Motif ID: Nkx1-1_Nkx1-2
Z-value: 0.583
Transcription factors associated with Nkx1-1_Nkx1-2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Nkx1-1 | ENSMUSG00000029112.5 | Nkx1-1 |
Nkx1-2 | ENSMUSG00000048528.7 | Nkx1-2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 4.0 | GO:0019532 | oxalate transport(GO:0019532) |
0.5 | 1.5 | GO:0002669 | positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913) |
0.5 | 3.0 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.3 | 1.0 | GO:2000812 | unidimensional cell growth(GO:0009826) establishment or maintenance of cell polarity regulating cell shape(GO:0071963) regulation of barbed-end actin filament capping(GO:2000812) |
0.3 | 1.4 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.2 | 0.2 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.2 | 0.5 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255) |
0.1 | 2.2 | GO:0033623 | regulation of integrin activation(GO:0033623) |
0.1 | 1.1 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
0.1 | 0.7 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
0.1 | 0.4 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
0.1 | 0.2 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
0.1 | 0.4 | GO:1903630 | regulation of aminoacyl-tRNA ligase activity(GO:1903630) positive regulation of aminoacyl-tRNA ligase activity(GO:1903632) |
0.1 | 0.5 | GO:0090365 | regulation of mRNA modification(GO:0090365) |
0.1 | 0.4 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
0.1 | 0.8 | GO:0016114 | terpenoid biosynthetic process(GO:0016114) |
0.1 | 0.2 | GO:0070649 | meiotic chromosome movement towards spindle pole(GO:0016344) formin-nucleated actin cable assembly(GO:0070649) |
0.1 | 0.2 | GO:0019085 | early viral transcription(GO:0019085) |
0.1 | 1.4 | GO:0007530 | sex determination(GO:0007530) |
0.1 | 0.4 | GO:2001181 | positive regulation of interleukin-10 secretion(GO:2001181) |
0.1 | 0.6 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
0.1 | 0.2 | GO:1904578 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
0.1 | 0.7 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.0 | 0.1 | GO:0002925 | positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925) |
0.0 | 1.6 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 0.2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing(GO:0090309) |
0.0 | 0.1 | GO:2000097 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
0.0 | 0.5 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.0 | 0.5 | GO:1903504 | regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504) |
0.0 | 0.2 | GO:0019240 | citrulline biosynthetic process(GO:0019240) |
0.0 | 0.1 | GO:2000481 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) positive regulation of cAMP-dependent protein kinase activity(GO:2000481) |
0.0 | 0.3 | GO:2000628 | regulation of miRNA metabolic process(GO:2000628) |
0.0 | 0.1 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 7.3 | GO:0043010 | camera-type eye development(GO:0043010) |
0.0 | 0.2 | GO:0043144 | snoRNA processing(GO:0043144) |
0.0 | 0.2 | GO:0001675 | acrosome assembly(GO:0001675) |
0.0 | 0.1 | GO:0070562 | regulation of vitamin D receptor signaling pathway(GO:0070562) |
0.0 | 0.1 | GO:0061622 | glycolytic process through glucose-1-phosphate(GO:0061622) |
0.0 | 0.2 | GO:0007398 | ectoderm development(GO:0007398) |
0.0 | 0.4 | GO:0018345 | protein palmitoylation(GO:0018345) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.7 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
0.1 | 0.4 | GO:0005638 | lamin filament(GO:0005638) |
0.0 | 0.7 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
0.0 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
0.0 | 0.6 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
0.0 | 0.3 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 1.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.1 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.6 | GO:0005685 | U1 snRNP(GO:0005685) |
0.0 | 0.4 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.0 | 0.5 | GO:0045120 | pronucleus(GO:0045120) |
0.0 | 0.1 | GO:0042583 | chromaffin granule(GO:0042583) |
0.0 | 0.6 | GO:0043034 | costamere(GO:0043034) |
0.0 | 0.4 | GO:0032433 | filopodium tip(GO:0032433) |
0.0 | 0.1 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
0.0 | 0.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.0 | 2.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
0.0 | 0.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 4.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 1.0 | GO:0030175 | filopodium(GO:0030175) |
0.0 | 0.2 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.4 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
0.4 | 4.0 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.2 | 2.2 | GO:0031005 | filamin binding(GO:0031005) |
0.1 | 0.8 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
0.1 | 0.6 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
0.1 | 0.4 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
0.1 | 0.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.1 | 1.2 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
0.1 | 0.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
0.1 | 7.8 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.1 | 0.2 | GO:0034618 | arginine binding(GO:0034618) |
0.0 | 0.5 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
0.0 | 1.4 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
0.0 | 0.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.0 | 0.2 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.0 | 0.6 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.3 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
0.0 | 0.7 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.0 | 0.1 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
0.0 | 0.4 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.4 | GO:0019707 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
0.0 | 0.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.0 | 0.1 | GO:0043495 | protein anchor(GO:0043495) |
0.0 | 2.5 | GO:0000287 | magnesium ion binding(GO:0000287) |
0.0 | 1.0 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
0.0 | 0.2 | GO:0051400 | BH domain binding(GO:0051400) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.0 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 1.5 | PID_CD40_PATHWAY | CD40/CD40L signaling |
0.0 | 0.4 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
0.0 | 0.4 | PID_ARF_3PATHWAY | Arf1 pathway |
0.0 | 0.1 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
0.0 | 0.7 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.2 | REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
0.1 | 1.4 | REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
0.1 | 0.5 | REACTOME_GLUCURONIDATION | Genes involved in Glucuronidation |
0.0 | 1.0 | REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION | Genes involved in Sema3A PAK dependent Axon repulsion |
0.0 | 0.4 | REACTOME_PD1_SIGNALING | Genes involved in PD-1 signaling |
0.0 | 1.5 | REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
0.0 | 3.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.0 | 0.8 | REACTOME_CHOLESTEROL_BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
0.0 | 1.2 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 0.2 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.0 | 0.5 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.0 | 0.4 | REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
0.0 | 0.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.4 | REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
0.0 | 1.8 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.0 | 0.7 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |