Motif ID: Nkx6-3_Dbx2_Barx2
Z-value: 0.559
Transcription factors associated with Nkx6-3_Dbx2_Barx2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Barx2 | ENSMUSG00000032033.10 | Barx2 |
Dbx2 | ENSMUSG00000045608.6 | Dbx2 |
Nkx6-3 | ENSMUSG00000063672.6 | Nkx6-3 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Dbx2 | mm10_v2_chr15_-_95655960_95655960 | 0.38 | 2.1e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.8 | 12.6 | GO:0019532 | oxalate transport(GO:0019532) |
0.6 | 2.6 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
0.4 | 1.2 | GO:0015866 | ADP transport(GO:0015866) |
0.4 | 1.1 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.3 | 1.1 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
0.3 | 1.3 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
0.2 | 1.2 | GO:1901164 | negative regulation of trophoblast cell migration(GO:1901164) |
0.2 | 0.6 | GO:1903903 | regulation of establishment of T cell polarity(GO:1903903) |
0.2 | 2.6 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
0.1 | 0.5 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.1 | 0.4 | GO:1902256 | apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256) |
0.1 | 3.6 | GO:0030903 | notochord development(GO:0030903) |
0.1 | 1.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
0.1 | 0.6 | GO:0015788 | UDP-N-acetylglucosamine transport(GO:0015788) |
0.1 | 1.3 | GO:0033572 | transferrin transport(GO:0033572) |
0.1 | 0.6 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.1 | 0.3 | GO:0061743 | motor learning(GO:0061743) |
0.1 | 0.2 | GO:2000564 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564) positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187) |
0.1 | 0.6 | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743) |
0.1 | 1.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.1 | 0.2 | GO:0009838 | abscission(GO:0009838) positive regulation of viral budding via host ESCRT complex(GO:1903774) |
0.1 | 0.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
0.1 | 0.5 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
0.0 | 0.4 | GO:0008343 | adult feeding behavior(GO:0008343) |
0.0 | 2.2 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
0.0 | 0.2 | GO:1900170 | negative regulation of glucocorticoid mediated signaling pathway(GO:1900170) |
0.0 | 0.4 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.2 | GO:0032275 | luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278) |
0.0 | 0.5 | GO:0032570 | response to progesterone(GO:0032570) |
0.0 | 0.2 | GO:1903056 | positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056) |
0.0 | 0.2 | GO:0002457 | T cell antigen processing and presentation(GO:0002457) |
0.0 | 0.2 | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268) |
0.0 | 0.1 | GO:0090472 | dibasic protein processing(GO:0090472) |
0.0 | 0.5 | GO:0016486 | peptide hormone processing(GO:0016486) |
0.0 | 0.2 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
0.0 | 1.0 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
0.0 | 0.4 | GO:0045187 | regulation of circadian sleep/wake cycle, sleep(GO:0045187) |
0.0 | 0.3 | GO:0097186 | amelogenesis(GO:0097186) |
0.0 | 0.2 | GO:0090091 | positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
0.0 | 0.2 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
0.0 | 0.3 | GO:0034308 | primary alcohol metabolic process(GO:0034308) |
0.0 | 0.1 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
0.0 | 0.1 | GO:0030223 | neutrophil differentiation(GO:0030223) |
0.0 | 0.1 | GO:0060690 | epithelial cell differentiation involved in salivary gland development(GO:0060690) |
0.0 | 1.0 | GO:0030032 | lamellipodium assembly(GO:0030032) |
0.0 | 0.2 | GO:0031468 | nuclear envelope reassembly(GO:0031468) |
0.0 | 1.7 | GO:0042742 | defense response to bacterium(GO:0042742) |
0.0 | 0.1 | GO:0090669 | telomerase RNA stabilization(GO:0090669) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0097637 | intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637) |
0.2 | 2.2 | GO:0042581 | specific granule(GO:0042581) |
0.1 | 0.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.1 | 1.9 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
0.1 | 0.5 | GO:0097524 | sperm plasma membrane(GO:0097524) |
0.1 | 0.6 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
0.1 | 0.4 | GO:0005796 | Golgi lumen(GO:0005796) |
0.1 | 0.4 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
0.1 | 0.2 | GO:1990730 | VCP-NSFL1C complex(GO:1990730) |
0.0 | 13.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 0.4 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.0 | 1.8 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.2 | GO:0030689 | Noc complex(GO:0030689) |
0.0 | 0.2 | GO:0030981 | cortical microtubule cytoskeleton(GO:0030981) |
0.0 | 0.4 | GO:0031462 | Cul2-RING ubiquitin ligase complex(GO:0031462) |
0.0 | 0.3 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.2 | GO:0090543 | ESCRT III complex(GO:0000815) Flemming body(GO:0090543) |
0.0 | 0.6 | GO:0035371 | microtubule plus-end(GO:0035371) |
0.0 | 0.7 | GO:0016235 | aggresome(GO:0016235) |
0.0 | 0.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 12.6 | GO:0019531 | secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531) |
0.4 | 2.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.4 | 1.2 | GO:0015228 | coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122) |
0.3 | 1.3 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
0.2 | 1.6 | GO:0045134 | uridine-diphosphatase activity(GO:0045134) |
0.2 | 0.9 | GO:0019770 | IgG receptor activity(GO:0019770) |
0.2 | 1.2 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.2 | 1.1 | GO:0001665 | alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665) |
0.1 | 0.3 | GO:0001716 | L-amino-acid oxidase activity(GO:0001716) |
0.1 | 1.4 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
0.1 | 1.8 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
0.1 | 1.1 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 3.6 | GO:0005504 | fatty acid binding(GO:0005504) |
0.1 | 0.4 | GO:0033188 | sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493) |
0.1 | 0.2 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.1 | 2.2 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.1 | 0.3 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.0 | 0.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
0.0 | 0.5 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 0.8 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 1.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.2 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.0 | 0.6 | GO:0005351 | sugar:proton symporter activity(GO:0005351) |
0.0 | 0.2 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.0 | 0.1 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.0 | 0.5 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
0.0 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
0.0 | 0.5 | GO:0004601 | peroxidase activity(GO:0004601) |
0.0 | 0.4 | GO:1990841 | promoter-specific chromatin binding(GO:1990841) |
0.0 | 0.6 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
0.0 | 0.4 | GO:0000993 | RNA polymerase II core binding(GO:0000993) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.4 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
0.0 | 0.4 | PID_SYNDECAN_3_PATHWAY | Syndecan-3-mediated signaling events |
0.0 | 1.2 | PID_RHOA_REG_PATHWAY | Regulation of RhoA activity |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 1.4 | REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES | Genes involved in The activation of arylsulfatases |
0.2 | 16.8 | REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
0.1 | 2.6 | REACTOME_DARPP_32_EVENTS | Genes involved in DARPP-32 events |
0.0 | 1.0 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
0.0 | 0.5 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
0.0 | 0.6 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 0.1 | REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
0.0 | 0.2 | REACTOME_ZINC_TRANSPORTERS | Genes involved in Zinc transporters |
0.0 | 0.6 | REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
0.0 | 0.3 | REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
0.0 | 0.4 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |