Motif ID: Nfic_Nfib

Z-value: 1.424

Transcription factors associated with Nfic_Nfib:

Gene SymbolEntrez IDGene Name
Nfib ENSMUSG00000008575.11 Nfib
Nfic ENSMUSG00000055053.11 Nfic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nficmm10_v2_chr10_-_81427114_814271870.473.3e-03Click!
Nfibmm10_v2_chr4_-_82505274_825053580.362.9e-02Click!


Activity profile for motif Nfic_Nfib.

activity profile for motif Nfic_Nfib


Sorted Z-values histogram for motif Nfic_Nfib

Sorted Z-values for motif Nfic_Nfib



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfic_Nfib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25470031 12.244 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr2_-_25469742 11.056 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr1_+_43730593 9.956 ENSMUST00000027217.8
 1500015O10Rik
RIKEN cDNA 1500015O10 gene
chr11_-_77894096 8.501 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr11_+_61485431 7.679 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr3_+_94933041 7.191 ENSMUST00000090839.5
 Selenbp1
selenium binding protein 1
chr2_+_32646586 6.138 ENSMUST00000009705.7
ENSMUST00000167841.1
 Eng

endoglin

chr11_+_78324200 5.984 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr10_+_57784859 5.371 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr13_-_97747373 5.354 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr14_-_118052235 4.870 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr11_+_115154139 4.858 ENSMUST00000021076.5
 Rab37
RAB37, member of RAS oncogene family
chr19_-_42752710 4.806 ENSMUST00000076505.3
 Pyroxd2
pyridine nucleotide-disulphide oxidoreductase domain 2
chr7_+_45017953 4.742 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr13_-_97747399 4.733 ENSMUST00000144993.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr3_+_94693556 4.493 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr3_-_85746266 4.374 ENSMUST00000118408.1
 Fam160a1
family with sequence similarity 160, member A1
chr7_-_97417730 4.293 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr2_-_180225812 3.948 ENSMUST00000015791.5
 Lama5
laminin, alpha 5
chr2_+_76650264 3.900 ENSMUST00000099986.2
 Dfnb59
deafness, autosomal recessive 59 (human)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 188 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.7 23.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.2 10.0 GO:0070314 G1 to G0 transition(GO:0070314)
0.5 8.6 GO:0060134 prepulse inhibition(GO:0060134)
2.8 8.5 GO:0006553 lysine metabolic process(GO:0006553)
0.9 8.3 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.8 8.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 7.7 GO:0071493 elastic fiber assembly(GO:0048251) cellular response to UV-B(GO:0071493)
0.2 7.0 GO:0050873 brown fat cell differentiation(GO:0050873)
2.0 6.1 GO:1905072 detection of oxygen(GO:0003032) cardiac jelly development(GO:1905072)
0.1 5.5 GO:0060325 face morphogenesis(GO:0060325)
0.1 5.0 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
1.2 4.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.8 4.8 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.0 4.4 GO:0008380 RNA splicing(GO:0008380)
0.1 4.2 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.4 4.1 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.1 4.1 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.4 4.0 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
1.1 3.4 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.2 3.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 78 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 19.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 11.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 10.5 GO:0031045 dense core granule(GO:0031045)
3.3 10.0 GO:0071953 elastic fiber(GO:0071953)
0.0 7.3 GO:0001650 fibrillar center(GO:0001650)
2.2 6.6 GO:0030934 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.1 5.4 GO:0072562 blood microparticle(GO:0072562)
0.1 5.0 GO:0030667 secretory granule membrane(GO:0030667)
1.2 4.8 GO:0097450 astrocyte end-foot(GO:0097450)
0.0 4.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 4.1 GO:0005682 U5 snRNP(GO:0005682)
0.1 4.0 GO:0005844 polysome(GO:0005844)
1.0 3.9 GO:0043259 laminin-10 complex(GO:0043259)
0.1 3.9 GO:0005902 microvillus(GO:0005902)
1.3 3.8 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 3.7 GO:0043292 contractile fiber(GO:0043292)
0.6 3.4 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.1 3.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 3.3 GO:0042383 sarcolemma(GO:0042383)
0.1 3.1 GO:0005924 cell-substrate adherens junction(GO:0005924) cell-substrate junction(GO:0030055)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.8 23.3 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
1.1 11.6 GO:0008430 selenium binding(GO:0008430)
0.1 8.8 GO:0005178 integrin binding(GO:0005178)
2.1 8.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
1.4 8.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 7.9 GO:0005504 fatty acid binding(GO:0005504)
1.2 6.1 GO:0005534 galactose binding(GO:0005534)
0.2 6.0 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 5.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 5.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 4.3 GO:0019003 GDP binding(GO:0019003)
0.4 4.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 4.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 4.0 GO:0005525 GTP binding(GO:0005525)
1.0 3.8 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.2 3.5 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 3.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.5 3.4 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.2 3.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.3 GO:0030506 ankyrin binding(GO:0030506)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.3 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 8.4 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 7.7 NABA_COLLAGENS Genes encoding collagen proteins
0.1 6.1 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 5.8 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.1 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.5 3.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.0 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.3 2.9 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 2.4 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.2 2.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 2.0 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.1 1.9 PID_MYC_PATHWAY C-MYC pathway
0.0 1.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
1.3 1.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 1.2 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.1 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.1 0.9 PID_S1P_S1P1_PATHWAY S1P1 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.1 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.2 8.7 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 7.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 4.8 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 4.7 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.2 3.5 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.1 3.3 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 3.3 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 3.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.4 2.9 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.8 REACTOME_GLYCOSPHINGOLIPID_METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 2.7 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.2 2.6 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.2 2.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.1 2.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 1.9 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.9 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.9 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.8 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds