Motif ID: Nr0b1

Z-value: 0.856


Transcription factors associated with Nr0b1:

Gene SymbolEntrez IDGene Name
Nr0b1 ENSMUSG00000025056.4 Nr0b1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr0b1mm10_v2_chrX_+_86191764_861917820.086.4e-01Click!


Activity profile for motif Nr0b1.

activity profile for motif Nr0b1


Sorted Z-values histogram for motif Nr0b1

Sorted Z-values for motif Nr0b1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr0b1

PNG image of the network

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Top targets:


Showing 1 to 20 of 84 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_45844228 4.768 ENSMUST00000076333.5
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr16_-_45844303 4.706 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr9_+_80165079 3.858 ENSMUST00000184480.1
 Myo6
myosin VI
chr11_+_102604370 3.729 ENSMUST00000057893.5
 Fzd2
frizzled homolog 2 (Drosophila)
chr9_+_80165013 3.466 ENSMUST00000035889.8
ENSMUST00000113268.1
 Myo6

myosin VI

chr7_+_79500081 3.443 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr7_+_79500018 3.398 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr5_+_64803513 3.162 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr1_-_9700209 2.839 ENSMUST00000088658.4
 Mybl1
myeloblastosis oncogene-like 1
chr18_+_35829798 2.558 ENSMUST00000060722.6
 Cxxc5
CXXC finger 5
chr17_-_70851189 2.339 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr10_-_81350389 2.200 ENSMUST00000020454.4
ENSMUST00000105324.2
ENSMUST00000154609.2
ENSMUST00000105323.1
 Hmg20b



high mobility group 20B



chr4_-_132422484 2.132 ENSMUST00000102568.3
 Phactr4
phosphatase and actin regulator 4
chrX_-_145505175 2.128 ENSMUST00000143610.1
 Amot
angiomotin
chr13_-_29984219 2.042 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr1_+_42697146 2.006 ENSMUST00000054883.2
 Pou3f3
POU domain, class 3, transcription factor 3
chr4_+_116221633 1.989 ENSMUST00000030464.7
 Pik3r3
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)
chr4_-_132422394 1.984 ENSMUST00000152271.1
ENSMUST00000084170.5
 Phactr4

phosphatase and actin regulator 4

chr14_+_11553523 1.938 ENSMUST00000022264.6
 Ptprg
protein tyrosine phosphatase, receptor type, G
chr7_+_19094594 1.833 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 9.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.6 7.3 GO:0071257 cellular response to electrical stimulus(GO:0071257)
0.1 5.2 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
1.0 4.1 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.7 3.7 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223) hard palate development(GO:0060022)
0.1 3.1 GO:0007520 myoblast fusion(GO:0007520)
0.1 2.3 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 2.2 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.5 2.1 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.5 2.0 GO:0072236 DCT cell differentiation(GO:0072069) metanephric loop of Henle development(GO:0072236) metanephric DCT cell differentiation(GO:0072240)
0.3 2.0 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 1.8 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.1 1.8 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0 1.8 GO:1901998 toxin transport(GO:1901998)
0.0 1.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.4 1.6 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.1 1.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 1.2 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.3 1.1 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2 1.1 GO:0072697 protein localization to cell cortex(GO:0072697)

Gene overrepresentation in cellular_component category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.5 GO:0045180 basal cortex(GO:0045180)
0.3 7.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 5.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 3.7 GO:0030027 lamellipodium(GO:0030027)
0.0 3.1 GO:0031965 nuclear membrane(GO:0031965)
0.5 2.2 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.0 2.1 GO:0008180 COP9 signalosome(GO:0008180)
0.0 2.0 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 1.8 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 1.4 GO:0097440 apical dendrite(GO:0097440)
0.3 1.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.9 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.1 0.9 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 0.8 GO:0045298 tubulin complex(GO:0045298)
0.0 0.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.1 0.5 GO:0000235 astral microtubule(GO:0000235)
0.0 0.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.1 GO:1902737 dendritic filopodium(GO:1902737)
0.0 0.1 GO:1990745 EARP complex(GO:1990745)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 GO:0003774 motor activity(GO:0003774)
0.7 5.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 4.8 GO:0045296 cadherin binding(GO:0045296)
0.8 4.1 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.2 3.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 3.4 GO:0008432 JUN kinase binding(GO:0008432)
0.1 3.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.4 2.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 2.2 GO:0000400 four-way junction DNA binding(GO:0000400)
0.4 2.1 GO:0043532 angiostatin binding(GO:0043532)
0.1 2.0 GO:0071837 HMG box domain binding(GO:0071837)
0.5 1.8 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.6 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0051018 protein kinase A binding(GO:0051018)
0.3 1.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328)
0.2 1.1 GO:0098634 protein binding involved in cell-matrix adhesion(GO:0098634)
0.1 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 0.8 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 5.2 PID_TRAIL_PATHWAY TRAIL signaling pathway
0.1 4.3 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 2.8 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 2.3 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 2.0 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.0 1.2 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 1.2 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.9 PID_NEPHRIN_NEPH1_PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 0.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 0.5 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.5 PID_TNF_PATHWAY TNF receptor signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.3 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.4 5.2 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 3.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 2.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.1 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.2 2.0 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.8 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1 1.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.1 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELL_ADHESION_PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP