Motif ID: Nkx2-1

Z-value: 0.401


Transcription factors associated with Nkx2-1:

Gene SymbolEntrez IDGene Name
Nkx2-1 ENSMUSG00000001496.9 Nkx2-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-1mm10_v2_chr12_-_56536895_565369370.105.5e-01Click!


Activity profile for motif Nkx2-1.

activity profile for motif Nkx2-1


Sorted Z-values histogram for motif Nkx2-1

Sorted Z-values for motif Nkx2-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Showing 1 to 20 of 113 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_89688196 3.278 ENSMUST00000052478.2
Dmrta1
doublesex and mab-3 related transcription factor like family A1
chr11_+_117849223 2.215 ENSMUST00000081387.4
Birc5
baculoviral IAP repeat-containing 5
chr14_-_47411666 2.214 ENSMUST00000111778.3
Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr16_+_48994185 1.852 ENSMUST00000117994.1
ENSMUST00000048374.5
C330027C09Rik

RIKEN cDNA C330027C09 gene

chr11_+_117849286 1.457 ENSMUST00000093906.4
Birc5
baculoviral IAP repeat-containing 5
chrX_+_58030622 1.223 ENSMUST00000088627.4
Zic3
zinc finger protein of the cerebellum 3
chr1_+_75450699 1.218 ENSMUST00000037708.9
Asic4
acid-sensing (proton-gated) ion channel family member 4
chr1_+_75450436 1.197 ENSMUST00000113577.1
Asic4
acid-sensing (proton-gated) ion channel family member 4
chrX_+_58030999 1.189 ENSMUST00000088631.4
ENSMUST00000088629.3
Zic3

zinc finger protein of the cerebellum 3

chr14_+_75455957 1.163 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr19_+_44493472 1.047 ENSMUST00000041163.4
Wnt8b
wingless related MMTV integration site 8b
chr10_+_88091070 0.981 ENSMUST00000048621.7
Pmch
pro-melanin-concentrating hormone
chr7_+_51879041 0.967 ENSMUST00000107591.2
Gas2
growth arrest specific 2
chr7_+_51878967 0.932 ENSMUST00000051912.6
Gas2
growth arrest specific 2
chrX_-_142390334 0.907 ENSMUST00000112907.1
Acsl4
acyl-CoA synthetase long-chain family member 4
chr9_+_75775355 0.802 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr4_+_9269285 0.785 ENSMUST00000038841.7
Clvs1
clavesin 1
chr5_+_30105161 0.773 ENSMUST00000058045.4
Gareml
GRB2 associated, regulator of MAPK1-like
chr2_-_121235689 0.739 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr2_+_121506748 0.721 ENSMUST00000099473.3
ENSMUST00000110602.2
Wdr76

WD repeat domain 76


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.7 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.3 3.3 GO:0060179 male mating behavior(GO:0060179)
0.4 2.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 2.4 GO:0006814 sodium ion transport(GO:0006814)
0.0 1.9 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.0 1.9 GO:0007050 cell cycle arrest(GO:0007050)
0.1 1.3 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.2 1.2 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.1 1.1 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.3 1.0 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 1.0 GO:0032288 myelin assembly(GO:0032288)
0.1 0.9 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.2 0.8 GO:0021502 neural fold elevation formation(GO:0021502)
0.0 0.7 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.7 GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.3 0.6 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 0.6 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.0 0.6 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.6 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 0.6 GO:0016126 sterol biosynthetic process(GO:0016126)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 3.7 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.1 2.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 0.9 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.7 GO:0002177 manchette(GO:0002177)
0.0 0.7 GO:1990391 DNA repair complex(GO:1990391)
0.1 0.6 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.6 GO:0032039 integrator complex(GO:0032039)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.4 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.4 GO:0071564 npBAF complex(GO:0071564)
0.0 0.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.4 GO:0005272 sodium channel activity(GO:0005272)
0.0 2.2 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.1 1.5 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 1.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 0.8 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.8 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.8 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.7 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 0.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.5 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0031702 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.0 0.5 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0071837 HMG box domain binding(GO:0071837)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.9 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.4 PID_WNT_SIGNALING_PATHWAY Wnt signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.0 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.9 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.1 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.9 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.7 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.5 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.4 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.1 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline