENSMUST00000107675.1
 Fbxw7
F-box and WD-40 domain protein 7
chr2_+_55435918 1.138 ENSMUST00000067101.3
 Kcnj3
potassium inwardly-rectifying channel, subfamily J, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.8 5.3 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 3.4 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 2.7 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.3 2.4 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.6 1.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.6 1.7 GO:0070428 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.2 1.5 GO:1904587 response to glycoprotein(GO:1904587)
0.1 1.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.4 1.3 GO:1902256 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.1 1.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 1.2 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.2 1.1 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.2 1.1 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 0.8 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.2 0.8 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.5 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.5 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.5 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 0.5 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 5.2 GO:0030017 sarcomere(GO:0030017)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0071564 npBAF complex(GO:0071564)
0.0 1.3 GO:0030315 T-tubule(GO:0030315)
0.0 1.3 GO:0005720 nuclear heterochromatin(GO:0005720)
0.3 1.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 0.5 GO:0098827 endoplasmic reticulum tubular network(GO:0071782) endoplasmic reticulum subcompartment(GO:0098827)
0.1 0.4 GO:0031673 H zone(GO:0031673)
0.1 0.4 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.2 GO:0090568 nuclear transcriptional repressor complex(GO:0090568) RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0034679 integrin alpha9-beta1 complex(GO:0034679)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 5.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 3.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.4 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 1.7 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 1.4 GO:0042809 vitamin D receptor binding(GO:0042809)
0.2 1.3 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 1.3 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.2 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.2 1.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 1.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3 0.8 GO:0003963 RNA-3'-phosphate cyclase activity(GO:0003963)
0.2 0.8 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.7 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.5 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.4 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.3 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 2.4 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 1.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 1.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.3 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.1 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.1 PID_MYC_PATHWAY C-MYC pathway
0.0 0.8 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.4 PID_ER_NONGENOMIC_PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.7 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.5 1.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.8 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.5 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.2 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.1 REACTOME_GRB2_SOS_PROVIDES_LINKAGE_TO_MAPK_SIGNALING_FOR_INTERGRINS_ Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins