Motif ID: Nfe2l2

Z-value: 0.454


Transcription factors associated with Nfe2l2:

Gene SymbolEntrez IDGene Name
Nfe2l2 ENSMUSG00000015839.6 Nfe2l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfe2l2mm10_v2_chr2_-_75704535_75704641-0.048.3e-01Click!


Activity profile for motif Nfe2l2.

activity profile for motif Nfe2l2


Sorted Z-values histogram for motif Nfe2l2

Sorted Z-values for motif Nfe2l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfe2l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 172 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_5725639 1.247 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr3_-_116968827 1.062 ENSMUST00000119557.1
 Palmd
palmdelphin
chr17_-_24644933 1.020 ENSMUST00000019684.5
 Slc9a3r2
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2
chr1_-_172219715 0.947 ENSMUST00000170700.1
ENSMUST00000003554.4
 Casq1

calsequestrin 1

chr18_+_61639542 0.928 ENSMUST00000183083.1
ENSMUST00000183087.1
 Gm20748

predicted gene, 20748

chr1_+_165769392 0.890 ENSMUST00000040298.4
 Creg1
cellular repressor of E1A-stimulated genes 1
chr17_-_25570678 0.871 ENSMUST00000025003.3
ENSMUST00000173447.1
 Sox8

SRY-box containing gene 8

chr2_+_25395866 0.869 ENSMUST00000028328.2
 Entpd2
ectonucleoside triphosphate diphosphohydrolase 2
chr3_-_116968969 0.861 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr8_+_65967157 0.832 ENSMUST00000072482.6
 March1
membrane-associated ring finger (C3HC4) 1
chr6_+_17463927 0.807 ENSMUST00000115442.1
 Met
met proto-oncogene
chr4_+_118961578 0.767 ENSMUST00000058651.4
 Lao1
L-amino acid oxidase 1
chr7_-_105482197 0.667 ENSMUST00000047040.2
 Prkcdbp
protein kinase C, delta binding protein
chr1_-_33907721 0.662 ENSMUST00000115161.1
ENSMUST00000062289.8
 Bend6

BEN domain containing 6

chrX_-_51681856 0.627 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr19_-_4037910 0.625 ENSMUST00000169613.1
 Gstp1
glutathione S-transferase, pi 1
chr2_+_155775333 0.619 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chrX_-_51681703 0.612 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr1_-_155146755 0.600 ENSMUST00000027744.8
 Mr1
major histocompatibility complex, class I-related
chr18_+_61045139 0.599 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 1.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.0 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 1.0 GO:0071451 cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
0.3 0.9 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3 0.9 GO:0072034 renal vesicle induction(GO:0072034)
0.1 0.9 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.3 0.8 GO:0072180 mesonephric duct development(GO:0072177) mesonephric duct morphogenesis(GO:0072180)
0.1 0.8 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.8 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 0.7 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 0.6 GO:0070488 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) neutrophil aggregation(GO:0070488)
0.2 0.6 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 0.6 GO:0003274 endocardial cushion fusion(GO:0003274)
0.1 0.6 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1 0.6 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 0.6 GO:0032620 interleukin-17 production(GO:0032620)
0.1 0.5 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 0.5 GO:0045541 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 1.2 GO:1990257 piccolo-bassoon transport vesicle(GO:1990257)
0.3 0.9 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.2 0.9 GO:0014802 terminal cisterna(GO:0014802)
0.1 0.9 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.9 GO:0005605 basal lamina(GO:0005605)
0.0 0.9 GO:0032420 stereocilium(GO:0032420)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.6 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.5 GO:0031045 dense core granule(GO:0031045)
0.0 0.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 0.4 GO:0090661 box H/ACA telomerase RNP complex(GO:0090661)
0.1 0.3 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.2 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 1.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 1.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 1.0 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.9 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.1 0.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.3 0.8 GO:0001716 L-amino-acid oxidase activity(GO:0001716)
0.2 0.8 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 0.8 GO:0042287 MHC protein binding(GO:0042287)
0.0 0.7 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.6 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.6 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.1 0.6 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 0.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.1 0.5 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.5 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.4 GO:0004155 6,7-dihydropteridine reductase activity(GO:0004155)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.1 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.5 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 0.3 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 0.3 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.1 ST_IL_13_PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.1 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.9 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.5 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.0 0.2 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.2 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 0.2 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase