Motif ID: Nkx6-2

Z-value: 1.031


Transcription factors associated with Nkx6-2:

Gene SymbolEntrez IDGene Name
Nkx6-2 ENSMUSG00000041309.11 Nkx6-2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nkx6-2mm10_v2_chr7_-_139582790_139582808-0.144.2e-01Click!


Activity profile for motif Nkx6-2.

activity profile for motif Nkx6-2


Sorted Z-values histogram for motif Nkx6-2

Sorted Z-values for motif Nkx6-2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_-_97584612 7.556 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584605 7.454 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr18_-_74207771 6.024 ENSMUST00000040188.8
ENSMUST00000177604.1
Ska1

spindle and kinetochore associated complex subunit 1

chr18_-_84086379 5.364 ENSMUST00000060303.8
Tshz1
teashirt zinc finger family member 1
chr8_-_61902669 4.618 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr4_-_117182623 4.493 ENSMUST00000065896.2
Kif2c
kinesin family member 2C
chr5_+_92809372 4.404 ENSMUST00000113054.2
Shroom3
shroom family member 3
chr9_+_65890237 4.366 ENSMUST00000045802.6
2810417H13Rik
RIKEN cDNA 2810417H13 gene
chr6_-_144209471 4.094 ENSMUST00000038815.7
Sox5
SRY-box containing gene 5
chr5_+_92683625 4.076 ENSMUST00000168878.1
Shroom3
shroom family member 3
chr10_+_37139558 4.065 ENSMUST00000062667.3
5930403N24Rik
RIKEN cDNA 5930403N24 gene
chr16_-_22161450 4.009 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr6_-_144209558 3.989 ENSMUST00000111749.1
ENSMUST00000170367.2
Sox5

SRY-box containing gene 5

chr17_-_48432723 3.298 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr13_+_44121167 3.192 ENSMUST00000163056.1
ENSMUST00000159595.1
Gm5083

predicted gene 5083

chr6_-_144209448 2.927 ENSMUST00000077160.5
Sox5
SRY-box containing gene 5
chr1_+_184034381 2.824 ENSMUST00000048655.7
Dusp10
dual specificity phosphatase 10
chr16_+_96467606 2.728 ENSMUST00000061739.8
Pcp4
Purkinje cell protein 4
chr4_-_21767173 2.630 ENSMUST00000029915.5
Tstd3
thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
chr10_+_26822560 2.400 ENSMUST00000135866.1
Arhgap18
Rho GTPase activating protein 18
chr4_-_83285141 2.144 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr15_-_13173607 2.115 ENSMUST00000036439.4
Cdh6
cadherin 6
chr9_+_96258697 2.037 ENSMUST00000179416.1
Tfdp2
transcription factor Dp 2
chr9_+_52047150 2.028 ENSMUST00000163153.1
Rdx
radixin
chr11_-_101171302 2.004 ENSMUST00000164474.1
ENSMUST00000043397.7
Plekhh3

pleckstrin homology domain containing, family H (with MyTH4 domain) member 3

chr5_+_110839973 1.969 ENSMUST00000066160.1
Chek2
checkpoint kinase 2
chr17_+_82539258 1.734 ENSMUST00000097278.3
Gm6594
predicted pseudogene 6594
chr18_+_57142782 1.693 ENSMUST00000139892.1
Megf10
multiple EGF-like-domains 10
chr9_+_96259246 1.684 ENSMUST00000179065.1
ENSMUST00000165768.2
Tfdp2

transcription factor Dp 2

chr4_+_98546919 1.590 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr4_+_140701466 1.553 ENSMUST00000038893.5
ENSMUST00000138808.1
Rcc2

regulator of chromosome condensation 2

chr4_+_98546710 1.543 ENSMUST00000102792.3
Inadl
InaD-like (Drosophila)
chr18_-_42899294 1.527 ENSMUST00000117687.1
Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr4_-_3938354 1.506 ENSMUST00000003369.3
Plag1
pleiomorphic adenoma gene 1
chr2_-_69789568 1.505 ENSMUST00000094942.3
Ccdc173
coiled-coil domain containing 173
chr1_+_15712303 1.392 ENSMUST00000170146.1
Kcnb2
potassium voltage gated channel, Shab-related subfamily, member 2
chr12_-_80760541 1.392 ENSMUST00000073251.6
Ccdc177
coiled-coil domain containing 177
chr19_+_58728887 1.389 ENSMUST00000048644.5
Pnliprp1
pancreatic lipase related protein 1
chr19_-_14597983 1.298 ENSMUST00000052011.7
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr11_+_23256566 1.257 ENSMUST00000136235.1
Xpo1
exportin 1, CRM1 homolog (yeast)
chr10_+_18407658 1.256 ENSMUST00000037341.7
Nhsl1
NHS-like 1
chr7_-_45062393 1.252 ENSMUST00000129101.1
Prrg2
proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
chr4_-_138913915 1.247 ENSMUST00000097830.3
Otud3
OTU domain containing 3
chr5_+_123142187 1.235 ENSMUST00000174836.1
ENSMUST00000163030.2
Setd1b

SET domain containing 1B

chr11_-_17953861 1.184 ENSMUST00000076661.6
Etaa1
Ewing's tumor-associated antigen 1
chr2_-_125625065 1.167 ENSMUST00000089776.2
Cep152
centrosomal protein 152
chr4_-_91376433 1.155 ENSMUST00000107109.2
ENSMUST00000107111.2
ENSMUST00000107120.1
Elavl2


ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)


chr1_+_194619815 1.151 ENSMUST00000027952.5
Plxna2
plexin A2
chr19_-_14598031 1.135 ENSMUST00000167776.2
Tle4
transducin-like enhancer of split 4, homolog of Drosophila E(spl)
chr2_+_62664279 1.134 ENSMUST00000028257.2
Gca
grancalcin
chr3_+_103575231 1.124 ENSMUST00000121834.1
Syt6
synaptotagmin VI
chr2_+_69789621 1.103 ENSMUST00000151298.1
ENSMUST00000028494.2
Phospho2

phosphatase, orphan 2

chr6_+_125049952 1.066 ENSMUST00000088294.5
ENSMUST00000032481.7
Acrbp

proacrosin binding protein

chr12_-_46818749 1.052 ENSMUST00000021438.6
Nova1
neuro-oncological ventral antigen 1
chr2_+_69789647 1.038 ENSMUST00000112266.1
Phospho2
phosphatase, orphan 2
chr7_+_39588931 0.994 ENSMUST00000178791.1
ENSMUST00000098511.3
Gm2058

predicted gene 2058

chr1_-_135585314 0.991 ENSMUST00000040599.8
ENSMUST00000067414.6
Nav1

neuron navigator 1

chr3_-_96220880 0.981 ENSMUST00000090782.3
Hist2h2ac
histone cluster 2, H2ac
chr19_-_12765447 0.975 ENSMUST00000112933.1
Cntf
ciliary neurotrophic factor
chr4_-_133756769 0.970 ENSMUST00000008024.6
Arid1a
AT rich interactive domain 1A (SWI-like)
chr15_+_34453285 0.957 ENSMUST00000060894.7
BC030476
cDNA sequence BC030476
chr17_+_35861318 0.946 ENSMUST00000074259.8
ENSMUST00000174873.1
Nrm

nurim (nuclear envelope membrane protein)

chr3_+_103575275 0.932 ENSMUST00000090697.4
Syt6
synaptotagmin VI
chr19_-_58454435 0.920 ENSMUST00000169850.1
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
chr19_-_44107447 0.920 ENSMUST00000119591.1
ENSMUST00000026217.4
Chuk

conserved helix-loop-helix ubiquitous kinase

chr16_+_44394771 0.919 ENSMUST00000099742.2
Wdr52
WD repeat domain 52
chrX_-_51018011 0.900 ENSMUST00000053593.7
Rap2c
RAP2C, member of RAS oncogene family
chr11_+_20543307 0.858 ENSMUST00000093292.4
Sertad2
SERTA domain containing 2
chr6_+_125049903 0.855 ENSMUST00000112413.1
Acrbp
proacrosin binding protein
chr10_-_37138863 0.774 ENSMUST00000092584.5
Marcks
myristoylated alanine rich protein kinase C substrate
chrX_+_7762652 0.741 ENSMUST00000077680.3
ENSMUST00000079542.6
ENSMUST00000115679.1
ENSMUST00000137467.1
Tfe3



transcription factor E3



chr18_+_61639542 0.725 ENSMUST00000183083.1
ENSMUST00000183087.1
Gm20748

predicted gene, 20748

chr4_+_90218820 0.717 ENSMUST00000107129.1
Zfp352
zinc finger protein 352
chr17_+_35861343 0.714 ENSMUST00000172931.1
Nrm
nurim (nuclear envelope membrane protein)
chr5_-_20951769 0.622 ENSMUST00000036489.5
Rsbn1l
round spermatid basic protein 1-like
chr11_+_98863610 0.608 ENSMUST00000142414.1
ENSMUST00000037480.8
Wipf2

WAS/WASL interacting protein family, member 2

chr3_+_96221111 0.590 ENSMUST00000090781.6
Hist2h2be
histone cluster 2, H2be
chr1_-_163725123 0.572 ENSMUST00000159679.1
Mettl11b
methyltransferase like 11B
chr11_+_87663087 0.562 ENSMUST00000165679.1
Rnf43
ring finger protein 43
chr1_+_66322102 0.553 ENSMUST00000123647.1
Map2
microtubule-associated protein 2
chrX_+_75382384 0.513 ENSMUST00000033541.4
Fundc2
FUN14 domain containing 2
chr9_-_113708209 0.511 ENSMUST00000111861.3
ENSMUST00000035086.6
Pdcd6ip

programmed cell death 6 interacting protein

chr4_+_3940747 0.508 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr15_+_35371498 0.467 ENSMUST00000048646.7
Vps13b
vacuolar protein sorting 13B (yeast)
chr7_-_84679346 0.446 ENSMUST00000069537.2
ENSMUST00000178385.1
Zfand6

zinc finger, AN1-type domain 6

chr11_+_62879449 0.439 ENSMUST00000014321.4
Tvp23b
trans-golgi network vesicle protein 23B
chr18_+_6332587 0.415 ENSMUST00000097682.2
Rpl27-ps3
ribosomal protein L27, pseudogene 3
chr9_-_22117123 0.414 ENSMUST00000013966.6
Elof1
elongation factor 1 homolog (ELF1, S. cerevisiae)
chr2_-_177267036 0.405 ENSMUST00000108963.1
Gm14409
predicted gene 14409
chr15_-_73061204 0.403 ENSMUST00000089770.3
ENSMUST00000170633.1
ENSMUST00000168191.1
Trappc9


trafficking protein particle complex 9


chr7_-_103741322 0.355 ENSMUST00000051346.2
Olfr629
olfactory receptor 629
chr14_+_29978337 0.344 ENSMUST00000016115.4
Actr8
ARP8 actin-related protein 8
chrM_+_10167 0.336 ENSMUST00000082414.1
mt-Nd4
mitochondrially encoded NADH dehydrogenase 4
chr2_+_163694015 0.327 ENSMUST00000109400.2
Pkig
protein kinase inhibitor, gamma
chr4_+_150853919 0.324 ENSMUST00000073600.2
Errfi1
ERBB receptor feedback inhibitor 1
chr3_+_10088173 0.308 ENSMUST00000061419.7
Gm9833
predicted gene 9833
chr2_+_69861562 0.305 ENSMUST00000090852.4
ENSMUST00000166411.1
Ssb

Sjogren syndrome antigen B

chr1_+_34005872 0.304 ENSMUST00000182296.1
Dst
dystonin
chr3_+_40540751 0.289 ENSMUST00000091186.3
Intu
inturned planar cell polarity effector homolog (Drosophila)
chr11_-_109995743 0.284 ENSMUST00000106669.2
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr8_+_46986913 0.281 ENSMUST00000039840.7
ENSMUST00000119686.1
Enpp6

ectonucleotide pyrophosphatase/phosphodiesterase 6

chr12_+_117843873 0.271 ENSMUST00000176735.1
ENSMUST00000177339.1
Cdca7l

cell division cycle associated 7 like

chr5_-_63968867 0.251 ENSMUST00000154169.1
Rell1
RELT-like 1
chr2_+_22622183 0.249 ENSMUST00000028123.3
Gad2
glutamic acid decarboxylase 2
chr2_-_84650760 0.228 ENSMUST00000111691.1
Ctnnd1
catenin (cadherin associated protein), delta 1
chr2_-_84650714 0.225 ENSMUST00000111697.2
ENSMUST00000111670.2
ENSMUST00000111696.1
ENSMUST00000111678.1
ENSMUST00000111690.1
ENSMUST00000111695.1
ENSMUST00000111677.1
ENSMUST00000111698.1
ENSMUST00000099941.2
ENSMUST00000111676.1
ENSMUST00000111694.1
ENSMUST00000111675.1
ENSMUST00000111689.1
ENSMUST00000111687.1
ENSMUST00000111692.1
ENSMUST00000111685.1
ENSMUST00000111686.1
ENSMUST00000111688.1
ENSMUST00000111693.1
ENSMUST00000111684.1
Ctnnd1



















catenin (cadherin associated protein), delta 1



















chr11_-_109995775 0.223 ENSMUST00000020948.8
Abca8b
ATP-binding cassette, sub-family A (ABC1), member 8b
chr18_+_34840575 0.210 ENSMUST00000043484.7
Reep2
receptor accessory protein 2
chr5_-_110839575 0.175 ENSMUST00000145318.1
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr5_-_110839757 0.161 ENSMUST00000056937.5
Hscb
HscB iron-sulfur cluster co-chaperone homolog (E. coli)
chr11_-_87826023 0.151 ENSMUST00000103177.3
Lpo
lactoperoxidase
chr18_+_4993795 0.144 ENSMUST00000153016.1
Svil
supervillin
chr3_+_19894855 0.140 ENSMUST00000059704.4
4632415L05Rik
RIKEN cDNA 4632415L05 gene
chr2_-_174346712 0.120 ENSMUST00000168292.1
Gm20721
predicted gene, 20721
chr1_-_185329331 0.109 ENSMUST00000027921.4
ENSMUST00000110975.1
ENSMUST00000110974.3
Iars2


isoleucine-tRNA synthetase 2, mitochondrial


chr5_-_51553896 0.103 ENSMUST00000132734.1
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
chr5_+_25246775 0.100 ENSMUST00000144971.1
Galnt11
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11
chr4_-_136835843 0.098 ENSMUST00000105846.2
ENSMUST00000059287.7
ENSMUST00000105845.2
Ephb2


Eph receptor B2


chr2_-_84650490 0.088 ENSMUST00000066177.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr5_+_140419248 0.073 ENSMUST00000100507.3
Eif3b
eukaryotic translation initiation factor 3, subunit B
chrM_+_9452 0.066 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr5_-_131308076 0.065 ENSMUST00000160609.1
Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr6_-_102464667 0.052 ENSMUST00000032159.6
Cntn3
contactin 3
chr2_-_84650676 0.046 ENSMUST00000067232.3
Ctnnd1
catenin (cadherin associated protein), delta 1
chr11_-_31671727 0.041 ENSMUST00000109415.1
Bod1
biorientation of chromosomes in cell division 1
chr6_+_127149389 0.030 ENSMUST00000180811.1
9330179D12Rik
RIKEN cDNA 9330179D12 gene
chr15_-_81104999 0.028 ENSMUST00000109579.2
Mkl1
MKL (megakaryoblastic leukemia)/myocardin-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0060023 soft palate development(GO:0060023)
1.4 11.0 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.1 3.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.9 4.5 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.7 2.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.6 2.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.5 2.0 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.4 1.2 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.3 1.0 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.3 2.0 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.3 1.7 GO:0043654 skeletal muscle satellite cell activation(GO:0014719) recognition of apoptotic cell(GO:0043654)
0.3 2.7 GO:0033603 positive regulation of dopamine secretion(GO:0033603)
0.3 1.6 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.3 4.6 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 0.5 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.2 1.2 GO:0098535 de novo centriole assembly(GO:0098535)
0.2 1.3 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.2 1.3 GO:0097475 motor neuron migration(GO:0097475)
0.1 1.2 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.1 1.0 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 0.6 GO:0060690 epithelial cell differentiation involved in salivary gland development(GO:0060690)
0.1 1.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.1 8.5 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
0.1 0.9 GO:1902741 type I interferon secretion(GO:0072641) interferon-alpha secretion(GO:0072642) regulation of interferon-alpha secretion(GO:1902739) positive regulation of interferon-alpha secretion(GO:1902741)
0.1 0.6 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.3 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.1 1.9 GO:0048240 sperm capacitation(GO:0048240)
0.1 1.5 GO:0060736 prostate gland growth(GO:0060736)
0.1 0.4 GO:0050913 sensory perception of bitter taste(GO:0050913)
0.1 0.3 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 1.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 0.6 GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway(GO:0010804)
0.0 0.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.3 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.8 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 3.7 GO:0051028 mRNA transport(GO:0051028)
0.0 3.1 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.0 0.3 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.1 GO:0090258 negative regulation of mitochondrial fission(GO:0090258) regulation of progesterone biosynthetic process(GO:2000182)
0.0 0.1 GO:0021631 optic nerve morphogenesis(GO:0021631)
0.0 0.4 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 3.6 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.3 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.6 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.0 0.4 GO:0006625 protein targeting to peroxisome(GO:0006625) peroxisomal transport(GO:0043574) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 2.4 GO:0030833 regulation of actin filament polymerization(GO:0030833)
0.0 0.1 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.0 0.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 1.0 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.1 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.4 GO:0007608 sensory perception of smell(GO:0007608)
0.0 1.0 GO:0006342 chromatin silencing(GO:0006342)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 6.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 2.7 GO:0005883 neurofilament(GO:0005883)
0.3 0.8 GO:0042585 germinal vesicle(GO:0042585)
0.2 1.2 GO:0098536 deuterosome(GO:0098536)
0.1 1.6 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 4.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 2.0 GO:0051286 cell tip(GO:0051286)
0.1 1.3 GO:0005642 annulate lamellae(GO:0005642)
0.1 4.6 GO:0002102 podosome(GO:0002102)
0.1 1.7 GO:0005652 nuclear lamina(GO:0005652)
0.1 1.7 GO:0001891 phagocytic cup(GO:0001891)
0.1 2.4 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 14.7 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.5 GO:0090543 Flemming body(GO:0090543)
0.1 0.5 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.1 1.0 GO:0071564 npBAF complex(GO:0071564)
0.1 1.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 7.1 GO:0043296 apical junction complex(GO:0043296)
0.0 1.0 GO:0043194 axon initial segment(GO:0043194)
0.0 1.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.3 GO:0031011 Ino80 complex(GO:0031011)
0.0 1.6 GO:0000786 nucleosome(GO:0000786)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 6.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.4 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.5 2.1 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.5 2.6 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.3 0.9 GO:0008384 IkappaB kinase activity(GO:0008384)
0.3 4.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 1.7 GO:0001849 complement component C1q binding(GO:0001849)
0.2 2.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 0.5 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 1.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 4.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 1.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.1 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 0.5 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.1 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.0 9.4 GO:0051015 actin filament binding(GO:0051015)
0.0 1.9 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.6 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.3 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 2.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 7.6 GO:0003779 actin binding(GO:0003779)
0.0 5.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.2 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 1.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 13.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 2.3 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.6 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 0.9 GO:0019003 GDP binding(GO:0019003)
0.0 0.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.3 GO:0008017 microtubule binding(GO:0008017)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 1.3 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 2.8 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.0 PID_ATM_PATHWAY ATM pathway
0.0 2.4 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 4.5 PID_E2F_PATHWAY E2F transcription factor network
0.0 1.5 PID_ATR_PATHWAY ATR signaling pathway
0.0 2.1 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.9 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.0 0.9 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.0 0.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 4.5 REACTOME_KINESINS Genes involved in Kinesins
0.1 3.1 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 0.8 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 0.9 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 7.6 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.2 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 2.0 REACTOME_CELL_CELL_JUNCTION_ORGANIZATION Genes involved in Cell-cell junction organization
0.0 1.6 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 2.0 REACTOME_RECYCLING_PATHWAY_OF_L1 Genes involved in Recycling pathway of L1
0.0 1.4 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.4 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 2.4 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.2 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation