Motif ID: Nkx2-4

Z-value: 0.406


Transcription factors associated with Nkx2-4:

Gene SymbolEntrez IDGene Name
Nkx2-4 ENSMUSG00000054160.2 Nkx2-4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-4mm10_v2_chr2_-_147085445_147085483-0.067.4e-01Click!


Activity profile for motif Nkx2-4.

activity profile for motif Nkx2-4


Sorted Z-values histogram for motif Nkx2-4

Sorted Z-values for motif Nkx2-4



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-4

PNG image of the network

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Top targets:


Showing 1 to 20 of 89 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_178798438 1.871 ENSMUST00000160789.1
 Kif26b
kinesin family member 26B
chr13_-_66852017 1.083 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr8_+_45627946 0.889 ENSMUST00000145458.1
 Sorbs2
sorbin and SH3 domain containing 2
chr8_+_45628176 0.888 ENSMUST00000130850.1
 Sorbs2
sorbin and SH3 domain containing 2
chr7_-_115824699 0.752 ENSMUST00000169129.1
 Sox6
SRY-box containing gene 6
chr2_+_169632996 0.739 ENSMUST00000109159.2
 Tshz2
teashirt zinc finger family member 2
chr7_-_34812677 0.697 ENSMUST00000078686.6
 Chst8
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
chr15_+_99055164 0.604 ENSMUST00000047104.7
ENSMUST00000024249.3
 Prph

peripherin

chr2_+_169633517 0.575 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr12_+_38780817 0.552 ENSMUST00000160856.1
 Etv1
ets variant gene 1
chr3_+_76593550 0.531 ENSMUST00000162471.1
 Fstl5
follistatin-like 5
chr13_+_108316395 0.528 ENSMUST00000171178.1
 Depdc1b
DEP domain containing 1B
chr9_-_71896047 0.520 ENSMUST00000184448.1
 Tcf12
transcription factor 12
chr14_-_47418407 0.507 ENSMUST00000043296.3
 Dlgap5
discs, large (Drosophila) homolog-associated protein 5
chr15_-_26895049 0.473 ENSMUST00000059204.9
 Fbxl7
F-box and leucine-rich repeat protein 7
chr12_+_38781093 0.459 ENSMUST00000161513.1
 Etv1
ets variant gene 1
chr10_+_88091070 0.369 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr11_+_87592897 0.367 ENSMUST00000119628.1
 Mtmr4
myotubularin related protein 4
chr3_+_88629499 0.366 ENSMUST00000175745.1
 Arhgef2
rho/rac guanine nucleotide exchange factor (GEF) 2
chr2_-_27507656 0.366 ENSMUST00000154316.1
 Brd3
bromodomain containing 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.6 1.9 GO:0072092 ureteric bud invasion(GO:0072092)
0.1 1.0 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.9 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.7 GO:0016486 peptide hormone processing(GO:0016486)
0.0 0.6 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.5 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.4 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.0 0.4 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.3 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0 0.3 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.3 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.2 GO:0051902 negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.0 0.2 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.1 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.0 0.1 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)

Gene overrepresentation in cellular_component category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.2 0.6 GO:0044299 C-fiber(GO:0044299)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.3 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 0.1 GO:0034457 Mpp10 complex(GO:0034457)
0.0 0.1 GO:0097550 transcriptional preinitiation complex(GO:0097550)

Gene overrepresentation in molecular_function category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.2 0.7 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity(GO:0001537)
0.0 0.5 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.3 GO:0044020 protein-arginine omega-N monomethyltransferase activity(GO:0035241) histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0 0.3 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.1 GO:0030519 snoRNP binding(GO:0030519)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.5 PID_AURORA_A_PATHWAY Aurora A signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.2 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins