Motif ID: Nfkb2

Z-value: 0.641


Transcription factors associated with Nfkb2:

Gene SymbolEntrez IDGene Name
Nfkb2 ENSMUSG00000025225.8 Nfkb2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfkb2mm10_v2_chr19_+_46305682_463057410.591.4e-04Click!


Activity profile for motif Nfkb2.

activity profile for motif Nfkb2


Sorted Z-values histogram for motif Nfkb2

Sorted Z-values for motif Nfkb2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfkb2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_74791516 6.215 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr2_+_172550991 5.346 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr2_+_172550761 5.104 ENSMUST00000099058.3
 Tfap2c
transcription factor AP-2, gamma
chr19_+_7268296 3.352 ENSMUST00000066646.4
 Rcor2
REST corepressor 2
chr7_+_29289300 3.308 ENSMUST00000048187.4
 Ppp1r14a
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_+_153740344 3.168 ENSMUST00000027748.7
 Rgs16
regulator of G-protein signaling 16
chr14_-_118237016 3.077 ENSMUST00000170662.1
 Sox21
SRY-box containing gene 21
chr3_-_116424007 2.484 ENSMUST00000090464.4
 Cdc14a
CDC14 cell division cycle 14A
chr3_-_116423930 2.419 ENSMUST00000106491.2
 Cdc14a
CDC14 cell division cycle 14A
chr5_-_114690906 2.246 ENSMUST00000112212.1
ENSMUST00000112214.1
 Gltp

glycolipid transfer protein

chr11_-_70656467 1.802 ENSMUST00000131642.1
 Gm12319
predicted gene 12319
chr1_-_5019342 1.674 ENSMUST00000002533.8
 Rgs20
regulator of G-protein signaling 20
chr4_-_42168603 1.444 ENSMUST00000098121.3
 Gm13305
predicted gene 13305
chr11_+_101176041 1.393 ENSMUST00000103109.3
 Cntnap1
contactin associated protein-like 1
chr11_+_77686155 1.392 ENSMUST00000100802.4
ENSMUST00000181023.1
 Nufip2

nuclear fragile X mental retardation protein interacting protein 2

chr8_+_108714644 1.374 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr14_-_30607808 1.301 ENSMUST00000112207.1
ENSMUST00000112206.1
ENSMUST00000112202.1
ENSMUST00000112203.1
 Prkcd



protein kinase C, delta



chrX_+_163909132 1.233 ENSMUST00000033734.7
ENSMUST00000112294.2
 Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr11_+_70657196 1.207 ENSMUST00000157027.1
ENSMUST00000072841.5
ENSMUST00000108548.1
ENSMUST00000126241.1
 Eno3



enolase 3, beta muscle



chr2_-_37422869 1.169 ENSMUST00000112936.1
ENSMUST00000112934.1
 Rc3h2

ring finger and CCCH-type zinc finger domains 2

chr19_+_46304709 1.154 ENSMUST00000073116.5
 Nfkb2
nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
chr11_+_70657687 1.142 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr14_-_30626196 1.137 ENSMUST00000112210.3
ENSMUST00000112211.2
ENSMUST00000112208.1
 Prkcd


protein kinase C, delta


chr11_-_54962903 1.039 ENSMUST00000108885.1
ENSMUST00000102730.2
ENSMUST00000018482.6
ENSMUST00000108886.1
ENSMUST00000102731.1
 Tnip1




TNFAIP3 interacting protein 1




chr13_-_111490111 0.982 ENSMUST00000047627.7
 Gpbp1
GC-rich promoter binding protein 1
chr13_-_111490028 0.941 ENSMUST00000091236.4
 Gpbp1
GC-rich promoter binding protein 1
chr3_+_89421619 0.939 ENSMUST00000094378.3
ENSMUST00000137793.1
 Shc1

src homology 2 domain-containing transforming protein C1

chr17_+_35379608 0.922 ENSMUST00000081435.4
 H2-Q4
histocompatibility 2, Q region locus 4
chr11_-_70015346 0.881 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr10_-_59221757 0.817 ENSMUST00000165971.1
 Sept10
septin 10
chr4_-_125127817 0.764 ENSMUST00000036188.7
 Zc3h12a
zinc finger CCCH type containing 12A
chr11_-_68386821 0.669 ENSMUST00000021284.3
 Ntn1
netrin 1
chr8_+_79028317 0.645 ENSMUST00000087927.4
ENSMUST00000098614.2
 Zfp827

zinc finger protein 827

chr1_-_66817536 0.508 ENSMUST00000068168.3
ENSMUST00000113987.1
 Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr1_-_63114516 0.498 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr4_+_100776664 0.453 ENSMUST00000030257.8
ENSMUST00000097955.2
 Cachd1

cache domain containing 1

chr18_-_77565050 0.444 ENSMUST00000182153.1
ENSMUST00000182146.1
ENSMUST00000026494.7
ENSMUST00000182024.1
 Rnf165



ring finger protein 165



chr1_+_135133272 0.442 ENSMUST00000167080.1
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr7_+_3290553 0.417 ENSMUST00000096744.5
 Myadm
myeloid-associated differentiation marker
chr1_+_135132693 0.408 ENSMUST00000049449.4
 Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr19_+_45015198 0.380 ENSMUST00000179108.1
 Lzts2
leucine zipper, putative tumor suppressor 2
chr11_-_84870812 0.367 ENSMUST00000168434.1
 Ggnbp2
gametogenetin binding protein 2
chr16_+_32914094 0.361 ENSMUST00000023491.6
ENSMUST00000170899.1
ENSMUST00000171118.1
ENSMUST00000170201.1
ENSMUST00000165616.1
ENSMUST00000135193.2
 Lrch3





leucine-rich repeats and calponin homology (CH) domain containing 3





chrX_+_163908982 0.339 ENSMUST00000069041.8
 Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr8_+_79028587 0.333 ENSMUST00000119254.1
 Zfp827
zinc finger protein 827
chr17_+_35866606 0.311 ENSMUST00000113814.4
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr17_+_35866056 0.286 ENSMUST00000122899.1
 Ppp1r18
protein phosphatase 1, regulatory subunit 18
chr1_-_63114255 0.268 ENSMUST00000153992.1
ENSMUST00000165066.1
ENSMUST00000172416.1
ENSMUST00000137511.1
 Ino80d



INO80 complex subunit D



chr11_-_84870188 0.262 ENSMUST00000154915.2
 Ggnbp2
gametogenetin binding protein 2
chr10_-_89686250 0.257 ENSMUST00000092227.5
ENSMUST00000174252.1
 Scyl2

SCY1-like 2 (S. cerevisiae)

chr5_+_90759299 0.249 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr2_+_102550012 0.247 ENSMUST00000028612.7
 Pamr1
peptidase domain containing associated with muscle regeneration 1
chr3_-_107760221 0.237 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr5_+_135887988 0.236 ENSMUST00000111155.1
 Hspb1
heat shock protein 1
chr11_-_68386974 0.227 ENSMUST00000135141.1
 Ntn1
netrin 1
chr11_-_84870712 0.226 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
 Ggnbp2



gametogenetin binding protein 2



chr11_-_84870646 0.207 ENSMUST00000018547.2
 Ggnbp2
gametogenetin binding protein 2
chr1_-_156718989 0.198 ENSMUST00000122424.1
 Fam20b
family with sequence similarity 20, member B
chrX_-_7671341 0.162 ENSMUST00000033486.5
 Plp2
proteolipid protein 2
chr1_-_156718894 0.117 ENSMUST00000086153.6
 Fam20b
family with sequence similarity 20, member B
chr2_-_102451792 0.116 ENSMUST00000099678.3
 Fjx1
four jointed box 1 (Drosophila)
chr17_+_35424842 0.075 ENSMUST00000174699.1
 H2-Q6
histocompatibility 2, Q region locus 6
chr5_+_135887905 0.074 ENSMUST00000005077.6
 Hspb1
heat shock protein 1
chr7_-_34654342 0.066 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr17_+_34898931 0.036 ENSMUST00000097342.3
ENSMUST00000013931.5
 Ehmt2

euchromatic histone lysine N-methyltransferase 2


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.6 6.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 4.9 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.5 2.4 GO:0006680 glucosylceramide catabolic process(GO:0006680)
0.5 1.4 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.3 1.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.3 0.8 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713) negative regulation of interferon-gamma secretion(GO:1902714) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.2 1.1 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.2 0.9 GO:1990839 response to endothelin(GO:1990839)
0.1 1.0 GO:1903003 positive regulation of protein deubiquitination(GO:1903003)
0.1 1.2 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.1 0.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 0.9 GO:0042760 very long-chain fatty acid catabolic process(GO:0042760)
0.1 0.4 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.1 0.2 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 1.2 GO:0002467 germinal center formation(GO:0002467)
0.1 3.3 GO:0035690 cellular response to drug(GO:0035690)
0.1 0.3 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0 0.3 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 1.6 GO:0060612 adipose tissue development(GO:0060612)
0.0 3.1 GO:0001942 hair follicle development(GO:0001942)
0.0 2.3 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.0 0.8 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0 0.4 GO:0060384 innervation(GO:0060384)
0.0 0.5 GO:0006816 calcium ion transport(GO:0006816)
0.0 3.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.8 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.4 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.2 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.1 0.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.4 GO:0033270 paranode region of axon(GO:0033270)
0.1 0.3 GO:0097512 cardiac myofibril(GO:0097512)
0.0 4.9 GO:0000922 spindle pole(GO:0000922)
0.0 3.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 2.4 GO:0016363 nuclear matrix(GO:0016363)
0.0 7.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.6 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0070976 calcium-independent protein kinase C activity(GO:0004699) TIR domain binding(GO:0070976)
0.3 0.9 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.3 2.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.2 0.9 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 6.2 GO:0005109 frizzled binding(GO:0005109)
0.1 2.2 GO:0051861 glycolipid binding(GO:0051861)
0.1 10.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 4.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.8 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.8 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 1.0 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 4.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.2 GO:0019956 chemokine binding(GO:0019956)
0.0 0.9 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 4.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 11.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 0.9 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.6 ST_G_ALPHA_I_PATHWAY G alpha i Pathway
0.1 6.2 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.3 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.2 ST_GAQ_PATHWAY G alpha q Pathway
0.0 0.9 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.2 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID_CMYB_PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.9 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 1.6 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.9 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.4 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 5.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.7 REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS Genes involved in G alpha (z) signalling events
0.1 2.3 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.2 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 0.9 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.9 REACTOME_SIGNAL_ATTENUATION Genes involved in Signal attenuation
0.0 1.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions