Motif ID: Nr2f6

Z-value: 0.837


Transcription factors associated with Nr2f6:

Gene SymbolEntrez IDGene Name
Nr2f6 ENSMUSG00000002393.8 Nr2f6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr2f6mm10_v2_chr8_-_71381907_713819770.019.3e-01Click!


Activity profile for motif Nr2f6.

activity profile for motif Nr2f6


Sorted Z-values histogram for motif Nr2f6

Sorted Z-values for motif Nr2f6



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr2f6

PNG image of the network

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Top targets:


Showing 1 to 20 of 128 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_121967822 5.127 ENSMUST00000137089.1
 Arhgap29
Rho GTPase activating protein 29
chr19_-_12501996 4.885 ENSMUST00000045521.7
 Dtx4
deltex 4 homolog (Drosophila)
chr12_+_74288735 4.515 ENSMUST00000095617.1
 1700086L19Rik
RIKEN cDNA 1700086L19 gene
chr4_+_85205120 3.834 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr9_+_109051153 3.789 ENSMUST00000155541.1
ENSMUST00000120305.1
ENSMUST00000154113.1
ENSMUST00000128976.1
ENSMUST00000135942.1
ENSMUST00000143754.1
 Shisa5





shisa homolog 5 (Xenopus laevis)





chr4_+_85205417 3.745 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr15_-_95528702 3.234 ENSMUST00000166170.1
 Nell2
NEL-like 2
chr7_+_45896941 3.144 ENSMUST00000069772.7
ENSMUST00000107716.1
 Tmem143

transmembrane protein 143

chr10_-_35711891 2.579 ENSMUST00000080898.2
 Amd2
S-adenosylmethionine decarboxylase 2
chr11_+_32283511 2.453 ENSMUST00000093209.3
 Hba-a1
hemoglobin alpha, adult chain 1
chr8_+_71469186 2.320 ENSMUST00000124745.1
ENSMUST00000138892.1
ENSMUST00000147642.1
 Dda1


DET1 and DDB1 associated 1


chr7_+_45897429 2.319 ENSMUST00000140243.1
 Tmem143
transmembrane protein 143
chr6_+_83156401 2.279 ENSMUST00000032106.4
 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr7_+_98494222 2.253 ENSMUST00000165205.1
 Lrrc32
leucine rich repeat containing 32
chr19_+_47228804 2.203 ENSMUST00000111807.3
 Neurl1a
neuralized homolog 1A (Drosophila)
chr15_+_89532816 2.179 ENSMUST00000167173.1
 Shank3
SH3/ankyrin domain gene 3
chr9_+_20868628 1.942 ENSMUST00000043911.7
 A230050P20Rik
RIKEN cDNA A230050P20 gene
chr9_-_86695897 1.922 ENSMUST00000034989.8
 Me1
malic enzyme 1, NADP(+)-dependent, cytosolic
chr2_+_25242929 1.864 ENSMUST00000114355.1
ENSMUST00000060818.1
 Rnf208

ring finger protein 208

chr2_+_59160838 1.853 ENSMUST00000102754.4
ENSMUST00000168631.1
ENSMUST00000123908.1
 Pkp4


plakophilin 4



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 53 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 7.6 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 6.2 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 4.6 GO:0007219 Notch signaling pathway(GO:0007219)
0.5 4.4 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.4 3.9 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.1 3.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2 2.9 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.9 2.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.3 2.5 GO:0080184 response to stilbenoid(GO:0035634) response to phenylpropanoid(GO:0080184)
0.3 2.3 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 2.3 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032434)
0.7 2.2 GO:0071929 alpha-tubulin acetylation(GO:0071929)
0.1 2.1 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.4 1.9 GO:1902031 regulation of NADP metabolic process(GO:1902031)
0.1 1.9 GO:0034340 response to type I interferon(GO:0034340)
0.1 1.9 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.3 1.7 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 1.7 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.5 1.6 GO:0046098 guanine metabolic process(GO:0046098)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.6 GO:0005769 early endosome(GO:0005769)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.6 2.5 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.7 2.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.2 2.2 GO:0097427 microtubule bundle(GO:0097427)
0.1 2.2 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.2 GO:0097440 apical dendrite(GO:0097440)
0.0 2.1 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 2.0 GO:0061574 ASAP complex(GO:0061574)
0.1 1.9 GO:0030057 desmosome(GO:0030057)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)
0.1 1.1 GO:0005686 U2 snRNP(GO:0005686)
0.1 0.9 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 0.9 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 0.8 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.1 0.7 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.7 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0030165 PDZ domain binding(GO:0030165)
0.1 3.8 GO:0050699 WW domain binding(GO:0050699)
0.0 3.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 2.8 GO:0008168 methyltransferase activity(GO:0008168)
0.6 2.6 GO:0019808 polyamine binding(GO:0019808)
0.6 2.5 GO:0031720 haptoglobin binding(GO:0031720)
0.5 2.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 2.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1 2.0 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.6 1.9 GO:0004473 malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473)
0.2 1.7 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 1.6 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines(GO:0016814)
0.0 1.6 GO:0045182 translation regulator activity(GO:0045182)
0.2 1.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.2 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.1 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.1 1.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.9 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 3.0 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.7 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 1.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.3 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 1.2 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.9 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.8 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.7 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.6 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 5.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.9 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 3.4 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 2.1 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 1.8 REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 1.7 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 1.7 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.6 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.1 1.6 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.3 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 1.0 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.1 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.6 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.6 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME_DEADENYLATION_OF_MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases