Motif ID: Nkx6-1_Evx1_Hesx1

Z-value: 0.730

Transcription factors associated with Nkx6-1_Evx1_Hesx1:

Gene SymbolEntrez IDGene Name
Evx1 ENSMUSG00000005503.8 Evx1
Hesx1 ENSMUSG00000040726.8 Hesx1
Nkx6-1 ENSMUSG00000035187.8 Nkx6-1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-1mm10_v2_chr5_-_101665195_1016652260.202.3e-01Click!


Activity profile for motif Nkx6-1_Evx1_Hesx1.

activity profile for motif Nkx6-1_Evx1_Hesx1


Sorted Z-values histogram for motif Nkx6-1_Evx1_Hesx1

Sorted Z-values for motif Nkx6-1_Evx1_Hesx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-1_Evx1_Hesx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_62766153 8.793 ENSMUST00000076623.4
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr15_+_25773985 7.907 ENSMUST00000125667.1
 Myo10
myosin X
chr14_-_118052235 7.214 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr3_-_49757257 5.278 ENSMUST00000035931.7
 Pcdh18
protocadherin 18
chr2_-_79456750 4.914 ENSMUST00000041099.4
 Neurod1
neurogenic differentiation 1
chr11_-_98053415 4.717 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr4_+_8690399 4.489 ENSMUST00000127476.1
 Chd7
chromodomain helicase DNA binding protein 7
chr9_+_118478182 4.434 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478344 4.217 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr13_+_44121167 3.862 ENSMUST00000163056.1
ENSMUST00000159595.1
 Gm5083

predicted gene 5083

chr2_+_116067213 3.664 ENSMUST00000152412.1
 G630016G05Rik
RIKEN cDNA G630016G05 gene
chr1_-_190170671 3.526 ENSMUST00000175916.1
 Prox1
prospero-related homeobox 1
chr2_+_20737306 3.399 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chrX_+_56454871 3.318 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr14_-_100149764 3.134 ENSMUST00000097079.4
 Klf12
Kruppel-like factor 12
chr2_-_116067391 2.933 ENSMUST00000140185.1
 2700033N17Rik
RIKEN cDNA 2700033N17 gene
chrM_+_11734 2.791 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr15_+_18818895 2.717 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr5_-_84417359 2.687 ENSMUST00000113401.1
 Epha5
Eph receptor A5
chr16_+_33684538 2.627 ENSMUST00000126532.1
 Heg1
HEG homolog 1 (zebrafish)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 179 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.9 8.7 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 7.7 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
1.2 7.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 6.2 GO:0051489 regulation of filopodium assembly(GO:0051489)
1.2 4.9 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.2 4.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
1.5 4.5 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
1.5 4.5 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
1.3 4.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.1 3.9 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 3.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
1.2 3.5 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 3.0 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 2.7 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.5 2.4 GO:0038032 termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.0 2.4 GO:0007528 neuromuscular junction development(GO:0007528)
0.5 2.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 2.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 2.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.7 2.0 GO:1904956 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0016459 myosin complex(GO:0016459)
0.1 8.6 GO:0070469 respiratory chain(GO:0070469)
0.3 7.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 6.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
1.1 4.5 GO:0060187 cell pole(GO:0060187)
0.0 2.4 GO:0031594 neuromuscular junction(GO:0031594)
0.5 2.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.1 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.5 2.0 GO:0008623 CHRAC(GO:0008623)
0.1 2.0 GO:0051286 cell tip(GO:0051286)
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.8 GO:0097440 apical dendrite(GO:0097440)
0.3 1.6 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.1 1.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 1.4 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 1.4 GO:0036064 ciliary basal body(GO:0036064)
0.0 1.1 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.1 1.0 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 121 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 10.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 8.9 GO:0030507 spectrin binding(GO:0030507)
0.3 7.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.6 7.2 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 4.3 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.5 4.0 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.1 3.9 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 3.5 GO:0050693 LBD domain binding(GO:0050693)
0.0 2.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 2.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 2.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 2.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 2.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 2.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 2.0 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.0 GO:0032452 histone demethylase activity(GO:0032452)
0.6 1.9 GO:0000822 inositol hexakisphosphate binding(GO:0000822)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.4 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.2 9.9 PID_ARF6_PATHWAY Arf6 signaling events
0.2 9.0 PID_CD8_TCR_DOWNSTREAM_PATHWAY Downstream signaling in naïve CD8+ T cells
0.2 4.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.0 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 3.8 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.5 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.4 NABA_COLLAGENS Genes encoding collagen proteins
0.0 2.2 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.8 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.1 1.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.4 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.2 ST_ADRENERGIC Adrenergic Pathway
0.1 0.9 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.9 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 0.8 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 5.2 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.2 4.8 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 2.6 REACTOME_G1_PHASE Genes involved in G1 Phase
0.0 2.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.7 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 1.6 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 1.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 1.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.5 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.1 1.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.4 REACTOME_CD28_DEPENDENT_PI3K_AKT_SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 1.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.4 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.1 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.0 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation