Motif ID: Nkx2-4

Z-value: 0.406


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.067.4e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_178798438 1.871 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr13_-_66852017 1.083 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr8_+_45627946 0.889 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 0.888 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_-_115824699 0.752 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr2_+_169632996 0.739 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_34812677 0.697 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr15_+_99055164 0.604 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr2_+_169633517 0.575 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr12_+_38780817 0.552 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_76593550 0.531 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr13_+_108316395 0.528 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr9_-_71896047 0.520 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr14_-_47418407 0.507 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_-_26895049 0.473 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr12_+_38781093 0.459 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr10_+_88091070 0.369 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_+_87592897 0.367 ENSMUST00000119628.1
 Mtmr4
myotubularin related protein 4
chr3_+_88629499 0.366 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_-_27507656 0.366 ENSMUST00000154316.1
 Brd3
bromodomain containing 3
chrX_-_143933089 0.353 ENSMUST00000087313.3
 Dcx
doublecortin
chr14_+_48446128 0.330 ENSMUST00000124720.1
 Tmem260
transmembrane protein 260
chr11_+_70026815 0.297 ENSMUST00000135916.2
 Dlg4
discs, large homolog 4 (Drosophila)
chr3_-_110250963 0.289 ENSMUST00000106567.1
 Prmt6
protein arginine N-methyltransferase 6
chr1_+_97024681 0.288 ENSMUST00000054664.7
 Gm6430
predicted gene 6430
chr11_+_98863610 0.280 ENSMUST00000142414.1
ENSMUST00000037480.8
 Wipf2

WAS/WASL interacting protein family, member 2

chr8_+_31091593 0.272 ENSMUST00000161713.1
 Dusp26
dual specificity phosphatase 26 (putative)
chr8_+_45627709 0.265 ENSMUST00000134321.1
ENSMUST00000135336.1
 Sorbs2

sorbin and SH3 domain containing 2

chr2_-_93046053 0.260 ENSMUST00000111272.1
ENSMUST00000178666.1
ENSMUST00000147339.1
 Prdm11


PR domain containing 11


chr7_-_132813095 0.250 ENSMUST00000106165.1
 Fam53b
family with sequence similarity 53, member B
chr6_+_30568367 0.249 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr2_+_25180737 0.249 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr13_+_65512678 0.233 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr12_-_91746020 0.232 ENSMUST00000166967.1
 Ston2
stonin 2
chr11_-_103697661 0.211 ENSMUST00000107013.2
 Gosr2
golgi SNAP receptor complex member 2
chr6_+_134929089 0.203 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr2_+_157456917 0.195 ENSMUST00000109529.1
 Src
Rous sarcoma oncogene
chr17_-_25844417 0.189 ENSMUST00000176591.1
 Rhot2
ras homolog gene family, member T2
chr1_+_85650008 0.177 ENSMUST00000054279.8
ENSMUST00000147552.1
ENSMUST00000153574.1
ENSMUST00000150967.1
 Sp100



nuclear antigen Sp100



chr10_+_20347788 0.166 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr11_+_101733011 0.165 ENSMUST00000129741.1
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr12_-_105685235 0.160 ENSMUST00000041055.7
 Atg2b
autophagy related 2B
chr8_-_31739763 0.158 ENSMUST00000178878.1
 Gm5117
predicted gene 5117
chr4_-_136892867 0.157 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr2_+_156840966 0.149 ENSMUST00000109564.1
 Tgif2
TGFB-induced factor homeobox 2
chr18_+_36952621 0.148 ENSMUST00000115661.2
 Pcdha2
protocadherin alpha 2
chr11_+_110968016 0.147 ENSMUST00000106636.1
ENSMUST00000180023.1
 Kcnj16

potassium inwardly-rectifying channel, subfamily J, member 16

chr2_-_147186389 0.145 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr4_+_62525369 0.145 ENSMUST00000062145.1
 4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr11_+_101732950 0.126 ENSMUST00000039152.7
 Dhx8
DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr10_+_4611971 0.125 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr1_+_34439851 0.122 ENSMUST00000027303.7
 Imp4
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr14_+_26514554 0.120 ENSMUST00000104927.1
 Gm2178
predicted gene 2178
chr17_-_25844514 0.113 ENSMUST00000176709.1
 Rhot2
ras homolog gene family, member T2
chr19_-_5457397 0.109 ENSMUST00000179549.1
 Ccdc85b
coiled-coil domain containing 85B
chr6_+_123229843 0.108 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chrX_-_140956675 0.105 ENSMUST00000033805.8
ENSMUST00000112978.1
 Psmd10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chr17_+_84956718 0.105 ENSMUST00000112305.3
 Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr10_+_128232065 0.092 ENSMUST00000055539.4
ENSMUST00000105244.1
ENSMUST00000105243.2
ENSMUST00000125289.1
ENSMUST00000105242.1
 Timeless




timeless circadian clock 1




chr6_+_29398920 0.088 ENSMUST00000181464.1
ENSMUST00000180829.1
 Ccdc136

coiled-coil domain containing 136

chr2_+_30061754 0.081 ENSMUST00000149578.1
ENSMUST00000102866.3
 Set

SET nuclear oncogene

chr13_+_108860072 0.078 ENSMUST00000177907.1
 Pde4d
phosphodiesterase 4D, cAMP specific
chrX_-_158043266 0.077 ENSMUST00000026750.8
ENSMUST00000112513.1
 Cnksr2

connector enhancer of kinase suppressor of Ras 2

chr12_+_69963452 0.076 ENSMUST00000110560.1
 Gm3086
predicted gene 3086
chr5_+_32136458 0.073 ENSMUST00000031017.9
 Fosl2
fos-like antigen 2
chr3_-_59220150 0.067 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr1_-_37536232 0.054 ENSMUST00000042161.8
 Mgat4a
mannoside acetylglucosaminyltransferase 4, isoenzyme A
chr15_+_99670574 0.048 ENSMUST00000023758.7
 Asic1
acid-sensing (proton-gated) ion channel 1
chr4_-_108848619 0.046 ENSMUST00000164855.1
 A730015C16Rik
RIKEN cDNA A730015C16 gene
chr11_-_102579461 0.044 ENSMUST00000107081.1
 Gm11627
predicted gene 11627
chr2_-_34755229 0.044 ENSMUST00000102800.1
 Gapvd1
GTPase activating protein and VPS9 domains 1
chr19_-_6969746 0.044 ENSMUST00000025912.8
 Plcb3
phospholipase C, beta 3
chr6_-_97060407 0.039 ENSMUST00000089295.4
 Fam19a4
family with sequence similarity 19, member A4
chr6_+_134929118 0.035 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr2_+_140170641 0.035 ENSMUST00000044825.4
 Ndufaf5
NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
chr6_-_29165003 0.034 ENSMUST00000007993.9
 Rbm28
RNA binding motif protein 28
chr11_+_110968056 0.034 ENSMUST00000125692.1
 Kcnj16
potassium inwardly-rectifying channel, subfamily J, member 16
chr8_-_40308331 0.033 ENSMUST00000118639.1
 Fgf20
fibroblast growth factor 20
chr1_-_63114516 0.028 ENSMUST00000097718.2
 Ino80d
INO80 complex subunit D
chr18_-_3281036 0.020 ENSMUST00000049942.6
ENSMUST00000139537.1
ENSMUST00000124747.1
 Crem


cAMP responsive element modulator


chr15_-_100669512 0.016 ENSMUST00000182574.1
ENSMUST00000182775.1
 Bin2

bridging integrator 2

chrX_+_56447965 0.015 ENSMUST00000079663.6
 Gm2174
predicted gene 2174
chr15_-_100669535 0.015 ENSMUST00000183211.1
 Bin2
bridging integrator 2
chr1_-_34439672 0.014 ENSMUST00000042493.8
 Ccdc115
coiled-coil domain containing 115
chr15_-_100669496 0.013 ENSMUST00000182814.1
ENSMUST00000182068.1
 Bin2

bridging integrator 2

chr10_-_26373956 0.013 ENSMUST00000105519.3
ENSMUST00000040219.6
 L3mbtl3

l(3)mbt-like 3 (Drosophila)

chr5_-_137533170 0.011 ENSMUST00000168746.1
ENSMUST00000170293.1
 Gnb2

guanine nucleotide binding protein (G protein), beta 2

chrX_-_143933204 0.007 ENSMUST00000112851.1
ENSMUST00000112856.2
ENSMUST00000033642.3
 Dcx


doublecortin


chr1_+_85650044 0.006 ENSMUST00000066427.4
 Sp100
nuclear antigen Sp100

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 0.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.1 1.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.9 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 2.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.0 0.1 GO:1904975 response to bleomycin(GO:1904975) cellular response to bleomycin(GO:1904976)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.3 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:0018377 N-terminal protein myristoylation(GO:0006499) protein myristoylation(GO:0018377)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.0 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.3 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0 0.0 GO:0031161 phosphatidylinositol catabolic process(GO:0031161)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0044299 C-fiber(GO:0044299)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.1 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.1 0.3 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME_MYOGENESIS Genes involved in Myogenesis