Motif ID: Nr2c2

Z-value: 1.050


Transcription factors associated with Nr2c2:

Gene SymbolEntrez IDGene Name
Nr2c2 ENSMUSG00000005893.8 Nr2c2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2c2mm10_v2_chr6_+_92092369_92092433-0.316.3e-02Click!


Activity profile for motif Nr2c2.

activity profile for motif Nr2c2


Sorted Z-values histogram for motif Nr2c2

Sorted Z-values for motif Nr2c2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2c2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_61485431 7.796 ENSMUST00000064783.3
ENSMUST00000040522.6
 Mfap4

microfibrillar-associated protein 4

chr4_-_97778042 5.621 ENSMUST00000146447.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr1_-_138847579 5.424 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr7_+_79500018 5.026 ENSMUST00000182495.1
ENSMUST00000183043.1
 AI854517

expressed sequence AI854517

chr14_-_52020698 4.986 ENSMUST00000067549.7
 Zfp219
zinc finger protein 219
chr7_+_79500081 4.942 ENSMUST00000181511.2
ENSMUST00000182937.1
 AI854517

expressed sequence AI854517

chr14_+_65806066 4.057 ENSMUST00000139644.1
 Pbk
PDZ binding kinase
chr1_-_120120138 3.944 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr3_-_52104891 3.942 ENSMUST00000121440.1
 Maml3
mastermind like 3 (Drosophila)
chr6_-_48841373 3.880 ENSMUST00000166247.1
 Tmem176b
transmembrane protein 176B
chr13_-_24761861 3.703 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr11_+_80300866 3.616 ENSMUST00000017836.7
 Rhbdl3
rhomboid, veinlet-like 3 (Drosophila)
chr11_-_77894096 3.482 ENSMUST00000017597.4
 Pipox
pipecolic acid oxidase
chr10_-_88146867 3.370 ENSMUST00000164121.1
ENSMUST00000164803.1
ENSMUST00000168163.1
ENSMUST00000048518.9
 Parpbp



PARP1 binding protein



chr15_-_10713537 3.346 ENSMUST00000090339.3
 Rai14
retinoic acid induced 14
chr17_+_35049966 3.263 ENSMUST00000007257.9
 Clic1
chloride intracellular channel 1
chr14_+_65805832 3.261 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr6_+_48841476 3.161 ENSMUST00000101426.4
 Tmem176a
transmembrane protein 176A
chr6_+_48841633 3.090 ENSMUST00000168406.1
 Tmem176a
transmembrane protein 176A
chr4_+_59581563 3.014 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 209 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.4 10.1 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
2.6 7.9 GO:0030421 defecation(GO:0030421)
0.9 7.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 7.3 GO:0070303 negative regulation of stress-activated MAPK cascade(GO:0032873) negative regulation of stress-activated protein kinase signaling cascade(GO:0070303)
1.1 5.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
1.1 5.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.4 5.2 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.3 5.2 GO:0072189 ureter development(GO:0072189)
0.1 4.6 GO:0035411 catenin import into nucleus(GO:0035411)
0.1 4.0 GO:0008156 negative regulation of DNA replication(GO:0008156)
0.4 3.9 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.9 3.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.2 3.6 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
1.2 3.5 GO:0006553 lysine metabolic process(GO:0006553)
0.4 3.3 GO:0015074 DNA integration(GO:0015074)
0.1 3.3 GO:1902476 chloride transmembrane transport(GO:1902476)
0.7 3.0 GO:0030997 regulation of centriole-centriole cohesion(GO:0030997)
0.6 3.0 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.4 3.0 GO:0060028 convergent extension involved in axis elongation(GO:0060028)
0.3 2.9 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 7.8 GO:0071953 elastic fiber(GO:0071953)
0.1 5.8 GO:0000791 euchromatin(GO:0000791)
0.4 5.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 5.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 5.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 3.6 GO:0005814 centriole(GO:0005814)
0.1 3.5 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 2.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 2.5 GO:0060187 cell pole(GO:0060187)
0.8 2.3 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.0 2.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.2 GO:0016514 SWI/SNF complex(GO:0016514)
0.5 2.1 GO:0032021 NELF complex(GO:0032021)
0.3 2.0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 2.0 GO:0005871 kinesin complex(GO:0005871)
0.5 1.9 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.1 1.9 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 1.8 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 6.3 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.9 5.6 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 5.3 GO:0008083 growth factor activity(GO:0008083)
1.3 5.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 5.0 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 4.6 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 4.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 3.9 GO:0004386 helicase activity(GO:0004386)
0.9 3.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 3.5 GO:0005254 chloride channel activity(GO:0005254)
0.2 3.4 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.6 2.9 GO:0032027 myosin light chain binding(GO:0032027)
0.1 2.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.2 2.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 2.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.9 2.6 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.2 2.5 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.5 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.1 2.5 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 7.9 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.1 4.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.1 3.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 3.2 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.7 PID_E2F_PATHWAY E2F transcription factor network
0.0 2.6 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 2.2 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.2 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 1.9 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 1.6 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.6 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 1.4 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.2 PID_IL1_PATHWAY IL1-mediated signaling events
0.1 0.9 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 0.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 8.7 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.3 5.4 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.3 4.5 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 3.2 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 3.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.2 2.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.3 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.1 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.1 1.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 1.5 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.1 1.4 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.4 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 1.2 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 1.2 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ Genes involved in Cleavage of Growing Transcript in the Termination Region
0.0 1.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.1 1.1 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 1.0 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.0 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.2 0.9 REACTOME_ANDROGEN_BIOSYNTHESIS Genes involved in Androgen biosynthesis