Motif ID: Nkx3-1

Z-value: 0.536


Transcription factors associated with Nkx3-1:

Gene SymbolEntrez IDGene Name
Nkx3-1 ENSMUSG00000022061.8 Nkx3-1



Activity profile for motif Nkx3-1.

activity profile for motif Nkx3-1


Sorted Z-values histogram for motif Nkx3-1

Sorted Z-values for motif Nkx3-1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-1

PNG image of the network

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Top targets:


Showing 1 to 20 of 140 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_100625737 3.496 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr6_+_128362919 2.440 ENSMUST00000073316.6
 Foxm1
forkhead box M1
chr2_-_84775388 2.377 ENSMUST00000023994.3
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr2_-_84775420 2.299 ENSMUST00000111641.1
 Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
chr9_+_72438534 2.019 ENSMUST00000034746.8
 Mns1
meiosis-specific nuclear structural protein 1
chr9_+_72438519 1.993 ENSMUST00000184604.1
 Mns1
meiosis-specific nuclear structural protein 1
chr4_+_116708571 1.662 ENSMUST00000106462.2
ENSMUST00000138305.1
ENSMUST00000125671.1
ENSMUST00000130828.1
 Ccdc163



coiled-coil domain containing 163



chr1_-_133907053 1.467 ENSMUST00000149380.1
ENSMUST00000124051.2
 Optc

opticin

chr9_-_62537036 1.432 ENSMUST00000048043.5
 Coro2b
coronin, actin binding protein, 2B
chrX_+_56454871 1.420 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr4_-_45530330 1.380 ENSMUST00000061986.5
 Shb
src homology 2 domain-containing transforming protein B
chr9_-_124493793 1.372 ENSMUST00000178787.1
 Gm21836
predicted gene, 21836
chr9_+_78191966 1.369 ENSMUST00000034903.5
 Gsta4
glutathione S-transferase, alpha 4
chr10_-_13324160 1.298 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr17_+_56304313 1.280 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chrX_+_164269371 1.270 ENSMUST00000145412.1
ENSMUST00000033749.7
 Pir

pirin

chr6_-_99632376 1.256 ENSMUST00000176255.1
 Gm20696
predicted gene 20696
chr2_-_93849679 1.160 ENSMUST00000068513.4
ENSMUST00000041593.8
ENSMUST00000130077.1
 Accs


1-aminocyclopropane-1-carboxylate synthase (non-functional)


chr1_-_133906973 1.130 ENSMUST00000126123.1
 Optc
opticin
chr4_+_32623985 1.109 ENSMUST00000108178.1
 Casp8ap2
caspase 8 associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.6 4.7 GO:0001869 regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
0.3 4.0 GO:0070986 left/right axis specification(GO:0070986)
0.3 3.5 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 2.6 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.2 2.4 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
0.5 2.1 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.1 2.0 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.2 1.7 GO:0030242 pexophagy(GO:0030242)
0.5 1.6 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.2 1.5 GO:0036394 amylase secretion(GO:0036394)
0.2 1.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 1.4 GO:0030224 monocyte differentiation(GO:0030224)
0.3 1.2 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 1.1 GO:0007089 traversing start control point of mitotic cell cycle(GO:0007089)
0.2 1.1 GO:0036337 Fas signaling pathway(GO:0036337)
0.2 1.1 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0 1.1 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 1.0 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.1 0.9 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.9 GO:0019240 citrulline biosynthetic process(GO:0019240)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0005871 kinesin complex(GO:0005871)
0.0 4.4 GO:0072562 blood microparticle(GO:0072562)
0.1 4.0 GO:0005882 intermediate filament(GO:0005882)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.4 GO:0005814 centriole(GO:0005814)
0.1 1.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.3 GO:0000791 euchromatin(GO:0000791)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.1 1.0 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 1.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 0.9 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.8 GO:0070938 contractile ring(GO:0070938)
0.1 0.7 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.7 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.4 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.3 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.3 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.2 GO:0032807 DNA ligase IV complex(GO:0032807)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0001848 complement binding(GO:0001848)
0.1 3.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.1 2.1 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.1 1.9 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.7 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.5 1.6 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.1 1.5 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 1.3 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 1.3 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 1.2 GO:0099609 microtubule lateral binding(GO:0099609)
0.2 1.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 0.9 GO:0034618 arginine binding(GO:0034618)
0.1 0.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 0.9 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 0.8 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 0.8 GO:0004342 glucosamine-6-phosphate deaminase activity(GO:0004342)
0.0 0.8 GO:0017166 vinculin binding(GO:0017166)
0.1 0.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.5 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.5 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 1.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.2 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 1.1 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 1.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.4 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.2 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.2 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.2 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.7 REACTOME_INTRINSIC_PATHWAY Genes involved in Intrinsic Pathway
0.1 2.1 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 1.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.0 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 0.9 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 0.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.7 REACTOME_REGULATORY_RNA_PATHWAYS Genes involved in Regulatory RNA pathways
0.0 0.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 0.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 0.3 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.1 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation