Motif ID: Nkx2-3
Z-value: 0.616
Transcription factors associated with Nkx2-3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nkx2-3 | ENSMUSG00000044220.12 | Nkx2-3 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-3 | mm10_v2_chr19_+_43612299_43612325 | -0.08 | 6.5e-01 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 109 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 28.3 | GO:0048934 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 1.3 | 7.7 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.6 | 7.4 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.4 | 4.1 | GO:0060539 | diaphragm development(GO:0060539) |
| 0.1 | 4.1 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 3.2 | GO:0048384 | retinoic acid receptor signaling pathway(GO:0048384) |
| 0.1 | 2.8 | GO:0007617 | mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705) |
| 0.0 | 2.8 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.9 | 2.6 | GO:0016095 | polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310) |
| 0.7 | 2.6 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) |
| 0.5 | 2.6 | GO:1903215 | negative regulation of protein targeting to mitochondrion(GO:1903215) |
| 0.0 | 2.6 | GO:0007601 | visual perception(GO:0007601) |
| 0.1 | 2.5 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.1 | 2.3 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.0 | 2.2 | GO:0050830 | defense response to Gram-positive bacterium(GO:0050830) |
| 0.7 | 2.0 | GO:0060023 | soft palate development(GO:0060023) |
| 0.1 | 2.0 | GO:0060236 | regulation of mitotic spindle organization(GO:0060236) |
| 0.2 | 1.8 | GO:0051798 | positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 1.8 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.2 | 1.6 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 51 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.5 | 2.8 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.2 | 2.8 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.2 | 2.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.0 | 2.3 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 2.0 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.2 | 1.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.2 | 1.7 | GO:0005818 | aster(GO:0005818) |
| 0.2 | 1.5 | GO:0001940 | male pronucleus(GO:0001940) |
| 0.2 | 1.4 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.3 | 1.3 | GO:0060187 | cell pole(GO:0060187) |
| 0.0 | 1.1 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 1.1 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.1 | 1.0 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 0.0 | 1.0 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.2 | 0.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 0.9 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.2 | 0.9 | GO:0098536 | deuterosome(GO:0098536) |
| 0.0 | 0.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 0.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 71 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.6 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 10.7 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 3.9 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.0 | 3.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 2.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 2.7 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.5 | 2.6 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.5 | 2.6 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.4 | 2.5 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
| 0.3 | 2.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.2 | 2.4 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.0 | 2.4 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 2.3 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.1 | 2.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 2.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.2 | 1.8 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.2 | 1.7 | GO:0061676 | importin-alpha family protein binding(GO:0061676) |
| 0.2 | 1.7 | GO:0048185 | activin binding(GO:0048185) |
| 0.1 | 1.5 | GO:0015197 | peptide transporter activity(GO:0015197) |
| 0.0 | 1.4 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 20 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 29.1 | PID_P38_MK2_PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.1 | 3.5 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 2.0 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.8 | PID_LKB1_PATHWAY | LKB1 signaling events |
| 0.0 | 1.7 | PID_AURORA_A_PATHWAY | Aurora A signaling |
| 0.0 | 1.7 | PID_BMP_PATHWAY | BMP receptor signaling |
| 0.0 | 1.6 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 1.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.4 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.4 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
| 0.0 | 1.0 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.6 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID_NEPHRIN_NEPH1_PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 0.5 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.5 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.4 | PID_NFKAPPAB_ATYPICAL_PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 0.4 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
| 0.0 | 0.2 | PID_IL23_PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.1 | PID_ERBB_NETWORK_PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 21 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.6 | REACTOME_GAP_JUNCTION_ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 2.5 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 2.4 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 1.5 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 1.5 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 1.4 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.3 | REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.0 | REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 1.0 | REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 0.7 | REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.0 | 0.5 | REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.5 | REACTOME_N_GLYCAN_ANTENNAE_ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.4 | REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL | Genes involved in NF-kB is activated and signals survival |
| 0.0 | 0.3 | REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.0 | 0.3 | REACTOME_PECAM1_INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.2 | REACTOME_PLATELET_SENSITIZATION_BY_LDL | Genes involved in Platelet sensitization by LDL |
| 0.0 | 0.2 | REACTOME_ABACAVIR_TRANSPORT_AND_METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.0 | 0.2 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
