Motif ID: Nkx2-5

Z-value: 0.635


Transcription factors associated with Nkx2-5:

Gene SymbolEntrez IDGene Name
Nkx2-5 ENSMUSG00000015579.4 Nkx2-5



Activity profile for motif Nkx2-5.

activity profile for motif Nkx2-5


Sorted Z-values histogram for motif Nkx2-5

Sorted Z-values for motif Nkx2-5



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_-_88978958 5.969 ENSMUST00000042594.6
ENSMUST00000109368.1
Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr4_+_103619580 4.292 ENSMUST00000106827.1
Dab1
disabled 1
chr14_+_80000292 3.570 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr8_+_124793061 3.244 ENSMUST00000041106.7
Trim67
tripartite motif-containing 67
chr12_+_74297474 3.195 ENSMUST00000072100.3
Dbpht2
DNA binding protein with his-thr domain
chr8_-_46294592 2.497 ENSMUST00000058636.7
Helt
helt bHLH transcription factor
chr3_+_52268337 2.420 ENSMUST00000053764.5
Foxo1
forkhead box O1
chr19_-_57360668 2.183 ENSMUST00000181921.1
B230217O12Rik
RIKEN cDNA B230217O12 gene
chr19_+_26753588 1.928 ENSMUST00000177116.1
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr13_+_30136498 1.891 ENSMUST00000047311.8
Mboat1
membrane bound O-acyltransferase domain containing 1
chr6_+_30541582 1.690 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr1_-_86359455 1.585 ENSMUST00000027438.6
Ncl
nucleolin
chr12_+_91400990 1.529 ENSMUST00000021346.7
ENSMUST00000021343.6
Tshr

thyroid stimulating hormone receptor

chr7_-_126897424 1.510 ENSMUST00000120007.1
Tmem219
transmembrane protein 219
chr7_-_4844665 1.486 ENSMUST00000066041.5
ENSMUST00000172377.1
Shisa7

shisa homolog 7 (Xenopus laevis)

chr9_-_53536608 1.360 ENSMUST00000150244.1
Atm
ataxia telangiectasia mutated homolog (human)
chr11_-_78550777 1.226 ENSMUST00000103242.4
Tmem97
transmembrane protein 97
chrX_+_114474312 1.225 ENSMUST00000113371.1
ENSMUST00000040504.5
Klhl4

kelch-like 4

chr4_-_4138432 1.124 ENSMUST00000070375.7
Penk
preproenkephalin
chrX_-_165327376 1.111 ENSMUST00000058787.8
Glra2
glycine receptor, alpha 2 subunit
chr9_+_57940104 0.980 ENSMUST00000043059.7
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr8_-_95113334 0.928 ENSMUST00000169353.1
Kifc3
kinesin family member C3
chr4_+_85205120 0.908 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr3_-_89160155 0.889 ENSMUST00000029686.3
Hcn3
hyperpolarization-activated, cyclic nucleotide-gated K+ 3
chr13_+_30136529 0.881 ENSMUST00000152798.1
Mboat1
membrane bound O-acyltransferase domain containing 1
chr8_+_3631109 0.836 ENSMUST00000004745.8
Stxbp2
syntaxin binding protein 2
chr4_+_42714926 0.830 ENSMUST00000178454.1
Gm21955
predicted gene, 21955
chr15_-_54919961 0.824 ENSMUST00000167541.2
ENSMUST00000041591.9
ENSMUST00000173516.1
Enpp2


ectonucleotide pyrophosphatase/phosphodiesterase 2


chr11_-_101987004 0.807 ENSMUST00000107173.2
ENSMUST00000107172.1
Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr14_+_51893610 0.773 ENSMUST00000047726.5
ENSMUST00000161888.1
Slc39a2

solute carrier family 39 (zinc transporter), member 2

chr15_-_10470490 0.752 ENSMUST00000136591.1
Dnajc21
DnaJ (Hsp40) homolog, subfamily C, member 21
chr12_+_4082596 0.723 ENSMUST00000049584.5
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr1_+_128103297 0.662 ENSMUST00000036288.4
R3hdm1
R3H domain containing 1
chr19_+_8819401 0.651 ENSMUST00000096753.3
Hnrnpul2
heterogeneous nuclear ribonucleoprotein U-like 2
chr4_+_85205417 0.650 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
Sh3gl2


SH3-domain GRB2-like 2


chr15_-_82224330 0.643 ENSMUST00000089161.2
ENSMUST00000109535.2
Tnfrsf13c

tumor necrosis factor receptor superfamily, member 13c

chr12_+_4082574 0.639 ENSMUST00000020986.7
Dnajc27
DnaJ (Hsp40) homolog, subfamily C, member 27
chr1_+_172341197 0.615 ENSMUST00000056136.3
Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr15_-_54920115 0.600 ENSMUST00000171545.1
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr4_+_148000722 0.581 ENSMUST00000103230.4
Nppa
natriuretic peptide type A
chr2_-_73892530 0.565 ENSMUST00000136958.1
ENSMUST00000112010.2
ENSMUST00000128531.1
ENSMUST00000112017.1
Atf2



activating transcription factor 2



chr1_-_66817536 0.564 ENSMUST00000068168.3
ENSMUST00000113987.1
Kansl1l

KAT8 regulatory NSL complex subunit 1-like

chr6_-_83572429 0.553 ENSMUST00000068054.7
Stambp
STAM binding protein
chr11_+_101155884 0.550 ENSMUST00000043654.9
Tubg2
tubulin, gamma 2
chr16_-_44139630 0.534 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chrX_-_75416533 0.514 ENSMUST00000033542.4
Mtcp1
mature T cell proliferation 1
chr7_+_100607660 0.505 ENSMUST00000098252.4
Rab6a
RAB6A, member RAS oncogene family
chr2_-_73892619 0.488 ENSMUST00000112007.1
ENSMUST00000112016.2
Atf2

activating transcription factor 2

chr2_-_5942740 0.482 ENSMUST00000026924.5
ENSMUST00000095147.2
ENSMUST00000169865.1
Dhtkd1


dehydrogenase E1 and transketolase domain containing 1


chr2_-_73892588 0.471 ENSMUST00000154456.1
ENSMUST00000090802.4
ENSMUST00000055833.5
Atf2


activating transcription factor 2


chr2_-_173276144 0.440 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr10_-_127311740 0.436 ENSMUST00000037290.5
ENSMUST00000171564.1
Mars

methionine-tRNA synthetase

chrX_-_75416562 0.417 ENSMUST00000114081.1
ENSMUST00000033543.7
ENSMUST00000149863.2
Mtcp1
Mtcp1

mature T cell proliferation 1
mature T cell proliferation 1

chr7_+_128246812 0.417 ENSMUST00000164710.1
ENSMUST00000070656.5
Tgfb1i1

transforming growth factor beta 1 induced transcript 1

chr7_+_128246953 0.402 ENSMUST00000167965.1
Tgfb1i1
transforming growth factor beta 1 induced transcript 1
chr9_+_44773027 0.389 ENSMUST00000125877.1
Ift46
intraflagellar transport 46
chr5_+_138085083 0.367 ENSMUST00000019660.4
ENSMUST00000066617.5
ENSMUST00000110963.1
Zkscan1


zinc finger with KRAB and SCAN domains 1


chr9_+_106170918 0.339 ENSMUST00000020490.5
Wdr82
WD repeat domain containing 82
chr11_+_4620067 0.338 ENSMUST00000109941.1
Gm11032
predicted gene 11032
chr9_+_44772909 0.323 ENSMUST00000002099.3
Ift46
intraflagellar transport 46
chr15_+_76351303 0.320 ENSMUST00000023212.8
ENSMUST00000160172.1
Maf1

MAF1 homolog (S. cerevisiae)

chr4_+_62619515 0.308 ENSMUST00000084521.4
ENSMUST00000107424.1
Rgs3

regulator of G-protein signaling 3

chr6_-_115853346 0.304 ENSMUST00000032469.6
Mbd4
methyl-CpG binding domain protein 4
chr17_+_88440711 0.299 ENSMUST00000112238.2
ENSMUST00000155640.1
Foxn2

forkhead box N2

chr17_-_56609689 0.287 ENSMUST00000052832.5
2410015M20Rik
RIKEN cDNA 2410015M20 gene
chr8_+_113643206 0.286 ENSMUST00000034219.4
ENSMUST00000095173.1
Syce1l

synaptonemal complex central element protein 1 like

chr4_-_87806276 0.277 ENSMUST00000148059.1
Mllt3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr2_+_127270208 0.274 ENSMUST00000110375.2
Stard7
START domain containing 7
chr4_+_137594140 0.265 ENSMUST00000105840.1
ENSMUST00000055131.6
ENSMUST00000105839.1
ENSMUST00000105838.1
Usp48



ubiquitin specific peptidase 48



chr2_-_127792467 0.261 ENSMUST00000135091.1
1500011K16Rik
RIKEN cDNA 1500011K16 gene
chr3_+_103739366 0.257 ENSMUST00000106852.1
Gm10964
predicted gene 10964
chr12_+_103314944 0.249 ENSMUST00000179363.1
Fam181a
family with sequence similarity 181, member A
chrX_-_7898950 0.249 ENSMUST00000115655.1
ENSMUST00000156741.1
Pqbp1

polyglutamine binding protein 1

chr18_-_31949571 0.242 ENSMUST00000064016.5
Gpr17
G protein-coupled receptor 17
chr4_-_87806296 0.236 ENSMUST00000126353.1
ENSMUST00000149357.1
Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr5_+_25247344 0.234 ENSMUST00000114950.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr10_-_42018363 0.229 ENSMUST00000162405.1
ENSMUST00000095729.4
ENSMUST00000161081.1
ENSMUST00000160262.2
Armc2



armadillo repeat containing 2



chr2_+_174076296 0.222 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr3_-_153725062 0.211 ENSMUST00000064460.5
St6galnac3
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr14_+_70530819 0.199 ENSMUST00000047331.6
Lgi3
leucine-rich repeat LGI family, member 3
chr5_-_124327883 0.194 ENSMUST00000031344.6
Mphosph9
M-phase phosphoprotein 9
chr4_-_140323302 0.194 ENSMUST00000063789.2
Gm9867
predicted gene 9867
chr16_+_44173271 0.193 ENSMUST00000088356.4
ENSMUST00000169582.1
Gm608

predicted gene 608

chr11_-_96916407 0.182 ENSMUST00000130774.1
Cdk5rap3
CDK5 regulatory subunit associated protein 3
chr11_-_96916366 0.155 ENSMUST00000144731.1
ENSMUST00000127048.1
Cdk5rap3

CDK5 regulatory subunit associated protein 3

chr5_-_124327812 0.154 ENSMUST00000184951.1
Mphosph9
M-phase phosphoprotein 9
chr16_+_44139821 0.145 ENSMUST00000159514.1
ENSMUST00000161326.1
ENSMUST00000063520.8
ENSMUST00000063542.7
Naa50



N(alpha)-acetyltransferase 50, NatE catalytic subunit



chr2_+_120609383 0.137 ENSMUST00000124187.1
Haus2
HAUS augmin-like complex, subunit 2
chr9_+_44772951 0.135 ENSMUST00000128150.1
Ift46
intraflagellar transport 46
chr6_+_42286709 0.120 ENSMUST00000163936.1
Clcn1
chloride channel 1
chr18_-_15063560 0.117 ENSMUST00000168989.1
Kctd1
potassium channel tetramerisation domain containing 1
chr5_+_145083830 0.111 ENSMUST00000031625.8
Arpc1a
actin related protein 2/3 complex, subunit 1A
chr11_+_4883186 0.103 ENSMUST00000139737.1
Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr2_+_32288317 0.088 ENSMUST00000131712.1
ENSMUST00000133113.1
ENSMUST00000081670.6
ENSMUST00000147707.1
ENSMUST00000129193.1
Golga2




golgi autoantigen, golgin subfamily a, 2




chrX_-_64276937 0.086 ENSMUST00000114679.1
ENSMUST00000069926.7
Slitrk4

SLIT and NTRK-like family, member 4

chr9_+_44773191 0.084 ENSMUST00000147559.1
Ift46
intraflagellar transport 46
chr18_-_79109391 0.083 ENSMUST00000025430.8
ENSMUST00000161465.2
Setbp1

SET binding protein 1

chr6_-_115676623 0.061 ENSMUST00000000451.7
Raf1
v-raf-leukemia viral oncogene 1
chr2_+_30807826 0.051 ENSMUST00000041830.3
ENSMUST00000152374.1
Ntmt1

N-terminal Xaa-Pro-Lys N-methyltransferase 1

chr9_-_44713196 0.043 ENSMUST00000144251.1
ENSMUST00000156918.1
Phldb1

pleckstrin homology-like domain, family B, member 1

chr8_+_107150621 0.043 ENSMUST00000034400.3
Cyb5b
cytochrome b5 type B
chr18_+_49832622 0.006 ENSMUST00000180611.1
Dmxl1
Dmx-like 1
chr16_+_44943737 0.001 ENSMUST00000114622.3
ENSMUST00000166731.1
Cd200r3

CD200 receptor 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.6 6.0 GO:0047484 regulation of response to osmotic stress(GO:0047484) cellular response to cholesterol(GO:0071397)
0.5 1.5 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.5 1.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.5 1.4 GO:0002331 pre-B cell allelic exclusion(GO:0002331) signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) regulation of microglial cell activation(GO:1903978) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.3 1.5 GO:1904587 response to glycoprotein(GO:1904587)
0.2 1.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.2 1.1 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.2 2.0 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.2 1.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.2 2.4 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.2 0.6 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.2 1.9 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.2 1.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.2 2.5 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.2 0.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 0.6 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.6 GO:1903764 regulation of potassium ion export across plasma membrane(GO:1903764)
0.1 0.8 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.1 3.2 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 1.0 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 3.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.8 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.1 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.1 0.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:0007128 meiotic prophase I(GO:0007128) prophase(GO:0051324)
0.0 0.3 GO:0016480 negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0 0.5 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.9 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.0 0.3 GO:0071569 protein ufmylation(GO:0071569)
0.0 0.2 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0 0.6 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0 0.8 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.2 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.1 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.3 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.6 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.3 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:0018201 peptidyl-glycine modification(GO:0018201)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0001651 dense fibrillar component(GO:0001651)
0.3 4.4 GO:0042581 specific granule(GO:0042581)
0.3 1.1 GO:0032280 symmetric synapse(GO:0032280)
0.2 0.9 GO:0044316 cone cell pedicle(GO:0044316)
0.2 0.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 1.9 GO:0071564 npBAF complex(GO:0071564)
0.1 0.9 GO:0005915 zonula adherens(GO:0005915)
0.1 0.6 GO:0042629 mast cell granule(GO:0042629)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 6.0 GO:0005901 caveola(GO:0005901)
0.0 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.5 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.0 1.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 1.5 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 4.3 GO:0005903 brush border(GO:0005903)
0.0 1.4 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.6 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.2 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.8 GO:0001772 immunological synapse(GO:0001772)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.6 GO:0005902 microvillus(GO:0005902)
0.0 0.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.3 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.4 1.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 1.4 GO:0004528 phosphodiesterase I activity(GO:0004528)
0.3 1.6 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 0.9 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 0.8 GO:0030348 syntaxin-3 binding(GO:0030348)
0.2 0.6 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 1.1 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 1.5 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.8 GO:0048495 Roundabout binding(GO:0048495)
0.1 4.3 GO:0042169 SH2 domain binding(GO:0042169)
0.1 1.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 0.3 GO:0000700 mismatch base pair DNA N-glycosylase activity(GO:0000700)
0.1 2.4 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 1.0 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.5 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 0.3 GO:0001032 RNA polymerase III type 3 promoter DNA binding(GO:0001032)
0.0 6.0 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.8 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 1.9 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.3 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.4 GO:0050699 WW domain binding(GO:0050699)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.3 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 2.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.1 3.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.6 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 1.5 PID_ARF6_PATHWAY Arf6 signaling events
0.0 1.9 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS Genes involved in Hormone ligand-binding receptors
0.3 2.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 1.4 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 2.4 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.5 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.2 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 1.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 0.8 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.1 0.6 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 1.1 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.8 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 1.0 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.3 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.5 REACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.9 REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.6 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.6 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels