Motif ID: Nkx1-1_Nkx1-2

Z-value: 0.583

Transcription factors associated with Nkx1-1_Nkx1-2:

Gene SymbolEntrez IDGene Name
Nkx1-1 ENSMUSG00000029112.5 Nkx1-1
Nkx1-2 ENSMUSG00000048528.7 Nkx1-2



Activity profile for motif Nkx1-1_Nkx1-2.

activity profile for motif Nkx1-1_Nkx1-2


Sorted Z-values histogram for motif Nkx1-1_Nkx1-2

Sorted Z-values for motif Nkx1-1_Nkx1-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 99 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_55782500 7.285 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_-_23248264 2.997 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr4_-_141599835 2.199 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr13_-_102906046 1.840 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr12_-_40037387 1.615 ENSMUST00000146905.1
 Arl4a
ADP-ribosylation factor-like 4A
chr4_-_14621805 1.586 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr13_-_102905740 1.585 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr16_+_52031549 1.529 ENSMUST00000114471.1
 Cblb
Casitas B-lineage lymphoma b
chr5_+_140607334 1.390 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr14_-_5863663 1.378 ENSMUST00000178594.1
 Gm8237
predicted gene 8237
chrX_-_60893430 1.367 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr4_-_14621669 1.350 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr7_-_143460989 1.200 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_-_14621494 1.102 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr11_+_43682038 1.037 ENSMUST00000094294.4
 Pwwp2a
PWWP domain containing 2A
chr11_+_43681998 0.984 ENSMUST00000061070.5
 Pwwp2a
PWWP domain containing 2A
chr19_+_5490475 0.977 ENSMUST00000116560.2
 Cfl1
cofilin 1, non-muscle
chr3_-_89101907 0.793 ENSMUST00000081848.8
 Fdps
farnesyl diphosphate synthetase
chr2_-_69712461 0.745 ENSMUST00000102706.3
ENSMUST00000073152.6
 Fastkd1

FAST kinase domains 1

chrX_+_106015699 0.719 ENSMUST00000033582.4
 Cox7b
cytochrome c oxidase subunit VIIb

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.3 GO:0043010 camera-type eye development(GO:0043010)
0.6 4.0 GO:0019532 oxalate transport(GO:0019532)
0.5 3.0 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.1 2.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 1.6 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 1.5 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.3 1.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 1.4 GO:0007530 sex determination(GO:0007530)
0.1 1.1 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 1.0 GO:2000812 unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812)
0.1 0.8 GO:0016114 terpenoid biosynthetic process(GO:0016114)
0.1 0.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.7 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.6 GO:0042989 sequestering of actin monomers(GO:0042989)
0.2 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.5 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.5 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.0 0.5 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 0.4 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.4 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 2.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0030175 filopodium(GO:0030175)
0.1 0.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.7 GO:0045277 respiratory chain complex IV(GO:0045277)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.6 GO:0005685 U1 snRNP(GO:0005685)
0.0 0.6 GO:0043034 costamere(GO:0043034)
0.0 0.5 GO:0045120 pronucleus(GO:0045120)
0.0 0.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.4 GO:0005638 lamin filament(GO:0005638)
0.0 0.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.4 GO:0032433 filopodium tip(GO:0032433)
0.0 0.3 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0030689 Noc complex(GO:0030689)
0.0 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.4 4.0 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 2.5 GO:0000287 magnesium ion binding(GO:0000287)
0.2 2.2 GO:0031005 filamin binding(GO:0031005)
0.0 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.5 1.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0 1.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.2 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.0 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 0.8 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 0.7 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.0 0.6 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.5 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 0.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 PID_CD40_PATHWAY CD40/CD40L signaling
0.1 1.0 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.7 PID_PTP1B_PATHWAY Signaling events mediated by PTP1B
0.0 0.4 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.4 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.1 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.2 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.4 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 1.0 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.4 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters