Motif ID: Nr2c1

Z-value: 0.725


Transcription factors associated with Nr2c1:

Gene SymbolEntrez IDGene Name
Nr2c1 ENSMUSG00000005897.8 Nr2c1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c1mm10_v2_chr10_+_94147982_94148023-0.421.0e-02Click!


Activity profile for motif Nr2c1.

activity profile for motif Nr2c1


Sorted Z-values histogram for motif Nr2c1

Sorted Z-values for motif Nr2c1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 119 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_29411736 4.514 ENSMUST00000115236.1
 Ntm
neurotrimin
chr9_-_29412204 4.136 ENSMUST00000115237.1
 Ntm
neurotrimin
chr15_+_80091320 3.997 ENSMUST00000009728.6
ENSMUST00000009727.5
 Syngr1

synaptogyrin 1

chr15_+_3270767 3.730 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr9_-_21037775 3.682 ENSMUST00000180870.1
 Gm26592
predicted gene, 26592
chr6_+_22875496 3.575 ENSMUST00000090568.3
 Ptprz1
protein tyrosine phosphatase, receptor type Z, polypeptide 1
chr10_+_58813359 3.472 ENSMUST00000135526.2
ENSMUST00000153031.1
 Sh3rf3

SH3 domain containing ring finger 3

chr4_-_46991842 3.317 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr3_+_68572245 3.099 ENSMUST00000170788.2
 Schip1
schwannomin interacting protein 1
chr11_-_76577701 3.005 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr7_+_45896941 2.509 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr10_-_86498836 2.445 ENSMUST00000120638.1
 Syn3
synapsin III
chr12_+_61523889 2.432 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_75193783 2.378 ENSMUST00000102514.3
 Rtn4rl1
reticulon 4 receptor-like 1
chr7_+_45897429 1.708 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr12_-_83487708 1.625 ENSMUST00000177959.1
ENSMUST00000178756.1
 Dpf3

D4, zinc and double PHD fingers, family 3

chr1_+_195017399 1.619 ENSMUST00000181273.1
 A330023F24Rik
RIKEN cDNA A330023F24 gene
chr11_-_26210553 1.535 ENSMUST00000101447.3
 5730522E02Rik
RIKEN cDNA 5730522E02 gene
chr15_-_79505241 1.511 ENSMUST00000057801.6
 Kcnj4
potassium inwardly-rectifying channel, subfamily J, member 4
chr10_-_86498872 1.355 ENSMUST00000121789.1
 Syn3
synapsin III

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.2 4.0 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.0 3.8 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
1.2 3.6 GO:1900149 positive regulation of Schwann cell migration(GO:1900149)
0.1 3.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 3.1 GO:0001553 luteinization(GO:0001553)
0.6 3.0 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.0 3.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 2.3 GO:0048681 negative regulation of axon regeneration(GO:0048681)
0.6 1.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.0 1.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.5 1.5 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 1.5 GO:0010107 potassium ion import(GO:0010107)
0.1 1.4 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.3 1.3 GO:0032275 luteinizing hormone secretion(GO:0032275) positive regulation of gonadotropin secretion(GO:0032278)
0.2 1.2 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.2 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) phosphate ion transmembrane transport(GO:0035435) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.2 GO:0032060 bleb assembly(GO:0032060)
0.0 1.2 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.1 1.1 GO:0051639 actin filament network formation(GO:0051639)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.6 GO:0031225 anchored component of membrane(GO:0031225)
0.1 7.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.2 3.6 GO:0072534 perineuronal net(GO:0072534)
0.1 3.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 3.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.7 3.3 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.2 1.7 GO:0097427 microtubule bundle(GO:0097427)
0.1 1.6 GO:0071565 nBAF complex(GO:0071565)
0.0 1.6 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 1.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 1.2 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.1 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.0 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.0 1.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 0.9 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.6 3.3 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.0 3.0 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 2.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.3 1.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 1.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 1.4 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.4 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.4 1.2 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.4 1.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.3 1.0 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 1.0 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 0.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.9 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.9 GO:0043022 ribosome binding(GO:0043022)
0.0 0.8 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 1.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 1.0 PID_LKB1_PATHWAY LKB1 signaling events
0.0 1.0 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.8 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.0 0.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 3.8 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 3.3 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 3.0 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 1.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 1.4 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.1 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 1.0 REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 0.9 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 0.6 REACTOME_ACYL_CHAIN_REMODELLING_OF_PS Genes involved in Acyl chain remodelling of PS
0.1 0.5 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME_CALNEXIN_CALRETICULIN_CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.2 REACTOME_ACYL_CHAIN_REMODELLING_OF_PG Genes involved in Acyl chain remodelling of PG
0.0 0.1 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol