Motif ID: Nkx6-3_Dbx2_Barx2

Z-value: 0.559

Transcription factors associated with Nkx6-3_Dbx2_Barx2:

Gene SymbolEntrez IDGene Name
Barx2 ENSMUSG00000032033.10 Barx2
Dbx2 ENSMUSG00000045608.6 Dbx2
Nkx6-3 ENSMUSG00000063672.6 Nkx6-3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dbx2mm10_v2_chr15_-_95655960_956559600.382.1e-02Click!


Activity profile for motif Nkx6-3_Dbx2_Barx2.

activity profile for motif Nkx6-3_Dbx2_Barx2


Sorted Z-values histogram for motif Nkx6-3_Dbx2_Barx2

Sorted Z-values for motif Nkx6-3_Dbx2_Barx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nkx6-3_Dbx2_Barx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 146 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_14621805 6.146 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr4_+_136143497 3.556 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr4_-_14621494 3.264 ENSMUST00000149633.1
 Slc26a7
solute carrier family 26, member 7
chr4_-_14621669 3.154 ENSMUST00000143105.1
 Slc26a7
solute carrier family 26, member 7
chr13_+_94083490 2.455 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr14_+_80000292 2.165 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr8_-_21906412 2.018 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr4_+_102589687 1.869 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr14_+_69347587 1.565 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr11_+_109543694 1.448 ENSMUST00000106696.1
 Arsg
arylsulfatase G
chr15_-_8710734 1.402 ENSMUST00000005493.7
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr5_-_70842617 1.367 ENSMUST00000031119.1
 Gabrg1
gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1
chr5_-_118244861 1.356 ENSMUST00000117177.1
ENSMUST00000133372.1
ENSMUST00000154786.1
ENSMUST00000121369.1
 Rnft2



ring finger protein, transmembrane 2



chr17_-_81649607 1.302 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr5_+_144100387 1.258 ENSMUST00000041804.7
 Lmtk2
lemur tyrosine kinase 2
chr15_-_8710409 1.180 ENSMUST00000157065.1
 Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr2_+_109917639 1.127 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr2_+_125136692 1.078 ENSMUST00000099452.2
 Ctxn2
cortexin 2
chr13_+_83732438 1.014 ENSMUST00000182701.1
 C130071C03Rik
RIKEN cDNA C130071C03 gene
chr7_+_57387304 1.006 ENSMUST00000085241.5
 Gm9962
predicted gene 9962

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.8 12.6 GO:0019532 oxalate transport(GO:0019532)
0.1 3.6 GO:0030903 notochord development(GO:0030903)
0.6 2.6 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.2 2.6 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 2.2 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1 1.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.7 GO:0042742 defense response to bacterium(GO:0042742)
0.3 1.3 GO:0098735 cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735)
0.1 1.3 GO:0033572 transferrin transport(GO:0033572)
0.4 1.2 GO:0015866 ADP transport(GO:0015866)
0.2 1.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 1.1 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.3 1.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 1.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 1.0 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 1.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 0.6 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.1 0.6 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.1 0.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.6 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 2.2 GO:0042581 specific granule(GO:0042581)
0.1 1.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 1.8 GO:0034707 chloride channel complex(GO:0034707)
0.5 1.6 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.1 0.6 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.6 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.5 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.4 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.4 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 0.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.2 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.0 0.2 GO:0030689 Noc complex(GO:0030689)
0.0 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 12.6 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.1 3.6 GO:0005504 fatty acid binding(GO:0005504)
0.4 2.6 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.2 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.2 1.6 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 1.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.3 1.3 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.4 1.2 GO:0015228 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.2 1.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 1.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.2 0.9 GO:0019770 IgG receptor activity(GO:0019770)
0.0 0.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.8 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 0.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 0.4 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.4 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.6 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.2 1.4 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 1.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.5 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.2 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins