Motif ID: Nr5a2

Z-value: 0.778


Transcription factors associated with Nr5a2:

Gene SymbolEntrez IDGene Name
Nr5a2 ENSMUSG00000026398.8 Nr5a2



Activity profile for motif Nr5a2.

activity profile for motif Nr5a2


Sorted Z-values histogram for motif Nr5a2

Sorted Z-values for motif Nr5a2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr5a2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_-_77347816 3.425 ENSMUST00000184138.1
ENSMUST00000184006.1
ENSMUST00000185144.1
ENSMUST00000034910.9
 Mlip



muscular LMNA-interacting protein



chr8_+_124793013 2.916 ENSMUST00000167588.1
 Trim67
tripartite motif-containing 67
chr8_+_124793061 2.859 ENSMUST00000041106.7
 Trim67
tripartite motif-containing 67
chr9_-_77347787 2.682 ENSMUST00000184848.1
ENSMUST00000184415.1
 Mlip

muscular LMNA-interacting protein

chr15_-_79804717 2.514 ENSMUST00000023057.8
 Nptxr
neuronal pentraxin receptor
chr3_-_54915867 2.337 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr2_+_121357714 2.202 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr19_+_6400523 2.111 ENSMUST00000146831.1
ENSMUST00000035716.8
ENSMUST00000138555.1
ENSMUST00000167240.1
 Rasgrp2



RAS, guanyl releasing protein 2



chr10_+_79716588 2.091 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr9_-_77347889 2.085 ENSMUST00000185039.1
 Mlip
muscular LMNA-interacting protein
chr19_-_57314896 1.982 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr11_+_67586520 1.949 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr2_+_121358591 1.825 ENSMUST00000000317.6
ENSMUST00000129130.1
 Ckmt1

creatine kinase, mitochondrial 1, ubiquitous

chr17_-_83631892 1.800 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr11_+_67586675 1.800 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr10_-_125328957 1.791 ENSMUST00000063318.2
 Slc16a7
solute carrier family 16 (monocarboxylic acid transporters), member 7
chr1_-_134235420 1.741 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_-_56296551 1.682 ENSMUST00000021970.9
 Cxcl14
chemokine (C-X-C motif) ligand 14
chr19_-_46327121 1.671 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr11_+_98741805 1.661 ENSMUST00000064187.5
 Thra
thyroid hormone receptor alpha

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 134 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.5 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.2 5.8 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0 3.7 GO:0030041 actin filament polymerization(GO:0030041)
0.1 3.6 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 2.8 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 2.7 GO:0009060 aerobic respiration(GO:0009060)
0.3 2.6 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 2.6 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 2.5 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.4 2.1 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.0 2.1 GO:0051453 regulation of intracellular pH(GO:0051453)
0.6 1.9 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.3 1.9 GO:1902287 trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637) semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.2 1.9 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.4 1.8 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.6 1.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256)
0.6 1.7 GO:2000501 natural killer cell chemotaxis(GO:0035747) regulation of natural killer cell chemotaxis(GO:2000501)
0.6 1.7 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.1 1.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 1.7 GO:0071805 potassium ion transmembrane transport(GO:0071805)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 69 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.8 GO:0016605 PML body(GO:0016605)
0.0 4.0 GO:0043204 perikaryon(GO:0043204)
0.0 3.4 GO:0005604 basement membrane(GO:0005604)
0.2 2.7 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 2.5 GO:0005884 actin filament(GO:0005884)
0.2 2.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.7 2.1 GO:0098855 HCN channel complex(GO:0098855)
0.2 2.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 2.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 2.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 1.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.9 GO:0043209 myelin sheath(GO:0043209)
0.1 1.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.8 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 1.5 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 1.5 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.5 GO:0000786 nucleosome(GO:0000786)
0.0 1.4 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.4 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 92 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.1 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 4.7 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
1.1 4.3 GO:0004111 creatine kinase activity(GO:0004111)
0.2 4.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.0 GO:0005518 collagen binding(GO:0005518)
0.1 2.8 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.2 2.6 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.6 2.5 GO:0001847 opsonin receptor activity(GO:0001847)
0.5 2.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.6 1.9 GO:0031403 lithium ion binding(GO:0031403)
0.2 1.9 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.4 1.8 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 1.8 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 1.7 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.2 1.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 1.7 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.7 GO:0008009 chemokine activity(GO:0008009)
0.2 1.6 GO:0015288 porin activity(GO:0015288)
0.4 1.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 1.5 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)

Gene overrepresentation in C2:CP category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.2 2.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 2.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.7 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 1.4 PID_MTOR_4PATHWAY mTOR signaling pathway
0.0 1.3 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.0 0.9 PID_ARF_3PATHWAY Arf1 pathway
0.0 0.9 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.0 0.7 PID_ENDOTHELIN_PATHWAY Endothelins
0.1 0.6 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.6 PID_INSULIN_PATHWAY Insulin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.6 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.2 5.6 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 3.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.0 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.2 2.7 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 2.4 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels
0.3 2.1 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 2.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.9 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 1.9 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 1.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 1.7 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 1.6 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.5 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 1.3 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 1.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 1.2 REACTOME_ALPHA_LINOLENIC_ACID_ALA_METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 1.2 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.1 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling