Motif ID: Nr1i3

Z-value: 1.080


Transcription factors associated with Nr1i3:

Gene SymbolEntrez IDGene Name
Nr1i3 ENSMUSG00000005677.8 Nr1i3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr1i3mm10_v2_chr1_+_171213969_1712140070.086.3e-01Click!


Activity profile for motif Nr1i3.

activity profile for motif Nr1i3


Sorted Z-values histogram for motif Nr1i3

Sorted Z-values for motif Nr1i3



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_25469742 4.626 ENSMUST00000114259.2
ENSMUST00000015234.6
 Ptgds

prostaglandin D2 synthase (brain)

chr10_-_102490418 3.884 ENSMUST00000020040.3
 Nts
neurotensin
chr11_+_113619318 2.557 ENSMUST00000146390.2
ENSMUST00000106630.1
 Sstr2

somatostatin receptor 2

chr11_-_3931960 2.424 ENSMUST00000109990.1
ENSMUST00000020710.4
ENSMUST00000109989.3
ENSMUST00000109991.1
ENSMUST00000109993.2
 Tcn2




transcobalamin 2




chr1_+_135729147 2.392 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr1_+_90203980 2.378 ENSMUST00000065587.4
ENSMUST00000159654.1
 Ackr3

atypical chemokine receptor 3

chr2_-_25470031 2.366 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr11_+_61485431 2.323 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr6_-_5256226 2.234 ENSMUST00000125686.1
ENSMUST00000031773.2
 Pon3

paraoxonase 3

chr10_+_57794335 2.228 ENSMUST00000151623.1
ENSMUST00000020022.7
 Smpdl3a

sphingomyelin phosphodiesterase, acid-like 3A

chr10_+_61171954 2.058 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr4_-_136892867 2.053 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_-_140183404 1.801 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chr6_+_134929118 1.728 ENSMUST00000185152.1
ENSMUST00000184504.1
 RP23-45G16.5

RP23-45G16.5

chr11_+_101468164 1.666 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr6_+_134929089 1.635 ENSMUST00000183867.1
ENSMUST00000184991.1
ENSMUST00000183905.1
 RP23-45G16.5


RP23-45G16.5


chr16_+_91269759 1.583 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr15_-_35938009 1.554 ENSMUST00000156915.1
 Cox6c
cytochrome c oxidase subunit VIc
chr5_-_116422858 1.541 ENSMUST00000036991.4
 Hspb8
heat shock protein 8
chr7_-_141010759 1.511 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 598 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 7.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.3 4.9 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 4.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 4.0 GO:0071493 cellular response to UV-B(GO:0071493)
0.9 3.5 GO:0015889 cobalamin transport(GO:0015889)
0.3 3.3 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.5 3.0 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.9 2.7 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.2 2.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 2.7 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 2.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.3 2.6 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 2.6 GO:0038092 nodal signaling pathway(GO:0038092)
0.1 2.6 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.4 2.5 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
0.2 2.5 GO:0030432 peristalsis(GO:0030432)
0.1 2.4 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.4 2.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 2.3 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.3 GO:0009409 response to cold(GO:0009409)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 243 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 20.1 GO:0005615 extracellular space(GO:0005615)
0.2 11.1 GO:0070469 respiratory chain(GO:0070469)
0.0 9.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 7.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 6.2 GO:0019866 organelle inner membrane(GO:0019866)
0.1 5.9 GO:0072562 blood microparticle(GO:0072562)
0.1 5.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.9 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 4.6 GO:0005657 replication fork(GO:0005657)
0.1 4.3 GO:0015934 large ribosomal subunit(GO:0015934)
0.1 4.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 3.6 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.5 GO:0000922 spindle pole(GO:0000922)
0.5 3.3 GO:0042627 chylomicron(GO:0042627)
0.3 2.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 2.7 GO:0045275 respiratory chain complex III(GO:0045275)
0.2 2.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 2.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.8 2.3 GO:0071953 elastic fiber(GO:0071953)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 373 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0003735 structural constituent of ribosome(GO:0003735)
1.7 7.0 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.3 6.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 5.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.2 4.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.4 3.9 GO:0008430 selenium binding(GO:0008430)
0.5 3.4 GO:0031419 cobalamin binding(GO:0031419)
1.1 3.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.5 3.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 3.2 GO:0071837 HMG box domain binding(GO:0071837)
0.1 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.8 3.1 GO:0001851 complement component C3b binding(GO:0001851)
0.4 3.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.7 2.9 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.3 2.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.7 GO:0030228 lipoprotein particle receptor activity(GO:0030228)
0.0 2.7 GO:0005178 integrin binding(GO:0005178)
0.9 2.6 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 2.6 GO:0005179 hormone activity(GO:0005179)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 5.6 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 5.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.2 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 4.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.4 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 4.2 PID_PLK1_PATHWAY PLK1 signaling events
0.1 2.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 2.6 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3 2.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 2.3 PID_BARD1_PATHWAY BARD1 signaling events
0.0 2.2 PID_AVB3_INTEGRIN_PATHWAY Integrins in angiogenesis
0.1 2.1 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.1 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.9 PID_IL12_2PATHWAY IL12-mediated signaling events
0.1 1.6 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.1 1.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 1.5 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID_ILK_PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 131 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 16.4 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 5.9 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.7 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 4.5 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 4.3 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 4.2 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.1 4.2 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 3.7 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 3.4 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 3.2 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.6 3.0 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.3 3.0 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 2.8 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.7 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.3 2.3 REACTOME_COMPLEMENT_CASCADE Genes involved in Complement cascade
0.1 2.2 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 2.1 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 2.0 REACTOME_KINESINS Genes involved in Kinesins