Motif ID: Nkx3-2

Z-value: 0.574


Transcription factors associated with Nkx3-2:

Gene SymbolEntrez IDGene Name
Nkx3-2 ENSMUSG00000049691.7 Nkx3-2



Activity profile for motif Nkx3-2.

activity profile for motif Nkx3-2


Sorted Z-values histogram for motif Nkx3-2

Sorted Z-values for motif Nkx3-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx3-2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66969616 3.627 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr16_+_41532851 3.624 ENSMUST00000078873.4
 Lsamp
limbic system-associated membrane protein
chr3_-_82074639 2.637 ENSMUST00000029635.8
 Gucy1b3
guanylate cyclase 1, soluble, beta 3
chr4_+_102421518 2.307 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr10_+_38965515 2.276 ENSMUST00000019992.5
 Lama4
laminin, alpha 4
chr3_-_80802789 2.131 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr9_-_21037775 2.114 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr2_-_104409992 2.089 ENSMUST00000149466.1
ENSMUST00000139015.1
 D430041D05Rik

RIKEN cDNA D430041D05 gene

chr6_-_138421379 1.966 ENSMUST00000163065.1
 Lmo3
LIM domain only 3
chr5_-_139130159 1.889 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr6_-_136171722 1.887 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr15_-_88978958 1.861 ENSMUST00000042594.6
ENSMUST00000109368.1
 Mlc1

megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

chr9_+_57940104 1.623 ENSMUST00000043059.7
 Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
chr3_+_123267445 1.527 ENSMUST00000047923.7
 Sec24d
Sec24 related gene family, member D (S. cerevisiae)
chr11_+_43474276 1.440 ENSMUST00000173002.1
ENSMUST00000057679.3
 C1qtnf2

C1q and tumor necrosis factor related protein 2

chr15_-_45114926 1.370 ENSMUST00000022967.5
 Kcnv1
potassium channel, subfamily V, member 1
chr15_-_37458523 1.323 ENSMUST00000116445.2
 Ncald
neurocalcin delta
chr2_-_156992021 1.269 ENSMUST00000109558.1
ENSMUST00000069600.6
ENSMUST00000072298.6
 Ndrg3


N-myc downstream regulated gene 3


chr14_+_80000292 1.243 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr17_+_70561739 1.240 ENSMUST00000097288.2
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.1 GO:0035641 locomotory exploration behavior(GO:0035641)
0.3 3.6 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.9 2.6 GO:0099548 trans-synaptic signaling by nitric oxide(GO:0099548)
0.2 2.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.3 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 2.1 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.5 1.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.2 1.9 GO:0071397 cellular response to cholesterol(GO:0071397)
0.2 1.9 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.6 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.4 1.5 GO:0099527 postsynapse to nucleus signaling pathway(GO:0099527)
0.3 1.5 GO:2000987 positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.1 1.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.4 1.4 GO:0009597 detection of virus(GO:0009597)
0.1 1.4 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
0.0 1.3 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.2 1.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0 1.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 1.2 GO:0050777 negative regulation of immune response(GO:0050777)
0.2 1.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0031225 anchored component of membrane(GO:0031225)
0.2 4.5 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 2.8 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.6 GO:0005923 bicellular tight junction(GO:0005923)
0.0 2.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.1 2.3 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.9 GO:0055037 recycling endosome(GO:0055037)
0.4 1.5 GO:0032280 symmetric synapse(GO:0032280)
0.1 1.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 1.5 GO:0097440 apical dendrite(GO:0097440)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 1.2 GO:0042581 specific granule(GO:0042581)
0.3 0.9 GO:0048179 activin receptor complex(GO:0048179)
0.2 0.8 GO:0035339 SPOTS complex(GO:0035339)
0.1 0.8 GO:0044327 dendritic spine head(GO:0044327)
0.0 0.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 72 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 2.6 GO:0004016 adenylate cyclase activity(GO:0004016)
0.4 2.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 2.1 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.0 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.9 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.2 1.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 1.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 1.6 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.5 GO:0001515 opioid peptide activity(GO:0001515)
0.0 1.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 1.3 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0 1.3 GO:0005244 voltage-gated ion channel activity(GO:0005244) voltage-gated channel activity(GO:0022832)
0.4 1.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 1.1 GO:0000149 SNARE binding(GO:0000149)
0.2 0.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.8 GO:0030742 GTP-dependent protein binding(GO:0030742)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 3.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.3 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 2.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 1.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.0 1.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.4 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.0 1.1 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 1.1 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.9 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 0.7 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.7 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.7 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 0.5 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.3 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.2 ST_G_ALPHA_S_PATHWAY G alpha s Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 4.0 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.6 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 2.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.9 REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1 1.6 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 1.4 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.0 0.7 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.7 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 0.6 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.6 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.6 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME_GLYCOLYSIS Genes involved in Glycolysis
0.1 0.5 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated
0.0 0.5 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 0.5 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation