Motif ID: Nfil3_Tef

Z-value: 1.622

Transcription factors associated with Nfil3_Tef:

Gene SymbolEntrez IDGene Name
Nfil3 ENSMUSG00000056749.7 Nfil3
Tef ENSMUSG00000022389.8 Tef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfil3mm10_v2_chr13_-_52981027_529810830.437.2e-03Click!
Tefmm10_v2_chr15_+_81811414_818114910.344.2e-02Click!


Activity profile for motif Nfil3_Tef.

activity profile for motif Nfil3_Tef


Sorted Z-values histogram for motif Nfil3_Tef

Sorted Z-values for motif Nfil3_Tef



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfil3_Tef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_22439570 15.937 ENSMUST00000170393.1
 Etv5
ets variant gene 5
chrX_-_51681703 11.032 ENSMUST00000088172.5
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chrX_-_51681856 11.011 ENSMUST00000114871.1
 Hs6st2
heparan sulfate 6-O-sulfotransferase 2
chr13_+_76579670 9.563 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr11_-_101785252 9.336 ENSMUST00000164750.1
ENSMUST00000107176.1
ENSMUST00000017868.6
 Etv4


ets variant gene 4 (E1A enhancer binding protein, E1AF)


chr14_+_65971049 8.796 ENSMUST00000128539.1
 Clu
clusterin
chr14_+_65970804 8.679 ENSMUST00000138191.1
 Clu
clusterin
chr12_+_74288735 8.622 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr2_-_25469742 8.478 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr9_-_40346290 8.382 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_-_25470031 7.911 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr5_+_117841839 7.724 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr14_+_65970610 7.579 ENSMUST00000127387.1
 Clu
clusterin
chr1_-_91459254 7.036 ENSMUST00000069620.8
 Per2
period circadian clock 2
chr3_+_141465564 6.590 ENSMUST00000106236.2
ENSMUST00000075282.3
 Unc5c

unc-5 homolog C (C. elegans)

chr9_-_21037775 6.482 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr15_-_8710734 6.387 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr14_+_65971164 6.029 ENSMUST00000144619.1
 Clu
clusterin
chr17_+_69156791 5.893 ENSMUST00000112680.1
ENSMUST00000080208.5
 Epb4.1l3

erythrocyte protein band 4.1-like 3

chr13_+_16011851 5.859 ENSMUST00000042603.6
 Inhba
inhibin beta-A

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.2 31.1 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
3.6 25.3 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
3.7 22.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
3.3 16.4 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
2.9 11.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.4 10.1 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 8.8 GO:0031032 actomyosin structure organization(GO:0031032)
1.2 8.5 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
2.6 7.7 GO:0099548 drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
2.3 7.0 GO:0031554 regulation of DNA-templated transcription, termination(GO:0031554)
0.7 7.0 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.8 6.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.0 6.1 GO:0072318 clathrin coat disassembly(GO:0072318)
0.3 6.1 GO:0046033 AMP metabolic process(GO:0046033)
1.5 6.0 GO:1901475 pyruvate transmembrane transport(GO:1901475)
1.2 5.9 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
1.1 5.4 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.7 5.2 GO:0015862 uridine transport(GO:0015862)
1.7 5.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.4 5.0 GO:0045161 neuronal ion channel clustering(GO:0045161)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 35.8 GO:0070062 extracellular exosome(GO:0070062)
4.4 31.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 21.2 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 13.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 10.7 GO:0005730 nucleolus(GO:0005730)
0.0 8.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.7 7.7 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 6.3 GO:0005930 axoneme(GO:0005930)
2.0 5.9 GO:0043512 inhibin A complex(GO:0043512)
1.3 5.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 5.4 GO:0016234 inclusion body(GO:0016234)
0.0 5.2 GO:0045202 synapse(GO:0045202)
0.2 5.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 5.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 4.9 GO:0035371 microtubule plus-end(GO:0035371)
0.1 4.9 GO:0005581 collagen trimer(GO:0005581)
1.2 4.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 4.4 GO:0072562 blood microparticle(GO:0072562)
0.3 4.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 31.1 GO:0051787 misfolded protein binding(GO:0051787)
5.5 22.0 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.0 17.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
4.1 16.4 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 10.0 GO:0005509 calcium ion binding(GO:0005509)
1.5 9.1 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
2.9 8.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.4 7.0 GO:1990226 histone methyltransferase binding(GO:1990226)
1.1 6.6 GO:0005042 netrin receptor activity(GO:0005042)
0.4 6.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 6.5 GO:0017124 SH3 domain binding(GO:0017124)
0.0 6.4 GO:0008017 microtubule binding(GO:0008017)
0.0 6.2 GO:0008289 lipid binding(GO:0008289)
2.0 6.1 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
1.5 6.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.0 5.9 GO:0070699 type II activin receptor binding(GO:0070699)
1.1 5.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.2 5.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 5.0 GO:0004385 guanylate kinase activity(GO:0004385)
0.2 5.0 GO:0046965 retinoid X receptor binding(GO:0046965)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 31.1 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.5 15.9 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 9.3 PID_LKB1_PATHWAY LKB1 signaling events
0.2 8.5 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 8.2 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.4 7.0 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.2 6.6 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 5.9 PID_ALK1_PATHWAY ALK1 signaling events
0.2 5.4 PID_MYC_PATHWAY C-MYC pathway
0.1 5.0 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.2 4.4 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 4.4 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.1 3.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 3.8 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 2.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 1.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.1 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.0 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 1.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 31.4 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.6 22.0 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 11.0 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.3 8.7 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.4 8.5 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.2 7.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 7.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 6.8 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 6.4 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 6.1 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
1.5 5.9 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 5.7 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 5.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 4.9 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.5 4.8 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.9 4.3 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.4 4.0 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.3 4.0 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX Genes involved in IRAK1 recruits IKK complex
0.1 3.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 3.3 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING Genes involved in Sema4D in semaphorin signaling