Motif ID: Nr2f6

Z-value: 0.837


Transcription factors associated with Nr2f6:

Gene SymbolEntrez IDGene Name
Nr2f6 ENSMUSG00000002393.8 Nr2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_713819770.019.3e-01Click!


Activity profile for motif Nr2f6.

activity profile for motif Nr2f6


Sorted Z-values histogram for motif Nr2f6

Sorted Z-values for motif Nr2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_121967822 5.127 ENSMUST00000137089.1
Arhgap29
Rho GTPase activating protein 29
chr19_-_12501996 4.885 ENSMUST00000045521.7
Dtx4
deltex 4 homolog (Drosophila)
chr12_+_74288735 4.515 ENSMUST00000095617.1
1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr4_+_85205120 3.834 ENSMUST00000107188.3
Sh3gl2
SH3-domain GRB2-like 2
chr9_+_109051153 3.789 ENSMUST00000155541.1
ENSMUST00000120305.1
ENSMUST00000154113.1
ENSMUST00000128976.1
ENSMUST00000135942.1
ENSMUST00000143754.1
Shisa5





shisa homolog 5 (Xenopus laevis)





chr4_+_85205417 3.745 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
Sh3gl2


SH3-domain GRB2-like 2


chr15_-_95528702 3.234 ENSMUST00000166170.1
Nell2
NEL-like 2
chr7_+_45896941 3.144 ENSMUST00000069772.7
ENSMUST00000107716.1
Tmem143

transmembrane protein 143

chr10_-_35711891 2.579 ENSMUST00000080898.2
Amd2
S-adenosylmethionine decarboxylase 2
chr11_+_32283511 2.453 ENSMUST00000093209.3
Hba-a1
hemoglobin alpha, adult chain 1
chr8_+_71469186 2.320 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
Dda1


DET1 and DDB1 associated 1


chr7_+_45897429 2.319 ENSMUST00000140243.1
Tmem143
transmembrane protein 143
chr6_+_83156401 2.279 ENSMUST00000032106.4
1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr7_+_98494222 2.253 ENSMUST00000165205.1
Lrrc32
leucine rich repeat containing 32
chr19_+_47228804 2.203 ENSMUST00000111807.3
Neurl1a
neuralized homolog 1A (Drosophila)
chr15_+_89532816 2.179 ENSMUST00000167173.1
Shank3
SH3/ankyrin domain gene 3
chr9_+_20868628 1.942 ENSMUST00000043911.7
A230050P20Rik
RIKEN cDNA A230050P20 gene
chr9_-_86695897 1.922 ENSMUST00000034989.8
Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_+_25242929 1.864 ENSMUST00000114355.1
ENSMUST00000060818.1
Rnf208

ring finger protein 208

chr2_+_59160838 1.853 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
Pkp4


plakophilin 4


chr10_+_78574492 1.735 ENSMUST00000105384.3
Ilvbl
ilvB (bacterial acetolactate synthase)-like
chr13_-_92131494 1.712 ENSMUST00000099326.3
ENSMUST00000146492.1
Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chr7_-_28766469 1.708 ENSMUST00000085851.5
ENSMUST00000032815.4
Nfkbib

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

chr6_+_85431970 1.685 ENSMUST00000045693.7
Smyd5
SET and MYND domain containing 5
chr16_-_4624984 1.663 ENSMUST00000014445.6
Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr7_-_30232186 1.573 ENSMUST00000006254.5
Tbcb
tubulin folding cofactor B
chr19_-_21472552 1.559 ENSMUST00000087600.3
Gda
guanine deaminase
chr7_-_89941084 1.547 ENSMUST00000075010.4
ENSMUST00000153470.1
l7Rn6

lethal, Chr 7, Rinchik 6

chr6_+_86365673 1.486 ENSMUST00000071492.7
Fam136a
family with sequence similarity 136, member A
chr2_+_91082362 1.456 ENSMUST00000169852.1
Spi1
spleen focus forming virus (SFFV) proviral integration oncogene
chr17_-_35910032 1.321 ENSMUST00000141662.1
ENSMUST00000056034.6
ENSMUST00000077494.6
ENSMUST00000149277.1
ENSMUST00000061052.5
Atat1




alpha tubulin acetyltransferase 1




chr5_-_24902315 1.317 ENSMUST00000131486.1
Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_89941196 1.304 ENSMUST00000117354.1
l7Rn6
lethal, Chr 7, Rinchik 6
chr2_-_59160644 1.254 ENSMUST00000077687.5
Ccdc148
coiled-coil domain containing 148
chr9_+_108460518 1.240 ENSMUST00000061209.5
Ccdc71
coiled-coil domain containing 71
chr10_-_67548944 1.225 ENSMUST00000075686.4
Ado
2-aminoethanethiol (cysteamine) dioxygenase
chr15_-_81871883 1.078 ENSMUST00000023117.8
Phf5a
PHD finger protein 5A
chr9_-_21073494 1.076 ENSMUST00000010348.5
Fdx1l
ferredoxin 1-like
chr10_+_43524080 1.075 ENSMUST00000057649.6
Gm9803
predicted gene 9803
chr18_+_74779190 1.058 ENSMUST00000041053.9
Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr4_-_103215147 1.023 ENSMUST00000150285.1
Slc35d1
solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1
chr5_-_137741601 1.006 ENSMUST00000119498.1
ENSMUST00000061789.7
Nyap1

neuronal tyrosine-phosphorylated phosphoinositide 3-kinase adaptor 1

chr13_-_59769751 0.988 ENSMUST00000057115.6
Isca1
iron-sulfur cluster assembly 1 homolog (S. cerevisiae)
chr13_-_73328442 0.987 ENSMUST00000022097.5
Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
chr5_+_134176358 0.918 ENSMUST00000180674.1
B230377A18Rik
RIKEN cDNA B230377A18 gene
chr17_-_35909626 0.899 ENSMUST00000141132.1
Atat1
alpha tubulin acetyltransferase 1
chr5_+_117120120 0.895 ENSMUST00000111978.1
Taok3
TAO kinase 3
chr15_-_27630644 0.884 ENSMUST00000059662.7
Fam105b
family with sequence similarity 105, member B
chr4_-_11076160 0.881 ENSMUST00000058183.8
Ndufaf6
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr4_-_130174691 0.877 ENSMUST00000132545.2
ENSMUST00000175992.1
ENSMUST00000105999.2
Tinagl1


tubulointerstitial nephritis antigen-like 1


chr12_-_79192248 0.875 ENSMUST00000161204.1
Rdh11
retinol dehydrogenase 11
chr16_+_4684070 0.852 ENSMUST00000060067.5
ENSMUST00000115854.3
Dnaja3

DnaJ (Hsp40) homolog, subfamily A, member 3

chr15_-_100422991 0.843 ENSMUST00000138843.1
ENSMUST00000023774.5
Slc11a2

solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2

chr2_+_25242227 0.843 ENSMUST00000154498.1
Rnf208
ring finger protein 208
chr9_+_110344185 0.740 ENSMUST00000142100.1
Scap
SREBF chaperone
chr3_+_115888139 0.737 ENSMUST00000106505.1
ENSMUST00000043342.9
Dph5

DPH5 homolog (S. cerevisiae)

chr19_-_3912711 0.728 ENSMUST00000075092.6
Ndufs8
NADH dehydrogenase (ubiquinone) Fe-S protein 8
chr10_-_119240006 0.728 ENSMUST00000020315.6
Cand1
cullin associated and neddylation disassociated 1
chr1_+_74284930 0.717 ENSMUST00000113805.1
ENSMUST00000027370.6
ENSMUST00000087226.4
Pnkd


paroxysmal nonkinesiogenic dyskinesia


chr7_-_19715395 0.707 ENSMUST00000032555.9
ENSMUST00000093552.5
Tomm40

translocase of outer mitochondrial membrane 40 homolog (yeast)

chr9_-_44767792 0.696 ENSMUST00000034607.9
Arcn1
archain 1
chr18_+_63708689 0.690 ENSMUST00000072726.5
Wdr7
WD repeat domain 7
chr6_+_124712279 0.686 ENSMUST00000004375.9
Phb2
prohibitin 2
chr14_+_57798156 0.673 ENSMUST00000128764.1
Sap18
Sin3-associated polypeptide 18
chr7_+_30232310 0.672 ENSMUST00000108193.1
ENSMUST00000108192.1
Polr2i

polymerase (RNA) II (DNA directed) polypeptide I

chr1_+_63176818 0.664 ENSMUST00000129339.1
Eef1b2
eukaryotic translation elongation factor 1 beta 2
chr10_+_93589413 0.640 ENSMUST00000181835.1
4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr6_+_125145235 0.633 ENSMUST00000119527.1
ENSMUST00000088276.6
ENSMUST00000051171.7
ENSMUST00000117675.1
Iffo1



intermediate filament family orphan 1



chr16_-_44139630 0.616 ENSMUST00000137557.1
ENSMUST00000147025.1
Atp6v1a

ATPase, H+ transporting, lysosomal V1 subunit A

chr11_+_116198853 0.611 ENSMUST00000021130.6
Ten1
TEN1 telomerase capping complex subunit
chr14_+_57798637 0.609 ENSMUST00000111267.1
Sap18
Sin3-associated polypeptide 18
chr11_-_33513736 0.605 ENSMUST00000102815.3
Ranbp17
RAN binding protein 17
chr10_-_93589621 0.603 ENSMUST00000020203.6
Snrpf
small nuclear ribonucleoprotein polypeptide F
chr11_-_33513626 0.571 ENSMUST00000037522.7
Ranbp17
RAN binding protein 17
chr5_+_36464998 0.549 ENSMUST00000031099.3
Grpel1
GrpE-like 1, mitochondrial
chr1_+_172499948 0.546 ENSMUST00000111230.1
Tagln2
transgelin 2
chr6_-_137649211 0.505 ENSMUST00000134630.1
ENSMUST00000058210.6
ENSMUST00000111878.1
Eps8


epidermal growth factor receptor pathway substrate 8


chr11_+_4986824 0.503 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr5_-_31202215 0.503 ENSMUST00000176245.1
ENSMUST00000177310.1
ENSMUST00000114590.1
Zfp513


zinc finger protein 513


chr13_+_43370710 0.500 ENSMUST00000066804.4
Sirt5
sirtuin 5
chr15_+_81872309 0.481 ENSMUST00000023116.6
Aco2
aconitase 2, mitochondrial
chr7_+_3617357 0.479 ENSMUST00000076657.4
ENSMUST00000108644.1
Ndufa3

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3

chr14_+_57798620 0.470 ENSMUST00000111268.1
Sap18
Sin3-associated polypeptide 18
chr3_-_8923796 0.468 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chrX_+_6415736 0.459 ENSMUST00000143641.3
Shroom4
shroom family member 4
chr1_+_74506044 0.459 ENSMUST00000087215.5
Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr2_+_30266721 0.457 ENSMUST00000113645.1
ENSMUST00000133877.1
ENSMUST00000139719.1
ENSMUST00000113643.1
ENSMUST00000150695.1
Phyhd1




phytanoyl-CoA dioxygenase domain containing 1




chr11_+_115475645 0.440 ENSMUST00000035240.6
Armc7
armadillo repeat containing 7
chr1_-_74284636 0.438 ENSMUST00000178235.1
ENSMUST00000006462.7
Aamp

angio-associated migratory protein

chr5_-_134176720 0.399 ENSMUST00000076228.2
Wbscr16
Williams-Beuren syndrome chromosome region 16 homolog (human)
chr19_-_45998479 0.391 ENSMUST00000045396.7
9130011E15Rik
RIKEN cDNA 9130011E15 gene
chr2_+_164805082 0.390 ENSMUST00000052107.4
Zswim3
zinc finger SWIM-type containing 3
chr11_+_101442298 0.373 ENSMUST00000077856.6
Rpl27
ribosomal protein L27
chr4_+_118409331 0.365 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr19_-_27429807 0.359 ENSMUST00000076219.4
D19Bwg1357e
DNA segment, Chr 19, Brigham & Women's Genetics 1357 expressed
chr2_+_30266513 0.341 ENSMUST00000091132.6
Phyhd1
phytanoyl-CoA dioxygenase domain containing 1
chr5_+_31697960 0.324 ENSMUST00000114515.2
Bre
brain and reproductive organ-expressed protein
chr16_+_18248866 0.313 ENSMUST00000115640.1
ENSMUST00000140206.1
Trmt2a

TRM2 tRNA methyltransferase 2A

chr9_-_22135675 0.310 ENSMUST00000165735.1
Acp5
acid phosphatase 5, tartrate resistant
chr5_+_31698050 0.306 ENSMUST00000114507.3
ENSMUST00000063813.4
ENSMUST00000071531.5
ENSMUST00000131995.1
Bre



brain and reproductive organ-expressed protein



chr11_+_101442440 0.302 ENSMUST00000107249.1
Rpl27
ribosomal protein L27
chr10_+_128747850 0.285 ENSMUST00000163377.2
Wibg
within bgcn homolog (Drosophila)
chr11_+_109485606 0.284 ENSMUST00000106697.1
Arsg
arylsulfatase G
chr11_-_84870712 0.265 ENSMUST00000170741.1
ENSMUST00000172405.1
ENSMUST00000100686.3
ENSMUST00000108081.2
Ggnbp2



gametogenetin binding protein 2



chr19_+_10001669 0.255 ENSMUST00000121418.1
Rab3il1
RAB3A interacting protein (rabin3)-like 1
chr14_+_57798182 0.226 ENSMUST00000111269.1
Sap18
Sin3-associated polypeptide 18
chr7_-_98119482 0.225 ENSMUST00000138627.1
ENSMUST00000107127.1
ENSMUST00000107128.1
Myo7a


myosin VIIA


chr5_-_31697598 0.207 ENSMUST00000031018.7
Rbks
ribokinase
chr16_-_18248697 0.188 ENSMUST00000115645.3
Ranbp1
RAN binding protein 1
chr6_+_113237843 0.185 ENSMUST00000113146.2
Mtmr14
myotubularin related protein 14
chr11_-_84870646 0.181 ENSMUST00000018547.2
Ggnbp2
gametogenetin binding protein 2
chr3_-_115888086 0.172 ENSMUST00000067500.5
A930005H10Rik
RIKEN cDNA A930005H10 gene
chr1_+_180726019 0.171 ENSMUST00000027780.4
Acbd3
acyl-Coenzyme A binding domain containing 3
chr2_-_164804876 0.169 ENSMUST00000103094.4
ENSMUST00000017451.6
Acot8

acyl-CoA thioesterase 8

chr11_-_84870812 0.163 ENSMUST00000168434.1
Ggnbp2
gametogenetin binding protein 2
chr5_+_31697665 0.152 ENSMUST00000080598.7
Bre
brain and reproductive organ-expressed protein
chr2_+_158028687 0.140 ENSMUST00000109518.1
ENSMUST00000029180.7
Rprd1b

regulation of nuclear pre-mRNA domain containing 1B

chr7_+_38183217 0.139 ENSMUST00000165308.1
1600014C10Rik
RIKEN cDNA 1600014C10 gene
chr1_-_171360798 0.130 ENSMUST00000061878.4
Klhdc9
kelch domain containing 9
chr10_-_14705459 0.122 ENSMUST00000149485.1
ENSMUST00000154132.1
Vta1

Vps20-associated 1 homolog (S. cerevisiae)

chr9_+_21002737 0.102 ENSMUST00000003386.5
Mrpl4
mitochondrial ribosomal protein L4
chr2_+_180710117 0.071 ENSMUST00000029090.2
Gid8
GID complex subunit 8 homolog (S. cerevisiae)
chr9_+_108662098 0.070 ENSMUST00000035222.5
Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr19_-_47536997 0.069 ENSMUST00000182808.1
ENSMUST00000049369.9
Obfc1

oligonucleotide/oligosaccharide-binding fold containing 1

chr16_+_18248961 0.058 ENSMUST00000100099.3
Trmt2a
TRM2 tRNA methyltransferase 2A
chr11_-_116199040 0.036 ENSMUST00000066587.5
Acox1
acyl-Coenzyme A oxidase 1, palmitoyl
chr14_+_122534305 0.013 ENSMUST00000154206.1
ENSMUST00000038374.6
ENSMUST00000135578.1
Pcca


propionyl-Coenzyme A carboxylase, alpha polypeptide


chr2_+_158028733 0.012 ENSMUST00000152452.1
Rprd1b
regulation of nuclear pre-mRNA domain containing 1B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.9 2.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.7 2.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.5 1.6 GO:0046098 guanine metabolic process(GO:0046098)
0.5 4.4 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.4 1.9 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.4 3.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.3 2.5 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.3 0.9 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.3 1.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.3 1.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.3 2.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.3 1.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2 0.7 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.2 0.7 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.2 0.7 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 2.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.2 0.8 GO:0015692 vanadium ion transport(GO:0015676) lead ion transport(GO:0015692)
0.1 1.0 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 0.5 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.6 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.9 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.1 1.0 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 0.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.1 0.5 GO:0006102 isocitrate metabolic process(GO:0006102)
0.1 1.9 GO:0034340 response to type I interferon(GO:0034340)
0.1 3.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 1.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.1 2.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 0.7 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.1 1.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 0.2 GO:0006014 D-ribose metabolic process(GO:0006014)
0.1 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 1.3 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.0 0.2 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
0.0 0.9 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 2.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 6.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.5 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.7 GO:0032933 response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.6 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.6 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.2 GO:0050957 equilibrioception(GO:0050957)
0.0 4.6 GO:0007219 Notch signaling pathway(GO:0007219)
0.0 0.1 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 1.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.2 GO:0043649 dicarboxylic acid catabolic process(GO:0043649)
0.0 2.3 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.0 0.7 GO:0045471 response to ethanol(GO:0045471)
0.0 0.1 GO:0015879 carnitine transport(GO:0015879)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.6 2.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 2.2 GO:0097427 microtubule bundle(GO:0097427)
0.2 2.0 GO:0061574 ASAP complex(GO:0061574)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 1.9 GO:0030057 desmosome(GO:0030057)
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 1.1 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.6 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 2.2 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.2 GO:0097440 apical dendrite(GO:0097440)
0.0 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.4 GO:0016342 catenin complex(GO:0016342)
0.0 0.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 7.6 GO:0005769 early endosome(GO:0005769)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.0 0.5 GO:0016460 myosin II complex(GO:0016460)
0.0 0.2 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.4 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.6 GO:0019808 polyamine binding(GO:0019808)
0.6 1.9 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.6 2.5 GO:0031720 haptoglobin binding(GO:0031720)
0.5 2.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 2.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.2 1.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.2 1.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.2 0.8 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) lead ion transmembrane transporter activity(GO:0015094) vanadium ion transmembrane transporter activity(GO:0015100) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.2 0.5 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 1.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.7 GO:0051525 NFAT protein binding(GO:0051525)
0.1 3.8 GO:0050699 WW domain binding(GO:0050699)
0.1 1.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.7 GO:0015288 porin activity(GO:0015288)
0.1 0.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.1 2.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.1 1.1 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 0.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 3.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.3 GO:0003993 acid phosphatase activity(GO:0003993)
0.0 5.1 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.5 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.6 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.3 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.7 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 0.7 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.2 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.0 2.8 GO:0008168 methyltransferase activity(GO:0008168)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.8 GO:0051213 dioxygenase activity(GO:0051213)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.1 1.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 1.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 0.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 1.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 4.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 3.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 5.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 1.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism