Motif ID: Nkx2-2

Z-value: 1.594


Transcription factors associated with Nkx2-2:

Gene SymbolEntrez IDGene Name
Nkx2-2 ENSMUSG00000027434.10 Nkx2-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-2mm10_v2_chr2_-_147186389_147186413-0.038.4e-01Click!


Activity profile for motif Nkx2-2.

activity profile for motif Nkx2-2


Sorted Z-values histogram for motif Nkx2-2

Sorted Z-values for motif Nkx2-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_5218516 8.441 ENSMUST00000175866.1
 Zfhx4
zinc finger homeodomain 4
chr1_-_135688094 7.191 ENSMUST00000112103.1
 Nav1
neuron navigator 1
chr14_-_19418930 6.481 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_72438534 6.325 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_3018753 6.047 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_72438519 6.037 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr4_+_46039202 5.944 ENSMUST00000156200.1
 Tmod1
tropomodulin 1
chr9_+_3017408 5.752 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3034599 5.630 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3015654 5.600 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr11_+_78301529 5.530 ENSMUST00000045026.3
 Spag5
sperm associated antigen 5
chr2_-_140170528 5.489 ENSMUST00000046030.7
 Esf1
ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
chr9_+_3005125 5.479 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3025417 5.453 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_-_84775388 4.995 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 4.963 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_114013619 4.933 ENSMUST00000090275.4
 Gjd2
gap junction protein, delta 2
chr4_+_59626189 4.917 ENSMUST00000070150.4
ENSMUST00000052420.6
 E130308A19Rik

RIKEN cDNA E130308A19 gene

chr2_+_62664279 4.873 ENSMUST00000028257.2
 Gca
grancalcin
chr1_-_166002613 4.540 ENSMUST00000177358.1
ENSMUST00000160908.1
ENSMUST00000027850.8
ENSMUST00000160260.2
 Pou2f1



POU domain, class 2, transcription factor 1




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 95 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 12.4 GO:0070986 left/right axis specification(GO:0070986)
3.3 10.0 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
2.6 7.9 GO:1904959 elastin biosynthetic process(GO:0051542) copper ion export(GO:0060003) regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)
0.3 7.9 GO:0010960 magnesium ion homeostasis(GO:0010960)
0.1 7.2 GO:0001578 microtubule bundle formation(GO:0001578)
1.2 5.9 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.1 5.7 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.0 5.7 GO:0006275 regulation of DNA replication(GO:0006275)
1.4 5.5 GO:0090235 regulation of metaphase plate congression(GO:0090235)
0.1 4.9 GO:0007601 visual perception(GO:0007601)
0.6 4.5 GO:0071699 olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699)
0.2 4.3 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.2 4.1 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0 3.6 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
1.2 3.5 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 3.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 3.3 GO:0035063 nuclear speck organization(GO:0035063)
0.4 3.3 GO:0030035 microspike assembly(GO:0030035)
0.1 3.3 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 3.3 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.4 GO:0072562 blood microparticle(GO:0072562)
0.2 12.4 GO:0005882 intermediate filament(GO:0005882)
0.3 8.6 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 7.2 GO:0043194 axon initial segment(GO:0043194)
0.2 5.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 5.9 GO:0015629 actin cytoskeleton(GO:0015629)
0.4 5.7 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.3 5.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 5.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.4 4.9 GO:0005922 connexon complex(GO:0005922)
0.0 4.2 GO:0000922 spindle pole(GO:0000922)
0.0 3.5 GO:0016607 nuclear speck(GO:0016607)
0.3 3.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 3.3 GO:0030673 axolemma(GO:0030673)
0.0 3.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 3.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 3.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.6 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0008270 zinc ion binding(GO:0008270)
0.5 10.0 GO:0001848 complement binding(GO:0001848)
2.6 7.9 GO:0043682 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
1.0 7.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.3 6.4 GO:0008327 methyl-CpG binding(GO:0008327)
0.7 5.9 GO:0005523 tropomyosin binding(GO:0005523)
0.6 5.7 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.3 4.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 4.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.9 4.3 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.1 4.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 4.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.3 GO:0017022 myosin binding(GO:0017022)
0.0 3.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.2 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.1 3.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.5 3.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213) endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.2 3.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 3.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 10.5 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 4.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 3.0 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 2.8 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.1 2.5 PID_ATM_PATHWAY ATM pathway
0.1 2.1 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 2.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.8 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.7 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.3 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.0 PID_INSULIN_PATHWAY Insulin Pathway
0.0 0.8 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.1 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.6 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 0.4 PID_FCER1_PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 10.0 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 7.9 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.2 5.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.3 5.7 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.4 4.9 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 4.5 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 3.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 3.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 2.9 REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 2.8 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 2.6 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.3 2.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 2.2 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 2.2 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.1 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.8 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 1.7 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.7 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS Genes involved in G alpha (q) signalling events
0.0 1.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.3 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression