Motif ID: Nr2f2

Z-value: 0.742


Transcription factors associated with Nr2f2:

Gene SymbolEntrez IDGene Name
Nr2f2 ENSMUSG00000030551.7 Nr2f2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f2mm10_v2_chr7_-_70366735_70366771-0.344.1e-02Click!


Activity profile for motif Nr2f2.

activity profile for motif Nr2f2


Sorted Z-values histogram for motif Nr2f2

Sorted Z-values for motif Nr2f2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_98053415 5.753 ENSMUST00000017544.2
 Stac2
SH3 and cysteine rich domain 2
chr11_+_50602072 2.721 ENSMUST00000040523.8
 Adamts2
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
chr7_+_48959089 1.853 ENSMUST00000183659.1
 Nav2
neuron navigator 2
chr7_-_79386943 1.802 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr3_-_85746266 1.755 ENSMUST00000118408.1
 Fam160a1
family with sequence similarity 160, member A1
chr3_-_116712198 1.745 ENSMUST00000120120.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr13_-_96132568 1.702 ENSMUST00000161263.1
 Sv2c
synaptic vesicle glycoprotein 2c
chr5_-_71658308 1.690 ENSMUST00000031121.5
 Gabra4
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
chr5_+_64803513 1.625 ENSMUST00000165536.1
 Klf3
Kruppel-like factor 3 (basic)
chr12_+_81026800 1.355 ENSMUST00000110347.2
ENSMUST00000021564.4
ENSMUST00000129362.1
 Smoc1


SPARC related modular calcium binding 1


chr9_+_51765325 1.343 ENSMUST00000065496.5
 Arhgap20
Rho GTPase activating protein 20
chr3_+_121723515 1.274 ENSMUST00000029771.8
 F3
coagulation factor III
chr17_-_46546275 1.251 ENSMUST00000182485.1
ENSMUST00000066026.7
 Cul9

cullin 9

chr3_+_83766300 1.214 ENSMUST00000029625.7
 Sfrp2
secreted frizzled-related protein 2
chr2_+_130406478 1.175 ENSMUST00000055421.4
 Tmem239
transmembrane 239
chr11_-_54068932 1.174 ENSMUST00000093109.4
ENSMUST00000018755.3
 Pdlim4

PDZ and LIM domain 4

chr3_-_116711820 1.163 ENSMUST00000153108.1
 Slc35a3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3
chr14_+_76504478 1.083 ENSMUST00000022587.9
ENSMUST00000134109.1
 Tsc22d1

TSC22 domain family, member 1

chr3_-_132950043 1.076 ENSMUST00000117164.1
ENSMUST00000093971.4
ENSMUST00000042729.9
ENSMUST00000042744.9
ENSMUST00000117811.1
 Npnt




nephronectin




chr7_+_130865835 1.039 ENSMUST00000075181.4
ENSMUST00000048180.5
 Plekha1

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 147 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.9 GO:0015788 UDP-N-acetylglucosamine transport(GO:0015788)
0.2 2.7 GO:0030574 collagen catabolic process(GO:0030574)
0.1 2.7 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 2.6 GO:0051453 regulation of intracellular pH(GO:0051453)
0.5 1.9 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.0 1.9 GO:0007601 visual perception(GO:0007601)
0.2 1.8 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 1.7 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 1.7 GO:2001023 regulation of response to drug(GO:2001023)
0.2 1.7 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 1.5 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.2 1.4 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 1.4 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.4 1.3 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
0.1 1.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.4 1.2 GO:1904956 dermatome development(GO:0061054) sclerotome development(GO:0061056) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.2 1.2 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.2 1.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)
0.4 1.1 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.6 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.7 GO:0031461 cullin-RING ubiquitin ligase complex(GO:0031461)
0.1 1.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.5 GO:0031985 Golgi cisterna(GO:0031985)
0.0 1.4 GO:0032587 ruffle membrane(GO:0032587)
0.2 1.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.3 1.1 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.2 1.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 1.0 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.9 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0005811 lipid particle(GO:0005811)
0.2 0.8 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.2 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.7 GO:0097443 sorting endosome(GO:0097443)
0.1 0.7 GO:0000439 core TFIIH complex(GO:0000439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 3.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 3.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.6 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 2.1 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.3 1.8 GO:0019841 retinol binding(GO:0019841)
0.2 1.8 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.4 1.7 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 1.7 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 1.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.1 1.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 1.4 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 1.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 1.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.2 GO:0042805 actinin binding(GO:0042805)
0.3 1.1 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 1.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.0 1.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.3 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.9 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.9 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.0 0.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.7 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.0 0.6 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 0.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.2 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.2 PID_IL23_PATHWAY IL23-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.9 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 3.2 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 2.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.8 REACTOME_FORMATION_OF_FIBRIN_CLOT_CLOTTING_CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 1.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.6 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 1.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.3 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.1 1.0 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.9 REACTOME_AMINE_COMPOUND_SLC_TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.9 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.9 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.8 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 0.7 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 0.6 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation