Motif ID: Nr1h2
Z-value: 0.893
Transcription factors associated with Nr1h2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Nr1h2 | ENSMUSG00000060601.6 | Nr1h2 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nr1h2 | mm10_v2_chr7_-_44553901_44553955 | 0.82 | 7.0e-10 | Click! |
Top targets:
Showing 1 to 20 of 122 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 57 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 8.7 | GO:0055099 | response to high density lipoprotein particle(GO:0055099) platelet dense granule organization(GO:0060155) |
| 0.9 | 6.9 | GO:0003062 | regulation of heart rate by chemical signal(GO:0003062) |
| 0.1 | 6.9 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.2 | 6.0 | GO:0010866 | regulation of triglyceride biosynthetic process(GO:0010866) |
| 0.6 | 3.5 | GO:0032196 | regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529) transposition(GO:0032196) |
| 0.3 | 3.5 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.0 | 3.5 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.7 | 3.4 | GO:0046208 | spermine catabolic process(GO:0046208) |
| 0.2 | 3.2 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 3.2 | GO:0006073 | glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) glucan metabolic process(GO:0044042) |
| 0.5 | 2.8 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.1 | 2.8 | GO:0060487 | lung epithelial cell differentiation(GO:0060487) |
| 0.2 | 2.5 | GO:0051574 | positive regulation of histone H3-K9 methylation(GO:0051574) |
| 0.1 | 2.5 | GO:0044381 | glucose import in response to insulin stimulus(GO:0044381) |
| 0.8 | 2.3 | GO:0014891 | striated muscle atrophy(GO:0014891) |
| 0.6 | 2.3 | GO:0090238 | positive regulation of arachidonic acid secretion(GO:0090238) |
| 0.5 | 2.0 | GO:2000158 | positive regulation of ubiquitin-specific protease activity(GO:2000158) |
| 0.1 | 2.0 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.3 | 1.9 | GO:0002317 | plasma cell differentiation(GO:0002317) |
| 0.1 | 1.6 | GO:0021684 | cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 23 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 8.7 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 3.5 | GO:0072686 | mitotic spindle(GO:0072686) |
| 0.5 | 3.2 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 3.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 2.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 2.7 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 2.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.5 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.4 | 2.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 1.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.4 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.3 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 1.3 | GO:0043196 | varicosity(GO:0043196) |
| 0.0 | 1.3 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.2 | 0.9 | GO:0031523 | Myb complex(GO:0031523) |
| 0.2 | 0.8 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.2 | 0.6 | GO:0045098 | type III intermediate filament(GO:0045098) |
| 0.1 | 0.5 | GO:0097447 | dendritic tree(GO:0097447) |
| 0.0 | 0.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.4 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 52 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 8.7 | GO:0030226 | apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556) |
| 0.1 | 6.9 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
| 0.1 | 6.9 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.9 | 3.5 | GO:0047844 | deoxycytidine deaminase activity(GO:0047844) |
| 0.1 | 3.5 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.5 | 3.2 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.3 | 3.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.5 | 2.8 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.6 | 2.5 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 2.5 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 0.3 | 2.3 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.2 | 2.3 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 0.5 | 2.0 | GO:0035800 | deubiquitinase activator activity(GO:0035800) |
| 0.6 | 1.9 | GO:0004145 | diamine N-acetyltransferase activity(GO:0004145) |
| 0.0 | 1.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.5 | 1.5 | GO:0046592 | polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901) |
| 0.0 | 1.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.3 | 1.3 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 1.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 1.3 | GO:0032947 | protein complex scaffold(GO:0032947) |
Gene overrepresentation in C2:CP category:
Showing 1 to 15 of 15 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.5 | PID_RXR_VDR_PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 3.2 | PID_CD8_TCR_PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.1 | 2.5 | PID_INSULIN_GLUCOSE_PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 2.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.1 | 1.9 | PID_INTEGRIN_A9B1_PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.4 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.9 | PID_E2F_PATHWAY | E2F transcription factor network |
| 0.0 | 0.8 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.8 | PID_FANCONI_PATHWAY | Fanconi anemia pathway |
| 0.0 | 0.8 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.8 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 0.7 | PID_ANTHRAX_PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 0.7 | PID_ARF6_TRAFFICKING_PATHWAY | Arf6 trafficking events |
| 0.0 | 0.5 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 24 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 8.7 | REACTOME_HDL_MEDIATED_LIPID_TRANSPORT | Genes involved in HDL-mediated lipid transport |
| 0.2 | 6.9 | REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION | Genes involved in RORA Activates Circadian Expression |
| 0.2 | 3.5 | REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE | Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase |
| 0.2 | 3.4 | REACTOME_METABOLISM_OF_POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.5 | 3.2 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.2 | 3.2 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 3.0 | REACTOME_ACYL_CHAIN_REMODELLING_OF_PC | Genes involved in Acyl chain remodelling of PC |
| 0.0 | 2.8 | REACTOME_AMINO_ACID_AND_OLIGOPEPTIDE_SLC_TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 2.5 | REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.2 | 2.3 | REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 2.0 | REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.2 | 1.2 | REACTOME_ENDOGENOUS_STEROLS | Genes involved in Endogenous sterols |
| 0.0 | 0.9 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
| 0.0 | 0.9 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 0.8 | REACTOME_PURINE_CATABOLISM | Genes involved in Purine catabolism |
| 0.0 | 0.8 | REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE | Genes involved in MyD88:Mal cascade initiated on plasma membrane |
| 0.0 | 0.7 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 0.6 | REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.5 | REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM | Genes involved in alpha-linolenic acid (ALA) metabolism |
| 0.0 | 0.5 | REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
