Motif ID: Nr2f1_Nr4a1

Z-value: 0.627

Transcription factors associated with Nr2f1_Nr4a1:

Gene SymbolEntrez IDGene Name
Nr2f1 ENSMUSG00000069171.7 Nr2f1
Nr4a1 ENSMUSG00000023034.6 Nr4a1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f1mm10_v2_chr13_-_78196373_78196440-0.231.7e-01Click!
Nr4a1mm10_v2_chr15_+_101266839_101266859-0.153.8e-01Click!


Activity profile for motif Nr2f1_Nr4a1.

activity profile for motif Nr2f1_Nr4a1


Sorted Z-values histogram for motif Nr2f1_Nr4a1

Sorted Z-values for motif Nr2f1_Nr4a1



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f1_Nr4a1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_106656081 2.519 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr2_+_71981184 2.390 ENSMUST00000090826.5
ENSMUST00000102698.3
 Rapgef4

Rap guanine nucleotide exchange factor (GEF) 4

chr12_+_61523889 2.226 ENSMUST00000119481.1
ENSMUST00000055815.7
 Lrfn5

leucine rich repeat and fibronectin type III domain containing 5

chr11_+_7063423 2.196 ENSMUST00000020706.4
 Adcy1
adenylate cyclase 1
chr15_-_79804717 1.885 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr5_+_63649335 1.851 ENSMUST00000159584.1
 3110047P20Rik
RIKEN cDNA 3110047P20 gene
chr8_+_124793013 1.750 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr1_-_164458345 1.716 ENSMUST00000027863.7
 Atp1b1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr8_+_124793061 1.568 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr11_-_3504766 1.520 ENSMUST00000044507.5
 Inpp5j
inositol polyphosphate 5-phosphatase J
chr2_-_113217051 1.498 ENSMUST00000080673.5
 Ryr3
ryanodine receptor 3
chr2_-_13011747 1.446 ENSMUST00000061545.5
 C1ql3
C1q-like 3
chr10_+_79716588 1.430 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr11_-_76577701 1.412 ENSMUST00000176179.1
 Abr
active BCR-related gene
chr6_+_91157373 1.319 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr9_-_70141484 1.315 ENSMUST00000034749.8
 Fam81a
family with sequence similarity 81, member A
chr17_+_29360923 1.306 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr2_-_59160644 1.294 ENSMUST00000077687.5
 Ccdc148
coiled-coil domain containing 148
chr10_-_78464853 1.205 ENSMUST00000105385.1
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase
chr10_-_78464969 1.180 ENSMUST00000041616.8
 Pdxk
pyridoxal (pyridoxine, vitamin B6) kinase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 238 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.1 3.2 GO:0014003 oligodendrocyte development(GO:0014003)
0.1 2.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.0 2.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.8 2.4 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.6 2.4 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.3 2.4 GO:0071420 cellular response to histamine(GO:0071420)
0.2 2.2 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 2.1 GO:0001553 luteinization(GO:0001553)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.6 1.8 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 1.8 GO:0014047 glutamate secretion(GO:0014047)
0.1 1.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 1.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.0 1.7 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.5 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 1.4 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.3 1.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.2 1.4 GO:0019388 galactose catabolic process(GO:0019388)
0.2 1.3 GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions(GO:0001980)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 3.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.5 GO:0043204 perikaryon(GO:0043204)
0.5 2.4 GO:0044316 cone cell pedicle(GO:0044316)
0.0 2.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 2.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 2.0 GO:0005930 axoneme(GO:0005930)
0.1 1.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.3 1.8 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 1.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 1.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.3 1.5 GO:0030314 junctional membrane complex(GO:0030314)
0.5 1.4 GO:0098855 HCN channel complex(GO:0098855)
0.1 1.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 1.4 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 1.3 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.3 GO:0030137 COPI-coated vesicle(GO:0030137)
0.1 1.2 GO:0009986 cell surface(GO:0009986)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 149 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 3.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.9 GO:0030552 cAMP binding(GO:0030552)
0.3 2.6 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.1 2.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.5 2.5 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.8 2.4 GO:0031403 lithium ion binding(GO:0031403)
0.1 2.4 GO:0004890 GABA-A receptor activity(GO:0004890)
0.5 2.1 GO:0004111 creatine kinase activity(GO:0004111)
0.3 2.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 2.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.5 1.9 GO:0001847 opsonin receptor activity(GO:0001847)
0.0 1.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.4 1.7 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.1 1.6 GO:0022839 ion gated channel activity(GO:0022839)
0.1 1.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 1.5 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.5 1.5 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.4 1.4 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 2.7 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.0 2.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 2.5 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 2.0 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.0 1.3 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.3 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.0 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.8 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 0.7 PID_P73PATHWAY p73 transcription factor network
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.6 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.6 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 0.4 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.0 0.4 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.3 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.2 3.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 3.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 2.7 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 2.5 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 2.3 REACTOME_G_ALPHA_S_SIGNALLING_EVENTS Genes involved in G alpha (s) signalling events
0.1 2.2 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.2 2.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.8 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.7 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.6 REACTOME_SIGNALING_BY_NOTCH1 Genes involved in Signaling by NOTCH1
0.2 1.5 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 1.1 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 1.1 REACTOME_TRANSPORT_OF_ORGANIC_ANIONS Genes involved in Transport of organic anions
0.1 1.1 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits