Motif ID: Nfia

Z-value: 1.808


Transcription factors associated with Nfia:

Gene SymbolEntrez IDGene Name
Nfia ENSMUSG00000028565.12 Nfia

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfiamm10_v2_chr4_+_97777606_977776320.251.3e-01Click!


Activity profile for motif Nfia.

activity profile for motif Nfia


Sorted Z-values histogram for motif Nfia

Sorted Z-values for motif Nfia



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfia

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_20665250 21.613 ENSMUST00000075312.3
 Ttr
transthyretin
chr19_+_5740885 15.465 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr6_+_141524379 13.154 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr10_+_127725392 10.213 ENSMUST00000026466.3
 Tac2
tachykinin 2
chr7_+_130936172 9.746 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr13_-_97747373 9.417 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr11_-_102897123 9.112 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr13_-_97747399 8.785 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_-_97417730 8.142 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr11_-_77894096 7.783 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr11_-_102897146 7.502 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr1_+_42229726 7.120 ENSMUST00000066196.1
 Gm9915
predicted gene 9915
chr11_+_78324200 7.108 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr2_-_25470031 6.968 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr10_+_58813359 6.954 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr2_-_25469742 6.713 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr3_+_89520152 6.570 ENSMUST00000000811.7
 Kcnn3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr13_+_94173992 6.399 ENSMUST00000121618.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr3_-_116129615 6.372 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr4_+_48045144 6.202 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 382 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.0 25.0 GO:0070327 thyroid hormone transport(GO:0070327)
2.4 16.6 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
5.2 15.5 GO:1902460 transforming growth factor beta activation(GO:0036363) regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
2.7 13.7 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.2 13.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
2.6 10.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.6 9.7 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
1.3 9.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 9.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
2.5 7.5 GO:0006553 lysine metabolic process(GO:0006553)
0.7 7.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 6.9 GO:0035994 response to muscle stretch(GO:0035994)
0.2 6.9 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
1.0 6.7 GO:0048251 elastic fiber assembly(GO:0048251)
0.6 6.4 GO:0060710 chorio-allantoic fusion(GO:0060710)
2.1 6.2 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.3 6.0 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.5 5.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.9 5.4 GO:0032196 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196)
0.2 5.4 GO:0007520 myoblast fusion(GO:0007520)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 32.6 GO:0005615 extracellular space(GO:0005615)
0.1 31.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 18.2 GO:0030175 filopodium(GO:0030175)
4.2 16.6 GO:0097450 astrocyte end-foot(GO:0097450)
0.1 15.2 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 10.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 9.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 9.2 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.0 8.8 GO:0005925 focal adhesion(GO:0005925)
0.1 8.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 7.1 GO:0005769 early endosome(GO:0005769)
0.2 5.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.8 5.1 GO:0035976 AP1 complex(GO:0035976)
1.5 4.5 GO:0071953 elastic fiber(GO:0071953)
0.2 4.3 GO:0005605 basal lamina(GO:0005605)
0.1 4.3 GO:0051233 spindle midzone(GO:0051233)
0.1 4.2 GO:0072562 blood microparticle(GO:0072562)
0.0 4.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 4.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.4 3.6 GO:1990712 HFE-transferrin receptor complex(GO:1990712)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 244 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.8 25.0 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 17.0 GO:0005178 integrin binding(GO:0005178)
0.7 15.5 GO:0050431 transforming growth factor beta binding(GO:0050431)
3.4 13.7 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
3.3 13.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.5 11.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
3.6 10.7 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 9.7 GO:0070412 R-SMAD binding(GO:0070412)
1.0 9.3 GO:0036122 BMP binding(GO:0036122)
1.9 7.8 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 7.6 GO:0019003 GDP binding(GO:0019003)
1.2 7.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
1.6 6.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
1.6 6.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.5 6.4 GO:0050693 LBD domain binding(GO:0050693)
0.6 6.2 GO:0070700 BMP receptor binding(GO:0070700)
0.1 5.7 GO:0005518 collagen binding(GO:0005518)
1.3 5.4 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.1 5.3 GO:0002020 protease binding(GO:0002020)
0.1 5.0 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 42.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.5 23.5 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.2 22.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 16.2 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.2 13.0 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.6 10.6 PID_INTEGRIN5_PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 9.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.5 9.0 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 8.5 PID_CDC42_PATHWAY CDC42 signaling events
0.5 8.2 ST_STAT3_PATHWAY STAT3 Pathway
0.2 5.7 PID_SHP2_PATHWAY SHP2 signaling
0.1 5.5 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 5.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 4.8 NABA_COLLAGENS Genes encoding collagen proteins
0.1 4.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.2 3.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.4 2.9 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 2.9 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 2.9 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 2.9 ST_ADRENERGIC Adrenergic Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 22.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 18.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 8.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
1.0 8.2 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 7.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 7.7 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 7.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 5.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 5.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 5.2 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 4.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.3 4.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.6 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 4.6 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 4.3 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.1 3.7 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.1 3.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.3 3.4 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 3.1 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation