Motif ID: Nhlh1

Z-value: 0.931


Transcription factors associated with Nhlh1:

Gene SymbolEntrez IDGene Name
Nhlh1 ENSMUSG00000051251.3 Nhlh1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nhlh1mm10_v2_chr1_-_172057573_1720575980.334.4e-02Click!


Activity profile for motif Nhlh1.

activity profile for motif Nhlh1


Sorted Z-values histogram for motif Nhlh1

Sorted Z-values for motif Nhlh1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nhlh1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 3.661 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr13_-_111808938 3.516 ENSMUST00000109267.2
 Map3k1
mitogen-activated protein kinase kinase kinase 1
chrX_+_35888808 2.813 ENSMUST00000033419.6
 Dock11
dedicator of cytokinesis 11
chr2_+_158375638 2.694 ENSMUST00000109488.1
 Snhg11
small nucleolar RNA host gene 11
chr9_+_83834684 2.639 ENSMUST00000070326.7
 Ttk
Ttk protein kinase
chr19_+_25610533 2.586 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr11_+_117849223 2.583 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr6_-_56362356 2.541 ENSMUST00000044505.7
ENSMUST00000166102.1
ENSMUST00000164037.1
ENSMUST00000114327.2
 Pde1c



phosphodiesterase 1C



chr8_+_105518736 2.485 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr5_+_139543889 2.446 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_60963192 2.419 ENSMUST00000028347.6
 Rbms1
RNA binding motif, single stranded interacting protein 1
chr1_-_52500679 2.385 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr1_+_74791516 2.144 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr5_-_72587544 2.098 ENSMUST00000031124.4
 Gm5868
predicted gene 5868
chr9_-_57836706 2.009 ENSMUST00000164010.1
ENSMUST00000171444.1
ENSMUST00000098686.3
 Arid3b


AT rich interactive domain 3B (BRIGHT-like)


chr2_+_102658640 2.000 ENSMUST00000080210.3
 Slc1a2
solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr14_+_56887795 1.967 ENSMUST00000022511.8
 Zmym2
zinc finger, MYM-type 2
chr7_+_122289297 1.935 ENSMUST00000064989.5
ENSMUST00000064921.4
 Prkcb

protein kinase C, beta

chr9_-_27155418 1.907 ENSMUST00000167074.1
ENSMUST00000034472.8
 Jam3

junction adhesion molecule 3

chr11_+_117849286 1.847 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 424 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.7 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.9 4.5 GO:0007386 compartment pattern specification(GO:0007386)
0.6 4.4 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.4 3.7 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 3.3 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.4 3.1 GO:0098762 meiotic cell cycle phase(GO:0098762) meiosis I cell cycle phase(GO:0098764)
0.6 2.8 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 2.8 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 2.8 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.2 2.7 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.2 2.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.3 2.5 GO:0098712 L-glutamate import across plasma membrane(GO:0098712)
0.2 2.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 2.5 GO:0001578 microtubule bundle formation(GO:0001578)
0.3 2.4 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 2.3 GO:0007608 sensory perception of smell(GO:0007608)
0.1 2.3 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 2.2 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.2 2.0 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 2.0 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 155 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.0 GO:0016605 PML body(GO:0016605)
0.1 4.8 GO:0031941 filamentous actin(GO:0031941)
0.9 4.4 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.0 4.1 GO:0000776 kinetochore(GO:0000776)
0.3 4.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 3.6 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 2.9 GO:0005667 transcription factor complex(GO:0005667)
0.1 2.8 GO:0030904 retromer complex(GO:0030904)
0.1 2.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.4 GO:0032993 protein-DNA complex(GO:0032993)
0.0 2.2 GO:0005902 microvillus(GO:0005902)
0.1 2.1 GO:0090544 BAF-type complex(GO:0090544)
0.5 1.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.3 1.9 GO:0033010 paranodal junction(GO:0033010)
0.1 1.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.2 1.8 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.7 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1 1.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 1.7 GO:0005871 kinesin complex(GO:0005871)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 247 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.8 GO:0005112 Notch binding(GO:0005112)
0.0 6.5 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 6.1 GO:0070888 E-box binding(GO:0070888)
0.0 5.5 GO:0001047 core promoter binding(GO:0001047)
0.1 5.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 4.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.3 GO:0005109 frizzled binding(GO:0005109)
0.0 3.7 GO:0003774 motor activity(GO:0003774)
0.1 3.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.9 3.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.0 3.3 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.1 3.0 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.7 2.8 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 2.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.3 2.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 2.7 GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor(GO:0033764)
0.5 2.6 GO:0043515 kinetochore binding(GO:0043515)
0.0 2.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 2.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 2.2 GO:0042393 histone binding(GO:0042393)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 9.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 8.4 PID_NOTCH_PATHWAY Notch signaling pathway
0.4 5.5 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.4 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 3.3 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.7 PID_E2F_PATHWAY E2F transcription factor network
0.1 2.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 2.3 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.3 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.1 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 2.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 2.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 1.9 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 1.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.2 1.7 PID_ALK2_PATHWAY ALK2 signaling events
0.1 1.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.4 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.8 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 4.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 4.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 3.6 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.1 3.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 2.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 1.8 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.1 1.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.7 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 1.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.6 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.5 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.5 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.0 1.5 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.2 1.3 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors