Motif ID: Nkx2-3

Z-value: 0.616


Transcription factors associated with Nkx2-3:

Gene SymbolEntrez IDGene Name
Nkx2-3 ENSMUSG00000044220.12 Nkx2-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-3mm10_v2_chr19_+_43612299_43612325-0.086.5e-01Click!


Activity profile for motif Nkx2-3.

activity profile for motif Nkx2-3


Sorted Z-values histogram for motif Nkx2-3

Sorted Z-values for motif Nkx2-3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_38783503 11.096 ENSMUST00000159334.1
Etv1
ets variant gene 1
chr12_+_38783455 9.013 ENSMUST00000161980.1
ENSMUST00000160701.1
Etv1

ets variant gene 1

chr6_-_23248264 6.867 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr5_+_139543889 4.038 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr1_+_6730051 3.811 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
St18



suppression of tumorigenicity 18



chr1_+_6734827 3.590 ENSMUST00000139838.1
St18
suppression of tumorigenicity 18
chr10_-_6980376 3.489 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr12_+_38780284 3.293 ENSMUST00000162563.1
ENSMUST00000161164.1
ENSMUST00000160996.1
Etv1


ets variant gene 1


chr12_+_38780817 3.122 ENSMUST00000160856.1
Etv1
ets variant gene 1
chr2_+_136057927 2.820 ENSMUST00000057503.6
Lamp5
lysosomal-associated membrane protein family, member 5
chr3_+_102010138 2.797 ENSMUST00000066187.4
Nhlh2
nescient helix loop helix 2
chr2_-_114013619 2.625 ENSMUST00000090275.4
Gjd2
gap junction protein, delta 2
chr14_+_75455957 2.590 ENSMUST00000164848.1
Siah3
seven in absentia homolog 3 (Drosophila)
chr6_+_34354119 2.562 ENSMUST00000038406.6
Akr1b8
aldo-keto reductase family 1, member B8
chr14_+_73237891 2.461 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr3_+_55782500 2.383 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chr18_+_50030977 2.243 ENSMUST00000145726.1
ENSMUST00000128377.1
Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr6_+_15196949 2.113 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
Foxp2



forkhead box P2



chr14_+_59625281 2.103 ENSMUST00000053949.5
Shisa2
shisa homolog 2 (Xenopus laevis)
chr3_+_134236483 1.996 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 28.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.3 7.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 7.4 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.4 4.1 GO:0060539 diaphragm development(GO:0060539)
0.1 4.1 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.2 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 2.8 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 2.8 GO:0043488 regulation of mRNA stability(GO:0043488)
0.9 2.6 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.7 2.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.5 2.6 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0 2.6 GO:0007601 visual perception(GO:0007601)
0.1 2.5 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.1 2.3 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.0 2.2 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.7 2.0 GO:0060023 soft palate development(GO:0060023)
0.1 2.0 GO:0060236 regulation of mitotic spindle organization(GO:0060236)
0.2 1.8 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 1.8 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.2 1.6 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.7 GO:0032993 protein-DNA complex(GO:0032993)
0.5 2.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 2.8 GO:0042788 polysomal ribosome(GO:0042788)
0.2 2.6 GO:0005922 connexon complex(GO:0005922)
0.0 2.3 GO:0043034 costamere(GO:0043034)
0.1 2.0 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 1.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 1.7 GO:0005818 aster(GO:0005818)
0.2 1.5 GO:0001940 male pronucleus(GO:0001940)
0.2 1.4 GO:0033269 internode region of axon(GO:0033269)
0.3 1.3 GO:0060187 cell pole(GO:0060187)
0.0 1.1 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.0 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 0.9 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 0.9 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 0.9 GO:0098536 deuterosome(GO:0098536)
0.0 0.9 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.7 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 28.6 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.1 10.7 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 3.9 GO:0001047 core promoter binding(GO:0001047)
0.0 3.5 GO:0051015 actin filament binding(GO:0051015)
0.1 2.8 GO:0017091 AU-rich element binding(GO:0017091)
0.0 2.7 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.5 2.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.5 2.6 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 2.5 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 2.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 2.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 2.4 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 2.3 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 2.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.2 1.7 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.2 1.7 GO:0048185 activin binding(GO:0048185)
0.1 1.5 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 29.1 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 3.5 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 2.0 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 1.8 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.7 PID_BMP_PATHWAY BMP receptor signaling
0.0 1.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.0 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.6 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.0 0.5 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.5 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID_NFKAPPAB_ATYPICAL_PATHWAY Atypical NF-kappaB pathway
0.0 0.4 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events
0.0 0.1 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.6 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.3 2.5 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 2.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 1.5 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.5 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.3 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.0 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.6 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.2 REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK