Motif ID: Nfix

Z-value: 0.974


Transcription factors associated with Nfix:

Gene SymbolEntrez IDGene Name
Nfix ENSMUSG00000001911.10 Nfix

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfixmm10_v2_chr8_-_84800024_848002830.932.0e-16Click!


Activity profile for motif Nfix.

activity profile for motif Nfix


Sorted Z-values histogram for motif Nfix

Sorted Z-values for motif Nfix



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfix

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_141524379 11.149 ENSMUST00000032362.9
 Slco1c1
solute carrier organic anion transporter family, member 1c1
chr16_+_41532851 10.317 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr13_+_16014457 7.207 ENSMUST00000164993.1
 Inhba
inhibin beta-A
chr1_-_56969864 7.066 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 6.535 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_48045144 6.432 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr16_+_42907563 5.410 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr7_-_103827922 5.318 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr5_+_66745835 5.023 ENSMUST00000101164.4
ENSMUST00000118242.1
ENSMUST00000119854.1
ENSMUST00000117601.1
 Limch1



LIM and calponin homology domains 1



chr5_+_66968961 5.005 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr7_-_97417730 4.963 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr9_+_89909775 3.938 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr10_+_57784859 3.877 ENSMUST00000020024.5
 Fabp7
fatty acid binding protein 7, brain
chr10_+_57784914 3.766 ENSMUST00000165013.1
 Fabp7
fatty acid binding protein 7, brain
chr11_-_102897123 3.532 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr13_-_97747373 3.399 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr7_+_130936172 3.326 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr4_-_46991842 2.938 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr7_+_120842824 2.937 ENSMUST00000047875.8
 Eef2k
eukaryotic elongation factor-2 kinase
chr6_-_126166726 2.929 ENSMUST00000112244.2
ENSMUST00000050484.7
 Ntf3

neurotrophin 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 106 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 13.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 11.7 GO:0031032 actomyosin structure organization(GO:0031032)
1.0 11.1 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.4 10.3 GO:0035641 locomotory exploration behavior(GO:0035641)
0.4 7.6 GO:0060134 prepulse inhibition(GO:0060134)
1.4 7.2 GO:0042636 negative regulation of hair cycle(GO:0042636) progesterone secretion(GO:0042701) negative regulation of hair follicle development(GO:0051799) positive regulation of ovulation(GO:0060279)
0.2 7.2 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
2.1 6.4 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.1 5.6 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.8 5.5 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.4 5.5 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.2 4.6 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.7 4.3 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.2 3.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.5 3.6 GO:0019532 oxalate transport(GO:0019532)
0.6 3.3 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.2 3.3 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.6 2.9 GO:0007403 glial cell fate determination(GO:0007403)
0.1 2.9 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.3 2.7 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 10.8 GO:0031225 anchored component of membrane(GO:0031225)
0.0 10.5 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
2.4 7.2 GO:0043512 inhibin A complex(GO:0043512)
1.4 5.5 GO:0097450 astrocyte end-foot(GO:0097450)
0.2 5.5 GO:0000930 gamma-tubulin complex(GO:0000930)
1.3 5.3 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 4.3 GO:0005911 cell-cell junction(GO:0005911)
0.2 3.9 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 3.8 GO:0014069 postsynaptic density(GO:0014069)
0.0 3.2 GO:0005901 caveola(GO:0005901)
0.0 3.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.6 2.9 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.3 2.8 GO:0097433 dense body(GO:0097433)
0.1 2.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 2.1 GO:0071565 nBAF complex(GO:0071565)
0.1 1.7 GO:0031430 M band(GO:0031430)
0.0 1.7 GO:0030017 sarcomere(GO:0030017)
0.3 1.4 GO:0014802 terminal cisterna(GO:0014802)
0.2 1.4 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
2.8 11.1 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.2 7.6 GO:0005504 fatty acid binding(GO:0005504)
1.1 6.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 6.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 5.9 GO:0003779 actin binding(GO:0003779)
0.1 5.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.9 5.6 GO:0004686 elongation factor-2 kinase activity(GO:0004686)
0.1 5.5 GO:0043015 gamma-tubulin binding(GO:0043015)
1.3 5.3 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
0.1 5.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 3.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 3.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.2 3.5 GO:0071949 FAD binding(GO:0071949)
0.1 3.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 3.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.6 2.9 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.5 2.9 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 2.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.4 2.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.4 PID_ALK1_PATHWAY ALK1 signaling events
0.2 5.7 ST_GA12_PATHWAY G alpha 12 Pathway
0.2 4.3 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.2 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.1 3.8 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.2 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 2.9 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.0 PID_IL2_1PATHWAY IL2-mediated signaling events
0.1 1.8 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 1.8 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.3 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 1.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction
0.0 1.1 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 0.7 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.0 0.7 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 11.1 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
1.8 7.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 6.7 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 5.5 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 5.1 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 3.9 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 3.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 2.9 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 2.2 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.0 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.2 1.7 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.7 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 1.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 1.5 REACTOME_IL1_SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.4 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.3 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.3 REACTOME_ADP_SIGNALLING_THROUGH_P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.0 1.3 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.1 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway