Motif ID: Nfe2_Bach1_Mafk

Z-value: 1.262

Transcription factors associated with Nfe2_Bach1_Mafk:

Gene SymbolEntrez IDGene Name
Bach1 ENSMUSG00000025612.5 Bach1
Mafk ENSMUSG00000018143.4 Mafk
Nfe2 ENSMUSG00000058794.6 Nfe2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mafkmm10_v2_chr5_+_139791513_1397915390.642.0e-05Click!
Bach1mm10_v2_chr16_+_87698904_87698959-0.473.4e-03Click!
Nfe2mm10_v2_chr15_-_103251465_103251705-0.411.2e-02Click!


Activity profile for motif Nfe2_Bach1_Mafk.

activity profile for motif Nfe2_Bach1_Mafk


Sorted Z-values histogram for motif Nfe2_Bach1_Mafk

Sorted Z-values for motif Nfe2_Bach1_Mafk



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2_Bach1_Mafk

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 22.582 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr1_-_33907721 15.531 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chr9_-_86695897 8.439 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr6_+_5725812 6.108 ENSMUST00000115554.1
ENSMUST00000153942.1
 Dync1i1

dynein cytoplasmic 1 intermediate chain 1

chr16_-_22439719 5.050 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr13_-_113663670 4.506 ENSMUST00000054650.4
 Hspb3
heat shock protein 3
chr16_+_17561885 4.263 ENSMUST00000171002.1
ENSMUST00000023441.4
 P2rx6

purinergic receptor P2X, ligand-gated ion channel, 6

chr13_-_54611274 4.187 ENSMUST00000049575.7
 Cltb
clathrin, light polypeptide (Lcb)
chr16_-_22439570 4.114 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chr4_-_136886187 4.058 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr19_-_12501996 4.052 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr16_+_90220742 3.809 ENSMUST00000023707.9
 Sod1
superoxide dismutase 1, soluble
chr5_-_139484475 3.790 ENSMUST00000110851.1
ENSMUST00000079996.6
 Zfand2a

zinc finger, AN1-type domain 2A

chr13_-_54611332 3.720 ENSMUST00000091609.4
 Cltb
clathrin, light polypeptide (Lcb)
chr5_-_139484420 3.620 ENSMUST00000150992.1
 Zfand2a
zinc finger, AN1-type domain 2A
chr1_-_134235420 3.461 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr2_+_156475803 3.453 ENSMUST00000029155.8
 Epb4.1l1
erythrocyte protein band 4.1-like 1
chr18_+_61045139 3.438 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr7_-_110862944 3.430 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr18_+_67133713 3.339 ENSMUST00000076605.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 28.7 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.4 15.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
1.8 9.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 8.9 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
1.7 8.4 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.6 4.5 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 4.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.2 4.3 GO:0033198 response to ATP(GO:0033198)
0.3 4.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 4.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 4.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.8 3.8 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.5 3.8 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.4 3.8 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.1 3.8 GO:0034605 cellular response to heat(GO:0034605)
0.4 3.6 GO:0005513 detection of calcium ion(GO:0005513)
1.2 3.5 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
1.1 3.4 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.6 3.3 GO:0009405 pathogenesis(GO:0009405)
0.0 3.3 GO:0007219 Notch signaling pathway(GO:0007219)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
9.6 28.7 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.7 8.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.1 7.9 GO:0000502 proteasome complex(GO:0000502)
0.1 5.5 GO:0005604 basement membrane(GO:0005604)
0.5 5.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.1 4.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.3 4.5 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 4.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 4.2 GO:0031045 dense core granule(GO:0031045)
0.1 4.2 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 3.8 GO:0071564 npBAF complex(GO:0071564)
0.0 3.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 3.6 GO:0005581 collagen trimer(GO:0005581)
0.2 3.5 GO:0032279 asymmetric synapse(GO:0032279)
0.0 3.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
1.0 3.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 3.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 2.7 GO:0032588 trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.7 28.7 GO:0045504 dynein heavy chain binding(GO:0045504)
0.4 16.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
2.8 8.4 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.7 7.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 5.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 5.3 GO:0046965 retinoid X receptor binding(GO:0046965)
1.1 4.5 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.7 4.3 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 4.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 4.2 GO:0005518 collagen binding(GO:0005518)
0.2 3.9 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 3.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.9 3.6 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 3.5 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.7 3.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 3.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.6 3.0 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 3.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 2.6 GO:0048365 Rac GTPase binding(GO:0048365)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 9.2 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.3 7.9 PID_ARF_3PATHWAY Arf1 pathway
0.2 7.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 6.0 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 5.7 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 4.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 4.2 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 3.8 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.1 3.6 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.1 3.4 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 3.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.2 3.3 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.1 2.7 PID_CXCR3_PATHWAY CXCR3-mediated signaling events
0.1 2.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.1 2.0 PID_IL27_PATHWAY IL27-mediated signaling events
0.1 2.0 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.2 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.2 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 34.0 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.6 10.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 8.3 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 7.1 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.5 7.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.4 4.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.7 4.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 4.1 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 3.9 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 3.6 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION Genes involved in Downstream signal transduction
0.7 3.5 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.3 3.5 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.1 3.0 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 2.6 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 2.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 2.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.3 1.8 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 1.7 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle