Motif ID: Nkx3-1

Z-value: 0.536


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_100625737 3.496 ENSMUST00000048962.3
Kif4
kinesin family member 4
chr6_+_128362919 2.440 ENSMUST00000073316.6
Foxm1
forkhead box M1
chr2_-_84775388 2.377 ENSMUST00000023994.3
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 2.299 ENSMUST00000111641.1
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr9_+_72438534 2.019 ENSMUST00000034746.8
Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 1.993 ENSMUST00000184604.1
Mns1
meiosis-specific nuclear structural protein 1
chr4_+_116708571 1.662 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
Ccdc163



coiled-coil domain containing 163



chr1_-_133907053 1.467 ENSMUST00000149380.1
ENSMUST00000124051.2
Optc

opticin

chr9_-_62537036 1.432 ENSMUST00000048043.5
Coro2b
coronin, actin binding protein, 2B
chrX_+_56454871 1.420 ENSMUST00000039374.2
ENSMUST00000101553.2
Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr4_-_45530330 1.380 ENSMUST00000061986.5
Shb
src homology 2 domain-containing transforming protein B
chr9_-_124493793 1.372 ENSMUST00000178787.1
Gm21836
predicted gene, 21836
chr9_+_78191966 1.369 ENSMUST00000034903.5
Gsta4
glutathione S-transferase, alpha 4
chr10_-_13324160 1.298 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr17_+_56304313 1.280 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chrX_+_164269371 1.270 ENSMUST00000145412.1
ENSMUST00000033749.7
Pir

pirin

chr6_-_99632376 1.256 ENSMUST00000176255.1
Gm20696
predicted gene 20696
chr2_-_93849679 1.160 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
Accs


1-aminocyclopropane-1-carboxylate synthase (non-functional)


chr1_-_133906973 1.130 ENSMUST00000126123.1
Optc
opticin
chr4_+_32623985 1.109 ENSMUST00000108178.1
Casp8ap2
caspase 8 associated protein 2
chr4_+_110397661 1.103 ENSMUST00000106589.2
ENSMUST00000106587.2
ENSMUST00000106591.1
ENSMUST00000106592.1
Agbl4



ATP/GTP binding protein-like 4



chr18_+_82910863 1.087 ENSMUST00000171238.1
Zfp516
zinc finger protein 516
chr2_+_23069210 1.083 ENSMUST00000155602.1
Acbd5
acyl-Coenzyme A binding domain containing 5
chr5_-_8422582 1.081 ENSMUST00000168500.1
ENSMUST00000002368.9
Dbf4

DBF4 homolog (S. cerevisiae)

chr4_+_110397764 0.982 ENSMUST00000097920.2
ENSMUST00000080744.6
Agbl4

ATP/GTP binding protein-like 4

chr8_-_123318553 0.966 ENSMUST00000118395.1
ENSMUST00000035495.8
Fanca

Fanconi anemia, complementation group A

chr4_-_140774196 0.947 ENSMUST00000026381.6
Padi4
peptidyl arginine deiminase, type IV
chr17_-_25727364 0.919 ENSMUST00000170070.1
ENSMUST00000048054.7
Chtf18

CTF18, chromosome transmission fidelity factor 18

chr19_+_5406815 0.889 ENSMUST00000174412.1
ENSMUST00000153017.2
4930481A15Rik

RIKEN cDNA 4930481A15 gene

chr8_+_114133557 0.867 ENSMUST00000073521.5
ENSMUST00000066514.6
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr7_+_75455534 0.852 ENSMUST00000147005.1
ENSMUST00000166315.1
Akap13

A kinase (PRKA) anchor protein 13

chr12_+_76324860 0.804 ENSMUST00000095610.2
ENSMUST00000154078.2
Akap5

A kinase (PRKA) anchor protein 5

chr18_-_6241486 0.804 ENSMUST00000025083.7
Kif5b
kinesin family member 5B
chr19_+_20601958 0.801 ENSMUST00000087638.3
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
chr10_-_12861735 0.799 ENSMUST00000076817.4
Utrn
utrophin
chr5_-_69592274 0.797 ENSMUST00000174233.1
ENSMUST00000120789.1
ENSMUST00000166298.1
Gnpda2


glucosamine-6-phosphate deaminase 2


chr2_-_155582656 0.754 ENSMUST00000126322.1
Gss
glutathione synthetase
chr1_-_156034800 0.749 ENSMUST00000169241.1
Tor1aip1
torsin A interacting protein 1
chr13_-_99900645 0.735 ENSMUST00000022150.6
Cartpt
CART prepropeptide
chr1_-_163289214 0.732 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr8_-_41041828 0.730 ENSMUST00000051379.7
Mtus1
mitochondrial tumor suppressor 1
chr10_+_4432467 0.725 ENSMUST00000095893.4
ENSMUST00000118544.1
ENSMUST00000117489.1
1700052N19Rik


RIKEN cDNA 1700052N19 gene


chr9_+_74976096 0.722 ENSMUST00000081746.5
Fam214a
family with sequence similarity 214, member A
chr10_-_62814539 0.710 ENSMUST00000173087.1
ENSMUST00000174121.1
Tet1

tet methylcytosine dioxygenase 1

chr8_+_114133635 0.703 ENSMUST00000147605.1
ENSMUST00000134593.1
Nudt7

nudix (nucleoside diphosphate linked moiety X)-type motif 7

chr1_-_53297001 0.699 ENSMUST00000126590.1
ENSMUST00000126412.1
ENSMUST00000135246.1
ENSMUST00000027267.7
Pms1



postmeiotic segregation increased 1 (S. cerevisiae)



chr12_+_76324905 0.690 ENSMUST00000172992.1
Akap5
A kinase (PRKA) anchor protein 5
chr7_+_123123870 0.690 ENSMUST00000094053.5
Tnrc6a
trinucleotide repeat containing 6a
chr6_-_108185552 0.686 ENSMUST00000167338.1
ENSMUST00000172188.1
ENSMUST00000032191.9
Sumf1


sulfatase modifying factor 1


chr11_-_80080928 0.682 ENSMUST00000103233.3
ENSMUST00000061283.8
Crlf3

cytokine receptor-like factor 3

chr9_+_89199319 0.670 ENSMUST00000138109.1
Mthfs
5, 10-methenyltetrahydrofolate synthetase
chrX_-_100625901 0.666 ENSMUST00000059099.6
Pdzd11
PDZ domain containing 11
chr13_-_74482943 0.618 ENSMUST00000074369.6
Zfp825
zinc finger protein 825
chr12_+_52516077 0.615 ENSMUST00000110725.1
Arhgap5
Rho GTPase activating protein 5
chr2_+_23068168 0.609 ENSMUST00000028121.7
ENSMUST00000114523.2
ENSMUST00000144088.1
Acbd5


acyl-Coenzyme A binding domain containing 5


chr13_+_80886095 0.606 ENSMUST00000161441.1
Arrdc3
arrestin domain containing 3
chr5_-_110046486 0.597 ENSMUST00000167969.1
Gm17655
predicted gene, 17655
chr3_+_30792876 0.593 ENSMUST00000029256.7
Sec62
SEC62 homolog (S. cerevisiae)
chr17_-_15564322 0.568 ENSMUST00000147532.1
Prdm9
PR domain containing 9
chr3_-_57575760 0.560 ENSMUST00000029380.7
Wwtr1
WW domain containing transcription regulator 1
chr2_+_62664279 0.547 ENSMUST00000028257.2
Gca
grancalcin
chr12_-_87233556 0.543 ENSMUST00000021423.7
Noxred1
NADP+ dependent oxidoreductase domain containing 1
chr2_+_84734050 0.527 ENSMUST00000090729.2
Ypel4
yippee-like 4 (Drosophila)
chr3_-_57575907 0.503 ENSMUST00000120977.1
Wwtr1
WW domain containing transcription regulator 1
chr10_+_94514825 0.491 ENSMUST00000065060.5
Tmcc3
transmembrane and coiled coil domains 3
chrX_-_111537947 0.480 ENSMUST00000132319.1
ENSMUST00000123951.1
Rps6ka6

ribosomal protein S6 kinase polypeptide 6

chr11_-_17008647 0.457 ENSMUST00000102881.3
Plek
pleckstrin
chr1_+_66364623 0.452 ENSMUST00000077355.5
ENSMUST00000114012.1
Map2

microtubule-associated protein 2

chr10_-_13324250 0.447 ENSMUST00000105543.1
Phactr2
phosphatase and actin regulator 2
chr14_+_79515618 0.446 ENSMUST00000110835.1
Elf1
E74-like factor 1
chr5_-_72559599 0.445 ENSMUST00000074948.4
ENSMUST00000087216.5
Nfxl1

nuclear transcription factor, X-box binding-like 1

chr18_-_6241470 0.443 ENSMUST00000163210.1
Kif5b
kinesin family member 5B
chr7_+_100537052 0.424 ENSMUST00000054310.3
Coa4
cytochrome c oxidase assembly factor 4
chr14_-_52213379 0.421 ENSMUST00000140603.1
Chd8
chromodomain helicase DNA binding protein 8
chr5_-_86676346 0.404 ENSMUST00000038448.6
Tmprss11bnl
transmembrane protease, serine 11b N terminal like
chr5_-_149051300 0.403 ENSMUST00000110505.1
Hmgb1
high mobility group box 1
chr2_+_110597298 0.387 ENSMUST00000045972.6
ENSMUST00000111026.2
Slc5a12

solute carrier family 5 (sodium/glucose cotransporter), member 12

chr17_-_21933022 0.387 ENSMUST00000074295.7
Zfp942
zinc finger protein 942
chr14_+_47663756 0.373 ENSMUST00000022391.7
Ktn1
kinectin 1
chr1_-_175688353 0.366 ENSMUST00000104984.1
Chml
choroideremia-like
chr16_+_20611585 0.356 ENSMUST00000115522.2
ENSMUST00000119224.1
ENSMUST00000079600.4
ENSMUST00000120394.1
Ece2



endothelin converting enzyme 2



chr16_-_11909398 0.355 ENSMUST00000127972.1
ENSMUST00000121750.1
ENSMUST00000096272.4
ENSMUST00000073371.6
Cpped1



calcineurin-like phosphoesterase domain containing 1



chr17_-_65772686 0.331 ENSMUST00000070673.7
Rab31
RAB31, member RAS oncogene family
chr5_-_21785115 0.329 ENSMUST00000115193.1
ENSMUST00000115192.1
ENSMUST00000115195.1
ENSMUST00000030771.5
Dnajc2



DnaJ (Hsp40) homolog, subfamily C, member 2



chr10_+_100488289 0.327 ENSMUST00000164751.1
Cep290
centrosomal protein 290
chr5_+_8422831 0.325 ENSMUST00000066921.3
Slc25a40
solute carrier family 25, member 40
chr10_-_62486575 0.309 ENSMUST00000092473.3
Vps26a
vacuolar protein sorting 26 homolog A (yeast)
chr13_+_23571382 0.301 ENSMUST00000079251.5
Hist1h2bg
histone cluster 1, H2bg
chr4_+_3940747 0.296 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr7_+_139214661 0.288 ENSMUST00000135509.1
Lrrc27
leucine rich repeat containing 27
chr5_+_72914264 0.282 ENSMUST00000144843.1
Slain2
SLAIN motif family, member 2
chrX_-_101222426 0.268 ENSMUST00000120389.1
ENSMUST00000156473.1
ENSMUST00000077876.3
Snx12


sorting nexin 12


chr10_-_4432312 0.256 ENSMUST00000126102.1
ENSMUST00000131853.1
ENSMUST00000042251.4
Rmnd1


required for meiotic nuclear division 1 homolog (S. cerevisiae)


chrX_+_163911401 0.256 ENSMUST00000140845.1
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr9_+_108049254 0.246 ENSMUST00000112295.2
ENSMUST00000047947.7
Gmppb

GDP-mannose pyrophosphorylase B

chr14_-_46831984 0.244 ENSMUST00000181311.1
ENSMUST00000074862.2
Gm10101

predicted gene 10101

chr5_+_107597760 0.232 ENSMUST00000112655.1
Rpap2
RNA polymerase II associated protein 2
chr10_-_4432285 0.225 ENSMUST00000155172.1
Rmnd1
required for meiotic nuclear division 1 homolog (S. cerevisiae)
chr1_-_75046639 0.222 ENSMUST00000152855.1
Nhej1
nonhomologous end-joining factor 1
chr7_+_100537192 0.206 ENSMUST00000120454.1
Coa4
cytochrome c oxidase assembly factor 4
chr9_-_20976762 0.203 ENSMUST00000054197.5
S1pr2
sphingosine-1-phosphate receptor 2
chr9_-_35570393 0.195 ENSMUST00000115110.4
Hyls1
hydrolethalus syndrome 1
chr17_-_56982120 0.192 ENSMUST00000056113.4
Acer1
alkaline ceramidase 1
chr12_+_17266545 0.182 ENSMUST00000057288.5
Pdia6
protein disulfide isomerase associated 6
chr7_-_63938862 0.177 ENSMUST00000063694.8
Klf13
Kruppel-like factor 13
chrX_+_56317608 0.176 ENSMUST00000151426.1
ENSMUST00000138262.1
1600025M17Rik

RIKEN cDNA 1600025M17 gene

chr1_+_135133272 0.174 ENSMUST00000167080.1
Ptpn7
protein tyrosine phosphatase, non-receptor type 7
chr4_+_134397380 0.169 ENSMUST00000105870.1
Pafah2
platelet-activating factor acetylhydrolase 2
chr4_+_33310306 0.168 ENSMUST00000108153.2
ENSMUST00000029942.7
Rngtt

RNA guanylyltransferase and 5'-phosphatase

chr15_-_50882806 0.160 ENSMUST00000184885.1
Trps1
trichorhinophalangeal syndrome I (human)
chr9_-_89092835 0.159 ENSMUST00000167113.1
Trim43b
tripartite motif-containing 43B
chr2_+_79707780 0.152 ENSMUST00000090760.2
ENSMUST00000040863.4
ENSMUST00000111780.2
Ppp1r1c


protein phosphatase 1, regulatory (inhibitor) subunit 1C


chr7_+_43607169 0.130 ENSMUST00000120935.1
ENSMUST00000127765.1
ENSMUST00000032661.7
Zfp819


zinc finger protein 819


chr17_-_25942821 0.127 ENSMUST00000148382.1
ENSMUST00000145745.1
Pigq

phosphatidylinositol glycan anchor biosynthesis, class Q

chr8_-_23237623 0.126 ENSMUST00000033950.5
Gins4
GINS complex subunit 4 (Sld5 homolog)
chr9_+_78051938 0.120 ENSMUST00000024104.7
Gcm1
glial cells missing homolog 1 (Drosophila)
chr13_-_41847482 0.118 ENSMUST00000072012.3
Adtrp
androgen dependent TFPI regulating protein
chr3_+_14863495 0.109 ENSMUST00000029076.4
Car3
carbonic anhydrase 3
chr11_-_21370452 0.108 ENSMUST00000102875.4
Ugp2
UDP-glucose pyrophosphorylase 2
chr12_-_100899436 0.106 ENSMUST00000053668.3
Gpr68
G protein-coupled receptor 68
chr9_-_43116514 0.105 ENSMUST00000061833.4
Tmem136
transmembrane protein 136
chr9_+_40873981 0.101 ENSMUST00000067375.3
Bsx
brain specific homeobox
chr19_-_59943000 0.099 ENSMUST00000170819.1
Rab11fip2
RAB11 family interacting protein 2 (class I)
chr17_-_35162969 0.099 ENSMUST00000174805.1
Prrc2a
proline-rich coiled-coil 2A
chr19_+_43689672 0.096 ENSMUST00000081079.5
Entpd7
ectonucleoside triphosphate diphosphohydrolase 7
chr10_-_14718191 0.092 ENSMUST00000020016.4
Gje1
gap junction protein, epsilon 1
chr7_-_28598140 0.067 ENSMUST00000108283.1
ENSMUST00000040531.8
Pak4
Samd4b
p21 protein (Cdc42/Rac)-activated kinase 4
sterile alpha motif domain containing 4B
chr1_-_193035651 0.066 ENSMUST00000016344.7
Syt14
synaptotagmin XIV
chr14_-_54864055 0.064 ENSMUST00000142283.2
Homez
homeodomain leucine zipper-encoding gene
chr11_+_101279092 0.060 ENSMUST00000103107.4
Cntd1
cyclin N-terminal domain containing 1
chr5_+_90367204 0.060 ENSMUST00000068250.3
Gm9958
predicted gene 9958
chrY_+_17874741 0.059 ENSMUST00000177639.1
Gm20831
predicted gene, 20831
chrX_+_7579666 0.041 ENSMUST00000115740.1
ENSMUST00000115739.1
Foxp3

forkhead box P3

chr2_+_174076296 0.041 ENSMUST00000155000.1
ENSMUST00000134876.1
ENSMUST00000147038.1
Stx16


syntaxin 16


chr19_-_61297069 0.038 ENSMUST00000179346.1
Gm21060
predicted gene, 21060
chr12_-_100159601 0.032 ENSMUST00000021596.7
Nrde2
nrde-2 necessary for RNA interference, domain containing
chr7_-_35318408 0.026 ENSMUST00000079693.5
Gpatch1
G patch domain containing 1
chr7_-_127930066 0.019 ENSMUST00000032988.8
Prss8
protease, serine, 8 (prostasin)
chr5_+_142629537 0.010 ENSMUST00000036872.9
ENSMUST00000110778.1
Wipi2

WD repeat domain, phosphoinositide interacting 2

chr17_+_84956718 0.010 ENSMUST00000112305.3
Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.5 1.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.5 2.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.3 3.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 1.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.3 0.8 GO:0007525 somatic muscle development(GO:0007525)
0.3 4.0 GO:0070986 left/right axis specification(GO:0070986)
0.2 1.5 GO:0036394 amylase secretion(GO:0036394)
0.2 0.7 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.2 2.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.2 1.7 GO:0030242 pexophagy(GO:0030242)
0.2 1.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 0.6 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.2 0.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.2 0.6 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
0.2 1.1 GO:0036337 Fas signaling pathway(GO:0036337)
0.2 1.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 1.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.1 2.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 0.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.5 GO:0006561 proline biosynthetic process(GO:0006561)
0.1 0.4 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.7 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.1 0.5 GO:0010920 negative regulation of inositol phosphate biosynthetic process(GO:0010920)
0.1 0.9 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.1 0.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.3 GO:2000642 negative regulation of early endosome to late endosome transport(GO:2000642)
0.1 0.7 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.1 0.7 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.7 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.0 0.7 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.4 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 1.4 GO:0030224 monocyte differentiation(GO:0030224)
0.0 0.0 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0 0.5 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 0.8 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.4 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.5 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.0 0.1 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.4 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 2.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.0 0.7 GO:0006298 mismatch repair(GO:0006298)
0.0 0.2 GO:0009301 snRNA transcription(GO:0009301)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.7 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.0 0.1 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.0 0.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.2 GO:0046512 sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520)
0.0 0.3 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
0.0 0.6 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.3 GO:0090382 phagosome maturation(GO:0090382)
0.0 0.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.1 GO:0060056 mammary gland involution(GO:0060056)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 4.7 GO:0005871 kinesin complex(GO:0005871)
0.1 0.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 4.0 GO:0005882 intermediate filament(GO:0005882)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 4.4 GO:0072562 blood microparticle(GO:0072562)
0.0 0.1 GO:0000811 GINS complex(GO:0000811)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 1.3 GO:0000791 euchromatin(GO:0000791)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 1.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.2 0.9 GO:0034618 arginine binding(GO:0034618)
0.2 4.7 GO:0001848 complement binding(GO:0001848)
0.2 1.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 0.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 0.8 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.2 1.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.5 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.1 0.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 1.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 2.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.2 GO:0071633 dihydroceramidase activity(GO:0071633)
0.1 0.3 GO:0070568 guanylyltransferase activity(GO:0070568)
0.1 0.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.0 0.7 GO:0005542 folic acid binding(GO:0005542)
0.0 0.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.2 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.7 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.4 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.6 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.6 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0016151 nickel cation binding(GO:0016151)
0.0 0.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.2 0.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 2.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 1.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.7 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK