Motif ID: Nkx2-9

Z-value: 0.367


Transcription factors associated with Nkx2-9:

Gene SymbolEntrez IDGene Name
Nkx2-9 ENSMUSG00000058669.7 Nkx2-9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx2-9mm10_v2_chr12_-_56613270_56613291-0.124.7e-01Click!


Activity profile for motif Nkx2-9.

activity profile for motif Nkx2-9


Sorted Z-values histogram for motif Nkx2-9

Sorted Z-values for motif Nkx2-9



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx2-9

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_117849223 1.670 ENSMUST00000081387.4
 Birc5
baculoviral IAP repeat-containing 5
chr11_+_117849286 1.068 ENSMUST00000093906.4
 Birc5
baculoviral IAP repeat-containing 5
chr10_+_88091070 1.056 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr14_+_75455957 1.047 ENSMUST00000164848.1
 Siah3
seven in absentia homolog 3 (Drosophila)
chr2_+_173022360 0.988 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr4_+_8690399 0.841 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr5_+_30105161 0.822 ENSMUST00000058045.4
 Gareml
GRB2 associated, regulator of MAPK1-like
chr8_+_95633500 0.816 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)
chr11_-_84068766 0.807 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr2_+_181767040 0.800 ENSMUST00000108756.1
 Myt1
myelin transcription factor 1
chr16_-_33380717 0.735 ENSMUST00000180923.1
 1700007L15Rik
RIKEN cDNA 1700007L15 gene
chr13_-_71963713 0.633 ENSMUST00000077337.8
 Irx1
Iroquois related homeobox 1 (Drosophila)
chrX_-_165004829 0.607 ENSMUST00000114890.2
 Gm17604
predicted gene, 17604
chr18_+_77185815 0.556 ENSMUST00000079618.4
 St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr4_-_72852622 0.555 ENSMUST00000179234.1
ENSMUST00000078617.4
 Aldoart1

aldolase 1 A, retrogene 1

chr7_-_101921186 0.533 ENSMUST00000106965.1
ENSMUST00000106968.1
ENSMUST00000106967.1
 Lrrc51


leucine rich repeat containing 51


chr11_+_88718442 0.515 ENSMUST00000138007.1
 C030037D09Rik
RIKEN cDNA C030037D09 gene
chr16_-_59555752 0.505 ENSMUST00000179383.1
ENSMUST00000044604.8
 Crybg3

beta-gamma crystallin domain containing 3

chr2_-_129699833 0.492 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr1_-_181842334 0.478 ENSMUST00000005003.6
 Lbr
lamin B receptor

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.7 GO:0031536 positive regulation of exit from mitosis(GO:0031536)
0.1 1.4 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.4 1.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 1.0 GO:1903215 negative regulation of protein targeting to mitochondrion(GO:1903215)
0.3 0.8 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 0.8 GO:0072272 proximal/distal pattern formation involved in metanephric nephron development(GO:0072272)
0.1 0.8 GO:0060539 diaphragm development(GO:0060539)
0.0 0.8 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 0.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.1 0.4 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) regulation of T-helper 17 cell differentiation(GO:2000319) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.4 GO:0032493 response to bacterial lipoprotein(GO:0032493)
0.1 0.4 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244)
0.0 0.4 GO:0009162 deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.1 0.3 GO:0021502 neural fold elevation formation(GO:0021502)
0.0 0.3 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.3 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:0055070 copper ion homeostasis(GO:0055070)
0.1 0.2 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.2 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0032133 interphase microtubule organizing center(GO:0031021) chromosome passenger complex(GO:0032133)
0.0 0.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.6 GO:0005652 nuclear lamina(GO:0005652)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.1 0.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.6 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.5 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.5 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 0.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.1 0.4 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.4 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.1 0.3 GO:0003844 1,4-alpha-glucan branching enzyme activity(GO:0003844)
0.0 0.3 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 0.8 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.2 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.0 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.7 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.0 0.5 REACTOME_P38MAPK_EVENTS Genes involved in p38MAPK events
0.0 0.5 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.0 0.4 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.2 REACTOME_SIGNALING_BY_CONSTITUTIVELY_ACTIVE_EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling