Motif ID: Nr4a2

Z-value: 0.496


Transcription factors associated with Nr4a2:

Gene SymbolEntrez IDGene Name
Nr4a2 ENSMUSG00000026826.7 Nr4a2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nr4a2mm10_v2_chr2_-_57124003_571240710.624.5e-05Click!


Activity profile for motif Nr4a2.

activity profile for motif Nr4a2


Sorted Z-values histogram for motif Nr4a2

Sorted Z-values for motif Nr4a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr4a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 110 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 3.865 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr18_+_86711059 3.056 ENSMUST00000068423.3
 Cbln2
cerebellin 2 precursor protein
chr2_+_121295437 1.845 ENSMUST00000110639.1
 Map1a
microtubule-associated protein 1 A
chr9_-_32344237 1.521 ENSMUST00000034533.5
 Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
chr13_+_94875600 1.226 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr2_-_129699833 1.133 ENSMUST00000028883.5
 Pdyn
prodynorphin
chr9_-_106656081 1.053 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr5_+_150259922 0.953 ENSMUST00000087204.5
 Fry
furry homolog (Drosophila)
chr13_+_93303757 0.904 ENSMUST00000109494.1
 Homer1
homer homolog 1 (Drosophila)
chr6_-_99096196 0.849 ENSMUST00000175886.1
 Foxp1
forkhead box P1
chr18_-_56975333 0.840 ENSMUST00000139243.2
ENSMUST00000025488.8
 C330018D20Rik

RIKEN cDNA C330018D20 gene

chr8_+_68880491 0.772 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr6_-_59024340 0.759 ENSMUST00000173193.1
 Fam13a
family with sequence similarity 13, member A
chr6_+_96113146 0.744 ENSMUST00000122120.1
 Fam19a1
family with sequence similarity 19, member A1
chr4_-_36136463 0.701 ENSMUST00000098151.2
 Lingo2
leucine rich repeat and Ig domain containing 2
chr13_+_93304066 0.692 ENSMUST00000109493.1
 Homer1
homer homolog 1 (Drosophila)
chr2_+_75832168 0.691 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr17_+_29360923 0.678 ENSMUST00000024810.6
 Fgd2
FYVE, RhoGEF and PH domain containing 2
chr6_-_59024470 0.662 ENSMUST00000089860.5
 Fam13a
family with sequence similarity 13, member A
chr5_+_111581422 0.637 ENSMUST00000064930.3
 C130026L21Rik
RIKEN cDNA C130026L21 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.8 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.6 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.3 1.5 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 1.2 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 1.1 GO:0014047 glutamate secretion(GO:0014047)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 0.9 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.2 0.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.1 0.8 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.1 0.8 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 0.6 GO:0006597 spermine biosynthetic process(GO:0006597)
0.1 0.6 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.6 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 0.5 GO:0019405 alditol catabolic process(GO:0019405) glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
0.1 0.5 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.5 GO:0032306 regulation of prostaglandin secretion(GO:0032306)
0.0 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.5 GO:0050832 defense response to fungus(GO:0050832)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 1.8 GO:0005875 microtubule associated complex(GO:0005875)
0.0 1.6 GO:0043034 costamere(GO:0043034)
0.0 1.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.1 0.8 GO:0042627 chylomicron(GO:0042627)
0.1 0.8 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 0.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 0.5 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 0.4 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0016460 myosin II complex(GO:0016460)
0.1 0.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.2 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 GO:0005518 collagen binding(GO:0005518)
0.1 1.6 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.2 1.2 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.1 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.9 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.6 GO:0019808 polyamine binding(GO:0019808)
0.1 0.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 0.5 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.5 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.5 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0 0.5 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 0.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 0.4 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.4 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.3 GO:0016174 NAD(P)H oxidase activity(GO:0016174)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.7 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 0.4 PID_EPHA_FWDPATHWAY EPHA forward signaling
0.0 0.2 PID_IL5_PATHWAY IL5-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.5 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.1 REACTOME_G_PROTEIN_ACTIVATION Genes involved in G-protein activation
0.1 1.1 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 0.9 REACTOME_ACTIVATION_OF_THE_AP1_FAMILY_OF_TRANSCRIPTION_FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.8 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.5 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.4 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.3 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.3 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.2 REACTOME_COPI_MEDIATED_TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.2 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.2 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.1 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway